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Ana M Cardoso et al.
International journal of pharmaceutics, 474(1-2), 57-69 (2014-08-12)
Gemini surfactants have been successfully used as components of gene delivery systems. In the present work, a family of gemini surfactants, represented by the general structure [CmH2m+1(CH3)2N(+)(CH2)sN(+)(CH3)2CmH2m+1]2Br(-), or simply m-s-m, was used to prepare cationic gene carriers, aiming at their
Robert G Elkin et al.
Journal of agricultural and food chemistry, 63(10), 2789-2797 (2015-03-11)
The desaturation of α-linolenic acid (ALA) to stearidonic acid (SDA) is considered to be rate-limiting for the hepatic conversion of ALA to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans, rodents, and chickens. Thus, we hypothesized that feeding laying
Isabel Sandez-Macho et al.
Colloids and surfaces. B, Biointerfaces, 133, 270-277 (2015-06-27)
Interactions of X-shaped poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) block copolymers with cell membranes were investigated recording the π-A isotherms of monolayer systems of dipalmitoylphosphatidylcholine (DPPC):cholesterol 100:0; 80:20 and 60:40 mol ratio and evaluating the capability of the copolymers to trigger haemolysis
Daisy L Daubert et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(2), R212-R224 (2014-05-16)
Repeated stress and chronically elevated glucocorticoids cause exaggerated cardiovascular responses to novel stress, elevations in baseline blood pressure, and increased risk for cardiovascular disease. We hypothesized that elevated corticosterone (Cort) within the dorsal hindbrain (DHB) would: 1) enhance arterial pressure
Ryeo-Eun Go et al.
Journal of medicinal food, 18(3), 363-369 (2014-11-14)
Palm oil is a common cooking ingredient used in the commercial food industry as the second largest consumed vegetable oil in the world. Because of its lower cost and highly saturated nature, it usually maintains a solid form at room
Katherine S Wainright et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(5), R594-R602 (2015-07-17)
Regular physical activity is effective in reducing visceral white adipose tissue (AT) inflammation and oxidative stress, and these changes are commonly associated with reduced adiposity. However, the impact of multiple periods of physical activity, intercalated by periods of inactivity, i.e.
S Bellanger et al.
Laboratory animals, 49(3), 228-240 (2015-01-08)
The dog is a widely-used model for conducting metabolic studies. This is mainly due to its large size and its physiology which is relatively similar to that of humans. Here, we attempted to optimize a postprandial metabolic study protocol used
Juergen Graessler et al.
Atherosclerosis. Supplements, 18, 170-175 (2015-05-06)
Previously we found a highly significant increase of phosphatidylethanolamines (PE) in response to acute lipoprotein apheresis (LA) with whole blood dextran sulfate adsorption (DSA) in contrast to the overall tendency of reduction of lipid metabolites of all lipid classes in
Ana M Gómez-Úriz et al.
Human molecular genetics, 24(5), 1432-1440 (2014-11-28)
Obesity and stroke are multifactorial diseases in which genetic, epigenetic and lifestyle factors are involved. The research aims were, first, the description of genes with differential epigenetic regulation obtained by an 'omics' approach in patients with ischemic stroke and, second
Megumi Nishimukai et al.
Clinica chimica acta; international journal of clinical chemistry, 437, 147-154 (2014-07-30)
Identifying risk factors is crucial for preventing cardiovascular events, but there are no widely accepted predictive biomarkers. In our previous study of Japanese asymptomatic cohorts, we performed global analysis of serum ether glycerophospholipids (Egp) molecular profiles, and found that choline
Jennifer Q Dong et al.
British journal of clinical pharmacology, 80(5), 1051-1063 (2015-05-06)
The aim of the present study was to evaluate the pharmacokinetics/pharmacodynamics (PK/PD), safety and tolerability of single intravenous (IV) doses of PF-05231023, a long acting fibroblast growth factor 21 (FGF21) analogue being developed for the treatment of type 2 diabetes
Yonghae Son et al.
Biochemical and biophysical research communications, 457(3), 324-327 (2015-01-13)
Hypertension is a high-risk symptom in atherosclerotic patients, and vascular rigidity is one of the main factors leading to hypertension. β1-Subunit of BKCa channel (KCNMB1; MaxiKβ1) has been reported as a modulator of vascular flexibility. To determine the relationship between
Adriana Riojas-Hernández et al.
Life sciences, 141, 32-43 (2015-09-27)
Obesity and diabetes mellitus type 2 (DM2) frequently coexist and increase the propensity of cardiovascular dysfunction by numerous mechanisms. Chief among them are oxidative stress and Ca(2+) dysregulation, and both are inducers of the mitochondrial permeability transition pore (MPTP). Nevertheless
E Thomas Danielsen et al.
PLoS genetics, 10(6), e1004343-e1004343 (2014-06-20)
Specialized endocrine cells produce and release steroid hormones that govern development, metabolism and reproduction. In order to synthesize steroids, all the genes in the biosynthetic pathway must be coordinately turned on in steroidogenic cells. In Drosophila, the steroid producing endocrine
Yan Liu et al.
Atherosclerosis, 238(1), 45-51 (2014-12-02)
This study was to examine the association between plasma retinol binding protein 4 (RBP4) levels and the complexity of angiographic coronary lesion in patients with coronary artery disease (CAD). A cross-sectional and prospective study was carried out in Guangzhou Chinese
Asma Javed et al.
Thyroid : official journal of the American Thyroid Association, 25(5), 478-484 (2015-03-18)
Thyrotropin (TSH) levels display a positive association with body mass index (BMI), and the prevalence of isolated hyperthyrotropinemia is higher in obese adolescents compared to their normal weight controls. However, the metabolic significance of the higher TSH in obese adolescents
Thomas Bonsen et al.
Journal of sleep research, 24(2), 140-147 (2014-11-18)
Sleep and sleep disorders are related to cardiovascular disease, and microvascular function is an early cardiovascular disease marker. Therefore, the relationship of sleep (measured in sleep quality and duration) with microvascular function was examined in healthy adults. Sleep quality was
Pulak R Manna et al.
Biochemical and biophysical research communications, 464(1), 312-317 (2015-06-30)
Removal of cholesterol from macrophage-derived foam cells is a critical step to the prevention of atherosclerotic lesions. We have recently demonstrated the functional importance of retinoids in the regulation of the steroidogenic acute regulatory (StAR) protein that predominantly mediates the
Anne Langsted et al.
The Journal of clinical endocrinology and metabolism, 100(7), 2690-2699 (2015-05-06)
It is unknown whether elevated lipoprotein(a) is causally associated with low-grade inflammation. We tested the hypothesis that elevated lipoprotein(a) is observationally and causally associated with low-grade inflammation together with aortic valve stenosis and myocardial infarction. Using a multidirectional Mendelian randomization
Andreas G Moraitis et al.
Journal of clinical lipidology, 9(1), 81-90 (2015-02-12)
Low high-density lipoprotein cholesterol (HDL-C) is a risk factor for coronary artery disease. Investigating mechanisms underlying acquired severe HDL deficiency in noncritically ill patients ("disappearing HDL syndrome") could provide new insights into HDL metabolism. To determine the cause of low
Assessing the clinical benefits of lipid-disorder drugs.
William R Hiatt et al.
The New England journal of medicine, 370(5), 396-399 (2014-01-31)
Larry A Barr et al.
Nitric oxide : biology and chemistry, 46, 145-156 (2015-01-13)
Diabetic cardiomyopathy is a significant contributor to the morbidity and mortality associated with diabetes and metabolic syndrome. However, the underlying molecular mechanisms that lead to its development have not been fully elucidated. Hydrogen sulfide (H2S) is an endogenously produced signaling
Victor M Victor et al.
Atherosclerosis, 242(1), 167-173 (2015-07-21)
We aim to assess the effect of metformin treatment on metabolic parameters, endothelial function and inflammatory markers in polycystic ovary syndrome (PCOS) subjects. The study population consisted of 40 reproductive-age women with PCOS, who underwent treatment with metformin during a
Marian Kampschulte et al.
Laboratory investigation; a journal of technical methods and pathology, 94(11), 1273-1282 (2014-09-10)
Nonalcoholic fatty liver disease has been linked to cardiovascular diseases and atherosclerosis. The aim of the current study was to characterize the hepatic pathology leading to fibrosis and tumors in a murine model of atherosclerosis. Male apolipoprotein E/low-density lipoprotein receptor
Milda Zilnyte et al.
Toxins, 7(1), 110-128 (2015-01-16)
Gardnerella vaginalis produces cytolysin vaginolysin (VLY), which has been suggested to be a contributor to bacterial vaginosis pathogenesis. VLY along with intermedilysin (ILY) from Streptococcus intermedius have been attributed to a group of cholesterol-dependent cytolysins (CDCs) whose pore-forming activity depends
Yunfei Zhang et al.
Oncology reports, 33(6), 2695-2702 (2015-05-13)
Tumor-derived heat shock proteins peptide complex (HSP.PC-Tu) has been regarded as a promising antitumor agent. However, inadequate immunogenicity and low bioavailability limit the clinical uses of this agent. In a previous study, we first produced an improved HSP70.PC-based vaccine purified
Berniza Calderón et al.
Obesity surgery, 24(10), 1686-1692 (2014-03-26)
Bariatric surgery results in the complete resolution of male obesity-associated secondary hypogonadism (MOSH) in many patients. However, the effects of different bariatric surgical procedures on male sexual hormone profiles and sexual dysfunction have not been compared to date. We compared
María Eugenia Vaquero et al.
Applied microbiology and biotechnology, 99(23), 10057-10067 (2015-08-15)
Lipases from the Candida rugosa-like family are enzymes with great biotechnological interest. In a previous work, several enzymes from this family were identified by in silico mining of fungal genomes. Here, we describe the cloning, expression, and characterization of putative
Ben J Wu et al.
International journal of cardiology, 199, 204-212 (2015-07-24)
High density lipoprotein (HDL) infusions increase new blood vessel formation (angiogenesis) in rodents with ischemic injury. This study asks if increasing HDL levels by inhibiting cholesteryl ester transfer protein (CETP) activity increases angiogenesis in New Zealand White (NZW) rabbits with
Preeya Leelahagul et al.
Asian Pacific journal of allergy and immunology, 33(1), 59-64 (2015-04-05)
To assess three plasma adipokines that might act as biomarkers useful in determining persons exposed to asbestos. Sixty subjects were included in the study, 30 male workers from factories manufacturing cement products using chrysotile asbestos, and 30 volunteer controls comprising
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