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Martine A Boks et al.
The Journal of investigative dermatology, 135(11), 2697-2704 (2015-06-18)
Dendritic cells (DCs) have an important role in tumor control via the induction of tumor-specific T-cell responses and are therefore an ideal target for immunotherapy. The human skin is an attractive site for tumor vaccination as it contains various DC
Jiang Ma et al.
Journal of ethnopharmacology, 162, 61-68 (2015-01-06)
Polygoni Multiflori Radix (PMR) has been traditionally used as a tonic and an anti-aging remedy for centuries; however, hepatic lesions linked to PMR have been frequently reported. This work attempted to investigate the hepatotoxic potential of PMR extract and the
You-Cheol Hwang et al.
Acta diabetologica, 51(6), 941-946 (2014-05-13)
The association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined. The aims of this study were to investigate whether AD, characterized by increased serum apoB and non-HDL
Sheida Shariat et al.
Cancer letters, 355(1), 54-60 (2014-09-17)
Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based
Chao Zeng et al.
Scientific reports, 5, 13765-13765 (2015-09-05)
This prospective study aimed to investigate the relationship between higher hematocrit (Hct) level and hyperuricemia (HU) incidence. A total of 27,540 subjects were included. Baseline Hct was classified into four categories based on the quartile distribution of the study population.
Michael R Preusch et al.
Drug design, development and therapy, 9, 5203-5211 (2015-09-24)
Thrombin has multiple proatherogenic effects including platelet activation and the induction of inflammatory processes. Recently, the cytokine oncostatin M has been shown to have proinflammatory effects. This study was designed to investigate the effects of thrombin inhibition on the initiation
Liwei Zhang et al.
Cardiovascular drugs and therapy, 28(4), 303-311 (2014-06-14)
Inflammation participates centrally in all stages of atherosclerosis (AS), which begins with pro-inflammatory processes and inflammatory changes in the endothelium, related to lipid metabolism. MicroRNA (miRNA) inhibition of inflammation related to SIRT1 has been shown to be a promising therapeutic
Huseyin Altug Cakmak et al.
Therapeutics and clinical risk management, 11, 1641-1648 (2015-11-21)
Hypertension, diabetes mellitus, and osteoporosis are important comorbidities commonly seen in postmenopausal women. The aim of the present study was to investigate the relationships between blood pressure, blood glucose, and bone mineral density (BMD) in postmenopausal Turkish women. In this
Caroline Damico Candido et al.
Journal of pharmaceutical sciences, 103(10), 3297-3301 (2014-08-08)
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich solid tumor (EST) and the heart
Yumin Wen et al.
BMC complementary and alternative medicine, 15, 155-155 (2015-05-28)
Yi Qi Qing Re Gao (YQQRG) formula is a traditional Chinese herbal medicine used to treat chronic nephritis. This study was designed to evaluate the underlying mechanism in the use of YQQRG formula to treat nephrosis induced by puromycin aminonucleoside
Paulo Cury Rezende et al.
Cardiovascular diabetology, 14, 66-66 (2015-05-31)
The influence of diabetes mellitus on myocardial ischemic preconditioning is not clearly defined. Experimental studies are conflicting and human studies are scarce and inconclusive. Identify whether diabetes mellitus intervenes on ischemic preconditioning in symptomatic coronary artery disease patients. Symptomatic multivessel
Viviam de Oliveira Silva et al.
PloS one, 10(8), e0134742-e0134742 (2015-08-21)
The objective of this study was to assess the effects of oral ingestion of β-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease.
Atsushi Izawa et al.
Circulation journal : official journal of the Japanese Circulation Society, 79(1), 161-168 (2014-11-14)
Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI). A prospective
C K H Wong et al.
Diabetes, obesity & metabolism, 17(2), 128-135 (2014-09-25)
To assess whether a structured diabetes education programme, the Patient Empowerment Programme (PEP), was associated with a lower risk of first cardiovascular disease (CVD) event and all-cause mortality in a population-based cohort of patients with type 2 diabetes mellitus (T2DM)
Zachary B Armstrong et al.
The Canadian journal of cardiology, 30(9), 1096-1103 (2014-04-15)
Aortic valve sclerosis (AVS) is a chronic progressive disease involving lipid infiltration, inflammation, and tissue calcification. Despite its high prevalence, there are currently no clinically approved pharmaceuticals for the management of AVS. The objective of the current study was to
Xiao-Ling Cai et al.
Chinese medical journal, 128(10), 1279-1287 (2015-05-13)
At present, China has listed the compound tablet containing a fixed dose of rosiglitazone and metformin, Avandamet, which may improve patient compliance. The aim of this study was to evaluate the efficacy and safety of Avandamet or uptitrated metformin treatment
Xiaobo He et al.
Environmental research, 137, 458-466 (2015-02-14)
Electronic waste (e-waste) has created a worldwide environmental and health problem, by generating a diverse group of hazardous compounds such as persistent organic pollutants (POPs). Our previous studies demonstrated that populations from e-waste exposed region have a significantly higher level
P J Forshaw et al.
Journal of neurochemistry, 79(2), 400-406 (2001-10-26)
In humans and other vertebrates, reaction of organophosphates with a neuronal membrane protein, neuropathy target esterase (NTE), initiates events which culminate in axonal degeneration. The initiation process appears to involve modification of a property of the protein distinct from its
Shunsuke Kanno et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 773-780 (2014-12-10)
Atherosclerosis is essentially a vascular inflammatory process in the presence of an excess amount of lipid. We have recently reported that oral administration of a nucleotide-binding oligomerization domain (Nod)-1 ligand, FK565, induced vascular inflammation in vivo. No studies, however, have
Nobuya Inagaki et al.
Journal of diabetes investigation, 6(2), 210-218 (2015-03-25)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor under development for the treatment of type 2 diabetes. Our aim was to examine its efficacy and safety as monotherapy or in combination with commonly used oral antihyperglycemic drugs in Japanese patients with
Hanna Shevalye et al.
Journal of neurophysiology, 114(1), 199-208 (2015-05-01)
The purpose of this study was to determine the effect of supplementing the diet of a mouse model of type 2 diabetes with menhaden (fish) oil or daily treatment with resolvin D1 on diabetic neuropathy. The end points evaluated included
Seiichiro Aoe et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1141-1146 (2015-04-03)
Konjac-mannan has been suggested to exert a protective effect against visceral obesity. However, there is little knowledge about the effects of liquid konjac (LK) that is partially alkali gelled. The purpose of the present work was to evaluate the potential
Rgia A Othman et al.
Atherosclerosis, 231(2), 291-299 (2013-11-26)
Sitosterolemia (STSL) is a rare autosomal recessive disease, manifested by extremely elevated plant sterols (PS) in plasma and tissue, leading to xanthoma and premature atherosclerotic disease. Therapeutic approaches include limiting PS intake, interrupting enterohepatic circulation of bile acid using bile
Lili Ding et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 474-483 (2014-09-11)
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acids, and triglycerides. We investigated the effect of the specific SREBP suppressor andrographolide, a natural compound isolated from Andrographis paniculata
Jun Zhou et al.
Carbohydrate polymers, 121, 199-206 (2015-02-11)
The present study was designed to investigate the hypoglycemic activity and the potential mechanisms of Misgurnus anguillicaudatus polysaccharide (MAP) in streptozotocin-induced diabetic mice. MAP oral administration significantly decreased the blood levels of glucose, TC, TG, LDL-C, and increased the blood
Karina Fischer et al.
The American journal of clinical nutrition, 101(4), 794-807 (2015-04-04)
Visceral (VAT) and subcutaneous abdominal (SAAT) and trunk (STRAT) adipose tissue (AT) have been suggested to be differentially influenced by diet. We investigated whether and to what extent usual patterns of nutrient intake are associated with VAT, SAAT, and STRAT
Constance Gayet-Boyer et al.
The British journal of nutrition, 112(12), 1914-1922 (2014-10-28)
The effects of ruminant (R) trans-fatty acids (TFA) on the risk of CVD are still under debate. It could be argued that the lack of the effect of R-TFA may be the result of the small amount of their intake.
Niloofar Moghadas-Sharif et al.
Drug development and industrial pharmacy, 41(3), 445-450 (2014-01-11)
The aim of the present study was to assess the in vitro antimicrobial activities of nanoliposomal formulations loaded with vancomycin or/and rifampin against the biofilm formed by Staphylococcus epidermidis at 37 °C under aerobic condition. Liposomal formulations were prepared by dehydration-rehydration
Giorgio Sesti et al.
PloS one, 9(8), e104941-e104941 (2014-08-12)
Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage) is associated with more pronounced cardiovascular organ
Edina Lump et al.
eLife, 4 (2015-08-19)
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we establish that CLR01, a 'molecular
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