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Katsumi Shibata et al.
Advances in experimental medicine and biology, 527, 435-441 (2004-06-23)
There is the report that the deaths by pellagra in women is approximately twofold excess that in men. In the present experiment, in order to clarify a factor in the etiology of pellagra in female and to get basic information
D Theofylaktopoulou et al.
Clinical and experimental immunology, 173(1), 121-130 (2013-04-24)
Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway. We measured neopterin, tryptophan, kynurenine, anthranilic acid
Andreas C Raabe et al.
Cellular microbiology, 13(7), 955-966 (2011-04-27)
Critical events in the life cycle of malaria parasites are controlled by calcium-dependent signalling cascades, yet the molecular mechanisms of calcium release remain poorly understood. The synchronized development of Plasmodium berghei gametocytes relies on rapid calcium release from internal stores
Caroline M Forrest et al.
Neurochemistry international, 100, 110-119 (2016-09-14)
To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy. There
Vadim V Yanshole et al.
Physical chemistry chemical physics : PCCP, 12(32), 9502-9515 (2010-07-10)
The properties of xanthurenic acid (XAN) in ground and photoexcited states have been studied using steady-state and time-resolved optical methods as well as quantum chemistry calculations. In neutral aqueous solution and in alcohols, XAN is present in a single tautomeric
Dezhen Wang et al.
Environmental pollution (Barking, Essex : 1987), 222, 532-542 (2017-01-04)
Epidemiological studies indicate that exposure to persistent organic pollutants is positively associated with the prevalence of obesity. To delineate the potential role of technical-grade chlordane in obesity development, chlordane metabolism and chlordane-induced metabolic changes were investigated in mice fed high-fat
Brian Crow et al.
Biomedical chromatography : BMC, 22(12), 1346-1353 (2008-07-26)
The separation and detection of 11 urinary aromatic acids was developed using HPLC-MS/MS. The method features a simple sample preparation involving a single-step dilution with internal standard and a rapid 8 min chromatographic separation. The accuracy was evaluated by the
Elena Lantero et al.
Biomolecules, 10(8) (2020-08-06)
Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes.
D S Raj et al.
Blood purification, 18(2), 97-102 (2000-06-06)
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.
Manuela Schmid et al.
The Journal of biological chemistry, 287(24), 20197-20207 (2012-04-27)
The obligate intracellular apicomplexan parasites, e.g. Toxoplasma gondii and Plasmodium species, induce an IFNγ-driven induction of host indoleamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme of tryptophan catabolism in the kynurenine pathway. Induction of IDO1 supposedly depletes cellular levels of
Microwave assisted synthesis of a small library of substituted N, N′-bis ((8-hydroxy-7-quinolinyl) methyl)-1, 10-diaza-18-crown-6 ethers.
Farruggia G, et al.
The Journal of Organic Chemistry, 75(18), 6275-6278 (2010)
Milane S Leite et al.
Experimental parasitology, 121(2), 137-143 (2008-11-26)
Trypanosoma brucei brucei is the causative agent of animal African trypanosomiasis, also called nagana. Procyclic vector form resides in the midgut of the tsetse fly, which feeds exclusively on blood. Hemoglobin digestion occurs in the midgut resulting in an intense
Badgar Battsetseg et al.
Parasitology research, 105(3), 669-679 (2009-04-22)
A complementary DNA coding a novel kynurenine aminotransferase (KAT) molecule from Haemaphysalis longicornis tick embryo was cloned and characterized. The transcription of the HlKAT occurs at all stages during tick development as well as in the midgut, salivary glands, ovary
T Igari et al.
The Tohoku journal of experimental medicine, 153(2), 79-86 (1987-10-01)
Tryptophan, its metabolites and related enzyme activity in synovial fluid, blood and urine in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were measured. The levels of tryptophan, kynurenine and anthranilic acid in the synovial fluid higher in RA were
Kentaro Kato et al.
Parasitology international, 58(4), 394-400 (2009-08-12)
In Plasmodium berghei, the orthologous gene of P. falciparum calcium-dependent protein kinase 4 (PfCDPK4) was reported to be essential for the exflagellation of male gametocytes. To elucidate the role of PfCDPK4 in P. falciparum gametogenesis, we characterized the biological function
Maria Penzo et al.
Scientific reports, 9(1), 7005-7005 (2019-05-09)
Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental stages. An imidazopyridine PKG inhibitor scaffold
Vitor L A Lima et al.
PloS one, 7(6), e38349-e38349 (2012-06-16)
In the midgut of the mosquito Aedes aegypti, a vector of dengue and yellow fever, an intense release of heme and iron takes place during the digestion of a blood meal. Here, we demonstrated via chromatography, light absorption and mass
Hala E Hussein et al.
PLoS neglected tropical diseases, 11(10), e0005965-e0005965 (2017-10-07)
Babesia bovis, is a tick borne apicomplexan parasite responsible for important cattle losses globally. Babesia parasites have a complex life cycle including asexual replication in the mammalian host and sexual reproduction in the tick vector. Novel control strategies aimed at
Yan Li et al.
International journal of molecular sciences, 16(7), 15150-15171 (2015-07-08)
Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestations of SLE. Among the potential pathophysiological mechanisms responsible for NP-SLE
C S Copeland et al.
Neuropharmacology, 66, 133-142 (2012-04-12)
Xanthurenic acid (XA), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, has recently been identified as an endogenous Group II (mGlu2 and mGlu3) metabotropic glutamate (mGlu) receptor ligand in vitro. Impairments in Group II mGlu receptor expression and
Namgyu Lee et al.
Oncogene, 39(35), 5709-5720 (2020-07-28)
It is well recognized that many metabolic enzymes play essential roles in cancer cells in producing building blocks such as nucleotides, which are required in greater amounts due to their increased proliferation. On the other hand, the significance of enzymes
Junichi Odo et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 27(1), 105-109 (2011-01-15)
The fluorescent derivatization of tryptophan metabolites (xanthurenic acid, nicotinic acid, picolinic acid, and 3-hydroxyanthranilic acid) by the catalytic activity of horseradish peroxidase (HRP) was investigated in the presence of excess H(2)O(2). Non-fluorescent xanthurenic acid (XA) and nicotinic acid (NA) were
D S Gill et al.
Journal of clinical pathology, 44(3), 243-245 (1991-03-01)
Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to
Sofia Basova et al.
Biomedicines, 8(8) (2020-08-05)
The rapid development of parasite drug resistance as well as the lack of medications targeting both the asexual and the sexual blood stages of the malaria parasite necessitate the search for novel antimalarial compounds. Eleven organoarsenic compounds were synthesized and
Mengying Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1086, 1-10 (2018-04-15)
Rheumatoid arthritis (RA) is a chronic disease with pain, swelling, and limitation in the motion and function of multiple joints thus leading to high disability. Previous studies have shown that flavonoids and saponins are the most abundant and active constituents
D O McGregor et al.
Kidney international, 59(6), 2267-2272 (2001-05-31)
Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine
Michael J Delves et al.
Nature communications, 9(1), 3805-3805 (2018-09-20)
Spread of parasite resistance to artemisinin threatens current frontline antimalarial therapies, highlighting the need for new drugs with alternative modes of action. Since only 0.2-1% of asexual parasites differentiate into sexual, transmission-competent forms, targeting this natural bottleneck provides a tangible
Ilona Sadok et al.
Journal of pharmaceutical and biomedical analysis, 176, 112805-112805 (2019-08-16)
Kynurenine pathway is the main route of tryptophan degradation generating a number of immunoregulatory compounds. Some conditions like oxidative stress, inflammatory factors might enhance tryptophan degradation. Process is active in several cells including fibroblasts, cancer cells, and immune cells, therefore
Zhidan Chen et al.
Journal of the American Society for Mass Spectrometry, 29(8), 1650-1664 (2018-05-08)
High-throughput methods to assess radiation exposure are a priority due to concerns that include nuclear power accidents, the spread of nuclear weapon capability, and the risk of terrorist attacks. Metabolomics, the assessment of small molecules in an easily accessible sample
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