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D2650

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Joana Soares et al.
Pharmacological research, 95-96, 42-52 (2015-03-31)
Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for...
Liang Chen et al.
Journal of hazardous materials, 286, 624-631 (2015-02-11)
Fluorides negatively affect the development of organisms and are a threat to human health and environmental safety. In this study, Bombyx mori N cell line (BmN) were used to explore effects of NaF on insect cells. We found that 8h...
Daysi Perez-Rea et al.
Analytical and bioanalytical chemistry, 407(15), 4315-4326 (2015-05-01)
We have investigated methods of starch dissolution with the aim of finding an optimum method to completely dissolve starch granules to form a molecularly dissolved starch solution without degradation of the polymers. Glycogen was used as a model molecule for...
Katarzyna Kaczyńska et al.
Neuropeptides, 54, 29-34 (2015-09-08)
The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to the cardiorespiratory responses produced by an intravenous injection of sulfated cholecystokinin octapeptide (CCK-8) in anesthetized rats. This compound...
Bret K Samelson et al.
The Journal of biological chemistry, 290(22), 14107-14119 (2015-04-18)
Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected substrates to control the efficacy, context, and duration of neuronal phosphorylation events. The A-kinase anchoring protein AKAP79/150 interacts with protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase...
María C Blanco et al.
European journal of medicinal chemistry, 86, 291-309 (2014-09-01)
New series of polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines were designed and synthesized in moderate to high yields using a three-step procedure from ortho-allylanilines. Their antiparasitic activity was evaluated against the extracellular and intracellular forms of Trypanosoma cruzi and Leishmania (Leishmania) infantum...
Nitira Anakkul et al.
Theriogenology, 82(8), 1137-1144 (2014-09-02)
Generally, laparoscopic artificial insemination (LAI) provides a higher success rate than of cervical insemination in goats. However, the sperm distribution after LAI in goats remains unknown, particularly when frozen-thawed semen is used. This study evaluated the distribution of frozen-thawed goat...
Isabel Meister et al.
Antimicrobial agents and chemotherapy, 58(9), 5466-5472 (2014-07-02)
A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth...
Elise Ivarsen et al.
Journal of AOAC International, 97(5), 1282-1290 (2015-04-24)
Clostridium perfringens is the causative agent of necrotic enteritis leading to significant losses in the poultry industry. Dichloromethane and n-hexane extracts of aerial parts of Artemisia annua (Asteraceae) exhibited activity against C. perfringens with minimum inhibitory concentrations (MIC) of 185...
Fengxiao Hu et al.
Environmental toxicology and pharmacology, 39(3), 997-1007 (2015-04-12)
Tetrabromobisphenol A (TBBPA) is currently the most widely used brominated flame retardant (BFR). In this study, the bioaccumulation of TBBPA and its consequent detoxification responses were examined in the scallop Chlamys farreri over 10 days' exposure. Chemical analysis showed that...
M A Caporizzo et al.
Langmuir : the ACS journal of surfaces and colloids, 31(10), 3027-3038 (2015-02-18)
This study systematically investigates how polymer composition changes nanoparticle (NP) grafting and diffusion in solvated random copolymer thin films. By thermal annealing from 135 to 200 °C, thin films with a range of hydrophobicity are generated by varying acrylic acid...
A S Garanina et al.
Biochemistry. Biokhimiia, 80(11), 1469-1477 (2015-11-30)
Entosis is a type of cell cannibalism during which one cell penetrates into another cell and usually dies inside it. Researchers mainly pay attention to initial and final stages of entosis. Besides, tumor cells in suspension are the primary object...
Jie Zhang et al.
Platelets, 26(5), 437-442 (2014-06-24)
Carmustine is one of the alkylating chemotherapeutic agents, which are used to treat various types of cancers, such as brain tumors, Hodgkins and non-Hodgkins lymphoma and multiple myeloma. However, carmustine has the side effect of thrombocytopenia, and the mechanism is...
Liping Teng et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 73, 29-34 (2015-07-28)
Stromal cell-derived factor-1 (SDF-1)/chemokine (CXC motif) ligand 12 (CXCL12) is involved in the process of tumor progression. Sulfated K5 polysaccharides have shown anti-cancer activity by acting on multiple targets, though it remains unclear whether sulfated K5 polysaccharides would disrupt SDF-1/CXCL12-stimulated...
Rui Shi et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 24(11), 2411-2424 (2015-08-01)
The potential of stem cell niches (SCNs) in the intervertebral disc (IVD) region, which may be of great significance in the regeneration process, was recently proposed. To the best of our knowledge, no previous in vitro study has examined the...
Aleta Pupovac et al.
Immunology and cell biology, 93(1), 77-85 (2014-08-27)
Activation of the P2X7 receptor by the extracellular damage-associated molecular pattern, adenosine 5'-triphosphate (ATP), induces the shedding of cell surface molecules including the low-affinity IgE receptor, CD23, from human leukocytes. A disintegrin and metalloprotease (ADAM) 10 mediates P2X7-induced shedding of...
Mabel Lum et al.
International journal of medical microbiology : IJMM, 304(5-6), 530-541 (2014-04-24)
Shigella infection in epithelial cells induces cell death which is accompanied by mitochondrial dysfunction. In this study the role of the mitochondrial fission protein, Drp1 during Shigella infection in HeLa cells was examined. Significant lactate dehydrogenase (LDH) release was detected...
Fan Li et al.
International journal of biological macromolecules, 72, 664-672 (2014-09-02)
The crude polysaccharides of Dendrobium huoshanense were fractionated by anion-exchange chromatography and gel permeation chromatography, giving one homogeneous fraction DHP-4A with molecular weight of 2.32 × 10(5)Da. UV spectrum indicated that there was no existence of proteins and nucleic acids...
Rishabh Agarwal et al.
ACS chemical neuroscience, 6(3), 494-504 (2015-02-18)
Luminescent semiconductor ∼9.5 nm nanoparticles (quantum dots: QDs) have intrinsic physiochemical and optical properties which enable us to begin to understand the mechanisms of nanoparticle mediated chemical/drug delivery. Here, we demonstrate the ability of CdSe/ZnS core/shell QDs surface functionalized with...
Daniela Surico et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(6), 2108-2120 (2015-08-19)
Previous reports have made it hypothetically possible that human chorionic gonadotropin (hCG) could protect against the onset of pregnancy-related pathological conditions by acting as an antioxidant. In the present study we planned to examine the effects of hCG against oxidative...
Louise Pallant et al.
Parasites & vectors, 8, 2-2 (2015-01-07)
Giardia is now considered the most common enteric parasite in well cared for dogs and cats in developed countries. The ecology, epidemiology and clinical impact of infections with this parasite in such animals is still not fully understood due to...
Yuki Kondo et al.
Drug metabolism and pharmacokinetics, 29(3), 237-243 (2013-12-18)
The use of human induced pluripotent stem (iPS) cells would be of great value for a variety of applications involving drug development studies. Several reports have been published on the differentiation of human iPS cells into hepatocyte-like cells; however, the...
Robert M Sharkey et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(22), 5131-5138 (2015-06-25)
This study examined the delivery of SN-38 to Trop-2-expressing tumors and assessed the constitutive products in the serum, liver, and small intestine in nude mice bearing human tumor xenografts (Capan-1 or NCI-N87) given a single injection of irinotecan (40 mg/kg;...
Afzal Hussain et al.
Drug development and industrial pharmacy, 41(5), 780-790 (2014-03-25)
To characterize the enhanced stability and permeation potential of amphotericin B nanoemulsion comprising sefsol-218 oil at varying pH and temperature of aqueous continuous phase. Several batches of amphotericin B loaded nanoemulsion were prepared and evaluated for their physical and chemical...
Alexandra Sorvina et al.
Cells, 9(2) (2020-02-09)
Innate immunity is critical for host defence against pathogen and environmental challenge and this involves the production and secretion of immune mediators, such as antimicrobial peptides and pro-inflammatory cytokines. However, when dysregulated, innate immunity can contribute to multifactorial diseases, including...
Elżbieta A Trafny et al.
International journal of medical microbiology : IJMM, 304(5-6), 554-564 (2014-04-29)
Haemophilus influenzae is one of the major pathogenic bacteria in upper respiratory tract of children. In this study, the presence of various H. influenzae genotypes were followed-up for at least 13 weeks, starting from one week before surgery. Forty-one children...
Mia Halme et al.
Rapid communications in mass spectrometry : RCM, 29(14), 1279-1287 (2015-09-26)
Sulfur mustard is a chemical warfare agent (CWA) with high toxicity and complex metabolism. This study aimed at identification of new metabolic biomarkers for sulfur mustard using in in vitro exposures and various mass spectrometric techniques. Human and pig liver...
João Kleber Novais Pereira et al.
European journal of cancer (Oxford, England : 1990), 51(14), 2076-2085 (2015-08-05)
Constitutive activation of the PI3K pathway in T cell acute lymphoblastic leukaemia (T-ALL) has been reported and in a mouse model, PI3K activation, together with MYC, cooperates in Burkitt lymphoma (BL) pathogenesis. We investigated the effects of NVP-BKM120, a potent...
Jiaojiao Zhang et al.
Mechanisms of development, 138 Pt 3, 328-335 (2015-08-08)
The zebrafish pronephric tubule consists of proximal and distal segments and a collecting duct. The proximal segment is subdivided into the neck, proximal convoluted tubule (PCT) and proximal straight tubule (PST) segments. The distal segment consists of the distal-early (DE)...
Rajaneesh Karimpurath Gopinath et al.
Genome biology and evolution, 6(10), 2851-2865 (2014-10-16)
Hsp90 is one of the most abundant and conserved proteins in the cell. Reduced levels or activity of Hsp90 causes defects in many cellular processes and also reveals genetic and nongenetic variation within a population. Despite information about Hsp90 protein-protein...
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