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Maciej J Smialek et al.
Cells, 9(4) (2020-04-23)
Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize
James S Rush et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(37), 13242-13247 (2005-09-06)
Class switch recombination (CSR) is the process by which B cells alter the effector function properties of their Ig molecules. The decision to switch to a particular Ig isotype is determined primarily by the mode of B cell activation and
Nicole C Grieder et al.
PloS one, 3(9), e3241-e3241 (2008-09-20)
There is increasing evidence that tissue-specific modifications of basic cellular functions play an important role in development and disease. To identify the functions of COPI coatomer-mediated membrane trafficking in Drosophila development, we were aiming to create loss-of-function mutations in the
Helen L Rose et al.
PloS one, 6(7), e22668-e22668 (2011-08-06)
Eight DNA extraction products or methods (Applied Biosystems PrepFiler Forensic DNA Extraction Kit; Bio-Rad Instagene Only, Bio-Rad Instagene & Spin Column Purification; EpiCentre MasterPure DNA & RNA Kit; FujiFilm QuickGene Mini80; Idaho Technologies 1-2-3 Q-Flow Kit; MoBio UltraClean Microbial DNA
I A Afonina et al.
BioTechniques, 32(4), 940-944 (2002-04-19)
Here we describe the properties of a novel class of oligonucleotide probes capable of sensitive hybridization-triggered fluorescence. These fluorogenic probes, known commercially as MGB Eclipse probes, are characterized by having a conjugated minor groove binder (MGB) ligand at the 5'-end
James L Lordan et al.
Journal of immunology (Baltimore, Md. : 1950), 169(1), 407-414 (2002-06-22)
In sensitized individuals, exposure to allergens such as Dermatophagoides pteronyssinus (Der p) causes Th2 polarization and release of cytokines, including IL-4 and IL-13. Because Der p extracts also have direct effects on epithelial cells, we hypothesized that allergen augments the
Dangeruta Kersulyte et al.
PloS one, 4(9), e6859-e6859 (2009-09-04)
Genes present in only certain strains of a bacterial species can strongly affect cellular phenotypes and evolutionary potentials. One segment that seemed particularly rich in strain-specific genes was found by comparing the first two sequenced Helicobacter pylori genomes (strains 26695
Isabelle Desitter et al.
Anticancer research, 31(2), 427-441 (2011-03-08)
Circulating tumor cells (CTCs) likely derive from clones in the primary tumor, suggesting that they can be used for all biological tests applying to the primary cells. The ScreenCell® devices are single-use and low-cost innovative devices that use a filter
Julia K Veir et al.
Veterinary therapeutics : research in applied veterinary medicine, 8(4), 229-238 (2008-01-10)
T evaluate the effect of supplementation with Enterococcus faecium strain SF68 (NCIMB10415) on immune function, responses to a multivalent vaccine were investigated in kittens given palatability enhancer with or without E. faecium SF68 daily. E. faecium SF68 was detected in
Michelle L Joachims et al.
Journal of immunology (Baltimore, Md. : 1950), 181(11), 8153-8161 (2008-11-20)
Mutations in the gene encoding adenosine deaminase (ADA), a purine salvage enzyme, lead to immunodeficiency in humans. Although ADA deficiency has been analyzed in cell culture and murine models, information is lacking concerning its impact on the development of human
Julian R Starr et al.
Molecular ecology resources, 9 Suppl s1, 151-163 (2009-05-01)
We investigate the species discriminatory power of a subset of the proposed plant barcoding loci (matK, rbcL, rpoC1, rpoB, trnH-psbA) in Carex, a cosmopolitan genus that represents one of the three largest plant genera on earth (c. 2000 species). To
Raymond E Soccio et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(10), 6943-6948 (2002-05-16)
Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet. StarD4 expression in cultured 3T3 cells was also sterol-regulated, and known sterol regulatory element binding protein
Dharmalingam Subramaniam et al.
PloS one, 7(2), e30590-e30590 (2012-03-01)
Curcumin inhibits the growth of esophageal cancer cell lines; however, the mechanism of action is not well understood. It is becoming increasingly clear that aberrant activation of Notch signaling has been associated with the development of esophageal cancer. Here, we
Maciej Jerzy Smialek et al.
Journal of cell science, 133(7) (2020-02-26)
Regulation of proliferation, apoptosis and cell cycle is crucial for the physiology of germ cells. Their malfunction contributes to infertility and germ cell tumours. The kinesin KIF18A is an important regulator of those processes in animal germ cells. Post-transcriptional regulation
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