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Yueqi Zhao et al.
Science advances, 6(12), eaaw9679-eaaw9679 (2020-03-29)
Rhesus D (RhD) is one of the most important immunogenic antigens on red blood cells (RBCs). However, the supply of RhD-negative blood frequently faces critical shortages in clinical practice, and the positive-to-negative transition of the RhD antigen remains a great
Tomo Yokomizo et al.
Transfusion, 55(2), 330-336 (2014-09-03)
Leukofiltration of blood components is currently implemented worldwide as a precautionary measure against white blood cell-associated adverse effects and the potential transmission of variant Creutzfeldt-Jakob disease (vCJD). A newly developed bifunctional filter (Sepacell Prima, Asahi Kasei Medical) was assessed for
Ida Stangerup et al.
Transfusion, 57(8), 1905-1911 (2017-04-30)
No former studies have examined how blood donation influences physical performance in women, who due to menstruation may have a slower recovery of performance. Therefore, the aim of this study was to clarify how VO VO VO VO
B Horowitz et al.
Vox sanguinis, 48(3), 143-149 (1985-01-01)
The biochemical status of whole blood stored in containers fabricated of ethylene ethylacrylate (EEA) film was monitored at several times during 4 weeks of storage at 4 degrees C. Fifteen biochemical indicators were studied to reflect on erythrocyte integrity, cellular
Andrew V Scott et al.
Anesthesia and analgesia, 122(3), 616-623 (2016-02-20)
Stored red blood cells (RBCs) are deficient in 2,3-diphosphoglycerate (2,3-DPG), but it is unclear how autologous salvaged blood (ASB) compares with stored blood and how rapidly 2,3-DPG levels return to normal after transfusion. Therefore, we compared levels of 2,3-DPG in
Ivan T Ivanov et al.
European biophysics journal : EBJ, 50(1), 69-86 (2021-01-15)
Two dielectric relaxations, βsp (1.5 MHz) and γ1sp (7 MHz), have been detected on spectrin-based membrane skeleton (MS) of red blood cells (RBCs) using the plot of admittance changes at the spectrin denaturation temperature (Ivanov and Paarvanova in Bioelectrochemistry 110: 59-68, 2016
Riza Aytaç Cetinkaya et al.
Turkish journal of medical sciences, 45(3), 638-643 (2015-08-19)
Currently, the provision of blood products largely depends on walking blood banks and limited amounts of stored blood with short shelf lives. We aimed to compare the efficacy of erythrocyte concentrate (ECs) by pre- and postfreezing in vitro tests. In
The oxygenation of hemoglobin in the presence of 2,3-diphosphoglycerate. Effect of temperature, pH, ionic strength, and hemoglobin concentration.
R E Benesch et al.
Biochemistry, 8(6), 2567-2571 (1969-06-01)
Konstantina C Fylaktakidou et al.
ChemMedChem, 6(1), 153-168 (2010-11-26)
Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobin. A study toward the construction of seven- and eight-membered cyclic pyrophosphates was also performed on the sugars which had
M Wiltshire et al.
Transfusion medicine (Oxford, England), 26(3), 208-214 (2016-03-24)
The pathogen inactivation (PI) INTERCEPT Blood System for Red Blood Cells utilises amustaline (S-303) to inactivate a broad range of pathogens in red cell concentrates (RCC). The aim of this study was to investigate the effect on red cell quality
Linda Larsson et al.
Vox sanguinis, 116(1), 60-70 (2020-09-13)
Commercial blood bags are predominantly made of polyvinyl chloride (PVC) plasticized with di(2-ethylhexyl) phthalate (DEHP). DEHP is favourable for storage of red blood cells (RBC). Historically, removal of DEHP from blood bags has been linked to unacceptable haemolysis levels. Oncoming
Xiaoming Zhou et al.
Cryo letters, 37(1), 53-58 (2016-03-11)
Previous studies have demonstrated that human RBCs can survival from freeze-drying, but there is still some uncertainty on whether and how the cell properties change during the processes. The present study is to evaluate the effects of lyophilization and rehydration
Akito Nakagawa et al.
ACS chemical biology, 9(10), 2318-2325 (2014-07-26)
Small molecules that increase the oxygen affinity of human hemoglobin may reduce sickling of red blood cells in patients with sickle cell disease. We screened 38,700 compounds using small molecule microarrays and identified 427 molecules that bind to hemoglobin. We
Wen-Biao Liang et al.
PloS one, 10(2), e0117928-e0117928 (2015-02-24)
Although periodic blood shortages are widespread in major Chinese cities, approximately 1 x 10(5) U of whole blood are discarded yearly because of under-collection. To reduce the wastage of acid citrate dextrose solution B (ACD-B) anticoagulated under-collected whole blood (UC-WB)
Sharon Graminske et al.
Transfusion, 58(5), 1100-1107 (2018-03-27)
Di(2-ethylhexyl)phthalate (DEHP) makes polyvinyl chloride flexible for use in blood bags and stabilizes the red blood cell (RBC) membrane preventing excessive hemolysis. DEHP migrates into the blood product and rodent studies have suggested that DEHP exposure may be associated with
H Gulliksson et al.
Vox sanguinis, 106(1), 61-67 (2013-10-15)
There are few studies on transient warming of red blood cells (RBCs). Occasional storage outside restricted temperature range often results in destroying of the RBC unit, even after a short period of time due to national guidelines. This study evaluates
Yuki Morishita et al.
PloS one, 12(9), e0185737-e0185737 (2017-09-29)
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells. However, a concern for detrimental effects of DEHP on human health has
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Yao-Xiong Huang et al.
Journal of cellular and molecular medicine, 20(2), 294-301 (2015-11-19)
Membrane sialic acid (SA) plays an important role in the survival of red blood cells (RBCs), the age-related reduction in SA content negatively impacts both the structure and function of these cells. We have therefore suggested that remodelling the SA
Xiangfu Liu et al.
Experimental and therapeutic medicine, 14(2), 1205-1211 (2017-08-07)
The present study aimed to characterize the function and hemorheology of red blood cells (RBCs) recovered during liver transplantation surgery in patients with hepatitis B and decompensation. A total of 15 hepatitis B patients with decompensation who underwent liver transplantation
Rui Zhong et al.
PloS one, 10(12), e0144201-e0144201 (2015-12-05)
Hypoxia has been reported to cause the significant enhancement of hemoglobin (Hb) and hematocrit (Hct), which stabilizes at relatively high levels after an individual ascends to a high altitude. However, the quality of the suspended red blood cells (SRBCs) obtained
Kelly M Winter et al.
Transfusion, 54(7), 1798-1807 (2014-03-13)
Over the past decade there has been a growth in the development of pathogen reduction technologies to protect the blood supply from emerging pathogens. This development has proven to be difficult for red blood cells (RBCs). However the S-303 system
W Schröter et al.
The Journal of membrane biology, 2(1), 31-40 (1970-12-01)
Gradual osmotic hemolysis of human erythrocytes reduces the cell content of whole protein, hemoglobin, 2,3-diphosphoglycerate and triosephosphate isomerase extensively, but not that of membrane protein and 2,3-diphosphoglycerate phosphatase. After the refilling of the ghosts with 2,3-diphosphoglycerate and reconstitution of the
H Gulliksson et al.
Vox sanguinis, 112(1), 33-39 (2016-12-22)
The present general plasticizer di-2-ethylhexyl-phthalate in polyvinylchloride (PVC) blood bags is only physically dispersed in PVC and will therefore leach into blood components. The objective of this study was to perform a first preliminary red blood cell (RBC) storage evaluation
J R Hess
Vox sanguinis, 107(1), 1-9 (2014-01-23)
Blood banking underpins modern medical care, but blood storage, necessary for testing and inventory management, reduces the safety and efficacy of individual units of red blood cells (RBCs). Stored RBCs are damaged by the accumulation of their own waste products
Minke A E Rab et al.
American journal of hematology, 94(5), 575-584 (2019-02-21)
In sickle cell disease (SCD), sickle hemoglobin (HbS) polymerizes upon deoxygenation, resulting in sickling of red blood cells (RBCs). These sickled RBCs have strongly reduced deformability, leading to vaso-occlusive crises and chronic hemolytic anemia. To date, there are no reliable
Jin Hyen Baek et al.
Transfusion, 58(6), 1474-1485 (2018-03-03)
Red blood cell (RBC) oxygen (O2 ) delivery may be impacted at the tissue, cellular, and molecular levels after storage duration, preservation strategies, and pathogen reduction. Collectively, the preclinical measurement of arterial and venous PO2 , systemic blood flow, tissue
Manon Bardyn et al.
Metabolites, 10(6) (2020-06-04)
After blood donation, the red blood cells (RBCs) for transfusion are generally isolated by centrifugation and then filtrated and supplemented with additive solution. The consecutive changes of the extracellular environment participate to the occurrence of storage lesions. In this study
Y S Loh et al.
Vox sanguinis, 111(4), 365-373 (2016-11-20)
Washing of red blood cells (RBC) can reduce unwanted biological response modifiers (BRMs) that can mediate transfusion complications in infants. The aim of this study was to examine the in vitro quality and the changes in BRMs following washing in
Charles C M Lelkens et al.
Transfusion, 57(6), 1448-1458 (2017-04-04)
We investigated whether improving the metabolic status of red blood cell concentrates before freezing could extend the postthaw shelf life beyond 14 days while still meeting the requirements for hemolysis (0.8%) and total adenylate (>82% of original values). At Day
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