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Yoonjeong Jeon et al.
Biochemical and biophysical research communications, 470(4), 818-823 (2016-01-24)
The regulation of food intake is important for body energy homeostasis. Hypothalamic insulin signaling decreases food intake by upregulating the expression of anorexigenic neuropeptides and downregulating the expression of orexigenic neuropeptides. INS-2, a Mn(2+) chelate of 4-O-(2-amino-2-deoxy-β-D-galactopyranosyl)-3-O-methyl-D-chiro-inositol, acts as an
Yiming Zhang et al.
Nature communications, 10(1), 1587-1587 (2019-04-10)
Caloric restriction and intermittent fasting are emerging therapeutic strategies against obesity, insulin resistance and their complications. However, the effectors that drive this response are not completely defined. Here we identify arginase 2 (Arg2) as a fasting-induced hepatocyte factor that protects
Risheng Ye et al.
The American journal of pathology, 189(4), 813-825 (2019-01-18)
Syntrophins are a family of proteins forming membrane-anchored scaffolds and serving as adaptors for various transmembrane and intracellular signaling molecules. To understand the physiological roles of β1 syntrophin, one of the least characterized members, we generated mouse models to eliminate
Andrew Pekosz et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73(9), e2861-e2866 (2021-01-23)
Individuals can test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by molecular assays following the resolution of their clinical disease. Recent studies indicate that SARS-CoV-2 antigen-based tests are likely to be positive early in the disease course, when
Yasuko Nakamura et al.
The Journal of biological chemistry, 295(35), 12330-12342 (2020-07-06)
GABA type A receptors (GABAARs) mediate fast synaptic inhibition and are trafficked to functionally diverse synapses. However, the precise molecular mechanisms that regulate the synaptic targeting of these receptors are unclear. Whereas it has been previously shown that phosphorylation events
Jinhee Hyun et al.
PLoS pathogens, 15(7), e1007883-e1007883 (2019-07-02)
Chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) affects an estimated 35 million and 75 million individuals worldwide, respectively. These viruses induce persistent inflammation which often drives the development or progression of organ-specific diseases and even
Miłosz Roliński et al.
Nucleic acids research, 49(3), 1470-1484 (2021-01-15)
Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, by using genome-wide CRISPR-Cas9 based screen, we identify transcriptional Mediator
Gedas Ereminas et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, 188-196 (2017-08-02)
The neuroprotective effect of several anthocyanins in combination with their stability and antioxidant/pro-oxidant activity has been investigated against H
Huijie Wang et al.
Molecular immunology, 92, 12-20 (2017-10-14)
In this study, we performed ENU mutagenesis and multi-parameter flow cytometric analysis in C57BL/6 mice to uncover novel genes or alleles regulating immune cell development. We identified a novel mutant allele of Cd4 gene which completely blocked development of a
A R Bonilla-Porras et al.
Cytotherapy, 20(1), 45-61 (2017-10-29)
Stem cell transplantation is an excellent option for regenerative or replacement therapy. However, deleterious microenvironmental and endogenous factors (e.g., oxidative stress) compromise ongoing graft survival and longevity. Therefore, (transient or stable) genetically modified cells may be reasonably thought to resist
Jana Key et al.
Neurogenetics, 21(3), 187-203 (2020-04-29)
Human RNF213, which encodes the protein mysterin, is a known susceptibility gene for moyamoya disease (MMD), a cerebrovascular condition with occlusive lesions and compensatory angiogenesis. Mysterin mutations, together with exposure to environmental trigger factors, lead to an elevated stroke risk
Kamlesh Awasthi et al.
Journal of photochemistry and photobiology. B, Biology, 165, 256-265 (2016-11-15)
Intracellular fluorescence lifetime images of the endogenous fluorophores of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), which are well known as autofluorescence chromophores, were obtained from rat normal fibroblast cells (WFB) and H-ras oncogene-transfected cancer cells among WFB
Akiyo Yokomizo et al.
Micromachines, 10(6) (2019-05-31)
In this paper, we propose an anchoring device with pillars to immobilize an adipocyte microfiber that has a fiber-shaped adipocyte tissue covered by an alginate gel shell. Because the device enabled the immobilization of the microfiber in a culture dish
Sung-Min Kim et al.
Oncotarget, 8(7), 11855-11867 (2017-01-07)
This study aimed to evaluate the levels of three major hydroxycholesterols (24-, 25-, and 27-hydroxycholesterols) in the serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS), as well as to show their role in the pathogenesis of
Jiri Vrba et al.
Toxicology in vitro : an international journal published in association with BIBRA, 57, 105-109 (2019-03-02)
Carbohelicenes are a group of helical-shaped polycyclic aromatic hydrocarbons. This study examined the effect of hexahelicene (or [6]helicene) and of its imidazolium derivative, 1-butyl-3-(2-methyl[6]helicenyl)-imidazolium bromide (I[6]H), on the activity of the aryl hydrocarbon receptor (AhR) and expression of cytochrome P450
Tadasuke Tsukiyama et al.
Nature communications, 11(1), 4586-4586 (2020-09-17)
Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity
Rineke Steenbergen et al.
Scientific reports, 8(1), 11685-11685 (2018-08-05)
Tissue culture medium routinely contains fetal bovine serum (FBS). Here we show that culturing human hepatoma cells in their native, adult serum (human serum, HS) results in the restoration of key morphological and metabolic features of normal liver cells. When
Leonardo M de Souza Mesquita et al.
Molecules (Basel, Switzerland), 26(13) (2021-07-03)
Currently, on an industrial scale, synthetic colorants are used in many fields, as well as those extracted with conventional organic solvents (COSs), leading to several environmental issues. Therefore, we developed a sustainable extraction and purification method mediated by ionic liquids
Takaaki Murakami et al.
Scientific reports, 11(1), 15014-15014 (2021-07-24)
Specifying the exact localization of insulinoma remains challenging due to the lack of insulinoma-specific imaging methods. Recently, glucagon-like peptide-1 receptor (GLP-1R)-targeted imaging, especially positron emission tomography (PET), has emerged. Although various radiolabeled GLP-1R agonist exendin-4-based probes with chemical modifications for
Tomoaki Inazumi et al.
Cell reports, 33(2), 108265-108265 (2020-10-15)
Lipolysis, the breakdown of triglyceride storage in white adipose tissue, supplies fatty acids to other tissues as a fuel under fasting conditions. In morbid obesity, fibrosis limits adipocyte expandability, resulting in enforced lipolysis, ectopic fat distribution, and ultimately insulin resistance.
Zhixiao Liu et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(15), 1903583-1903583 (2020-08-11)
The physical cues in the extracellular environment play important roles in cancer cell metastasis. However, how metastatic cancer cells respond to the diverse mechanical environments of metastatic sites is not fully understood. Here, substrates with different mechanical properties are prepared
Koshiki Mino et al.
Bioscience, biotechnology, and biochemistry, 78(6), 1010-1017 (2014-07-19)
Tissue factor pathway inhibitor-2 (TFPI-2) is a major inhibitor of extracellular matrix degradation. Decreases in TFPI-2 contribute to malignant tumor cell production, and TFPI-2 is a presumed tumor suppressor. TFPI-2 gene transcription is regulated by two epigenetic mechanisms: DNA methylation
Masanori Kobayashi et al.
Scientific reports, 6, 36780-36780 (2016-11-11)
Ubiquitination is a crucial post-translational modification; however, the functions of ubiquitin-coding genes remain unclear. UBA52 encodes a fusion protein comprising ubiquitin at the N-terminus and ribosomal protein L40 (RPL40) at the C-terminus. Here we showed that Uba52-deficient mice die during
Plaque production by the polyoma virus.
Virology, 8(3), 396-397 (1959-07-01)
Zunling Li et al.
Cellular & molecular immunology, 17(3), 272-282 (2019-11-09)
We recently demonstrated that leukocyte Ig-like receptor 4 (LILRB4) expressed by monocytic acute myeloid leukemia (AML) cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain. The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs);
Iman Abdollahzadeh et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-16)
Subcellular structures containing autophagy-related proteins of the Atg8 protein family have been investigated with conventional wide-field fluorescence and single molecule localisation microscopy. Fusion proteins of GABARAP and LC3B, respectively, with EYFP were overexpressed in HEK293 cells. While size distributions of
Ying Shen et al.
Cancer cell, 37(6), 800-817 (2020-06-10)
Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which
C Chang et al.
Transplantation proceedings, 39(10), 3363-3368 (2007-12-20)
Extracellular microenvironment and intrinsic genetic programs determine the fate of stem cells. We observed whether mesenchymal stem cells (MSCs) contributed to insulin-producing cells in a manipulated microenvironment. We delivered pancreatic pieces into Niobium-Coated Dynamatrix to construct a simulated pancreatic microenvironment
Anna Di Vito et al.
Cell transplantation, 28(1), 129-139 (2018-10-30)
The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has
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