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Erik de Blois et al.
Current topics in medicinal chemistry, 12(23), 2677-2685 (2013-01-24)
An overview how to measure and to quantify radiolysis by the addition of quenchers and to maintain Radio-Chemical Purity (RCP) of vulnerable methionine-containing regulatory peptides is presented. High RCP was only achieved with a combination of quenchers. However, quantification of
Leonor C Costa et al.
Environmental science and pollution research international, 22(23), 18574-18589 (2015-09-24)
This study aimed to assess the mechanisms of innate immune function responses to silica-coated iron oxide nanoparticle functionalized with dithiocarbamate groups (IONP) exposure alone and its associated mercury (Hg) in European eel (Anguilla anguilla L.) phagocytes isolated from peritoneum (P-phagocytes)
P C Braga et al.
Drug research, 65(5), 244-251 (2014-06-12)
A new diclofenac salt called diclofenac-choline (DC) has recently been proposed for the symptomatic treatment of oropharyngeal inflammatory processes and pain because its greater water solubility allows the use of high concentrations, which are useful when the contact time between
Fikadu G Tafesse et al.
Bio-protocol, 4(15) (2014-08-05)
Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids. The resulting hydrolysis product DAG binds to proteins such as protein
Takuya Matsui et al.
Chemical research in toxicology, 32(9), 1760-1771 (2019-08-21)
Quinones may be formed metabolically or abiotically from environmental pollutants and polycyclic aromatic hydrocarbons (PAHs); many are recognized as toxicological intermediates that cause a variety of deleterious cellular effects including mutagenicity. The PAH-o-quinone, 1,2-naphthoquinone (1,2-NQ), may exert its genotoxic effects
Julia E Martin et al.
PLoS genetics, 11(3), e1004977-e1004977 (2015-03-17)
Escherichia coli does not routinely import manganese, but it will do so when iron is unavailable, so that manganese can substitute for iron as an enzyme cofactor. When intracellular manganese levels are low, the cell induces the MntH manganese importer
Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2
Choi S and Love PE
Bio-protocol, 8(1) (2018)
Frank B Jensen et al.
The Journal of experimental biology, 218(Pt 13), 2015-2022 (2015-04-25)
Nitrite secures essential nitric oxide (NO) bioavailability in hypoxia at low endogenous concentrations, whereas it becomes toxic at high concentrations. We exposed brown trout to normoxic and hypoxic water in the absence and presence of added ambient nitrite to decipher
A A Bobko et al.
Free radical research, 49(8), 919-926 (2015-03-20)
Nitronyl nitroxides (NNs) are the paramagnetic probes that are capable of scavenging physiologically relevant reactive oxygen (ROS) and nitrogen (RNS) species, namely superoxide, nitric oxide (NO), and nitroxyl (HNO). NNs are increasingly considered as potent antioxidants and potential therapeutic agents.
Eric McGivney et al.
Environmental science & technology, 53(3), 1287-1295 (2018-12-29)
Gold nanoparticles (Au NPs) are often used to study the physiochemical behavior and distribution of nanomaterials in natural systems because they are assumed to be inert under environmental conditions, even though Au can be oxidized and dissolved by a common
Zhen Gao et al.
Biochemical pharmacology, 91(4), 474-482 (2014-08-26)
Palmitic acid, one of the saturated free fatty acids, impairs cardiovascular function as manifested by inducing vascular inflammation, apoptosis and over-production of reactive oxygen species (ROS) although the origin for ROS remains unclear. The present study investigated the cellular mechanisms
Yakov Y Woldman et al.
Biochemical and biophysical research communications, 465(2), 232-238 (2015-08-09)
A chemiluminescent method is proposed for quantitation of NO generation in cell cultures. The method is based on activation of soluble guanylyl cyclase by NO. The product of the guanylyl cyclase reaction, pyrophosphate, is converted to ATP by ATP sulfurylase
Ken-ichiro Matsumoto et al.
Chemical & pharmaceutical bulletin, 63(3), 195-199 (2015-03-12)
The density of hydroxyl radicals (·OH) produced in aqueous samples by exposure to X-ray or carbon-ion beams was investigated. The generation of ·OH was detected by the electron paramagnetic resonance (EPR) spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin-trapping agent.
Fabian aus dem Siepen et al.
Clinical research in cardiology : official journal of the German Cardiac Society, 104(8), 640-647 (2015-04-10)
T1 mapping by cardiac magnetic resonance imaging (CMR) is able to determine the extracellular volume fraction. Wild-type transthyretin amyloidosis (WT-ATTR) is characterized by extracellular amyloid deposition in the heart. Recent reports indicated a reduction of left ventricular (LV) myocardial mass
Bioconjugate Techniques (2013)
Rajendra Kurapati et al.
Small (Weinheim an der Bergstrasse, Germany), 11(32), 3985-3994 (2015-05-12)
Understanding human health risk associated with the rapidly emerging graphene-based nanomaterials represents a great challenge because of the diversity of applications and the wide range of possible ways of exposure to this type of materials. Herein, the biodegradation of graphene
Katsuhiko Sueda et al.
Health physics, 105(2), 208-214 (2013-06-27)
Diethylenetriaminepentaacetic acid (DTPA) is a chelating agent that is used to facilitate the elimination of radionuclides such as americium from contaminated individuals. Its primary site of action is in the blood, where it competes with various biological ligands, including transferrin
Arutselvan Natarajan et al.
Molecular imaging, 14 (2015-03-13)
Manufacturing of 64Cu-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-rituximab injection under good manufacturing practices (GMP) was validated for imaging of patients with CD20+ B-cell non-Hodgkin lymphoma. Rituximab was purified by size exclusion high performance liquid chromatography (HPLC) and conjugated to DOTA-mono-(N-hydroxysuccinimidyl) ester. 64CuCl2, buffers
Karthickeyan Chella Krishnan et al.
Infection and immunity, 82(7), 2992-3001 (2014-05-07)
Streptococcal cysteine protease (SpeB), the major secreted protease produced by group A streptococcus (GAS), cleaves both host and bacterial proteins and contributes importantly to the pathogenesis of invasive GAS infections. Modulation of SpeB expression and/or its activity during invasive GAS
Brianne R O'Leary et al.
Radiation research, 189(5), 456-465 (2018-03-17)
Gastric adenocarcinoma most often presents at an advanced stage and overall five-year survival of ∼30%. Pharmacological ascorbate (high-dose IV ascorbate) has been proposed as a promising nontoxic adjuvant to standard radio-chemotherapies in several cancer types. In the current study, pharmacological
Jie Yang et al.
Communications biology, 2, 194-194 (2019-05-28)
Hydrogen sulfide (H2S) plays important roles in metabolism and health. Its enzymatic generation from sulfur-containing amino acids (SAAs) is well characterized. However, the existence of non-enzymatic H2S production from SAAs, the chemical mechanism, and its biological implications remain unclear. Here
Yu-Tsai Yang et al.
Carbohydrate polymers, 92(2), 1915-1920 (2013-02-13)
A penta-ethyl ester prodrug of the radionuclide decorporation agent diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was encapsulated in alginate beads by the ionotropic gelation method. An optimal formulation was found by varying initial concentrations of DTPA penta-ethyl
Meenakshi Ravichandran et al.
Cell metabolism, 27(4), 914-925 (2018-03-20)
Whether and how regulation of genes and pathways contributes to physiological aging is topic of intense scientific debate. By performing an RNA expression-based screen for genes downregulated during aging of three different species, we identified glycine-C-acetyltransferase (GCAT, EC Impairing gcat
Claire M Doskey et al.
PloS one, 10(7), e0132572-e0132572 (2015-07-15)
The biological consequences upon exposure of cells in culture to a dose of xenobiotic are not only dependent on biological variables, but also the physical aspects of experiments e.g. cell number and media volume. Dependence on physical aspects is often
Monal B Shah et al.
Journal of bioscience and bioengineering, 120(2), 167-173 (2015-02-01)
Metal pollution due to the huge electronic waste (E-waste) accumulation is widespread across the globe. Extraction of copper, zinc and nickel from computer printed circuit boards (c-PCB) with a two-step bleaching process using ferric sulphate generated by Leptospirillum ferriphilum dominated
Sébastien Leguay et al.
Inorganic chemistry, 51(23), 12638-12649 (2012-11-17)
Complexation of trivalent actinides with DTPA (diethylenetriamine pentaacetic acid) was studied as a function of pcH and temperature in (Na,H)Cl medium of 0.1 M ionic strength. Formation constants of both complexes AnHDTPA(-) and AnDTPA(2-) (where An stands for Am, Cm
Janhvi Pandey et al.
Ecotoxicology and environmental safety, 122, 296-302 (2015-08-25)
A field experiment using tannery sludge as a soil amendment material and palmarosa (Cymbopogon martinii) as a potential phytostabilizer was conducted to investigate their synergistic effect in relation to the improvement in soil quality/property. Three consecutive harvests of two cultivars
Daniil Karnaushenko et al.
Advanced materials (Deerfield Beach, Fla.), 27(42), 6582-6589 (2015-09-24)
A novel method relying on strain engineering to realize arrays of on-chip-integrated giant magneto-impedance (GMI) sensors equipped with pick-up coils is put forth. The geometrical transformation of an initially planar layout into a tubular 3D architecture stabilizes favorable azimuthal magnetic
Michael R Bukowski et al.
Analytical biochemistry, 469, 54-64 (2014-12-03)
Protein S-glutathionylation is a posttranslational modification that links oxidative stimuli to reversible changes in cellular function. Protein-glutathione mixed disulfide (PSSG) is commonly quantified by reduction of the disulfide and detection of the resultant glutathione species. This methodology is susceptible to
Vladimir Mishin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 344-352 (2014-07-26)
Microsomal enzymes generate H2O2 in the presence of NADPH. In this reaction, referred to as "oxidase" activity, H2O2 is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H2O2 can form
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