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D8418

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Kerstin Kiefer et al.
The Journal of biological chemistry, 290(5), 2822-2830 (2014-12-19)
The orosomucoid-like (ORMDL) protein family is involved in the regulation of de novo sphingolipid synthesis, calcium homeostasis, and unfolded protein response. Single nucleotide polymorphisms (SNPs) that increase ORMDL3 expression have been associated with various immune/inflammatory diseases, although the pathophysiological mechanisms...
Zoltán-István Szabó et al.
Journal of pharmaceutical and biomedical analysis, 117, 398-404 (2015-10-07)
The enantiomers of asenapine maleate (ASN), a novel antipsychotic against schizophrenia and mania with bipolar I disorder have been separated by cyclodextrin (CD) modified capillary zone electrophoresis for the first time. 15 different CDs were screened as complexing agents and...
Xiaolian Song et al.
Inflammation, 38(2), 485-492 (2014-06-25)
The reparative and immunoregulatory properties of mesenchymal stromal cells (MSCs) have made them attractive candidates for cellular therapy. However, the underlying mechanism of the effects of transplanted MSCs on allergic asthma remains elusive. Here, we show that administration of MSCs...
Amandeep Kaur et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 69(3-4), 110-116 (2014-05-31)
The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam. was investigated in vitro against promastigotes of Leishmania donavani. The 70% ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of...
Lai Wei et al.
International journal of molecular medicine, 34(5), 1257-1267 (2014-09-02)
Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase than normal healthy rats, and the activation of this signaling pathway leads to portal hypertension. Sodium ferulate (SF) has been shown to decrease the production of geranylgeranyl pyrophosphate (GGPP)...
Phanuel Saroni Arwa et al.
Journal of ethnopharmacology, 174, 410-418 (2015-09-01)
Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study were to analyze the chemical constituents of...
Penny H Hamid et al.
Parasitology research, 113(11), 4165-4176 (2014-09-10)
Eimeria bovis macromeront formation in bovine endothelial host cells is an energy- and nutrient-demanding process. Obligate intracellular replicating coccidians are generally considered as auxotrophic for cholesterol synthesis and scavenge cholesterol from the host cell by either enhancing the uptake of...
Kathrin Schönberg et al.
Cancer research, 75(11), 2187-2199 (2015-04-03)
Ruxolitinib is a small-molecule inhibitor of the JAK kinases, which has been approved for the treatment of myelofibrosis, a rare myeloproliferative neoplasm (MPN), but clinical trials are also being conducted in inflammatory-driven solid tumors. Increased infection rates have been reported...
Thomas C Chen et al.
Journal of biomedical science, 22, 71-71 (2015-08-19)
Many patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite initially successful treatment with radiation and cisplatin, many patients will relapse and succumb to the disease....
Lara Mouttham et al.
Journal of assisted reproduction and genetics, 32(8), 1239-1250 (2015-08-08)
The objective of this study is to characterize the impact of exposure to cryoprotectants followed by vitrification on primordial follicle survival and activation using a fetal bovine model. In the first study, fetal bovine cortical pieces were exposed to cryoprotectants...
Daniel Kanmert et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10851-10865 (2015-08-01)
Recent evidence suggests that tau aggregation may spread via extracellular release and subsequent uptake by synaptically connected neurons, but little is known about the processes by which tau is released or the molecular forms of extracellular tau. To gain insight...
Sana Thabet et al.
Applied and environmental microbiology, 80(24), 7527-7535 (2014-09-28)
We have investigated the antimicrobial effects of photocatalysis on the yeast model Saccharomyces cerevisiae. To accurately study the antimicrobial mechanisms of the photocatalytic process, we focused our investigations on two questions: the entry of the nanoparticles in treated cells and...
Min-Min Lee et al.
Chemico-biological interactions, 236, 19-30 (2015-04-23)
Pipoxolan has been reported to have antitumor activity. However, the effects of pipoxolan on lung cancer cell metastasis remains unclear. This study examined the anti-metastatic effects of pipoxolan on lung adenocarcinoma cancer cells (i.e. CL1-5, CL1-0, and A549) and its...
Hua Sun et al.
Journal of Asian natural products research, 17(6), 638-648 (2015-08-04)
Overexpression of ATP-dependent efflux pump P-glycoprotein (P-gp) is the main cause of multidrug resistance (MDR) and chemotherapy failure in cancer treatment. Inhibition of P-gp-mediated drug efflux is an effective way to overcome cancer drug resistance. The present study investigated the...
Saifullah Afridi et al.
Biochemical and biophysical research communications, 456(3), 774-779 (2014-12-20)
Major histocompatibility complex (MHC)-loading enhancers (MLE) have recently attracted attention because of their ability to enhance the efficacy of peptide immunotherapeutics. As small molecular weight compounds, they influence the loading of peptides in MHC molecules by converting them from a...
Franca Vulinovic et al.
Human mutation, 35(9), 1114-1122 (2014-06-17)
A three-nucleotide (GAG) deletion (ΔE) in TorsinA (TOR1A) has been identified as the most common cause of dominantly inherited early-onset torsion dystonia (DYT1). TOR1A encodes a chaperone-like AAA+-protein localized in the endoplasmic reticulum. Currently, only three additional, likely mutations have...
Min-Cheol Kang et al.
Carbohydrate polymers, 127, 38-46 (2015-05-13)
In this study, the antioxidative effects of a purified polysaccharide isolated from the stems of Acanthopanax koreanum Nakai (ASP) on hydrogen peroxide-induced oxidative stress was investigated both in vitro and in vivo using a zebrafish model. A. koreanum Nakai stem...
Ping Huang et al.
Pharmaceutical research, 32(7), 2328-2343 (2015-01-17)
A novel hydrophilic conjugate of arginine-glycine-aspartic acid (RGD) and polyethylene glycol (PEG), i.e., RGD-PEG Mw (M W = 300, 600, 1000 or 4000), was synthesized and employed in epirubicin (EPI) loaded poly L-lactic acid (PLLA) nanoparticles (NPs) to improve its...
Eman Y Gohar et al.
The Journal of pharmacology and experimental therapeutics, 376(1), 98-105 (2020-11-01)
The G protein-coupled estrogen receptor 1 (GPER1) mediates rapid estrogenic signaling. We recently reported that activation of GPER1 in the renal medulla evokes endothelin-1-dependent natriuresis in female, but not male, rats. However, the involvement of the ET receptors, ETA and...
Xi Tang et al.
Oncotarget, 5(5), 1352-1362 (2014-03-25)
The development of effective therapies inhibiting prostate cancer progression and metastasis may substantially impact prostate cancer mortality and potentially reduce the rates of invasive treatments by enhancing the safety of active surveillance strategies. Hepsin (HPN) is a cell surface serine...
Jannatul Firdous et al.
Acta biomaterialia, 10(11), 4606-4617 (2014-08-12)
Respiratory syncytial virus (RSV) is one of the most common causes of viral deaths in infants worldwide, yet no effective vaccines are available. Here, we report an osmotically active polysaccharide-based polysorbitol transporter (PST) prepared from sorbitol diacrylate and low-molecular-weight polyethylenimine...
Minjia Sheng et al.
Journal of peptide science : an official publication of the European Peptide Society, 20(10), 803-810 (2014-06-27)
LfcinB9 is a peptide derived from lactoferricin B. In the present study, the effect and relative mechanism of LfcinB9 on human ovarian cancer cell line (SK-OV-3) in vitro and in vivo was investigated. The data obtained indicated that LfcinB9 exhibited...
Tian-Yu Fan et al.
International journal of clinical and experimental pathology, 7(10), 6662-6670 (2014-11-18)
Glioblastoma remains among the most devastating cancers with a median survival of less than 15 months and virtually no survival beyond five years. Currently, the treatment of glioma includes surgery, radiation therapy, chemotherapy, and comprehensive treatment. Intrinsic or acquired resistance...
Daniel Paull et al.
Nature methods, 12(9), 885-892 (2015-08-04)
Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic variants impact cellular function in disease, as well as an emerging source of tissue for regenerative medicine. The preparation of somatic cells, their reprogramming and the...
Mimi C Yung et al.
Journal of bacteriology, 197(19), 3160-3172 (2015-07-22)
The ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. To gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn)...
Weirong Wang et al.
Cancer letters, 356(2 Pt B), 791-799 (2014-12-03)
Imatinib (IM) represents a breakthrough in the treatment of chronic myeloid leukemia (CML) by inhibiting the activity of Bcr-Abl tyrosine kinase. However, many patients exhibit resistance to IM in the clinic. Recent studies have indicated that sirtuin 1 (SIRT1), a...
I J Fernández-Sainz et al.
Virology, 456-457, 121-130 (2014-06-04)
E2, along with E(rns) and E1, is an envelope glycoprotein of Classical Swine Fever Virus (CSFV). E2 is involved in several virus functions: cell attachment, host range susceptibility and virulence in natural hosts. Here we evaluate the role of a...
Nora V Lieske et al.
PloS one, 10(11), e0141903-e0141903 (2015-11-07)
Human regulatory T cells (Tregs) are essential in maintaining immunological tolerance and suppress effector T cells. Tregs are commonly up-regulated in chronic infectious diseases such as tuberculosis (TB) and human immunodeficiency virus (HIV) infection and thereby hamper disease-specific immune responses...
Kriangkrai Chawansuntati et al.
Human vaccines & immunotherapeutics, 11(9), 2253-2265 (2015-06-20)
Unlike well-studied antibody responses to pandemic 2009 H1N1 influenza A virus vaccines in human immunodeficiency virus-infected (HIV+) individuals, less well understood are cell-mediated immune (CMI) responses to this antigen in this susceptible population. We investigated such influenza-specific CMI responses in...
Li Ren Kong et al.
Nature communications, 11(1), 1556-1556 (2020-03-28)
c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here, we discover that the most common polymorphism known to...
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