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Whole genome DNA methylation analysis based on high throughput sequencing technology
Li N, et al.
Methods, 52(3), 203-212 (2010)
Daniel Fil et al.
Disease models & mechanisms, 13(7) (2020-06-27)
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin (FXN). Most FRDA patients are homozygous for large expansions of GAA repeat sequences in intron 1 of FXN, whereas a fraction of patients
Yue Hu et al.
BMC genetics, 21(1), 112-112 (2020-09-23)
In order to study the relations of hepatocellular functions, weight gain and metabolic imbalance caused by low-dose antibiotics (LDA) via epigenetic regulation of gene transcription, 32 weaned piglets were employed as animal models and randomly allocated into two groups with
Helen L Rose et al.
PloS one, 6(7), e22668-e22668 (2011-08-06)
Eight DNA extraction products or methods (Applied Biosystems PrepFiler Forensic DNA Extraction Kit; Bio-Rad Instagene Only, Bio-Rad Instagene & Spin Column Purification; EpiCentre MasterPure DNA & RNA Kit; FujiFilm QuickGene Mini80; Idaho Technologies 1-2-3 Q-Flow Kit; MoBio UltraClean Microbial DNA
Memory T Cells Expressing an NKG2D-CAR Efficiently Target Osteosarcoma Cells.
Lucía Fernández et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(19), 5824-5835 (2017-07-01)
Valentina Lo Sardo et al.
Cell, 175(7), 1796-1810 (2018-12-12)
The 9p21.3 cardiovascular disease locus is the most influential common genetic risk factor for coronary artery disease (CAD), accounting for ∼10%-15% of disease in non-African populations. The ∼60 kb risk haplotype is human-specific and lacks coding genes, hindering efforts to
Germán Gastón Leparc et al.
Nucleic acids research, 35(21), e146-e146 (2007-11-15)
One important goal of genomics is to explore the extent of alternative splicing in the transcriptome and generate a comprehensive catalog of splice forms. New computational and experimental approaches have led to an increase in the number of predicted alternatively
Alain P Gobert et al.
Cell reports, 33(11), 108510-108510 (2020-12-17)
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine.
Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice
Xiong X, et al.
Oncogenesis, 1(9), e26-e26 (2012)
Sebastian Thams et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(1), 87-101 (2018-11-18)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease selectively targeting motor neurons in the brain and spinal cord. The reasons for differential motor neuron susceptibility remain elusive. We developed a stem cell-based motor neuron assay to study cell-autonomous mechanisms causing
Daniel Clemente de Moraes et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 51(3), 1051-1060 (2020-03-12)
The aim of this study was to evaluate the ability of lapachones in disrupting the fungal multidrug resistance (MDR) phenotype, using a model of study which an azole-resistant Saccharomyces cerevisiae mutant strain that overexpresses the ATP-binding cassette (ABC) transporter Pdr5p.
Michelle L Joachims et al.
Journal of immunology (Baltimore, Md. : 1950), 181(11), 8153-8161 (2008-11-20)
Mutations in the gene encoding adenosine deaminase (ADA), a purine salvage enzyme, lead to immunodeficiency in humans. Although ADA deficiency has been analyzed in cell culture and murine models, information is lacking concerning its impact on the development of human
X Xiong et al.
Oncogenesis, 1, e26-e26 (2012-01-01)
Prostate cancer is one of the leading causes of cancer-related deaths in the United States and a leading diagnosed non-skin cancer in American men. Genetic mutations underlying prostate tumorigenesis include alterations of tumor suppressor genes. We tested the tumor suppressor
Jason Fan et al.
Molecular metabolism, 34, 97-111 (2020-03-18)
Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-cell's response to an adverse metabolic environment with impaired mitochondrial function remains unclear. Here
High quality bisulfite sequencing using nanogram amounts of genomic DNA
Sun J, et al.
International journal of biochemistry and biotechnology, 2, 449-456 (2013)
Masakazu Kamata et al.
Human gene therapy, 21(11), 1555-1567 (2010-06-08)
The recent development of induced pluripotent stem cells (iPSCs) by ectopic expression of defined reprogramming factors offers enormous therapeutic opportunity. To deliver these factors, murine leukemia virus (MLV)-based vectors have been broadly used in the setting of hematopoietic stem cell
Dongju Park et al.
Cancer research, 80(19), 4172-4184 (2020-08-01)
Heterozygous mutations in the BRCA1 gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental abnormalities, early-onset bone marrow failure, increased risk of cancers
Federico González et al.
Cell reports, 3(3), 651-660 (2013-03-13)
Induced pluripotent stem cells (iPSCs) hold great promise for personalized regenerative medicine. However, recent studies show that iPSC lines carry genetic abnormalities, suggesting that reprogramming may be mutagenic. Here, we show that the ectopic expression of reprogramming factors increases the
Seohee Chang et al.
Biomolecules, 10(4) (2020-04-03)
Phage display is one of the most frequently used platform technologies utilized to screen and select therapeutic antibodies, and has contributed to the development of more than 10 therapeutic antibodies used in the clinic. Despite advantages like efficiency and low
Alexandra M Pinzaru et al.
Genes & development, 34(23-24), 1619-1636 (2020-10-31)
Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genetic
Kunpeng Chang et al.
Oncology letters, 20(4), 80-80 (2020-08-31)
Laryngeal squamous cell carcinoma (LSCC) is one of the most frequently diagnosed head and neck cancers worldwide. Increasing evidence suggests that microRNAs (miRNAs/miRs) regulate the progression of tumorigenesis and the malignant behaviors of cancer cells. The aim of this study
Shivendra Singh et al.
Science advances, 7(47), eabj5405-eabj5405 (2021-11-18)
[Figure: see text].
Dangeruta Kersulyte et al.
PloS one, 4(9), e6859-e6859 (2009-09-04)
Genes present in only certain strains of a bacterial species can strongly affect cellular phenotypes and evolutionary potentials. One segment that seemed particularly rich in strain-specific genes was found by comparing the first two sequenced Helicobacter pylori genomes (strains 26695
Comparison of anthracnose resistance with the presence of two SCAR markers associated with the Rca2 gene in strawberry.
Miller-Butler MA, et al.
Hortscience: a Publication of the American Society For Horticultural Science Hortscience, 793- 798 (2019)
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