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V Suresh et al.
Journal of ethnopharmacology, 156, 309-315 (2014-09-16)
Phyllanthusrheedei Wight is a plant used by Muthuvan tribes of Kerala for treating liver related diseases. The different extracts of Phyllanthus rheedei were analysed on cell lines were viz, PLC/PRF, Hep3B, FLCII10 and HepG2215 for its anti-HBV property. The analysis
N A Davies et al.
Thrombosis research, 135(6), 1075-1080 (2015-04-22)
Venous thromboembolism (VTE) is common in patients with cancer, contributing significantly to morbidity and mortality Currently, no test reliably identifies patients at increased risk of developing VTE who would therefore benefit from prophylactic intervention. The aim of the current study
Semih Otles et al.
TheScientificWorldJournal, 2012, 564367-564367 (2012-05-18)
Types of nettles (Urtica dioica) were collected from different regions to analyze phenolic compounds in this research. Nettles are specially grown in the coastal part. According to this kind of properties, nettle samples were collected from coastal part of (Mediterranean
Sudha Mishra et al.
Molecular biology reports, 40(2), 1417-1428 (2012-11-01)
Protein Kinase C (PKC) isozymes are key components involved in cell proliferation and their over activation leads to abnormal tumor growth. PKC follows signalling pathway by activation of downstream gene NF-kB and early transcription factor c-Myc. Over activation of NF-kB
Rostand Manfouo Ngoumfo et al.
Journal of natural products, 71(11), 1906-1910 (2008-11-14)
An ellagitannin with a 2,4-acyl group, named macabarterin (1), and a new ellagic acid glycoside, 3-O-methylellagic acid 4-O-β-d-xylopyranoside (2), were isolated from the stem bark extract of Macaranga barteri along with five known phenolic compounds, ellagic acid (3), 3-O-methylellagic acid
Parijat Kabiraj et al.
ACS chemical neuroscience, 5(12), 1209-1220 (2014-09-24)
Nitrosative stress mediated S-nitrosylation (SNO) of protein disulfide isomerase (PDI), a housekeeping oxidoreductase, has been implicated in the pathogenesis of sporadic Parkinson's (PD) and Alzheimer's (AD) diseases. Previous cell line studies have indicated that SNO-PDI formation provokes synphilin-1 aggregation, the
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 18(6), 2159-2164 (2010-02-27)
A series of phenolic acids and phenol natural products, such as p-hydroxybenzoic acid, p-coumaric acid, caffeic acid, ferulic acid, gallic acid, syringic acid, quercetin, and ellagic acid, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC
Alisson S P Caldeira et al.
Food chemistry, 345, 128734-128734 (2020-12-15)
Pequi fruit peels are an underexploited source of polyphenols. The anti-diabetic potential of an extract and fractions from the peels were evaluated in a panel of assays. The extract and fractions thereof inhibited the release of cytokines involved in insulin
Navindra P Seeram et al.
Journal of medicinal food, 11(2), 390-394 (2008-07-05)
Pomegranate juice (PJ), a rich source of polyphenols including ellagitannins, has attracted much attention due to its reported health benefits. This has resulted in the consumption of liquid and powder pomegranate extracts as alternatives to PJ. Therefore establishing the bioavailability
Shosuke Ito et al.
Journal of dermatological science, 80(1), 18-24 (2015-08-01)
Tyrosinase is able to oxidize a great number of phenols and catechols to form ortho-quinones. Ortho-quinones are highly reactive compounds that exert cytotoxicity through binding with thiol enzymes and the production of reactive oxygen species. Certain phenolic (and catecholic) compounds
Paula Aranaz et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-20)
Phenolic compounds might modulate adiposity. Here, we report our observation that polyphenols and phenolic acids inhibit adipogenesis in 3T3-L1 with different intensity depending on the family and the stage of differentiation. While quercetin and resveratrol inhibited lipid accumulation along the
Jaquelini Luber et al.
Anais da Academia Brasileira de Ciencias, 87(2), 903-913 (2015-05-21)
Guava (Psidium guajava L.) is a plant often employed in popular medicine. Recently several studies have alerted about the toxicity of substances present in medicinal plants, which can pose risks to the human health. In this sense, the present work
Navindra P Seeram et al.
Clinica chimica acta; international journal of clinical chemistry, 348(1-2), 63-68 (2004-09-17)
Ellagic acid (EA) and hydrolyzable ellagitannins (ETs) are dietary polyphenols found in fruits and nuts and implicated with potent antioxidant, anticancer and antiatherosclerotic biological properties. Unfortunately, there are no reports on the bioavailability studies of EA or ETs in the
Lalida Rojanathammanee et al.
The Journal of nutrition, 143(5), 597-605 (2013-03-08)
Alzheimer disease (AD) brain is characterized by extracellular plaques of amyloid β (Aβ) peptide with reactive microglia. This study aimed to determine whether a dietary intervention could attenuate microgliosis. Memory was assessed in 12-mo-old male amyloid precursor protein/presenilin 1 (APP/PS1)
Rubén del Barrio-Galán et al.
Journal of the science of food and agriculture, 95(10), 2132-2144 (2014-09-27)
The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to subsequent aging on lees with or without oak wood chips as well
Cassandra L Quave et al.
PloS one, 10(8), e0136486-e0136486 (2015-08-22)
The Mediterranean is home to a rich history of medical traditions that have developed under the influence of diverse cultures over millennia. Today, many such traditions are still alive in the folk medical practices of local people. Investigation of botanical
Janique Vandal et al.
Pharmaceutical biology, 53(6), 800-806 (2015-02-24)
The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only a few antimicrobial agents left that can be used against MDR
Burcu Bekdeşer et al.
Journal of agricultural and food chemistry, 62(46), 11109-11115 (2014-11-05)
Hypochlorous acid (HOCl) is an important reactive oxygen species (ROS) and non-radical and is taking part in physiological processes concerned with the defense of the organism, but there has been limited information regarding its scavenging by polyphenols. This study was
Jose Valdo Madeira et al.
Biotechnology progress, 31(5), 1273-1279 (2015-06-18)
Recent studies have pointed to a reduction in the incidence of some cancers, diabetes, and neuro-degenerative diseases as a result of human health benefits from flavanones. Currently, flavanones are obtained by chemical synthesis or extraction from plants, and these processes
Dinesh Dhingra et al.
Pharmacological reports : PR, 64(4), 796-807 (2012-10-23)
The aim of present study was to evaluate antidepressant-like activity of ellagic acid in Swiss young male albino mice; and to explore the possible underlying mechanisms for this activity. Mice were immobilized for 150 min once only for induction of
Sadaf Naeem et al.
Bioorganic & medicinal chemistry, 20(3), 1251-1258 (2012-01-21)
Data on phytochemical constituents of plants commonly used in traditional Indonesian medicine have been compiled as a computer database. This database (the Indonesian Herbal constituents database, IHD) currently contains details on ∼1,000 compounds found in 33 different plants. For each
H U Gali et al.
International journal of cancer, 51(3), 425-432 (1992-05-28)
The anti-oxidant and the anti-tumor-promotion activities of several hydrolyzable tannins (HTs), including a commercial tannic-acid (TA) mixture, were examined in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo. A single application of TPA gradually increases the hydroperoxide (HPx)-producing activity of
Jinquan Liu et al.
Biosensors & bioelectronics, 70, 54-60 (2015-03-22)
A highly sensitive electrochemiluminescence (ECL) strategy was developed for the protein kinase A (PKA) activity and inhibition assay based on double-quenching of graphene quantum dots (GQDs) ECL by G-quadruplex-hemin DNAzyme and gold nanoparticles (AuNPs). In this strategy, the GQDs were
Sonal Dubey et al.
European journal of medicinal chemistry, 42(9), 1159-1168 (2007-03-21)
HIV-1 integrase (IN) is an essential enzyme for retroviral replication. It is involved in the integration of HIV DNA into host chromosomal DNA. The unique properties of IN makes it an ideal target for drug design. First, there appears to
Jiao Mo et al.
Phytotherapy research : PTR, 28(4), 629-632 (2013-07-23)
The present study evaluated the topical anti-inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol-induced mouse ear edema, topical
Zhi-Jian Li et al.
Phytotherapy research : PTR, 29(7), 1019-1025 (2015-04-29)
Ellagic acid (EA) has been shown to have antioxidant, antibacterial, and anti-inflammatory activities. In Uighur traditional medicine, Euphorbia humifusa Willd is used to treat fungal diseases, and recent studies suggest that it is the EA content which is responsible for
Navindra P Seeram et al.
The Journal of nutrition, 136(10), 2481-2485 (2006-09-22)
Ellagitannins (ETs) from pomegranate juice (PJ) are reported to have numerous biological properties, but their absorption and metabolism in humans are poorly understood. To investigate the pharmacokinetics of pomegranate ETs, 18 healthy volunteers were given 180 mL of PJ concentrate
Patrice Njomnang Soh et al.
Antimicrobial agents and chemotherapy, 53(3), 1100-1106 (2008-11-19)
Malaria is one of the most significant causes of infectious disease in the world. The search for new antimalarial chemotherapies has become increasingly urgent due to the parasites' resistance to current drugs. Ellagic acid is a polyphenol found in various
Xueliang Fang et al.
Journal of medicinal chemistry, 48(5), 1481-1488 (2005-03-04)
A comprehensive herbal medicine information system for cancer (CHMIS-C) has been developed. The current version of the database integrates information on more than 200 anticancer herbal recipes that have been used for the treatment of different types of cancer in
Jana Sádecká et al.
Food chemistry, 135(3), 893-897 (2012-09-08)
Two spectrofluorimetric methods have been developed for the rapid determination of ellagic acid. The first method is based on the complex formation between ellagic acid and borax in methanol solution. The fluorescence of the complex is monitored at an emission
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