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EphrinA1-Fc attenuates myocardial ischemia/reperfusion injury in mice.

Augustin DuSablon et al.

PloS one, 12(12), e0189307-e0189307 (2017-12-14)

EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy cardiomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection of chimeric ephrinA1-Fc at the time of ischemia reduced injury in the

Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation.

Matthieu Chavent et al.

Biochemistry, 53(42), 6641-6652 (2014-10-07)

EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system. EphA1, in common with other RTKs, contains an N-terminal extracellular domain, a

Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma.

Marieta I Toma et al.

PloS one, 9(7), e102262-e102262 (2014-07-16)

The EPH receptor tyrosine kinases and their cell-bound ligands, the ephrins, have been shown to be associated with cancer development and progression. In this study, mRNA and protein expression of the receptors EPHA1 and EPHA2 as well as of their

High expression of EphA1 in esophageal squamous cell carcinoma is associated with lymph node metastasis and advanced disease.

Jiandong Wang et al.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 121(1), 30-37 (2012-10-04)

Eph receptors play important roles in the development of cancer. The present study aimed to investigate the expression of EphA1 and its clinicopathologic significance in esophageal squamous cell carcinoma (ESCC). The expression levels of the EphA1 transcript and protein were

EphrinA1-Fc Attenuates Ventricular Remodeling and Dysfunction in Chronically Nonreperfused WT but not EphA2-R-M mice.

K'Shylah S Whitehurst et al.

International journal of molecular sciences, 21(16) (2020-08-23)

EphrinA1-Fc abolishes acute I/R injury and attenuates nonreperfused cardiac injury 4 days after permanent occlusion in mice. The goal of this study was to assess the capacity of a single intramyocardial administration of ephrinA1-Fc at the time of coronary artery

Increased expression of EphA1 protein in prostate cancers correlates with high Gleason score.

Libo Peng et al.

International journal of clinical and experimental pathology, 6(9), 1854-1860 (2013-09-17)

The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression

Effect of EPHA1 genetic variation on cerebrospinal fluid and neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.

Hui-Fu Wang et al.

Journal of Alzheimer's disease : JAD, 44(1), 115-123 (2014-09-04)

Ephrin type-A receptor 1 (EPHA1) (11771145) was documented to be one of the most strongly associated locus with Alzheimer's disease (AD) in a recent meta-analysis of five genome wide association studies. However, its contribution to the pathogenesis of AD remains

Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B.

Takahiro Sawada et al.

PloS one, 12(7), e0180785-e0180785 (2017-07-08)

We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal body growth. In the

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