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STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma.

Balaram Thota et al.

Journal of neurosurgery, 121(2), 374-383 (2014-06-01)

Insulin-like growth factor binding proteins (IGFBPs) have been implicated in the pathogenesis of glioma. In a previous study the authors demonstrated that IGFBP-3 is a novel glioblastoma biomarker associated with poor survival. Since signal transducer and activator of transcription 1

Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons.

Yu Gao et al.

Stem cells (Dayton, Ohio), 33(5), 1618-1629 (2015-02-03)

In both the embryonic and adult brain, a critical step in neurogenesis is neuronal maturation. Deficiency of MeCP2 leads to Rett syndrome, a severe neurodevelopmental disorder. We have previously shown that MeCP2 plays critical roles in the maturation step of

Functional analyses and prognostic significance of SFRP1 expression in bladder cancer.

Anja Rogler et al.

Journal of cancer research and clinical oncology, 141(10), 1779-1790 (2015-03-04)

We previously showed that the Wnt-signaling antagonist SFRP1 (secreted frizzled-related protein 1) is a promising marker in bladder cancer. The aim of this study was to validate the prognostic role and analyze the functional significance of SFRP1. Four bladder cancer

STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis.

Riddhi Atul Jani et al.

Journal of cell science, 128(17), 3263-3276 (2015-07-26)

Melanosomes are a class of lysosome-related organelles produced by melanocytes. Biogenesis of melanosomes requires the transport of melanin-synthesizing enzymes from tubular recycling endosomes to maturing melanosomes. The SNARE proteins involved in these transport or fusion steps have been poorly studied.

Sortilin regulates progranulin action in castration-resistant prostate cancer cells.

Ryuta Tanimoto et al.

Endocrinology, 156(1), 58-70 (2014-11-05)

The growth factor progranulin is as an important regulator of transformation in several cellular systems. We have previously demonstrated that progranulin acts as an autocrine growth factor and stimulates motility, proliferation, and anchorage-independent growth of castration-resistant prostate cancer cells, supporting

Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells.

V O Okoh et al.

British journal of cancer, 112(10), 1687-1702 (2015-05-13)

17β-Oestradiol (E2)-induced reactive oxygen species (ROS) have been implicated in regulating the growth of breast cancer cells. However, the underlying mechanism of this is not clear. Here we show how ROS through a novel redox signalling pathway involving nuclear respiratory

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