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Yan Wang et al.
JAMA ophthalmology, 131(2), 194-204 (2013-04-02)
To develop a reliable, reproducible rat model of posterior ischemic optic neuropathy (PION) and study the cellular responses in the optic nerve and retina. Posterior ischemic optic neuropathy was induced in adult rats by photochemically induced ischemia. Retinal and optic
Sixiang Shi et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(6), 927-932 (2015-04-18)
The critical challenge in abdominal aortic aneurysm (AAA) research is the accurate diagnosis and assessment of AAA progression. Angiogenesis is a pathologic hallmark of AAA, and CD105 is highly expressed on newly formed vessels. Our goal was to use (64)Cu-labeled
Shlomit Radom-Aizik et al.
Brain, behavior, and immunity, 39, 121-129 (2014-01-16)
Physical activity can prevent and/or attenuate atherosclerosis, a disease clearly linked to inflammation. Paradoxically, even brief exercise induces a stress response and increases inflammatory cells like monocytes in the circulation. We hypothesized that exercise would regulate the expression of genes
M Tahara et al.
Clinical and experimental immunology, 179(2), 197-209 (2014-09-16)
Programmed cell death-1 (PD-1) plays an important role in peripheral T cell tolerance, but whether or not it affects the differentiation of helper T cell subsets remains elusive. Here we describe the importance of PD-1 in the control of T
Fangyang Wang et al.
Molecular oncology, 8(8), 1640-1652 (2014-07-24)
Procaspase-3, a proenzyme of apoptotic executioner caspase-3, is overexpressed in numerous tumors. We aimed to characterize a novel procaspase-3 activator, WF-210, which may have potential as an anticancer drug. The procaspase-3 activating ability, antitumor efficacy, mechanisms of action, and toxicity
Oliver Sterthaus et al.
Cellular reprogramming, 16(3), 185-195 (2014-05-09)
Four normal-karyotype human embryonic stem cell (hESC) lines were generated using the same protocol and maintained under identical conditions. Despite these precautions, gene expression patterns were found to be dissimilar among the four lines. The observed differences were typical of
Chun-Ping Jen et al.
PloS one, 9(7), e102050-e102050 (2014-07-16)
Sample preconcentration is an important step that increases the accuracy of subsequent detection, especially for samples with extremely low concentrations. Due to the overlapping of electrical double layers in the nanofluidic channel, the concentration polarization effect can be generated by
Philippe Foubert et al.
Cell transplantation, 24(7), 1343-1361 (2013-09-28)
Endothelial progenitor cell (EPC) transplantation has beneficial effects for therapeutic neovascularization. We therefore assessed the effect of a therapeutic strategy based on EPC administration in the healing of radiation-induced damage. To improve cell therapy for clinical use, we used pretreatment
Q Li et al.
Cancer gene therapy, 22(5), 227-237 (2015-04-04)
An increasing number of studies indicate that during development, endothelial and hematopoietic cells derive from common progenitors named hemangioblasts that have important roles in the pathogenesis. This is particularly true in chronic myeloid leukemia (CML). Here, we isolated fetal liver
Ashok K Chakraborty et al.
Breast cancer research and treatment, 152(3), 533-544 (2015-07-22)
The insulin-like growth factor I receptor (IGF1R) has been linked to resistance to HER2-directed therapy with trastuzumab (Herceptin). We examined the anti-tumor activity of figitumumab (CP-751,871), a human monoclonal antibody that blocks IGF1R ligand binding, alone and in combination with
Yanhong Li et al.
PloS one, 10(3), e0121884-e0121884 (2015-03-27)
Nosema bombycis, the first identified microsporidium, is a destructive pathogen of the silkworm Bombyx mori and causes severe worldwide economic losses in sericulture. Major microsporidian structural proteins, such as the spore wall protein (SWP), are known to be involved in
Jia Chen et al.
BMC infectious diseases, 14, 487-487 (2014-09-07)
Toxoplasma gondii can infect all warm-blooded animals including humans. Infection with T. gondii is probably the leading cause of posterior uveitis in humans and the most comment route of transmission is raw and undercooked meat from infected animals. T. gondii
Andreas Lenshof et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 85(11), 933-941 (2014-07-24)
Processing of peripheral blood progenitor cells (PBPC) for clinical transplantation or research applications aims to effectively isolate or deplete specific cell populations, utilizing primarily magnetic or fluorescence activated sorting methods. Here, we investigated the performance of microfluidic acoustophoresis for the
N Tormo-Badia et al.
Scandinavian journal of immunology, 80(4), 250-260 (2014-06-27)
The intestinal microbiota is important for tolerance induction through mucosal immunological responses. The composition of the gut microbiota of an infant is affected by environmental factors such as diet, disease and antibiotic treatment. However, already in utero, these environmental factors
Marie-Pierre Valignat et al.
Nature communications, 5, 5213-5213 (2014-10-18)
A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here we investigate a model of lymphocyte migration on the inner surface
M W Laschke et al.
European cells & materials, 28, 287-298 (2014-10-24)
Adipose tissue-derived microvascular fragments are promising vascularisation units for applications in the field of tissue engineering. Elderly patients are the major future target population of such applications due to an increasing human life expectancy. Therefore, we herein investigated the effect
Jae Sam Lee et al.
Biochimica et biophysica acta, 1830(10), 4621-4627 (2013-05-22)
Although microcalcifications of hydroxyapatite can be found in both benign and malignant osteotropic tumors, they are mostly seen in proliferative lesions, including carcinoma. The aim of this present study is to develop a molecular imaging contrast agent for selective identification
Chia-Lo Chang et al.
Journal of pineal research, 59(2), 206-220 (2015-05-28)
We tested the hypothesis that combined melatonin and autologous adipose-derived mesenchymal stem cells (ADMSC) was superior to either alone against small bowel ischemia-reperfusion (SBIR) injury induced by superior mesenteric artery clamping for 30 min followed by reperfusion for 72 hr.
L Dumont et al.
Andrology, 3(3), 611-625 (2015-05-28)
Testicular tissue cryopreservation offers the hope of preserved future fertility to pre-pubertal boys with cancer before exposition to gonadotoxic treatments. The objective of this study was to compare controlled slow freezing (CSF) with five vitrification techniques for cryopreservation of murine
K Zarschler et al.
Nanoscale, 6(11), 6046-6056 (2014-04-30)
For effective localization of functionalized nanoparticles at diseased tissues such as solid tumours or metastases through biorecognition, appropriate targeting vectors directed against selected tumour biomarkers are a key prerequisite. The diversity of such vector molecules ranges from proteins, including antibodies
Pegah Abdollahi et al.
Anti-cancer drugs, 26(5), 487-497 (2015-01-21)
Silibinin, with a strong antioxidant activity and a weak cytotoxic property, is considered a candidate for cancer prevention. As there is no information on its effect on breast cancer tumor-initiating cells [cancer stem cells (CSCs)] in a 3D culture model
Ruud W J Meijers et al.
Transplant international : official journal of the European Society for Organ Transplantation, 27(12), 1272-1284 (2014-08-02)
The uremia-induced inflammatory environment in end-stage renal disease (ESRD) patients is associated with premature T-cell aging resulting in a defective T-cell immunity. As kidney transplantation (KTx) reduces the pro-inflammatory environment, we hypothesized that KTx would rejuvenate the aged T-cell system.
Letitia E Bible et al.
Surgery, 158(3), 595-601 (2015-07-26)
Propranolol has been shown previously to decrease the mobilization of hematopoietic progenitor cells (HPCs) after acute injury in rodent models; however, this acute injury model does not reflect the prolonged period of critical illness after severe trauma. Using our novel
Yong Sang Kim et al.
The American journal of sports medicine, 42(10), 2424-2434 (2014-08-12)
Marrow stimulation for the treatment of osteochondral lesions of the talus (OLTs) is controversial in patients with poor prognostic factors of OLTs. Currently, mesenchymal stem cells (MSCs) are expected to biologically augment the treatment of OLTs. To compare the clinical
L M Campero et al.
Experimental parasitology, 155, 8-12 (2015-04-29)
Neospora caninum is one of the most important causes of bovine abortion, but isolation of live parasites from infected tissue is difficult. The aims of the present study were to obtain new isolates of N. caninum from congenitally infected asymptomatic
Woan-Ruoh Lee et al.
Journal of pharmaceutical sciences, 103(11), 3542-3552 (2014-09-05)
Alopecia usually cannot be cured because of the available drug therapy being unsatisfactory. To improve the efficiency of treatment, erbium-yttrium-aluminum-garnet (Er-YAG) laser treatment was conducted to facilitate skin permeation of antialopecia drugs such as minoxidil (MXD), diphencyprone (DPCP), and peptide.
Tai L Guo et al.
Toxicology and applied pharmacology, 280(3), 455-466 (2014-09-03)
Diet and phytoestrogens affect the development and progression of diabetes. The objective of the present study was to determine if oral exposure to phytoestrogen genistein (GE) by gavage changed blood glucose levels (BGL) through immunomodulation in streptozotocin (STZ)-induced diabetic male
David B Meya et al.
The Journal of infectious diseases, 211(10), 1597-1606 (2014-12-11)
Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM) is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid (CSF). The immunopathogenesis of CM immune reconstitution inflammatory syndrome (IRIS) after initiation of antiretroviral therapy at the site of infection
Fuxiao Liu et al.
Journal of virological methods, 207, 78-85 (2014-07-06)
Peste des petits ruminants virus (PPRV), an etiological agent of peste des petits ruminants (PPR), is classified into the genus Morbillivirus in the family Paramyxovirida. In this study, two full-length open reading frames (ORF) corresponding to the PPRV matrix (M)
Xikuang Yao et al.
Biomacromolecules, 16(7), 2059-2071 (2015-05-30)
Cisplatin-incorporating pseudoblock copolymer nanoparticles with high drug loading efficiency (ca. 50%) were prepared built on host-guest inclusion complexation between β-cyclodextrin end-capped poly(N-vinylpyrrolidone) block and admantyl end-capped poly(aspartic acid) block, followed by the coordination between cisplatin and carboxyl groups in poly(aspartic
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