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Michael W Butler et al.
PloS one, 7(5), e38043-e38043 (2012-06-06)
Environmental conditions early in life can affect an organism's phenotype at adulthood, which may be tuned to perform optimally in conditions that mimic those experienced during development (Environmental Matching hypothesis), or may be generally superior when conditions during development were
Zhaojun Yin et al.
ACS chemical biology, 10(10), 2364-2372 (2015-08-12)
Development of an effective vaccine targeting tumor associated carbohydrate antigens (TACAs) is an appealing approach toward tumor immunotherapy. While much emphasis has been typically placed on generating high antibody titers against the immunizing antigen, the impact of immunogen design on
Verónica Viñuela-Berni et al.
Scientific reports, 10(1), 467-467 (2020-01-18)
The blood-brain barrier (BBB) plays a significant pathophysiological role in multiple sclerosis (MS). Vasopressin (AVP) is released after brain injury and contributes to the inflammatory response. We propose that AVP may be modulating BBB permeability and hence affecting EAE clinical
Cuiling Li et al.
Cell cycle (Georgetown, Tex.), 16(7), 649-659 (2017-01-20)
Lysine acetylation is known as a post translational modification (PTM) by histone acetyltransferases (HAT) that modifies histones and non-histone proteins to regulate gene expression. Serine acetylation, however, is reported in mammalian hosts by serine acetyltransferase of Yersinia pestis (YopJ) during
Hunter S Futch et al.
The Journal of experimental medicine, 216(11), 2479-2491 (2019-08-31)
Hypothalamic-pituitary-adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody, CTRND05, targeting corticotropin-releasing factor (CRF). In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent
Vikas Kumar Singh et al.
3 Biotech, 10(11), 463-463 (2020-10-14)
Glycoprotein D (gD) of Herpes Simplex Virus-2 is used as an antigen in various anti-herpes subunit vaccines owing to its involvement in binding the host cell receptors for host infectivity. However, most of these monomeric protein based candidates have shown
Liangyue Peng et al.
International journal of biological sciences, 15(11), 2340-2349 (2019-10-09)
Induced pluripotent stem (iPS) cells provide a powerful platform for the study of development, regeneration, and disease. Although many stable iPS cell lines have been established for mammals, few attempts have been made to induce iPS cells in nonmammalian species.
Tong Du et al.
Frontiers in immunology, 11, 1603-1603 (2020-08-15)
Guillain-Barré syndrome (GBS), an immune-mediated disorder affecting the peripheral nervous system, is the most common and severe acute paralytic neuropathy. GBS remains to be potentially life-threatening and disabling despite the increasing availability of current standard therapeutic regimens. Therefore, more targeted
Tegwen Marlais et al.
PloS one, 15(9), e0238840-e0238840 (2020-09-15)
Diagnosis of visceral leishmaniasis (VL) relies on invasive and risky aspirate procedures, and confirmation of cure after treatment is unreliable. Detection of Leishmania donovani antigens in urine has the potential to provide both a non-invasive diagnostic and a test of
Thomas M Clausen et al.
The Journal of biological chemistry, 287(28), 23332-23345 (2012-05-10)
Malaria is a major global health problem. Pregnant women are susceptible to infection regardless of previously acquired immunity. Placental malaria is caused by parasites capable of sequestering in the placenta. This is mediated by VAR2CSA, a parasite antigen that interacts
Claudia Ribeiro de Almeida et al.
Molecular cell, 70(4), 650-662 (2018-05-08)
Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form
Michelle L Scalley-Kim et al.
PloS one, 7(8), e43332-e43332 (2012-08-23)
Chemokines play a key role in leukocyte recruitment during inflammation and are implicated in the pathogenesis of a number of autoimmune diseases. As such, inhibiting chemokine signaling has been of keen interest for the development of therapeutic agents. This endeavor
Lisha Wei et al.
The Journal of biological chemistry, 295(47), 15988-16001 (2020-09-12)
Metaflammation is a primary inflammatory complication of metabolic disorders characterized by altered production of many inflammatory cytokines, adipokines, and lipid mediators. Whereas multiple inflammation networks have been identified, the mechanisms by which metaflammation is initiated have long been controversial. As
Josué Hernández-Pasos et al.
Journal of experimental zoology. Part B, Molecular and developmental evolution, 328(3), 259-274 (2017-02-24)
Melanotransferrin (MTf) is a protein associated with oncogenetic, developmental, and immune processes which function remains unclear. The MTf gene has been reported in numerous vertebrate and invertebrate species, including echinoderms. We now report the finding of four different MTfs in
Suchandan Sikder et al.
The Journal of infectious diseases, 218(2), 324-335 (2017-12-14)
Acute rheumatic fever and rheumatic heart disease (ARF/RHD) have long been described as autoimmune sequelae of Streptococcus pyogenes or group A streptococcal (GAS) infection. Both antibody and T-cell responses against immunodominant GAS virulence factors, including M protein, cross-react with host
Yannic C Bartsch et al.
The Journal of allergy and clinical immunology, 146(3), 652-666 (2020-05-24)
Effector functions of IgG Abs are regulated by their Fc N-glycosylation pattern. IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity of inflammatory (auto)immune disorders and have also been linked to protection against viral
Noha M Shafik et al.
Archives of biochemistry and biophysics, 675, 108095-108095 (2019-09-03)
Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease manifested by joint destruction and deformity, hence decreasing patient's life quality. The aim of the present work is to explore the mechanistic effects of glycyrrhizin (GL)and/or platelet rich plasma (PRP) treatment
Xing Xie et al.
Frontiers in microbiology, 12, 747421-747421 (2021-10-22)
Mycoplasma hyopneumoniae (Mhp) is the main pathogen that causes enzootic pneumonia, a disease that has a significant impact on the pig industry worldwide. The pathogenesis of enzootic pneumonia, especially possible virulence factors of Mhp, has still not been fully elucidated.
Samra Sardar et al.
Archivum immunologiae et therapiae experimentalis, 66(5), 365-377 (2018-06-29)
The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence
Yan Lin et al.
Journal of immunology research, 2021, 8899674-8899674 (2021-01-26)
Tuberculosis is the world's most deadly infectious disease, with 10 million people falling ill and 1.5 million people dying from the disease every year. With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence of coinfection of MTB
Xiaoyun Wen et al.
PLoS neglected tropical diseases, 5(11), e1399-e1399 (2011-11-22)
The current knowledge of immunological responses to schistosomiasis, a major tropical helminthic disease, is insufficient, and a better understanding of these responses would support vaccine development or therapies to control granuloma-associated immunopathology. CD4(+) T cells play critical roles in both
Grant R Zimmermann et al.
Arthritis research & therapy, 11(1), R12-R12 (2009-01-28)
Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. Previous efforts to design glucocorticoid structures with an increased therapeutic window have focused on dissociating anti-inflammatory transcriptional repression from adverse effects primarily driven by transcriptional
Elisabeth J M Huijbers et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(11), 4535-4544 (2010-07-17)
Monoclonal antibody-based therapies have made an important contribution to current treatment strategies for cancer and autoimmune disease. However, the cost for these new drugs puts a significant strain on the health-care economy, resulting in limited availability for patients. Therapeutic vaccination
Christopher J M Piper et al.
Cell reports, 29(7), 1878-1892 (2019-11-14)
Regulatory B cells (Bregs) play a critical role in the control of autoimmunity and inflammation. IL-10 production is the hallmark for the identification of Bregs. However, the molecular determinants that regulate the transcription of IL-10 and control the Breg developmental
Jifang Gao et al.
Scientific reports, 7(1), 604-604 (2017-04-06)
The decrease of gelsolin (GSN) in the blood has been reported in multiple sclerosis (MS) patients and experimental allergic encephalomyelitis (EAE) animals, but the protective effect of GSN on EAE/MS lacks of evidence. In our study, we increased the GSN
Liliana R Loureiro et al.
Scientific reports, 8(1), 12196-12196 (2018-08-17)
Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities
Suttipun Sungsuwan et al.
Methods in enzymology, 597, 359-376 (2017-09-25)
Tumor-associated carbohydrate antigens (TACAs) are attractive targets for anticancer vaccine development. Due to the low immunogenicity of TACAs, a powerful carrier system is needed to boost immune responses. Virus-like particles (VLPs) are an exciting platform for delivering TACAs to the
Ti Wen et al.
Arthritis and rheumatism, 64(9), 2896-2906 (2012-05-12)
To analyze the effects of a novel compound, NK-007, on the prevention and treatment of collagen-induced arthritis (CIA) and the underlying mechanisms. We determined the effect of NK-007 on lipopolysaccharide (LPS)-triggered tumor necrosis factor α (TNFα) production by murine splenocytes
Katarina Radulovic et al.
Journal of immunology (Baltimore, Md. : 1950), 188(4), 2001-2013 (2012-01-18)
CD69 is highly expressed by lymphocytes at mucosal surfaces. We aimed to investigate the role of CD69 in mucosal immune responses. The expression of CD69 by CD4 T cells isolated from the spleen, mesenteric lymph nodes, small intestinal lamina propria
Alan Gillett et al.
PloS one, 4(11), e7773-e7773 (2009-11-17)
Multiple Sclerosis (MS) is a chronic inflammatory disease causing demyelination and nerve loss in the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is widely used to investigate complex pathogenic mechanisms. Transcriptional control through
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