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Wei-liang Ye et al.
PloS one, 9(5), e97358-e97358 (2014-05-16)
A PEG-based, folate mediated, active tumor targeting drug delivery system using DOX-hyd-PEG-FA nanoparticles (NPs) were prepared. DOX-hyd-PEG-FA NPs showed a significantly faster DOX release in pH 5.0 medium than in pH 7.4 medium. Compared with DOX-hyd-PEG NPs, DOX-hyd-PEG-FA NPs increased
Xiali Zhu et al.
Journal of drug targeting, 22(9), 822-828 (2014-06-26)
This report focuses on the in vitro and in vivo anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free
Per Ashorn et al.
The American journal of clinical nutrition, 101(2), 387-397 (2015-02-04)
Small birth size, often associated with insufficient maternal nutrition, contributes to a large share of global child undernutrition, morbidity, and mortality. We developed a small-quantity lipid-based nutrient supplement (SQ-LNS) to enrich the diets of pregnant women. The objective was to
Manuela Curcio et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 281-292 (2015-04-29)
The aim of this work was to prepare polysaccharide-based nanoparticles (NPs) sensitive to glutathione (GSH), and to elucidate the effect of the concentration of glucose used as cryoprotectant during freeze-drying on the GSH-responsiveness. NPs were obtained via ionic interaction between
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Yarlini Balarajan et al.
The Journal of nutrition, 143(8), 1309-1315 (2013-06-14)
Improving maternal nutrition is an important step toward reducing low birth weight (LBW) and its sequelae. In India, an estimated 7.5 million babies are born each year with LBW, which accounts for more than one-third of the global burden. In
Audrey J Gaskins et al.
Obstetrics and gynecology, 124(1), 23-31 (2014-06-06)
To evaluate prospectively the relationship between prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Women in the Nurses' Health Study II who self-reported a pregnancy between 1992 and 2009 were included in this analysis. Dietary folate and supplement
Arnold L M Dekkers et al.
The Journal of nutrition, 144(12), 2083-2091 (2014-10-17)
For the evaluation of both the adequacy of intakes and the risk of excessive intakes of micronutrients, all potential sources should be included. In addition to micronutrients naturally present in foods, micronutrients can also be derived from fortified foods and
Henrik Kempe et al.
Pharmaceutical research, 32(2), 375-388 (2014-08-12)
To develop and evaluate molecularly imprinted nanocarriers for sustained release of erythromycin in physiological buffer media. Erythromycin-imprinted poly(methacrylic acid-co-trimethylolpropane trimethacrylate) nanocarriers and corresponding control nanocarriers were prepared by free-radical precipitation polymerization. The nanocarriers were characterized by transmission electron microscopy, dynamic
Susanna Kariluoto et al.
International journal of food microbiology, 176, 38-48 (2014-02-25)
The objective was to study folate production of yeast strains, bacteria isolated from oat bran, and selected lactic acid bacteria as well as one propionibacterium in oat and barley based models. Simultaneously, we aimed at sustaining the stability of viscosity
Myra A Carpenter et al.
Journal of the American Society of Nephrology : JASN, 25(7), 1554-1562 (2014-03-15)
The optimal BP level in kidney transplant recipients remains uncertain. This post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial cohort assessed associations of BP with a pooled cardiovascular disease (CVD) outcome and with
Thommey P Thomas et al.
Journal of medicinal chemistry, 48(11), 3729-3735 (2005-05-27)
The cellular uptake and cytotoxicity of an engineered multifunctional dendritic nanodevice containing folic acid (FA) as the targeting molecule, methotrexate (MTX) as the chemotherapeutic drug, and fluorescein (FI) as the detecting agent were studied in vitro. FI and FA were
Yoshinori Yamada et al.
Annals of nuclear medicine, 29(9), 792-798 (2015-08-05)
Technetium etarfolatide ((99m)Tc-EF) is a radioactive diagnostic imaging agent that was developed to assess the expression of folate receptors in tumors. Administering folic acid prior to the administration of (99m)Tc-EF has been shown to improve SPECT images. Here, we conducted
R Wendel Naumann et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4400-4406 (2013-10-16)
Vintafolide (EC145) is a folic acid-desacetylvinblastine conjugate that binds to the folate receptor (FR), which is expressed on the majority of epithelial ovarian cancers. This randomized phase II trial evaluated vintafolide combined with pegylated liposomal doxorubicin (PLD) compared with PLD
Rongqiang Liao et al.
Chembiochem : a European journal of chemical biology, 16(11), 1622-1628 (2015-06-03)
A targeting gene carrier for cancer-specific delivery was successfully developed through a "multilayer bricks-mortar" strategy. The gene carrier was composed of adamantane-functionalized folic acid (FA-AD), an adamantane-functionalized poly(ethylene glycol) derivative (PEG-AD), and β-cyclodextrin-grafted low-molecular-weight branched polyethylenimine (PEI-CD). Carriers produced by
Qiusha Tang et al.
PloS one, 9(9), e106483-e106483 (2014-09-05)
A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN) was developed. For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with
Vanesa Crujeiras et al.
Molecular genetics and metabolism, 115(4), 145-150 (2015-07-01)
Natural sources of protein and some vitamins and minerals are limited in phenylketonuria (PKU) treated patients, who should receive optimal supplementation although this is not yet fully established. We conducted a cross-sectional observational multicenter study including 156 patients with hyperphenylalaninemia.
Mattias Johansson et al.
Journal of the National Cancer Institute, 106(12), doi:10-doi:10 (2014-11-08)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants
Rima Obeid et al.
Journal of perinatal medicine, 41(5), 469-483 (2013-03-14)
Women have higher requirements for folate during pregnancy. An optimal folate status must be achieved before conception and in the first trimester when the neural tube closes. Low maternal folate status is causally related to neural tube defects (NTDs). Many
Inong R Gunanti et al.
The Journal of nutrition, 144(12), 2027-2033 (2014-11-21)
Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however
P M Tedeschi et al.
Cell death & disease, 4, e877-e877 (2013-10-26)
Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed
Victoriano Corpas-Lopez et al.
STAR protocols, 2(3), 100704-100704 (2021-09-02)
Here, we detail our optimized protocol for the identification of drug targets in Leishmania donovani using thermal proteome profiling. This approach is based on the principle that binding of a drug to its protein target can significantly alter the thermal
Alvin Nursalim et al.
Acta medica Indonesiana, 45(2), 150-156 (2013-06-19)
to determine whether the administration of folic acid, vitamin B6 and vitamin B12 would lead to reduction of cardiovascular complication and mortality among CKD patients. a search was conducted on PubMed and Google. The selection of title and abstract was
Suranjana Mukherjee et al.
PloS one, 10(2), e0118153-e0118153 (2015-02-28)
Natural Killer (NK) cells perform many functions that depend on actin assembly, including adhesion, chemotaxis, lytic synapse assembly and cytolysis. HS1, the hematopoietic homolog of cortactin, binds to Arp2/3 complex and promotes actin assembly by helping to form and stabilize
Aline H Guariento et al.
International journal of cancer, 135(1), 7-18 (2013-12-05)
The steady increase in the incidence and mortality of hepatocellular carcinoma (HCC) signifies a crucial need to understand better its pathogenesis to improve clinical management and prevention of the disease. The aim of this study was to investigate molecular mechanisms
Targeted molecular therapy for lung cancer: exuberance reestablished.
Timothy Craig Allen
Archives of pathology & laboratory medicine, 137(6), 747-747 (2013-06-01)
Juan M Rodriguez et al.
Nutrition and cancer, 67(4), 706-711 (2015-03-25)
Folic acid (FA) consumption at high levels has been associated with colon cancer risk. Several mechanisms have been proposed to explain this association. The Notch signal pathway has been implicated in the regulation of cellular proliferation. Our aim was to
Cynthia K Colapinto et al.
The British journal of nutrition, 112(11), 1873-1881 (2014-10-09)
Fortification of select grain products with folic acid and periconceptional supplementation recommendations in Canada and the USA have improved folate status, and have been associated with a reduced risk of neural tube defects. In the present study, we aimed to
Hongyu Chen et al.
Molecular pharmaceutics, 12(6), 1885-1892 (2015-04-15)
Monitoring of drugs in vivo has been recognized as an urgent need for successful chemotherapy treatment. However, to find an appropriate tool for this purpose has been proved as a great challenge. Here, we report a PLA-PEG coated hollow X-ray
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age
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