ADC and bioconjugation

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Dynamic Live Cell Imaging of Caspase Mediated Apoptosis and Cellular Hypoxia in Lymphocytes and Cancer Cells Using the CellASIC® ONIX2 Microfluidic Platform

Application note on how the CellASIC® ONIX2 microfluidic system can be used to analyze caspase-3 mediated apoptosis/cell death and cellular hypoxia in live immune and cancer cell lines.

Live Cell Calcium Indicators

Fluorescent calcium indicators and dyes to measure Ca+ flux used in calcium imaging experiments. Calcium ions (Ca2+) play vital cellular physiology roles in signal transduction pathways, in neurotransmitter release, in contraction of all muscle cell types, as enzyme cofactors, and

Fluorescent in situ Hybridization (FISH)

Available Fluorescent in situ hybridization (FISH) procedures, reagents and equipment.

Corning® High Content Screening Microplates – Frequently Asked Questions

A frequently asked questions guide for users of the Corning® high content screening microplates.

Oxygen & Nitric Oxide Probes

Our company's Detection Chelators and Ion Probes products are reviewed including oxygen and NO probe products, oxygen probes and NO probes.

Mesenchymal Stem Cell Markers and Antibodies

Mesenchymal stem cell markers and antibodies suitable for investigating targets in fibroblasts, chondrocytes, adipocytes, osteoblasts, and muscle cells.

Live Cell Imaging of β-Actin Cytoskeleton Proteins using LentiBrite™ Fluorescent Biosensors

Mesenchymal Stem Cell Characterization

Are your mesenchymal stem cells really MSCs? Learn more about the MSC characterization guidelines proposed by the International Society for Cellular Therapy (ISCT).

Long-Term Live Cell Tracking of Cancer and Stem Cells Using a Biocompatible Fluorescent Nanoparticle Based Upon Aggregation Induced Emission (AIE Dot) Nanotechnology

Biocompatible organic fluorescent nanoparticles (AIE Dots) that can be used to label cells and vasculature for long-term live cell tracking and tracing experiments.

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Cancer Stem Cell Detection with AldeRed™ 588-A

AldeRed™ 588-A detects ALDH activity in cancer stem cells, aiding in cancer research.

Cell Cycle Analysis Using NTP Transporter

Cell cycle regulates vital processes like DNA repair, cancer prevention. Four stages: G1, S, G2, M. NTPs don't permeate membranes.

Fluorescent Retinoid Probes

Fluorescent retinoic acid analogues for use in cellular imaging, protein-ligand binding assays, and flow cytometry to bypass traditional problems associated with fluorescent probes.

Fragment-Based DNA-Encoded Library

Dynamic Library technology in drug discovery delivers reliable results with high chemical diversity, suitable for various targets.

Triazolylphenylglyoxal Reagents: Bioconjugation

Chemical ligation modifies biological macromolecules for biotech and medicine, expanding functional material development.

GlycoProfile™ Azido Sugars

GlycoProfile™ Azido Sugar portfolio offers peracetylated azido sugars for glycan structure modification via chemical or biosynthetic pathways.

Crosslinkers Selection Guide

Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.

Guanylation of Amines

Introduce guanidinyl group using guanylating reagents like bis(tert-butoxycarbonyl)thiopseudourea, polymer-bound, from substituted amines.

Staudinger Ligation

Azides react with triarylphosphines to form iminophophoranes, a chemoselective synthetic method known as Staudinger Ligation.

Polybrene^® Technical Bulletin

Polybrene® neutralizes red blood cell charge, a vital anti-heparin agent in various laboratory applications.

Click Chemistry in Drug Discovery

Explore the principles and applications of click chemistry in drug discovery, highlighting efficient reactions that streamline the synthesis of bioactive compounds.

Future of Drug Discovery with DNA Encoded Libraries

DNA encoded libraries (DELs) offer a paradigm shift in drug discovery by leveraging molecular biology and high-throughput screening. DELs offer a full high-throughput screening library in one vial. Along with our DEL data package, machine learning and AI can be

Cellular Fluorescence Imaging with Millicell^® Cell Culture Inserts

Millicell® hanging cell culture inserts for staining and microscopic analysis directly from the insert. Learn to utilize hanging cell culture inserts in barrier measurements.

Fluorescence Lifetime Measurement

Fluorescence lifetime measurement is advantageous over intensity-based measurements. Applications include fluorescence lifetime assays, sensing and FLI.

Lipophilic Dye Kits for Cell Tracking

Lipophilic cell tracking dyes enable cancer biologists to track tumor and immune cell functions both in vitro and in vivo. Read the article to choose a right membrane dye kit for cell tracking and proliferation monitoring.

Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

PKH and CellVue® Claret Fluorescent Cell Linker Dyes

PKH and CellVue® Fluorescent Cell Linker Kits provide fluorescent labeling of live cells over an extended period of time, with no apparent toxic effects.

Fluorescent Live Cell Imaging of Cytoskeleton Structure Proteins using LentiBrite™ Lentiviral Biosensors

High titer lentiviral particles including beta-actin, alpha-tubulin and vimentin used for live cell analysis of cytoskeleton structure proteins.

Neural Stem Cell Markers and Antibodies

Neural stem cell markers and antibodies for prominent neural cell types and targets, including neurons, glial cells, neuronal differentiation markers, Nestin, and SOX2.

PKH Linker Kits for Fluorescent Cell Labeling

PKH dyes are easy to use and achieve stable, uniform, and reproducible fluorescent labeling of live cells. PKH dyes are non-toxic membrane stains which produce high signal to noise ratio.

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