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Of the thousands of chiral ligands used in asymmetric synthesis a relatively large number exhibit C2-symmetry. More recently, non-symmetrical modular P,N-ligands have been introduced independently by Pfaltz, Helmchen, and Williams and applied successfully in various metal-catalyzed reactions.
Gold Catalyst
We are proud to offer a treasure-trove of gold precatalysts and silver salts, as well as an extensive portfolio of unsaturated building blocks to accelerate your research success in this exciting field.
Hydrosilylation Catalyst
A Highly Efficient Hydrosilylation Catalyst, sigma-aldrich is pleased to offer [Cp*Ru(MeCN)3]PF6, as well as a number of other catalysts for hydrosilylation.
PEPPSI™ Catalysts
Professor Mike Organ at York University, along with co-workers Dr. Chris O’Brien and Dr. Eric Kantchev, have developed an palladium N-heterocyclic-carbene (NHC) catalyst system. They reacted PdCl2with a bulky NHC ligand, 2,6-diisopropylphenyllimidazolium chloride (IPr), and an α-donating 3-chloropyridine ligand for...
N-Heterocyclic Carbene (NHC) Ligands
Rapid progress in cross-coupling reactions of unactivated substrates catalyzed by metal complexes has transformed the chemical market-place through introduction of an extensive library of achiral and chiral phosphine ligands.
Kwon Phosphines: P-Chiral Monodentate Phosphines from Hydroxyproline
Chiral phosphines have been the staple ligands for asymmetric transition metal catalysis and more recently operate as catalysts in organic phosphinocatalysis.
Direct Arylation of Heterocycles
Lewis and co-workers have recently disclosed a highly functional-group compatible Rh-catalyzed C-H bond activation for the rapid synthesis of functionalized heterocycles.
Palladium-catalyzed Cross-coupling Reactions
A variety of palladium-catalyzed cross-coupling reactions can be run under mild room temperature conditions in water with TPGS- 750-M, using a variety of commercially available palladium complexes and ligands.
Trost Ligands
The Trost group at Stanford University has pioneered the use of C-2 symmetric diaminocyclohexyl (DACH) ligands in AAA, allowing for the rapid synthesis of a diverse range of chiral products with a limited number of chemical transformations.
N-Heterocyclic Carbene (NHC) Ligands
Emerging class of privileged ligands
PEPPSI™-IPent for Demanding Cross-Coupling Reactions
Professor Mike Organ and co-workers have developed the PEPPSI™ (Pyridine-Enhanced Precatalyst Preparation Stabilization and Initiation) precatalysts for palladium-catalyzed cross-coupling reactions.
Shvo’s Catalyst
Efficient epimerization catalyst for enzyme mediated dynamic kinetic resolution (DKR).
MRT - Mono-Boc-Protection of Diamines
Mono-Boc-protected diamines are versatile building blocks for chemical synthesis. Their production is a lot more challenging than the simple reaction scheme might imply, because the Boc-anhydride reagent cannot differentiate between the two identical amino moieties in the substrate.
catASium® Ligands
catASium - Essential Elements for Asymmetric Hydrogenations
Solvias MeOBIPHEP Ligands: State-of-the-art atropisomeric MeOBIPHEP ligands, also referred to as MeO-BIPHEP, originally developed by Roche, have an extraordinarily broad performance profile for many synthetic applications due to their modular ligand design.
ChemBeads Solid Catalyst Coated Glass Beads
ChemBeads, catalyst-coated glass beads, offer a simple and cost-efficient solution for dispensing miniscule amounts of solid chemical reagents for nanomole-scale use in high-throughput reaction screening.
Cinchona Alkaloids
Asymmetric phase-transfer catalysis (PTC) has been recognized as a “green” alternative to many homogeneous synthetic organic transformations, and has found widespread application. Synthetically modified cinchona alkaloids are typical chiral organocatalysts used in asymmetric PTC.
KitAlysis™ High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit
Materials included in your KITALYSIS-CUCN-2PK High-Throughput Screening Kit
N-Heterocyclic Carbene (NHC) Compounds
Rovis has demonstrated that triazolium salt in the presence of a base can act as an N-heterocyclic carbene organocatalyst1 in highly enantioselective intramolecular Stetter reactions.
Ir(I)-Catalyzed C–H Borylation
Arylboronic acids and esters are invaluable tools for the chemical community. These powerful reagents are used for a variety of transformations, most notably the Suzuki-Miyaura cross-coupling reaction.
KitAlysis™ Suzuki-Miyaura Cross-Coupling Reaction Screening Kit
Multiple tools have been created to ensure your success with kit set up. Start with the more detailed guide to ensure you are comfortable with all of the steps before using the quick guides on the excel worksheet. Remember that...
2nd Generation Buchwald Precatalysts
Buchwald precatalysts and ligands are bulky electron-rich dialkylbiaryl phospine-based catalysts and structurally related ligands that improve reactivity in Pd-catalyzed cross - coupling reactions
Scale-Up Guide: Suzuki-Miyaura Cross-Coupling Reaction
All of the preformed catalysts used in the kit are air and moisture stable complexes in their commercially available form.
KitAlysis™ C-N (Buchwald-Hartwig) High-Throughput Screening Kit
All contents in the foil bag are weighed, plated, packed, and sealed in a glove box under nitrogen.
NHC-based Palladium Catalysts
In collaboration with Umicore AG and Co.,1 we are pleased to offer a series of robust Pd(II) and Pd(0) complexes employed as the linchpin in C–C bond forming reactions.
NHC-Based Pd Catalysts and Ligands for C–C Bond Formation
Sigma-Aldrich presents an article concerning NHC-based Pd catalysts and ligands for C–C bond formation at
Rewarded by a Nobel Prize in 2001 for his pioneering work in asymmetric synthesis, Knowles was the first to develop a transition-metal chiral catalyst based on a chiral diphosphine ligand, DIPAMP, that could transfer chirality to a prochiral substrate with...
1-tBu-Indenyl Supported Palladium Precatalysts for Cross-Coupling
The Hazari group has developed an improved palladium precatalyst scaffold for a wide range of cross-coupling reactions
KitAlysis™ High-Throughput Screening Platform
KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.
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