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Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development
Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.
Polyelectrolyte Multilayer Films and Membrane Functionalization
We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.
Electrospun Nanofibers for Drug Delivery Systems
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
Collagen in Gene Delivery Applications
Collagen-based delivery systems effectively deliver a range of viral and non-viral gene carriers by providing spatiotemporal control over delivery and reducing degradation rates and immune responses.
Poly(2-oxazoline)s (POx) in Biomedical Applications
Poly(2-oxazoline)s (POx) can be viewed as conformational isomers of polypeptides. They are synthesized via living cationic ringopening polymerization (LCROP) of 2-oxazolines and were almost simultaneously discovered in 1966 by the groups of Litt, Tomalia, Fukui and Seeliger.
Protein- and Peptide- Polymer Conjugates by RAFT Polymerization
The modification of biomacromolecules, such as peptides and proteins, through the attachment of synthetic polymers has led to a new family of highly advanced biomaterials with enhanced properties.
Microfluidic-Assisted Manufacturing of Materials for Nanomedicine
Professor Nicola Tirelli (Istituto Italiano di Tecnologia, Italy) highlights the microfluidic-assisted method for fabricating well-defined and reproducible nanoparticles for drug delivery research.
Fluorescent Microparticles and Nanobeads
Fluorescently labeled microparticles are useful as standards in flow cytometry, confocal laser scanning microscopy, and with light scattering instruments..
Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting
Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.
Poly(2-Oxazoline)s: The Versatile Polymer Platform for Biomedicine
The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.
Chitosan-based Biomaterials
Chitin, a natural polysaccharide, is the second most abundant natural biopolymer in the world, after cellulose.
Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials
Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the...
Block Copolymer Synthesis Using a Nitroxide-mediated Radical Polymerization (NMP) Approach
A detailed article on block copolymer synthesis using a nitroxide-mediated radical polymerization (NMP) approach.
Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique...
Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers
One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated...
Silicon Carbide: The Return of an Old Friend
In recent years silicon carbide, SiC, has re-emerged as a vital technological material that is crucial in many materials and engineering applications.
Chitosan: A Versatile Platform for Pharmaceutical Applications
The development of new medical devices and pharmaceuticals plays an integral role in the medical industry. Both natural and synthetic polymers possess benefits that make them valuable components in therapeutics.
Functional Polymers for Biomedical Applications
Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization...
Applications of Glucose Polymers in the Synthesis of Diagnostic and Drug Delivery Nanoparticles
Dmitri Simberg (University of Colorado Anschutz Medical Campus, USA) reviews the used of dextran and cyclodextrin for the synthesis of nanoparticles used in drug delivery applications.
Flash NanoPrecipitation (FNP) – Principles and Applications in Medical Imaging and Drug Delivery
Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.