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Sachie Nakatani et al.
Biological & pharmaceutical bulletin, 30(3), 433-438 (2007-03-03)
Osteoarthritis (OA) is a slowly progressing chronic joint disease. Glucosamine (GlcN) is a saccharide that is widely used to relieve symptoms associated with OA. However, the mechanism of the effects of GlcN on articular cartilage remains unclear. We studied the
Nutrients and Dietary Supplements for Osteoarthritis
Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 97-137 (2019)
Anna Maria Piras et al.
International journal of biological macromolecules, 67, 124-131 (2014-03-26)
A commercially available chitosan (CS) was employed in the formulation of nanoparticles loaded with lysozyme (LZ) as antimicrobial protein drug model. Due to the variability of commercially available batches of chitosans and to the strict dependence of their physical and
Oshra Betzer et al.
ACS nano, 8(9), 9274-9285 (2014-08-19)
A critical problem in the development and implementation of stem cell-based therapy is the lack of reliable, noninvasive means to image and trace the cells post-transplantation and evaluate their biodistribution, final fate, and functionality. In this study, we developed a
Nathaniel S Hwang et al.
Biomaterials, 27(36), 6015-6023 (2006-07-29)
Differentiation of embryonic stem (ES) cells generally occurs after formation of three-dimensional cell aggregates, known as embryoid bodies (EBs). We have previously reported that hydrogels provide EBs a supportive environment for in vitro chondrogenic differentiation and three dimensional tissue formation
Sports Medicine and Concussion Management
Orthopaedic Physical Therapy Secrets, 172-182 (2017)
Viktor Chesnokov et al.
Cancer cell international, 14, 45-45 (2014-06-17)
We have reported that the glucosamine suppressed the proliferation of the human prostate carcinoma cell line DU145 through inhibition of STAT3 signaling. DU145 cells autonomously express IL-6 and the IL-6/STAT3 signaling is activated. IL-6 receptor subunits are subject to N-glycosylation
Lin Zhou et al.
Pathology, research and practice, 215(12), 152681-152681 (2019-11-07)
The hexosamine biosynthetic pathway (HBP), a branch of glucose metabolism, provides a substrate for glycosylation modification, which has a wide-ranging effect on cellular functions. Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) has been reported to regulate the HBP as the first and rate-limiting
Benan Pelin Sermikli et al.
Molecular biology reports, 47(8), 5927-5942 (2020-07-22)
O-linked N-acetyl-glucosamine (O-GlcNAc) is a post-translational protein modification that regulates cell signaling and involves in several pathological conditions. O-GlcNAc transferase (OGT) catalyzes the attachment, while O-GlcNAcase (OGA) splits the GlcNAc molecules from the serine or threonine residues of the nuclear
Marcus Gutmann et al.
ACS biomaterials science & engineering, 5(1), 215-233 (2019-01-14)
Metabolic glycoengineering allows insertion of non-natural monosaccharides into glycan structures during biosynthesis thereby enabling extracellular matrices (ECMs), cell surfaces, or tissues for decoration with functional cues with ultimate spatial control while deploying aqueous and toxicologically benign coupling chemistries. In this
Chia-Hung Lin et al.
International journal of molecular sciences, 22(7) (2021-04-04)
Protein O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine (GlcNAc) to the hydroxyl groups of Ser/Thr residues on numerous nucleocytoplasmic proteins. Two enzymes are responsible for O-GlcNAc cycling on substrate proteins: O-GlcNAc transferase (OGT) catalyzes the addition
David R Jones et al.
The FEBS journal, 281(16), 3591-3608 (2014-06-19)
Glucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glucose deprivation specifically modulates the phosphatidylinositol 3-kinase/protein kinase B (PI3K/PKB) cell survival pathway.
Glucosamine Chondroitin Sulfate
Saunders Handbook of Veterinary Drugs, 357-358 (2016)
Tali Ilovitsh et al.
Biomedical optics express, 6(4), 1262-1272 (2015-04-25)
Localization microscopy provides valuable insights into cellular structures and is a rapidly developing field. The precision is mainly limited by additive noise and the requirement for single molecule imaging that dictates a low density of activated emitters in the field
Khadijeh Jamialahmadi et al.
Environmental toxicology and pharmacology, 38(1), 212-219 (2014-06-25)
Glucosamine (GlcN) is an important precursor in the biochemical synthesis of glycosylated proteins and lipids in human body. It gains importance because of its contribution to human health and its multiple biological and therapeutic effects. In this study, the in
Ji-Sun Hwang et al.
Metabolism: clinical and experimental, 64(3), 368-379 (2014-12-18)
This study investigated the potential of glucosamine (GlcN) to affect body weight gain and insulin sensitivity in mice normal and at risk for developing diabetes. Male C57BL/6J mice were fed either chow diet (CD) or a high fat diet (HFD)
Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses
Laverty S, et al.
Arthritis, 52(1), 181-191 (2005)
C Hubert et al.
Journal of chromatography. A, 1395, 88-98 (2015-04-22)
When using an analytical method, defining an analytical target profile (ATP) focused on quantitative performance represents a key input, and this will drive the method development process. In this context, two case studies were selected in order to demonstrate the
Han Na Suh et al.
Journal of cellular physiology, 229(10), 1557-1568 (2014-03-05)
The aim of this study is to determine whether GlcN could recover the endoplasmic reticulum (ER) stress-induced dysfunction of Na(+) /glucose cotransporter (SGLT) in renal proximal tubule cells (PTCs) under hypoxia. With the rabbit model, the renal ischemia induced tubulointerstitial
Jessica M Bryant et al.
Molecular systems biology, 16(8), e9569-e9569 (2020-08-21)
Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role. We adapted a CRISPR-based proteomics approach to identify novel factors associated
Patrícia Anacleto et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 145, 111717-111717 (2020-09-06)
Human exposure to mercury (Hg) and methylmercury (MeHg) through the ingestion of seafood raises human health-related concerns. In contrast, green tea has health benefits and its consumption potentially reduces bioaccessibility of dietary Hg. The present study aimed to assess the
Chunmei He et al.
Plant molecular biology, 88(3), 219-231 (2015-05-01)
Dendrobium officinale is a traditional Chinese medicinal plant. The stems of D. officinale contain mannan polysaccharides, which are promising bioactive polysaccharides for use as drugs. However, the genes involved in the biosynthesis of mannan polysaccharides in D. officinale have not
Yuliya Hrynets et al.
Journal of agricultural and food chemistry, 63(27), 6249-6261 (2015-06-27)
This experiment compared the in vitro degradation of glucosamine (GlcN), N-acetylglucosamine, and glucose in the presence of NH3 incubated at 37 °C in phosphate buffer from 0.5 to 12 days. The reactions were monitored with UV-vis absorption and fluorescence emission
Hiba Al-Hamidi et al.
Pharmaceutical development and technology, 20(1), 74-83 (2014-01-08)
The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being selected. The work presented explores amino sugars (d-glucosamine HCl
Hsiao-Wen Chiu et al.
Scientific reports, 9(1), 5603-5603 (2019-04-05)
The NLRP3 inflammasome promotes the pathogenesis of metabolic, neurodegenerative and infectious diseases. Increasing evidences show that the NLRP3 inflammasome is a promising therapeutic target in inflammatory diseases. Glucosamine is widely used as a dietary supplement to promote the health of
Barbara Prandi et al.
Analytical and bioanalytical chemistry, 406(19), 4765-4775 (2014-05-21)
During wheat digestion, gluten-derived proteolytic resistant peptides are generated, some of them involved in celiac disease. In vitro digestion models able to mimic the peptides generated in the human gastrointestinal tract are extremely useful to assess the pathogenicity of wheat-derived
N Henry et al.
International journal of cosmetic science, 37(2), 196-206 (2014-11-18)
The objective of this study was to synthesize a novel glucosamine-imprinted sorbent based on ionic and non-covalent dual approach to purify glucosamine from chicory root extracts. The synthesis of the molecularly imprinted polymer was optimized in terms of choice of
Wan-Yu Chou et al.
Journal of cellular physiology, 230(9), 2240-2251 (2015-03-11)
Breast cancer is a common cancer leading to many deaths among females. Cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) are two highly expressed inflammatory mediators to be induced by the protein kinase C (PKC) signaling via various inflammatory stimuli and both contribute
Ahmad Mohammed Gumel et al.
Biomedical materials (Bristol, England), 10(4), 045001-045001 (2015-07-15)
Wound management and healing in several physiological or pathological conditions, particularly when comorbidities are involved, usually proves to be difficult. This presents complications leading to socio-economic and public health burdens. The accelerative wound healing potential of biocompatible poly(3-hydroxyalkanoates)-co-(6-hydroxyhexanoate) (PHA-PCL) composite
I Redonnet-Vernhet et al.
Biochimica et biophysica acta, 1317(2), 127-133 (1996-11-15)
The molecular defects in the HEXB gene encoding the common beta-subunit of lysosomal beta-hexosaminidase A (beta-Hex A, alpha beta) and beta-Hex B (beta beta) were investigated in a Portuguese family affected with late onset Sandhoff disease (GM2-gangliosidosis variant 0). This
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