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Ashley R Flory et al.
BMC biotechnology, 13, 28-28 (2013-03-28)
It is important for industries to find green chemistries for manufacturing their products that have utility, are cost-effective and that protect the environment. The paper industry is no exception. Renewable resources derived from plant components could be an excellent substitute
Nor Fazliyana Mohtar et al.
Food chemistry, 155, 64-73 (2014-03-07)
Chemical modifications of gelatin from New Zealand hoki (Macruronus novaezelandiae) skins were carried out using three different cross-linking agents, namely, genipin, glutaraldehyde and caffeic acid, at different concentrations. The chemically modified gelatins exhibited better physical properties, such as higher gel
Iva Gudernova et al.
Oncotarget, 8(65), 109319-109331 (2018-01-10)
Many tyrosine kinase inhibitors (TKIs) have failed to reach human use due to insufficient activity in clinical trials. However, the failed TKIs may still benefit patients if their other kinase targets are identified by providing treatment focused on syndromes driven
M Alizadeh et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 3958-3967 (2013-08-06)
A combined freeze-drying and particulate leaching method for scaffold synthesis showed an improvement in the horizontal microstructure of the gelatin/chitosan scaffolds. Type and concentration of the cross-linking agent, freezing temperature, concentration of the polymeric solution and gelatin/chitosan weight ratio were
Dai-Hung Ngo et al.
Food chemistry, 143, 246-255 (2013-09-24)
Skin gelatin of skate (Okamejei kenojei) was hydrolyzed using Alcalase, flavourzyme, Neutrase and protamex. It was found that the Alcalase hydrolysate exhibited the highest angiotensin-I converting enzyme (ACE) inhibitory activity. Then, Alcalase hydrolysate was further hydrolyzed with protease and separated
Marcel Reichen et al.
Journal of laboratory automation, 18(6), 519-529 (2013-08-24)
We present a multiplexed platform for a microfabricated stem cell culture device. The modular platform contains all the components to control stem cell culture conditions in an automated fashion. It does not require an incubator during perfusion culture and can
Tüzer Kalkan et al.
Cell stem cell, 24(5), 785-801 (2019-04-30)
The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing components of the ESC transcription factor circuitry. However, TCF3 depletion only delays and does not prevent
Johno Breeze et al.
Journal of the Royal Army Medical Corps, 159(2), 84-89 (2013-05-31)
Ballistic gelatin is the most common tissue simulant used to reproduce the penetration of projectiles into muscle but published data to support its use are primarily based on bullets, despite explosive fragments being the most common cause of injury to
Rampurna Prasad Gullapalli
Journal of pharmaceutical sciences, 99(10), 4107-4148 (2010-08-26)
It is estimated that more than 40% of new chemical entities (NCEs) coming out of the current drug discovery process have poor biopharmaceutical properties, such as low aqueous solubility and/or permeability. These suboptimal properties pose significant challenges for the oral
Ronghui Li et al.
STAR protocols, 2(3), 100745-100745 (2021-08-26)
Extended/expanded pluripotent stem (EPS) cells can efficiently contribute to both embryonic and extraembryonic lineages in vitro and in vivo. Starting from these cells, we established a 3D differentiation system that enabled the generation of blastocyst-like structures (EPS-blastoids) through lineage segregation
Daniel Cirera-Salinas et al.
Bio-protocol, 7(16), e2507-e2507 (2017-08-20)
A novel method to assess the dissolution of the core pluripotency transcription-factor circuit of mouse Embryonic Stem Cells (mESCs) has been developed ( Ying et al., 2003 ; Betschinger et al., 2013 ). In order to efficiently identify genes essential
Muskan Kanungo et al.
Polymers, 13(19) (2021-10-14)
A major challenge in tissue engineering is the formation of vasculature in tissue and organs. Recent studies have shown that positively charged microspheres promote vascularization, while also supporting the controlled release of bioactive molecules. This study investigated the development of
Dan Huang et al.
International journal of nanomedicine, 12, 7483-7500 (2017-10-27)
Titanium (Ti) and its alloys have been widely used in clinics for years. However, their bio-inert surface challenges application in patients with compromised surgical conditions. Numerous studies were conducted to modify the surface topography and chemical composition of Ti substrates
Ravi L Rungta et al.
Neuron, 99(2), 362-375 (2018-06-26)
Functional hyperemia, a regional increase of blood flow triggered by local neural activation, is used to map brain activity in health and disease. However, the spatial-temporal dynamics of functional hyperemia remain unclear. Two-photon imaging of the entire vascular arbor in
Shaohua Ma
Soft matter, 15(19), 3848-3853 (2019-04-30)
Ordered microgel networks have undergone extensive research and shown translational promise in tissue engineering, precision and regenerative medicine, controlled delivery, optics and electronics, etc. Here, we introduce a new low-cost and efficient synthesizer for ordered microgel networks. The gel precursor
Emine Alarçin et al.
Biomaterials science, 6(6), 1604-1615 (2018-05-08)
Bone nonunion may occur when the fracture is unstable, or blood supply is impeded. To provide an effective treatment for the healing of nonunion defects, we introduce an injectable osteogenic hydrogel that can deliver cells and vasculogenic growth factors. We
Ramona Schmitt et al.
PloS one, 14(2), e0212859-e0212859 (2019-02-23)
Elevated matrix metalloproteinase-2 (MMP-2) tissue levels have been associated with ascending thoracic aortic aneurysm (aTAA). As MMP-2 activation is controlled by interactions among matrix metalloproteinase-14 (MMP-14), a tissue inhibitor of metalloproteinases-2 (TIMP-2) and Pro-MMP-2 in cell culture, this activation process
Teresa Robert-Finestra et al.
Nature communications, 12(1), 7000-7000 (2021-12-03)
At initiation of X chromosome inactivation (XCI), Xist is monoallelically upregulated from the future inactive X (Xi) chromosome, overcoming repression by its antisense transcript Tsix. Xist recruits various chromatin remodelers, amongst them SPEN, which are involved in silencing of X-linked
Claudio Schonauer et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 13 Suppl 1, S89-S96 (2004-06-29)
The use of local agents to achieve hemostasis is an old and complex subject in surgery. Their use is almost mandatory in spinal surgery. The development of new materials in chemical hemostasis is a continuous process that may potentially lead
Chandra Prajapati et al.
Stem cell research, 51, 102176-102176 (2021-01-24)
The human induced pluripotent stem cells (hiPSCs) derived cardiomyocytes (CMs) (hiPSC-CMs) retain the same genetic information as the donor, and they have been shown to faithfully recapitulate the disease phenotypes of various genetic cardiac diseases. The hiPSC-CMs can be utilized
Fuquan Chen et al.
Stem cells international, 2021, 6657597-6657597 (2021-02-26)
Pluripotency and self-renewal of embryonic stem cells (ESCs) are marked by core transcription regulators such as Oct4, Sox2, and Nanog. Another important marker of pluripotency is the long noncoding RNA (lncRNA). Here, we ind that a novel long noncoding RNA
Samantha J Stehbens et al.
Nature cell biology, 16(6), 561-573 (2014-05-27)
Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs assemble near the leading edge, grow and mature as a result of contractile forces and disassemble underneath
Leslie Crews et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(16), 4250-4260 (2008-04-18)
Altered expression and mutations in alpha-synuclein (alpha-syn) have been linked to Parkinson's disease (PD) and related disorders. The neurological alterations in PD patients have been associated with degeneration of dopaminergic cells and other neuronal populations. Moreover, recent studies in murine
Ayşegül Karataş et al.
Acta poloniae pharmaceutica, 70(5), 883-897 (2013-10-24)
The aim of the study was to investigate the physical stability of the semi-solid dispersions into the hard gelatine capsules prepared with Gelucire 44/14, Labrasol and different additives such as microcrystalline cellulose (MCC), mannitol and lactose (alpha-monohydrate) used for enhancing
Endoscopic injection of gelatin solution for severe hemorrhagic gastric cancer.
M Tajika et al.
Gastrointestinal endoscopy, 43(3), 247-250 (1996-03-01)
Raja Mohd Hafidz Raja Nhari et al.
Journal of food science, 77(1), R42-R46 (2012-01-21)
Usage of gelatin in food products has been widely debated for several years, which is about the source of gelatin that has been used, religion, and health. As an impact, various analytical methods have been introduced and developed to differentiate
Matteo Bolomini-Vittori et al.
Scientific reports, 9(1), 3556-3556 (2019-03-07)
Local membrane phospholipid enrichment serves as docking platform for signaling proteins involved in many processes including cell adhesion and migration. Tissue-resident dendritic cells (DCs) assemble actomyosin-based structures called podosomes, which mediate adhesion and degradation of extracellular matrix for migration and
Caitlin Regan et al.
Biomedical optics express, 8(12), 5708-5723 (2018-01-04)
Due to its simplicity and low cost, laser speckle imaging (LSI) has achieved widespread use in biomedical applications. However, interpretation of the blood-flow maps remains ambiguous, as LSI enables only limited visualization of vasculature below scattering layers such as the
Zhaowei Chen et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(17), e2101027-e2101027 (2021-07-16)
Tissue architecture is a prerequisite for its biological functions. Recapitulating the three-dimensional (3D) tissue structure represents one of the biggest challenges in tissue engineering. Two-dimensional (2D) tissue fabrication methods are currently in the main stage for tissue engineering and disease
Mitsumasa Kawago et al.
The Journal of thoracic and cardiovascular surgery, 147(5), 1644-1649 (2013-09-12)
Intra-airway and intra-arterial administration of gelatin-embedded, sustained-release basic fibroblast growth factor has stimulated regeneration of emphysematous lungs in animal experiments, but these routes of administration may also cause harm. This study investigated the effectiveness of intrapleural administration of gelatin-embedded, sustained-release
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