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Joo-Hee Park et al.
Scientific reports, 11(1), 8183-8183 (2021-04-16)
Nitric oxide (NO) has the potential to modulate myofibroblast differentiation. In this study, we investigated the effect of exogenous NO on the myofibroblast differentiation of human keratocytes using sodium nitrite as a NO donor. Myofibroblasts were induced by exposing resting
Mónica Cicuéndez et al.
Colloids and surfaces. B, Biointerfaces, 186, 110709-110709 (2019-12-17)
The preparation of graphene-based nanomaterials (GBNs) with appropriate stability and biocompatibility is crucial for their use in biomedical applications. In this work, three GBNs differing in size and/or functionalization have been synthetized and characterized, and their in vitro biological effects
Bin Yang et al.
Oxidative medicine and cellular longevity, 2019, 5820415-5820415 (2019-12-31)
Doxorubicin (Dox) with cardiotoxicity and endotheliotoxicity limits its clinical application for cancer. The toxicitic mechanism involves excess ROS generation. 14-3-3s have the protective effects on various injured tissues and cells. Tetramethylpyrazine (TMP) is an alkaloid extracted from the rhizome of
Susan M Gribble et al.
Nature protocols, 4(12), 1722-1736 (2009-11-07)
Array painting is a technique that uses microarray technology to rapidly map chromosome translocation breakpoints. Previous methods to map translocation breakpoints have used fluorescence in situ hybridization (FISH) and have consequently been labor-intensive, time-consuming and restricted to the low breakpoint
A Pavani Sowjanya et al.
Nitric oxide : biology and chemistry, 52, 21-28 (2015-10-06)
Cervical cancer is caused by infection with high risk human papillomavirus (HR-HPV). Inducible nitric oxide synthase (iNOS), a soluble factor involved in chronic inflammation, may modulate cervical cancer risk among HPV infected women. The aim of the study was to
Min-Hee Yi et al.
Scientific reports, 6, 34901-34901 (2016-10-13)
The heterogeneity of microglial functions have either beneficial or detrimental roles in specific physiological or pathological environments. However, the details of what transcriptional mechanisms induce microglia to take beneficial phenotypes remain unknown. Here, we report that Foxp3 is essential for
Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes
Pufe T, et al.
Osteoarthritis and Cartilage, 15(2), 155-162 (2007)
Nancy Saji et al.
Foods (Basel, Switzerland), 9(6) (2020-07-01)
Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB)
Bartłomiej Taciak et al.
PloS one, 13(6), e0198943-e0198943 (2018-06-12)
Established cell lines are widely used in research, however an appealing question is the comparability of the cells between various laboratories, their characteristics and stability in time. Problematic is also the cell line misidentification, genetic and phenotypic shift or Mycoplasma
Omar H Khalaf et al.
Infection and immunity, 88(4) (2020-01-15)
Osteoarticular disease is a frequent complication of human brucellosis. Vaccination remains a critical component of brucellosis control, but there are currently no vaccines for use in humans, and no in vitro models for assessing the safety of candidate vaccines in
Satoru Kyo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(3), 525-537 (2010-12-07)
Despite the therapeutic utility of progestin in invasive and preinvasive endometrial neoplasias, the molecular mechanisms through which it exerts inhibitory effects on endometrial epithelial growth are largely unknown. The aim of the study was to clarify the molecular mechanisms of
Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids
Green LC, et al.
Analytical biochemistry, 126(1), 131-138 (1982)
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Nathan Klopfenstein et al.
PLoS pathogens, 17(3), e1009387-e1009387 (2021-03-11)
The skin innate immune response to methicillin-resistant Staphylococcus aureus (MRSA) culminates in the formation of an abscess to prevent bacterial spread and tissue damage. Pathogen recognition receptors (PRRs) dictate the balance between microbial control and injury. Therefore, intracellular brakes are
Jeffrey Lee Jensen et al.
Cancer immunology research, 3(8), 881-890 (2015-05-06)
Myeloma remains a virtually incurable malignancy. The inevitable evolution of multidrug-resistant clones and widespread clonal heterogeneity limit the potential of traditional and novel therapies to eliminate minimal residual disease (MRD), a reliable harbinger of relapse. Here, we show potent anti-myeloma
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Tae-Hwan Kim et al.
PLoS pathogens, 15(8), e1008004-e1008004 (2019-08-15)
Fas-associated factor 1 is a death-promoting protein that induces apoptosis by interacting with the Fas receptor. Until now, FAF1 was reported to interact potentially with diverse proteins and to function as a negative and/or positive regulator of several cellular possesses.
Natalia Areiza-Mazo et al.
Frontiers in chemistry, 6, 276-276 (2018-09-04)
The use of medicinal plants to counteract the oxidative damage in neurodegenerative diseases has steadily increased over the last few years. However, the rationale for using these natural compounds and their therapeutic benefit are not well explored. In this study
Özge Canli et al.
Cancer cell, 32(6), 869-883 (2017-12-13)
Increased oxidative stress has been suggested to initiate and promote tumorigenesis by inducing DNA damage and to suppress tumor development by triggering apoptosis and senescence. The contribution of individual cell types in the tumor microenvironment to these contrasting effects remains
Liuke Sun et al.
Scientific reports, 8(1), 383-383 (2018-01-13)
Neuroinflammation is involved in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. We show that lack of PINK1- a mitochondrial kinase linked to recessive familial PD - leads to glia type-specific abnormalities of innate immunity. PINK1 loss enhances
Praveen Papareddy et al.
The Journal of biological chemistry, 285(36), 28387-28398 (2010-07-02)
Tissue factor pathway inhibitor (TFPI) inhibits tissue factor-induced coagulation, but may, via its C terminus, also modulate cell surface, heparin, and lipopolysaccharide interactions as well as participate in growth inhibition. Here we show that C-terminal TFPI peptide sequences are antimicrobial
Mahesh Ramalingam et al.
Journal of cellular biochemistry, 117(4), 917-926 (2015-09-15)
Parkinson's disease (PD) is a common chronic neurodegenerative disorder associated with aging that primarily caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SN). Retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells (SH-SY5Y+RA) have been broadly utilized
Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade.
Alexander, et al.
Molecular Cancer Therapeutics, 19, 2012-2022 (2021)
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Vahid Reza Askari et al.
Journal of ethnopharmacology, 194, 1112-1121 (2016-11-16)
The anti-inflammatory and anti-oxidants activity of Portulaca oleracea L. (P. oleracea) were mentioned in traditional texts. In previous studies, different anti-inflammatory and anti-oxidant effects of P. oleracea were demonstrated. However, the mechanism of action and immunomodulatory property of this plant
Gopinath Kasetty et al.
Antimicrobial agents and chemotherapy, 55(6), 2880-2890 (2011-03-16)
Peptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds. In this study, we wanted to investigate minimal determinants, as well as structural features, governing the antimicrobial and immunomodulating activity of this peptide
Vahid Reza Askari et al.
Life sciences, 219, 40-73 (2019-01-09)
Neuroinflammation is observed as a routine characterization of neurodegenerative disorders such as dementia, multiple sclerosis (MS) and Alzheimer's diseases (AD). Scientific evidence propounds both of the neuromodulatory and immunomodulatory effects of CB2 in the immune system. β-Caryophyllene (BCP) is a
Ondřej Vašíček et al.
Journal of physiology and biochemistry, 76(1), 49-60 (2020-01-05)
In this study, we focused on comparing the effects of serotonin and its metabolites on the functions of RAW264.7 cells (emphasis on oxidative burst and production of nitric oxide and cytokines), thereby expanding the scope of existing knowledge with advent
Li-ping Yang et al.
Molecular vision, 13, 1083-1093 (2007-07-27)
To elucidate the inhibitory effect of minocycline and sulforaphane on lipopolysaccharide (LPS)-induced retinal microglial activation and the mechanisms through which they exerted their inhibitory effects. Primary retinal microglial cultures were exposed to LPS with or without minocycline and sulforaphane. The
T Tikka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(8), 2580-2588 (2001-04-18)
Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined whether minocycline reduces excitotoxicity in primary neuronal cultures. Minocycline (0.02 microm) significantly increased neuronal survival in mixed spinal cord (SC) cultures treated with 500
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