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Tomohiro Hamada et al.
Brain research. Molecular brain research, 139(1), 42-51 (2005-06-15)
Transgenic rats expressing enhanced green fluorescent protein (EGFP) under the control of an estrogen receptor (ER) alpha promoter were generated to tag ERalpha-positive neurons in the brain. Two transgenes, one containing sequences for promoter A and DsRed and the other
Tomohiro Ohgomori et al.
Neurotoxicity research, 33(4), 768-780 (2017-10-02)
Chronic administration of 3,3'-iminodipropionitrile (IDPN) causes axonal impairment. Although controversy still remains, it has been suggested that IDPN intoxication mimics the axonopathy of amyotrophic lateral sclerosis (ALS). Interestingly, recent studies including our own showed that signal transducer and activator of
Gabriella Hannah Wolff et al.
eLife, 6 (2017-09-28)
Mushroom bodies are the iconic learning and memory centers of insects. No previously described crustacean possesses a mushroom body as defined by strict morphological criteria although crustacean centers called hemiellipsoid bodies, which serve functions in sensory integration, have been viewed
Nathan L Brown et al.
Development, growth & differentiation, 45(2), 153-165 (2003-05-20)
The mammalian face is assembled in utero in a series of complex and interdependent molecular, cell and tissue processes. The orofacial complex appears to be exquisitely sensitive to genetic and environmental influence and this explains why clefts of the lip
D D Wang et al.
The Journal of physiology, 550(Pt 3), 785-800 (2003-06-17)
Previous studies have reported the presence of migrating and dividing neuronal progenitors in the subventricular zone (SVZ) and rostral migratory stream (RMS) of the postnatal mammalian brain. Although the behaviour of these progenitors is thought to be influenced by local
Aberrant accumulation of the diabetes autoantigen GAD65 in Golgi membranes in conditions of ER stress and autoimmunity.
Phelps E A, et al.
Diabetes, db160180 (2016)
Yun Zhang et al.
The journal of headache and pain, 21(1), 72-72 (2020-06-12)
Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to migraine had not been well elucidated. Thus, the present study investigated vestibular dysfunction in a rat model of chronic migraine
Samantha J Murray et al.
Journal of chemical neuroanatomy, 97, 43-56 (2019-01-22)
The substantia nigra is an integral component of the basal ganglia circuitry for limbic and motor functions. Dysfunction and degeneration of the basal ganglia are fundamental aspects of neurodegenerative diseases such as Parkinson's disease and Huntington's disease. With the increasing
Yuichi Abe et al.
Neuroscience research, 63(2), 138-148 (2008-12-17)
Ligands for the epidermal growth factor receptor ErbB1, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGFalpha), negatively regulate synaptic maturation of GABAergic neurons in the developing neocortex. Here, we evaluated the effects of these ligands in
Alexander W M Hooper et al.
Molecular therapy. Methods & clinical development, 22, 196-209 (2021-09-07)
Fragile X syndrome (FXS), a neurodevelopmental disorder with no known cure, is caused by a lack of expression of the fragile X mental retardation protein (FMRP). As a single-gene disorder, FXS is an excellent candidate for viral-vector-based gene therapy, although
S Baekkeskov et al.
Nature, 347(6289), 151-156 (1990-09-13)
The pancreatic islet beta-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mellitus (IDDM) has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory
Hanne Halkinrud Thoen et al.
The Journal of comparative neurology, 528(7), 1079-1094 (2019-10-18)
Mantis shrimps (Stomatopoda) possess in common with other crustaceans, and with Hexapoda, specific neuroanatomical attributes of the protocerebrum, the most anterior part of the arthropod brain. These attributes include assemblages of interconnected centers called the central body complex and in
Nicholas J Strausfeld et al.
The Journal of comparative neurology, 528(2), 261-282 (2019-08-04)
Brain centers possessing a suite of neuroanatomical characters that define mushroom bodies of dicondylic insects have been identified in mantis shrimps, which are basal malacostracan crustaceans. Recent studies of the caridean shrimp Lebbeus groenlandicus further demonstrate the existence of mushroom
Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.
Can Peng et al.
PloS one, 12(7), e0182142-e0182142 (2017-08-02)
Nicotinic acetylcholine receptors containing α4 subunits (α4β2* nAChRs) are critical for nicotinic cholinergic transmission and the addictive action of nicotine. To identify specific activities of these receptors in the adult mouse brain, we coupled targeted deletion of α4 nAChR subunits
B K Michelsen et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(19), 8754-8758 (1991-10-01)
A 64-kDa islet protein is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). Autoantibodies against the 64-kDa protein were recently shown to immunoprecipitate glutamic acid decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) from brain and from islets. We present evidence that
Zachary J Hall et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(8), 2000-2014 (2018-01-25)
Postembryonic brain development is sensitive to environmental input and sensory experience, but the mechanisms underlying healthy adaptive brain growth are poorly understood. Here, we tested the importance of visual experience on larval zebrafish (Danio rerio) postembryonic development of the optic
Lorise C Gahring et al.
PloS one, 9(8), e103861-e103861 (2014-08-06)
The nicotinic acetylcholine receptor alpha 7 (α7) is a ligand-activated ion channel that contributes to a diversity of cellular processes involved in development, neurotransmission and inflammation. In this report the expression of α7 was examined in the mouse developing and
Julie-Christine Lévesque et al.
Movement disorders : official journal of the Movement Disorder Society, 20(5), 574-584 (2005-01-13)
The subthalamic nucleus (STN) is considered a homogeneous structure composed essentially of projection neurons that exert a profound glutamate-mediated excitatory influence upon the main output structures of the basal ganglia. It is currently the most efficient target for deep brain
Gabriel Lepousez et al.
The Journal of comparative neurology, 518(11), 1976-1994 (2010-04-16)
Neuropeptides play a major role in the modulation of information processing in neural networks. Somatostatin, one of the most concentrated neuropeptides in the brain, is found in many sensory systems including the olfactory pathway. However, its cellular distribution in the
Lars-Oliver Tykocinski et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19426-19431 (2010-10-23)
Thymic central tolerance comprehensively imprints the T-cell receptor repertoire before T cells seed the periphery. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process by virtue of promiscuous expression of tissue-restricted autoantigens. The molecular regulation of this
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Chihiro Sato et al.
Neuroscience research, 117, 1-13 (2016-11-27)
Although the anatomical and physiological properties of subtypes of retinal ganglion cells (RGCs) have been extensively investigated, their molecular properties are still unclear. Here, we examined the expression patterns of FoxP2 in the retina of ferrets and mice. We found
Nicholas Strausfeld et al.
eLife, 10 (2021-02-10)
Neural organization of mushroom bodies is largely consistent across insects, whereas the ancestral ground pattern diverges broadly across crustacean lineages resulting in successive loss of columns and the acquisition of domed centers retaining ancestral Hebbian-like networks and aminergic connections. We
Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation?
Domschke K, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 46, 189-196 (2013)
G Brückner et al.
Neuroscience, 151(2), 489-504 (2007-12-07)
The extracellular matrix is known to be involved in neuronal communication and the regulation of plastic changes, and also considered to protect neurons and synapses against damage. The goal of this study was to investigate how major extracellular matrix components
Lauren Faget et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(21), 7301-7310 (2012-05-25)
G-protein-coupled receptors (GPCRs) mediate numerous physiological functions and represent prime therapeutic targets. Receptor trafficking upon agonist stimulation is critical for GPCR function, but examining this process in vivo remains a true challenge. Using knock-in mice expressing functional fluorescent delta opioid
E Erbs et al.
Neuroscience, 221, 203-213 (2012-07-04)
Delta opioid receptors participate to the control of chronic pain and emotional responses. Recent data also identified their implication in spatial memory and drug-context associations pointing to a critical role of hippocampal delta receptors. We examined the distribution of delta
Matthew T Colonnese et al.
The Journal of comparative neurology, 494(5), 738-751 (2005-12-24)
During a short perinatal interval, N-methyl-D-aspartate receptor (NMDAR) function is essential to a process in which spontaneous retinal waves focus retinal axon arbors in the superficial layers of the rodent superior colliculus (sSC). Here we provide evidence that this NMDAR-dependent
Mary M Feng et al.
International journal of physiology, pathophysiology and pharmacology, 5(2), 91-101 (2013-06-12)
Gamma-aminobutyric acid (GABA) is produced and secreted by adult pancreatic β-cells, which also express GABA receptors mediating autocrine signaling and regulating β-cell proliferation. However, whether the autocrine GABA signaling involves in β-cell progenitor development or maturation remains uncertain. By means
Heidi O Nousiainen et al.
PloS one, 9(5), e97851-e97851 (2014-05-23)
Prostatic acid phosphatase (PAP), the first diagnostic marker and present therapeutic target for prostate cancer, modulates nociception at the dorsal root ganglia (DRG), but its function in the central nervous system has remained unknown. We studied expression and function of
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