Shao-Jing Hong et al.
Biochimica et biophysica acta, 1840(12), 3335-3344 (2014-09-02)
Filopodia are actin-rich membrane protrusions that play instrumental roles in development, cell migration, pathogen detection, and wound healing. During neurogenesis, filopodium formation precedes the formation of dendrites and spines. The insulin receptor substrate protein of 53kDa (IRSp53) has been implicated