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Rodrigo W Santos et al.
Protoplasma, 252(5), 1203-1215 (2015-01-08)
Copper and lead, as remnants of industrial activities and urban effluents, have heavily contaminated many aquatic environments. Therefore, this study aimed to determine their effects on the physiological, biochemical, and cell organization responses of Hypnea musciformis under laboratory conditions during
Xiujin Wang et al.
Veterinary microbiology, 178(3-4), 217-229 (2015-06-06)
Japanese encephalitis virus (JEV) is an important zoonotic pathogen causing viral encephalitis in human and reproductive failure in pigs. In the present study, we first examined the autophagy induced by JEV infection in host cells, and then analyzed the JEV
Nicholas B Last et al.
Journal of molecular biology, 427(22), 3607-3612 (2015-10-10)
Anion channels and antiporters of the ClC superfamily have been found to be exclusively dimeric in nature, even though each individual monomer contains the complete transport pathway. Here, we describe the destabilization through mutagenesis of the dimer interface of a
Alice H Huang et al.
Development (Cambridge, England), 142(14), 2431-2441 (2015-06-13)
The long tendons of the limb extend from muscles that reside in the zeugopod (arm/leg) to their skeletal insertions in the autopod (paw). How these connections are established along the length of the limb remains unknown. Here, we show that
Mohammed A Mansour et al.
Experimental cell research, 332(1), 78-88 (2014-12-20)
Invadopodia are specialized actin-based microdomains of the plasma membrane that combine adhesive properties with matrix degrading activities. Proper functioning of the bone, immune, and vascular systems depend on these organelles, and their relevance in cancer cells is linked to tumor
Yolanda Osuna et al.
Bioprocess and biosystems engineering, 38(8), 1437-1445 (2015-03-12)
Aspergillus niger lipase immobilization by covalent binding on chitosan-coated magnetic nanoparticles (CMNP), obtained by one-step co-precipitation, was studied. Hydroxyl and amino groups of support were activated using glycidol and glutaraldehyde, respectively. Fourier transform infrared spectrometry, high-resolution transmission electron microscopy and
Yishan Fang et al.
Biosensors & bioelectronics, 73, 71-78 (2015-06-06)
This work reports on a facile, novel multianalyte electrochemical immunoassay for simultaneous detection of a-fetoprotein (AFP) and human epidermal growth factor receptor type-2 (HER-2) using metal-containing nanomaterials confined in the ordered mesoporous carbon matrix (OMC-M) as labels. Well-dispersed uniform metallic
Ludmila Perelygina et al.
Journal of virology, 89(10), 5515-5524 (2015-03-06)
Glycoprotein D (gD) plays an essential role in cell entry of many simplexviruses. B virus (Macacine herpesvirus 1) is closely related to herpes simplex virus 1 (HSV-1) and encodes gD, which shares more than 70% amino acid similarity with HSV-1
Jennifer L Wehmeyer et al.
Tissue engineering. Part C, Methods, 21(7), 649-659 (2014-12-05)
Numerous techniques have been reported for preparing and sterilizing amniotic membrane (AM) for use in clinical applications. However, these preparations either do not produce completely sterile tissue or are detrimental to molecules unique to the tissue matrix, thus compromising beneficial
Carlamaria Zoja et al.
Nephron, 129(1), 52-61 (2014-12-23)
Experimental and clinical evidence suggested that monocyte chemoattractant protein-1 (MCP-1/CCL2) has a role in the development of interstitial inflammation and renal failure in polycystic kidney disease (PKD). We investigated whether bindarit, an inhibitor of MCP-1/CCL2 synthesis, could influence the evolution
Kyle R Pomraning et al.
PloS one, 10(4), e0123188-e0123188 (2015-04-24)
Yarrowia lipolytica is an oleaginous ascomycete yeast that accumulates large amounts of lipids and has potential as a biofuel producing organism. Despite a growing scientific literature focused on lipid production by Y. lipolytica, there remain significant knowledge gaps regarding the
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Mina Sharbatoghli et al.
Cell journal, 17(3), 547-553 (2015-10-16)
Melatonin, the chief secretory product of the pineal gland, regulates dynamic physiological adaptations that occur in seasonally breeding mammals as a response to changes in daylight hours. Because of the presence of melatonin in semen and the mem- brane melatonin
Tingting Xie et al.
Laboratory investigation; a journal of technical methods and pathology, 99(5), 625-633 (2019-02-15)
Pulmonary fibrosis is a major cause of death in patients with acute respiratory distress syndrome (ARDS). Our previous study revealed that lipopolysaccharide (LPS) challenge could lead to mouse lung fibroblast proliferation. Additionally, inhibition of autophagy in lung fibroblasts was also
Shuqi Wang et al.
Nanoscale, 7(26), 11460-11467 (2015-06-18)
One-dimensional Pt nanostructures are of considerable interest for the development of highly stable and sensitive electrochemical sensors. This paper describes a self-interconnecting Pt nanowire network electrode (PtNNE) for the detection of hydrogen peroxide (H2O2) and glucose with ultrahigh sensitivity and
Hui Liu et al.
International journal of medical microbiology : IJMM, 305(3), 392-403 (2015-03-26)
Helicobacter pylori from different individuals exhibits substantial genetic diversity. However, the kinetics of bacterial diversification after infection with a single strain is poorly understood. We investigated evolution of H. pylori following long-term infection in the primate stomach; Rhesus macaques were
Nicole McKinney et al.
Journal of neuro-oncology, 121(1), 109-118 (2014-09-27)
Eph receptors and ephrin ligands are master regulators of oncogenic signaling required for proliferation, migration, and metastasis. Yet, Eph/ephrin expression and activity in medulloblastoma (MB), the most common malignant brain tumor of childhood, remains poorly defined. We hypothesized that Eph/ephrins
Raghavendra Havale et al.
Oral health and dental management, 12(1), 24-31 (2013-03-12)
This in vivo study aimed to assess and compare the relative clinical and radiographic success of formocresol, glutaraldehyde and ferric sulphate as medicaments following pulpotomies in primary molars at three-monthly intervals over one year. The study was carried out on
Caixia Guo et al.
Journal of cellular and molecular medicine, 19(9), 2273-2285 (2015-06-25)
Podocyte injuries are associated with progression of diabetic nephropathy (DN). Apelin, an adipocyte-derived peptide, has been reported to be a promoting factor for DN. In this study, we aim to determine whether apelin promotes progression of DN by inducing podocyte
Jingjing Zhang et al.
Experimental dermatology, 24(8), 605-610 (2015-04-15)
Claudins (Cldn) are the major components of tight junctions (TJs) sealing the paracellular cleft in tissue barriers of various organs. Zebrafish Cldnb, the homolog of mammalian Cldn4, is expressed at epithelial cell-cell contacts and is important for regulating epidermal permeability.
Xia Zhai et al.
Biochemistry. Biokhimiia, 80(8), 1001-1009 (2015-11-08)
Viral myocarditis is a common disease that contributes to dilated cardiomyopathy or heart failure. Coxsackievirus B (CVB) is one of the major causative pathogens of viral myocarditis. Previous studies have shown that autophagy is exploited to promote CVB replication in
Ariana Q Farrand et al.
Neurobiology of aging, 36(3), 1569-1576 (2015-01-13)
Glial cell line-derived neurotrophic factor (GDNF) helps protect dopaminergic neurons in the nigrostriatal tract. Although the cause of nigrostriatal degeneration is unknown, one theory is that excess glutamate from the subthalamic nucleus results in excitotoxic events in the substantia nigra
S Goericke-Pesch et al.
Micron (Oxford, England : 1993), 77, 66-73 (2015-07-06)
Membrane vesicles (MV) have been identified in seminal plasma from various species and they are thought to have a significant impact on semen quality and fertilisation. Although recently presence of MV has been also described in the canine ejaculate, detailed
S Oz et al.
Molecular psychiatry, 19(10), 1115-1124 (2014-09-03)
The NAP motif of activity-dependent neuroprotective protein (ADNP) enhanced memory scores in patients suffering from mild cognitive impairment and protected activities of daily living in schizophrenia patients, while fortifying microtubule (MT)-dependent axonal transport, in mice and flies. The question is
Marzena Szwed et al.
Chemico-biological interactions, 220, 140-148 (2014-07-08)
In our research we compared the effect of doxorubicin (DOX) and doxorubicin-transferrin (DOX-TRF) conjugate on the induction of programmed cell death. All experiments were carried out on human leukemia cells: CCRF-CEM, K562 sensitive and resistant to DOX, (K562/DOX), which are
Stefania Paparella et al.
Phytochemistry, 111, 114-123 (2015-02-11)
In the present work, eleven saponins and three sapogenins purified from Medicago sativa were tested for their cytotoxicity against highly proliferating white poplar (Populus alba L.) cell suspension cultures. After preliminary screening, four saponins with different structural features in terms
Subburayan Karthikeyan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)
Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell
Jingwen Song et al.
Molecular and cellular biology, 35(11), 1926-1939 (2015-03-18)
The requirement for alternative splicing during adipogenesis is poorly understood. The Sam68 RNA binding protein is a known regulator of alternative splicing, and mice deficient for Sam68 exhibit adipogenesis defects due to defective mTOR signaling. Sam68 null preadipocytes were monitored
Yukichi Kabuto et al.
Tissue engineering. Part A, 21(13-14), 2025-2033 (2015-03-31)
Bone morphogenetic protein-7 (BMP-7) promotes not only osteogenesis but also matrix production in chondrocytes and tenocytes. However, because of its short half-life, maintaining local concentrations of BMP-7 is difficult. We examined the use of a gelatin hydrogel sheet (GHS) for
Jingjing Li et al.
PloS one, 10(3), e0120440-e0120440 (2015-03-12)
Astaxanthin, a potent antioxidant, exhibits a wide range of biological activities, including antioxidant, atherosclerosis and antitumor activities. However, its effect on concanavalin A (ConA)-induced autoimmune hepatitis remains unclear. The aim of this study was to investigate the protective effects of
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