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G6013

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Yuqin Fan et al.
Immunopharmacology and immunotoxicology, 43(1), 58-67 (2020-12-08)
Glutathione is a potential therapy for systemic lupus erythematosus, but its role in allergic rhinitis (AR) has not been determined. This report probed into the actions of glutathione in AR, so as to supplement evidence for a therapeutical countermeasure for...
Calista K L Ng et al.
Human molecular genetics, 24(11), 3163-3171 (2015-02-26)
mRNA decay is an essential and active process that allows cells to continuously adapt gene expression to internal and environmental cues. There are two mRNA degradation pathways: 3' to 5' and 5' to 3'. The DCPS protein is the scavenger...
Yong Chen et al.
The Biochemical journal, 469(2), 189-198 (2015-05-06)
NAD(+) plays essential roles in cellular energy homoeostasis and redox state, functioning as a cofactor along the glycolysis and citric acid cycle pathways. Recent discoveries indicated that, through the NAD(+)-consuming enzymes, this molecule may also be involved in many other...
James M Kuczmarski et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(5), 482-491 (2014-07-26)
The purpose of this investigation was to determine the effect of 4 wk of voluntary wheel running on cardiac performance in the 5/6 ablation-infarction (AI) rat model of chronic kidney disease (CKD). We hypothesized that voluntary wheel running would be...
B Uzun et al.
Human & experimental toxicology, 34(4), 415-429 (2014-07-19)
Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and prostaglandins play important roles in the regulation of reproductive functions...
Kh Iu Nedoshytko
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 154-162 (2014-02-01)
The state of antioxidant system and fatty acid composition of lipids in the liver tissues of rats of different sex at the ethanol and tetracycline action and at the influence of biologically active additives (BAA) "Alpha + Omega" at a...
Vittoria Locato et al.
Journal of experimental botany, 66(10), 2991-3000 (2015-04-22)
Ophiobolin A, a tetracyclic sesterpenoid produced by phytopathogenic fungi, is responsible for catastrophic losses in crop yield but its mechanism of action is not understood. The effects of ophiobolin A were therefore investigated on the growth and redox metabolism of...
Maryanne Nunes de Melo et al.
The Journal of pharmacy and pharmacology, 67(8), 1107-1118 (2015-04-14)
Phyllanthus niruri L. belongs to the Euphorbiaceae, and is known by the common name of 'stonebreaker' in Brazil. Some species within the Phyllanthus genus are widely used in traditional medicine to counteract different types of anti-inflammatory diseases. In this study, the...
Hitomi Kanno et al.
PloS one, 9(12), e116275-e116275 (2015-01-01)
Effects of the kampo medicine yokukansan on gene expression of the cystine/glutamate antiporter system Xc-, which protects against glutamate-induced cytotoxicity, were examined in Pheochromocytoma cells (PC12 cells). Yokukansan inhibited glutamate-induced PC12 cell death. Similar cytoprotective effects were found in Uncaria...
Kwang-Min Choi et al.
Fish & shellfish immunology, 45(2), 277-285 (2015-04-29)
Lectins are carbohydrate-binding proteins that play important roles in the recognition and elimination of pathogens via the innate immune system. Pentraxins (PTX) are humoral lectins, which are multifunctional proteins in vertebrates. Pentraxins can be divided into two groups based on...
Wei Li et al.
Food & function, 6(5), 1418-1427 (2015-05-01)
Platycodin D (PD) is the main active saponin of Platycodon grandiflorum (PG) and is reported to exhibit multiple biological effects, including anti-tumor, anti-inflammation, and anti-obesity properties. Although recently there have been many research reports on the chemical constituents of the...
Joon Ha Park et al.
Chinese medical journal, 128(21), 2932-2937 (2015-11-03)
Water dropwort (Oenanthe javanica) as a popular traditional medicine in Asia shows various biological properties including antioxidant activity. In this study, we firstly examined the neuroprotective effect of Oenanthe javanica extract (OJE) in the hippocampal cornus ammonis 1 region (CA1...
Zheng Li et al.
Nucleic acids research, 43(8), 3986-3997 (2015-04-08)
Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in vertebrates. However, it remained unclear how they contribute to the demethylation process. Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA...
Hongmei Cui et al.
Nature communications, 6, 6752-6752 (2015-04-14)
Tat-interactive protein 60 (Tip60) is a MYST histone acetyltransferase that catalyses acetylation of the major DNA damage kinase Ataxia telangiectasia mutated (ATM), thereby triggering cellular signalling required for the maintenance of genomic stability on genotoxic insults. The Tip60 activity is...
Chul Han et al.
Experimental gerontology, 48(10), 1091-1095 (2013-03-05)
Reducing calorie intake extends the lifespan of a variety of experimental models and delays progression of age-related hearing loss (AHL). AHL is a common feature of aging and is characterized by age-related decline of hearing associated with loss of sensory...
Sema Demirci Çekiç et al.
Analytica chimica acta, 865, 60-70 (2015-03-04)
A colourimetric sensor capable of simultaneously measuring oxidative status (OS) in terms of the hazard produced by reactive oxygen species (ROS) and antioxidant activity (AOA) in regard to ROS-scavenging ability of antioxidant compounds was developed. The coloured cationic semi-quinone derivatives...
Sebastian Mana-Capelli et al.
Molecular biology of the cell, 25(10), 1676-1685 (2014-03-22)
The Hippo pathway regulates the transcriptional coactivator YAP to control cell proliferation, organ size, and stem cell maintenance. Multiple factors, such as substrate stiffness, cell density, and G protein-coupled receptor signaling, regulate YAP through their effects on the F-actin cytoskeleton...
Joung-Woo Choi et al.
Journal of controlled release : official journal of the Controlled Release Society, 219, 181-191 (2015-10-11)
Oncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. Many clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies. However, the systemic injection of oncolytic Ad in clinical applications is restricted due to...
Richard C Silva et al.
PloS one, 10(7), e0131070-e0131070 (2015-07-16)
The Saccharomyces cerevisiae protein Yih1, when overexpressed, inhibits the eIF2 alpha kinase Gcn2 by competing for Gcn1 binding. However, deletion of YIH1 has no detectable effect on Gcn2 activity, suggesting that Yih1 is not a general inhibitor of Gcn2, and...
Yosuke Nakazawa et al.
Molecular vision, 21, 804-810 (2015-08-19)
This study investigated the ability of hesperetin, a natural flavonoid, to prevent selenite-induced cataracts in a rat model. Animals were divided into four treatment groups: G1 (control group), G2 (hesperetin-treated group), G3 (selenite-induced cataract group), and G4 (hesperetin-treated selenite cataract...
Lijian Xue et al.
International journal of clinical and experimental medicine, 8(4), 4911-4921 (2015-07-02)
This study aimed to investigate the MC-LR induced oxidative injury and apoptosis in Chinese hamster ovary (CHO) cells, and the protective effects of N-acetylcysteine (NAC) on these cells. Cell viability was determined by MTT assay after exposure to NAC at...
Sławomir Kasperczyk et al.
Toxicology and applied pharmacology, 280(1), 36-41 (2014-07-20)
The aim of this study was to determine whether beta-carotene administration reduces oxidative stress and influences antioxidant, mainly glutathione-related, defense systems in workers chronically exposed to lead. The population consisted of two randomly divided groups of healthy male volunteers exposed...
Xing Tian et al.
Environmental toxicology and pharmacology, 38(1), 189-198 (2014-06-24)
Many studies have shown that glutamate-induced oxidative stress can lead to neuronal cell death involved in the development of neurodegenerative diseases. In this work, protective effects of ethyl acetate extract (EAE) of Arctium lappa L. roots against glutamate-induced oxidative stress...
Yi-Syuan Lai et al.
Journal of agricultural and food chemistry, 62(25), 5897-5906 (2014-05-27)
This study investigated the protective properties of garlic essential oil (GEO) and its major organosulfur component (diallyl disulfide, DADS) against the development of nonalcoholic fatty liver disease (NAFLD). C57BL/6J mice were fed a normal or high-fat diet (HFD) with/without GEO...
Jan Simon Boerma et al.
Chemico-biological interactions, 207, 32-40 (2013-11-20)
Reactive metabolites have been suggested to play a role in the idiosyncratic hepatotoxicity observed with diclofenac (DF). By structural identification of the GSH conjugates formed after P450-catalyzed bioactivation of DF, it was shown that three types of reactive intermediates were...
Prabhakar Tiwari et al.
Nature communications, 6, 6059-6059 (2015-01-23)
Toxin-antitoxin (TA) systems are highly conserved in members of the Mycobacterium tuberculosis (Mtb) complex and have been proposed to play an important role in physiology and virulence. Nine of these TA systems belong to the mazEF family, encoding the intracellular...
Roberta Moschini et al.
Free radical biology & medicine, 83, 66-76 (2015-02-15)
An NADP(+)-dependent dehydrogenase activity on 3-glutathionyl-4-hydroxynonanal (GSHNE) was purified to electrophoretic homogeneity from a line of human astrocytoma cells (ADF). Proteomic analysis identified this enzymatic activity as associated with carbonyl reductase 1 (EC 1.1.1.184). The enzyme is highly efficient at...
Naveen Kaushal et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3683-3692 (2014-09-05)
Inflammation is a hallmark of inflammatory bowel disease (IBD) that involves macrophages. Given the inverse link between selenium (Se) status and IBD-induced inflammation, our objective was to demonstrate that selenoproteins in macrophages were essential to suppress proinflammatory mediators, in part...
Choon-Ho Park et al.
Biochimica et biophysica acta, 1853(7), 1738-1748 (2015-04-23)
Vaccinia-related kinase 3 (VRK3) is known as a pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity. Although VRK3 has been regarded as a genuine pseudokinase from structural and biochemical studies, recent reports...
Rosario Planelló et al.
Environmental toxicology, 30(4), 383-395 (2013-07-31)
Biomarkers are an important tool in laboratory assays that link exposure or effect of specific toxicants to key molecular and cellular events, but they have not been widely used in invertebrate populations exposed to complex mixtures of environmental contaminants in...
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