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Katarina Rubin et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 119-125 (2014-11-06)
The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect
Cynthia H Canan et al.
Journal of leukocyte biology, 96(3), 473-480 (2014-06-18)
Systemic inflammation that occurs with increasing age (inflammaging) is thought to contribute to the increased susceptibility of the elderly to several disease states. The elderly are at significant risk for developing pulmonary disorders and infectious diseases, but the contribution of
Sneha Arora et al.
Stem cells and development, 24(17), 2065-2077 (2015-04-30)
It is the promise of regeneration and therapeutic applications that has sparked an interest in mesenchymal stem cells (MSCs). Following infusion, MSCs migrate to sites of injury or inflammation by virtue of their homing property. To exert optimal clinical benefits
Seong-Jin Yu et al.
PloS one, 10(7), e0132487-e0132487 (2015-07-18)
Recent studies have indicated that type 2 cannabinoid receptor (CB2R) agonists reduce neurodegeneration after brain injury through anti-inflammatory activity. The purpose of this study was to examine the time-dependent interaction of CB2R and inflammation in stroke brain. Adult male rats
Matthias Lingemann et al.
Journal of virology, 89(6), 3318-3331 (2015-01-16)
Human parainfluenza virus type 3 (HPIV3), a paramyxovirus, is a major viral cause of severe lower respiratory tract disease in infants and children. The gene-end (GE) transcription signal of the HPIV3 matrix (M) protein gene is identical to those of
Jin Hee Kim et al.
In vitro cellular & developmental biology. Animal, 51(2), 157-164 (2014-09-25)
Brain inflammation causes cell damage and death in diseases such as Alzheimer's and Parkinson's. In this study, we investigated whether early induced neural stem cells (iNSCs) could protect against cell death after treatment with THP1-derived macrophages. We developed an inflammatory
Ulf Schnetzke et al.
Cytometry. Part B, Clinical cytometry, 86(4), 229-235 (2013-04-12)
Paradoxical activation of the MAP-kinases, ERK1, and ERK2 (ERK1/2) is observed in CML cell lines and primary CML patient cells treated with tyrosine kinase inhibitors (TKI) in vitro. The commonly accepted assumption is that activated ERK1/2 is key regulators of
Sandrine Bouchet et al.
Oncotarget, 5(18), 8211-8222 (2014-09-24)
Secreted matrix metalloproteinases (MMP)-2 and MMP-9 and membrane-anchored aminopeptidase-N/CD13 are abnormally expressed in human acute myeloid leukaemia (AML). We previously showed that CD13 ligation by anti-CD13 monoclonal antibodies can induce apoptosis in AML cells. Here, we assessed ADAM17 expression in
Shao-Jing Hong et al.
Biochimica et biophysica acta, 1840(12), 3335-3344 (2014-09-02)
Filopodia are actin-rich membrane protrusions that play instrumental roles in development, cell migration, pathogen detection, and wound healing. During neurogenesis, filopodium formation precedes the formation of dendrites and spines. The insulin receptor substrate protein of 53kDa (IRSp53) has been implicated
Rebecca N Bauer et al.
American journal of respiratory cell and molecular biology, 52(3), 285-294 (2014-07-24)
The initial innate immune response to ozone (O3) in the lung is orchestrated by structural cells, such as epithelial cells, and resident immune cells, such as airway macrophages (Macs). We developed an epithelial cell-Mac coculture model to investigate how epithelial
P Mabeta
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 611-617 (2014-04-30)
The phosphoinositide 3-kinase (PI3k) signaling pathway is involved in the regulation of numerous cellular activities. The pathway has also been implicated in the development of various tumors. In the context of vascular tumors, the role of the PI3k signaling still
Zhonglu Yang et al.
Medical oncology (Northwood, London, England), 31(12), 337-337 (2014-11-25)
3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been reported to be closely correlated with proliferation, apoptosis and invasion of esophageal cancer cells. However, its expression pattern and clinical significance in human esophageal squamous cell carcinoma (ESCC) remain unclear. To address this problem
Gerald Bachler et al.
Particle and fibre toxicology, 12, 18-18 (2015-06-28)
The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very
Frantiescoli Dimer et al.
Pharmaceutical research, 32(12), 3850-3861 (2015-06-27)
The aim of this work was to develop clarithromycin microparticles (CLARI-MP) and evaluate their aerodynamic behavior, safety in bronchial cells and anti-bacterial efficacy. Microparticles containing clarithromycin were prepared as dry powder carrier for inhalation, using leucine and chitosan. CLARI-MP were
Heather J Szerlong et al.
Journal of molecular biology, 427(11), 2056-2071 (2015-01-15)
To investigate the relationship between linker histone H1 and protein-protein interactions in the nucleolus, we used biochemical and proteomics approaches to characterize nucleoli purified from cultured human and mouse cells. Mass spectrometry identified 175 proteins in human T cell nucleolar
Carola H Schrader et al.
Molecular cancer, 14, 107-107 (2015-05-21)
Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable prognosis. However, the expression of KLK6 in carcinomas derived from mucosal
S A A Patel et al.
British journal of cancer, 111(12), 2287-2296 (2014-10-22)
The pro-inflammatory cytokine interleukin-6 (IL6) promotes colorectal cancer (CRC) development. It is also known to regulate cytochrome P450 (CYP450) enzymes, which are involved in CRC tumour initiation and promotion via activation of chemical carcinogens. Here, IL6 regulation of CYP450 expression
Andrey Alexeyenko et al.
Journal of experimental & clinical cancer research : CR, 34, 62-62 (2015-06-18)
There is growing evidence that emerging malignancies in solid tissues might be kept under control by physical intercellular contacts with normal fibroblasts. Here we characterize transcriptional landscapes of fibroblasts that confronted cancer cells. We studied four pairs of in vitro
Widyawilis Selamat et al.
PloS one, 10(6), e0129634-e0129634 (2015-06-13)
The serine/threonine kinase PAK4 is a Cdc42 effector whose role is not well understood; overexpression of PAK4 has been associated with some cancers, and there are reports that correlate kinase level with increased cell migration in vitro. Here we report
Kristina B V Døssing et al.
Genes, 6(1), 1-21 (2014-12-30)
Expression of miRNAs in Neuroendocrine Neoplasms (NEN) is poorly characterized. We therefore wanted to examine the miRNA expression in Neuroendocrine Tumors (NETs), and identify their targets and importance in NET carcinogenesis. miRNA expression in six NEN primary tumors, six NEN
A Schmitz et al.
Journal of veterinary pharmacology and therapeutics, 37(4), 338-347 (2014-02-01)
Testosterone (TES) 6-β-hydroxylation is a significant metabolic step in the biotransformation of TES in human liver microsomes and reflects cytochrome P450 (CYP) 3A4/5 specific metabolic activity. Several CYP3A enzymes have been annotated in the horse genome, but functional characterization is
Guilai Liu et al.
Cancer biology & therapy, 16(1), 52-59 (2014-11-27)
Functional membrane androgen receptors (mAR) have previously been described in MCF-7 breast cancer cells. Their stimulation by specific testosterone albumin conjugates (TAC) activate rapidly non-genomic FAK/PI3K/Rac1/Cdc42 signaling, trigger actin reorganization and inhibit cell motility. PI3K stimulates serum and glucocorticoid inducible
John Hwa Lee et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(3), 229-234 (2015-07-02)
In this study, the immune responses to and protective efficacy of a live attenuated Salmonella-delivered vaccine candidate secreting the papA, papG, iutA, and clpG antigens of Escherichia coli were evaluated against infection with avian pathogenic E. coli (APEC) in layer
Y Gu et al.
Cell death & disease, 5, e1580-e1580 (2014-12-19)
BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to
N Bostanci et al.
Molecular oral microbiology, 30(4), 323-335 (2015-03-20)
Periodontitis is the chronic inflammatory destruction of periodontal tissues as a result of bacterial biofilm formation on the tooth surface. Proteins secreted by the gingival epithelium challenged by subgingival biofilms represent an important initial response for periodontal inflammation. The aim
Santiago Roura et al.
International journal of cardiology, 176(3), 805-814 (2014-08-19)
Idiopathic dilated cardiomyopathy (IDCM) is characterized by adverse ventricular remodeling attributed to altered activity of extracellular matrix metalloproteinase (MMP). MMP overactivation is linked to changes in extracellular signal-regulated kinases (ERK), reportedly modulated by the low-density lipoprotein receptor-related protein 1 (LRP1)
Hod Dana et al.
Nature communications, 5, 3997-3997 (2014-06-06)
Planar neural networks and interfaces serve as versatile in vitro models of central nervous system physiology, but adaptations of related methods to three dimensions (3D) have met with limited success. Here, we demonstrate for the first time volumetric functional imaging
Shanice V Hudson et al.
Cancer research, 74(21), 6271-6279 (2014-09-14)
Detection of orthotopic xenograft tumors is difficult due to poor spatial resolution and reduced image fidelity with traditional optical imaging modalities. In particular, light scattering and attenuation in tissue at depths beyond subcutaneous implantation hinder adequate visualization. We evaluate the
Sarmistha Bandyopadhyay et al.
PloS one, 9(10), e109525-e109525 (2014-10-09)
Francisella tularensis is a Gram-negative, facultative intracellular pathogen that replicates in the cytosol of macrophages and is the causative agent of the potentially fatal disease tularemia. A characteristic feature of F. tularensis is its limited proinflammatory capacity, but the mechanisms
Heidi Stoll et al.
Biomicrofluidics, 9(3), 034111-034111 (2015-07-17)
Aptamers are promising cell targeting ligands for several applications such as for the diagnosis, therapy, and drug delivery. Especially, in the field of regenerative medicine, stem cell specific aptamers have an enormous potential. Using the combinatorial chemistry process SELEX (Systematic
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