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Tim C Chang et al.
Lab on a chip, 14(23), 4540-4551 (2014-10-03)
There is a critical unmet need to tailor chemotherapies to individual patients. Personalized approaches could lower treatment toxicity, improve the patient's quality of life, and ultimately reduce mortality. However, existing models of drug activity (based on tumor cells in culture...
Katsuro Iwase et al.
Journal of neurochemistry, 128(2), 233-245 (2013-10-12)
Cooperative gene regulation by different neurotransmitters likely underlies the long-term forms of associative learning and memory, but this mechanism largely remains to be elucidated. Following cDNA microarray analysis for genes regulated by Ca(2+) or cAMP, we found that the secretogranin...
Mamoru Yotsuya et al.
Scientific reports, 9(1), 56-56 (2019-01-13)
The degeneration of articular cartilage underscores the clinical pathology of temporomandibular joint osteoarthritis (TMJ-OA) and is promoted through dysfunctional biochemical or biophysical signaling. Transduction of these signals has a multifaceted regulation that includes important cell-matrix derived interactions. The matrix encapsulating...
Taha Azad et al.
Oncogene, 39(2), 334-355 (2019-09-04)
The Hippo pathway has emerged as a key signaling pathway that regulates various biological functions. Dysregulation of the Hippo pathway has been implicated in a broad range of human cancer types. While a number of stimuli affecting the Hippo pathway...
Fabian Nagelreiter et al.
Biotechnology journal, 13(4), e1700492-e1700492 (2018-01-26)
Accurate measurement of global and specific protein synthesis rates is becoming increasingly important, especially in the context of biotechnological applications such as process modeling or selection of production cell clones. While quantification of total protein translation across whole cell populations...
Steffen K Meurer et al.
Cellular signalling, 74, 109731-109731 (2020-08-08)
Chemoresistance is a multifactorial and complex phenomenon, leading to re-adjustment of several intracellular signaling pathways and expression patterns which compromises the efficacy of cancer drug chemo-therapy. Via comparative analysis of sensitive and doxorubicin-resistant 4T1 cells, here we show that Lipocalin...
Jennifer V E Brown et al.
The Cochrane database of systematic reviews, 12(12), CD005947-CD005947 (2014-12-17)
Endogenous glutamine biosynthesis may be insufficient to meet the needs of people with severe gastrointestinal disease. Results from studies using experimental animal models of gastrointestinal disease have suggested that glutamine supplementation improves clinical outcomes. This review examines evidence on the...
S Martin et al.
Biochemical pharmacology, 93(3), 290-304 (2014-12-23)
Vemurafenib (PLX4032), an inhibitor of BRAF(V600E), has demonstrated significant clinical anti-melanoma effects. However, the majority of treated patients develop resistance, due to a variety of molecular mechanisms including MAPK reactivation through MEK. The induction of a cancer cell death modality...
Louise T Henriksen et al.
British journal of haematology, 166(2), 213-220 (2014-04-08)
L-asparaginase is an important drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Cerebrospinal fluid (CSF) asparagine depletion is considered a marker of asparaginase effect in the central nervous system (CNS) and may play a role in CNS-directed anti-leukaemia...
Suman Santra et al.
PloS one, 15(7), e0236992-e0236992 (2020-08-01)
We wanted to investigate whether Isoniazid (INH) can directly stimulate activation of hepatic stellate cells (HSCs) and enhance production of collagen. Treatment of human hepatic stellate cell line LX2 with or without 5μM INH for 24 to 72 hours was...
Nadia Nabil Haj-Yasein et al.
Biochimica et biophysica acta, 1862(6), 623-635 (2017-02-22)
Plasma cysteine is strongly associated with body fat mass in human cohorts and diets low in cysteine prevents fat accumulation in mice. It is unclear if plasma cysteine affects fat development or if fat accumulation raises plasma cysteine. To determine...
I Kusumoto
The Journal of nutrition, 131(9 Suppl), 2552S-2555S (2001-09-05)
The industrial production of L-glutamine (L-Gln) started with its fermentation in the late 1960s. Currently, it is manufactured for use as pharmaceuticals and health foods at the worldwide annual production of approximately 2000 metric tons. To manufacture high quality L-Gln...
Abdullah Yalçin et al.
Turkish journal of biology = Turk biyoloji dergisi, 44(2), 93-102 (2020-04-08)
Type 2 diabetes mellitus is characterized by insulin resistance and hypersecretion of insulin from the pancreas to compensate for decreased insulin sensitivity in the peripheral tissues. In later stages of the disease insulin-secreting beta cell degeneration commences and patients require...
Low glutamine levels during critical illness--adaptive or maladaptive?
Greet Van den Berghe
The New England journal of medicine, 368(16), 1549-1550 (2013-04-19)
Ethan B Butler et al.
Cancer research, 73(9), 2709-2717 (2013-04-24)
Cancer cells are markedly different from normal cells with regards to how their metabolic pathways are used to fuel cellular growth and survival. Two basic metabolites that exemplify these differences through increased uptake and altered metabolic usage are glucose and...
Yakir Guri et al.
Cancer cell, 32(6), 807-823 (2017-12-13)
Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de...
Letizia Vallino et al.
Journal of traditional and complementary medicine, 10(3), 217-229 (2020-07-17)
Non-coding RNAs control cell functioning through affecting gene expression and translation and their dysregulation is associated with altered cell homeostasis and diseases, including cancer. Nutraceuticals with anti-cancer therapeutic potential have been shown to modulate non-coding RNAs expression that could impact...
Eder Ricardo Petry et al.
Life sciences, 94(2), 130-136 (2013-11-26)
We hypothesized that oral l-glutamine supplementations could attenuate muscle damage and oxidative stress, mediated by glutathione (GSH) in high-intensity aerobic exercise by increasing the 70-kDa heat shock proteins (HSP70) and heat shock factor 1 (HSF1). Adult male Wistar rats were...
Marta Sidoryk-Wegrzynowicz et al.
BMC pharmacology & toxicology, 14, 23-23 (2013-04-19)
Astrocytes are responsible for numerous aspects of metabolic support, nutrition, control of the ion and neurotransmitter environment in central nervous system (CNS). Failure by astrocytes to support essential neuronal metabolic requirements plays a fundamental role in the pathogenesis of brain...
R H H van den Heuvel et al.
Cellular and molecular life sciences : CMLS, 61(6), 669-681 (2004-03-31)
Glutamate synthase is a multicomponent iron-sulfur flavoprotein belonging to the class of N-terminal nucleophile amidotransferases. It catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate. In recent years the X-ray structures of the ferredoxin-dependent glutamate synthase and...
Federico Alessandro Ruffinatti et al.
ACS sensors, 5(8), 2388-2397 (2020-07-24)
Ca2+ is among the most important intracellular second messengers participating in a plethora of biological processes, and the measurement of Ca2+ fluctuations is significant in the phenomenology of the underlying processes. Aequorin-based Ca2+ probes represent an invaluable tool for reliable...
Navaporn Posayapisit et al.
International journal for parasitology, 51(8), 635-642 (2021-03-14)
Antimalarial drugs capable of targeting multiple parasite stages, particularly the transmissible stages, can be valuable tools for advancing the malaria elimination agenda. Current antifolate drugs such as pyrimethamine can inhibit replicative parasite stages in both humans and mosquitoes, but antifolate...
Neha Ahuja et al.
NAR cancer, 2(3), zcaa021-zcaa021 (2020-10-23)
Hypoxic microenvironment heralds epithelial-mesenchymal transition (EMT), invasion and metastasis in solid tumors. Deregulation of alternative splicing (AS) of several cancer-associated genes has been instrumental in hypoxia-induced EMT. Our study in breast cancer unveils a previously unreported mechanism underlying hypoxia-mediated AS...
Claudia A Hana et al.
Frontiers in pharmacology, 11, 636533-636533 (2021-02-12)
Ectopic lipid accumulation in skeletal muscle and liver drives the pathogenesis of diabetes mellitus type 2 (DMT2). Mild hyperbilirubinaemia has been repeatedly suggested to play a role in the prevention of DMT2 and is known for its capacity to shape...
Akihiko Wada et al.
AJNR. American journal of neuroradiology, 26(9), 2311-2315 (2005-10-13)
Intravenous immunoglobulin therapy is useful against various immune system disorders and viral infections. It is generally safe, and serious adverse reactions are uncommon. We report a rare case of acute encephalopathy following intravenous immunoglobulin therapy for human herpes virus 6...
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Anne B Walls et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(8), 1340-1346 (2014-05-16)
Despite the well-established use of kainate as a model for seizure activity and temporal lobe epilepsy, most studies have been performed at doses giving rise to general limbic seizures and have mainly focused on neuronal function. Little is known about...
Gabriella Marucci et al.
Life sciences, 205, 155-163 (2018-05-16)
A3 adenosine receptor (A3AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of potent and selective A3AR agonists could be crucial for cancer drug development. In the present study was determined...
Samantha Kent et al.
Cell reports, 33(2), 108248-108248 (2020-10-15)
Compartmentalization by liquid-liquid phase separation is implicated in transcription. It remains unclear whether and how transcriptional condensates accelerate the search of transcriptional regulatory factors for their target sites. Furthermore, the molecular mechanisms by which regulatory factors nucleate on chromatin to...
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