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Kentaro Matsuzaki et al.
The Journal of comparative neurology, 523(8), 1190-1201 (2015-01-06)
This study investigated age-dependent changes in heat exposure-induced hypothalamic neurogenesis and acquired heat tolerance in rats. We previously reported that neuronal progenitor cell proliferation and neural differentiation are enhanced in the hypothalamus of long-term heat-acclimated (HA) rats. Male Wistar rats
Kadiombo Bantubungi et al.
Molecular and cellular neurosciences, 37(3), 454-470 (2007-12-18)
Neural and mesenchymal stem cells have been proposed as alternative sources of cells for transplantation into the brain in neurodegenerative disorders. However, the endogenous factors controlling their engraftment within the injured parenchyma remain ill-defined. Here, we demonstrate significant engraftment of
S M Dombrowski et al.
Neuroscience, 152(2), 346-359 (2008-02-12)
Chronic hydrocephalus (CH) is a neurological disease characterized by increased cerebrospinal fluid volume and pressure that is often associated with impaired cognitive function. By and large, CH is a complex and heterogeneous cerebrospinal fluid (CSF) disorder where the exact site
Xiaoying Fan et al.
Cell research, 28(7), 730-745 (2018-06-06)
The cellular complexity of human brain development has been intensively investigated, although a regional characterization of the entire human cerebral cortex based on single-cell transcriptome analysis has not been reported. Here, we performed RNA-seq on over 4,000 individual cells from
Beatrice Beck-Schimmer et al.
European journal of anaesthesiology, 34(11), 764-775 (2017-08-02)
Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation of the immune system is a property of volatile anaesthetics. We aimed to investigate the systemic and cerebral inflammatory response in
Kimia Kamal et al.
Neurobiology of disease, 145, 105084-105084 (2020-09-18)
Aneurysmal intraventricular hemorrhage (IVH) survivors may recover with significant deficits in learning and memory. The goal of this study was to investigate the mechanism of memory decline after intraventricular aneurysm rupture. We developed an aneurysmal IVH rat model by injecting
Natália Ferreira Mendes et al.
Frontiers in neurology, 10, 382-382 (2019-05-02)
The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is involved in many central nervous system diseases, including epilepsy. Evidence demonstrates that BBB breakdown may induce epileptic seizures, and
Heather L McConnell et al.
Nanomedicine : nanotechnology, biology, and medicine, 12(6), 1535-1542 (2016-04-14)
Ferumoxytol ultrasmall superparamagnetic iron oxide nanoparticles can enhance contrast between neuroinflamed and normal-appearing brain tissue when used as a contrast agent for high-sensitivity magnetic resonance imaging (MRI). Here we used an anti-dextran antibody (Dx1) that binds the nanoparticle's carboxymethyldextran coating
Divya Pathak et al.
The Journal of biological chemistry, 290(37), 22325-22336 (2015-07-02)
Synaptic mitochondria are thought to be critical in supporting neuronal energy requirements at the synapse, and bioenergetic failure at the synapse may impair neural transmission and contribute to neurodegeneration. However, little is known about the energy requirements of synaptic vesicle
Wenshu Zhou et al.
Stem cell research & therapy, 12(1), 174-174 (2021-03-14)
Spinal cord injury (SCI) is a debilitating medical condition that can result in the irreversible loss of sensorimotor function. Current therapies fail to provide an effective recovery being crucial to develop more effective approaches. Mesenchymal stem cell (MSC) exosomes have
Cátia Gomes et al.
Experimental cell research, 395(2), 112209-112209 (2020-08-03)
Astrocytes are major contributors of motor neuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). We investigated whether regional and cell maturation differences influence ALS astrocyte malfunction. Spinal and cortical astrocytes from SOD1G93A (mSOD1) 7-day-old mice were cultured for 5 and
Ashish Kaul et al.
Molecules (Basel, Switzerland), 27(1) (2022-01-12)
Propolis, also known as bee-glue, is a resinous substance produced by honeybees from materials collected from plants they visit. It contains mixtures of wax and bee enzymes and is used by bees as a building material in their hives and
Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons.
Parpura, et al.
Proceedings of the National Academy of Sciences of the USA, 97, 8629-8634 (2019)
Tayloria N G Adams et al.
Biosensors & bioelectronics, 152, 111982-111982 (2020-02-15)
Human neural stem and progenitor cells (hNSPCs) have therapeutic potential to treat neural diseases and injuries since they provide neuroprotection and differentiate into astrocytes, neurons, and oligodendrocytes. However, cultures of hNSPCs are heterogeneous, containing cells linked to distinct differentiated cell
Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR.
Yao, et al.
The Journal of Pathology, 215, 369-376 (2021)
Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure.
Marina Di Domenico et al.
Cells, 10(9) (2021-09-29)
Profilin functions have been discussed in numerous cellular processes, including actin polymerization. One puzzling aspect is the concomitant expression of more than one profilin isoform in most tissues. In neuronal precursors and in neurons, profilin 1 and profilin 2 are
Adi Tzameret et al.
The Journal of comparative neurology, 528(10), 1672-1682 (2020-01-01)
In humans, carotid stenosis of 70% and above might be the cause of clinical symptoms such as transient ischemic attack and stroke. No clinical or animal studies have evaluated mild carotid occlusion, and few examined unilateral occlusion. Here, Westar rats
Anne-Cécile Boulay et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4427-4439 (2015-03-13)
In the normal brain, immune cell trafficking and immune responses are strictly controlled and limited. This unique homeostatic equilibrium, also called brain immune quiescence, is crucial to maintaining proper brain functions and is altered in various pathological processes, from chronic
Hilit Levy-Barazany et al.
Journal of neuroinflammation, 9, 120-120 (2012-06-09)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by damage to the neuronal myelin sheath. One of the key effectors for inflammatory injury is the antigen-presenting cell (APC). The class A scavenger receptor (SRA)
Anna G Orr et al.
Nature neuroscience, 18(3), 423-434 (2015-01-27)
Astrocytes express a variety of G protein-coupled receptors and might influence cognitive functions, such as learning and memory. However, the roles of astrocytic Gs-coupled receptors in cognitive function are not known. We found that humans with Alzheimer's disease (AD) had
Lien Beckers et al.
Molecular imaging and biology, 20(1), 94-102 (2017-07-12)
Activation of the innate immune system plays a significant role in pathologies of the central nervous system (CNS). In order to follow disease progression and evaluate effectiveness of potential treatments involved in neuroinflammation, it is important to track neuroinflammatory markers
Viviana Guadagni et al.
Scientific reports, 6, 35919-35919 (2016-10-25)
Retinitis pigmentosa (RP) comprises a group of inherited pathologies characterized by progressive photoreceptor degeneration. In rodent models of RP, expression of defective genes and retinal degeneration usually manifest during the first weeks of postnatal life, making it difficult to distinguish
Fei Liu et al.
The European journal of neuroscience, 37(10), 1714-1725 (2013-02-26)
Deposition of β -amyloid (Aβ) peptides, cleavage products of β-amyloid precursor protein (APP) by β-secretase-1 (BACE1) and γ-secretase, is a neuropathological hallmark of Alzheimer's disease (AD). γ-Secretase inhibition is a therapeutical anti-Aβ approach, although changes in the enzyme's activity in
Yan Su et al.
Frontiers in cellular neuroscience, 13, 249-249 (2019-06-20)
Haploinsufficiency of the bromodomain and PHD finger-containing protein 1 (BRPF1) gene causes intellectual disability (ID), which is characterized by impaired intellectual and cognitive function; however, the neurological basis for ID and the neurological function of BRPF1 dosage in the brain
Steffen B E Wolff et al.
Science advances, 8(8), eabk0231-eabk0231 (2022-02-26)
The acquisition and execution of motor skills are mediated by a distributed motor network, spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog in this network, yet the roles of its two main inputs, from motor
Erica L Littlejohn et al.
Frontiers in cell and developmental biology, 9, 663456-663456 (2021-06-08)
Adult hippocampal neurogenesis is stimulated acutely following traumatic brain injury (TBI). However, many hippocampal neurons born after injury develop abnormally and the number that survive long-term is debated. In experimental TBI, insulin-like growth factor-1 (IGF1) promotes hippocampal neuronal differentiation, improves
Keodavanh Chounlamountry et al.
Journal of neurochemistry, 134(5), 857-864 (2015-06-18)
Besides the well-described inflammatory and dysfunction effects on the respiratory tract, accumulating evidence indicates that ozone (O3 ) exposure also affects central nervous system functions. However, the mechanisms through which O3 exerts toxic effects on the brain remain poorly understood.
Alexa N Bramall et al.
PloS one, 8(2), e58023-e58023 (2013-03-08)
Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(-/-) mice carrying homozygous Pde6b(rd1) alleles or
Lauren C Boudewyn et al.
Neurobiology of disease, 105, 257-270 (2017-06-15)
Mucolipidosis type IV (MLIV) is a lysosomal storage disease exhibiting progressive intellectual disability, motor impairment, and premature death. There is currently no cure or corrective treatment. The disease results from mutations in the gene encoding mucolipin-1, a transient receptor potential
Luyan Jiao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12239-12254 (2020-10-02)
α-Synuclein (α-syn)-induced neurotoxicity has been generally accepted as a key step in the pathogenesis of Parkinson's disease (PD). Microtubule-associated protein tau, which is considered second only to α-syn, has been repeatedly linked with PD in association studies. However, the underlying
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