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Bao-Xi Qu et al.
Journal of the neurological sciences, 260(1-2), 204-213 (2007-06-19)
Abeta42 peptide aggregation and deposition is an important component of the neuropathology of Alzheimer's disease (AD). Gene-gun mediated gene vaccination targeting Abeta42 is a potential method to prevent and treat AD. APPswe/PS1DeltaE9 transgenic (Tg) mice were immunized with an Abeta42
Anabel Pérez-Gómez et al.
BMC neuroscience, 14, 72-72 (2013-07-20)
We have previously reported evidence of cell proliferation and increased neurogenesis in rat organotypic hippocampal slice cultures (OHSC) after a transient excitotoxic injury to the hippocampal CA1 area induced by low concentrations of the AMPA/kainate agonist domoic acid (DOM). An
Xuefeng Yuan et al.
Frontiers in neuroanatomy, 12, 4-4 (2018-02-08)
Past studies have suggested that non-neuronal brain cells express the leptin receptor. However, the identity and distribution of these leptin receptor-expressing non-neuronal brain cells remain debated. This study assessed the distribution of the long form of the leptin receptor (LepRb)
Jorge S Valadas et al.
Journal of neurochemistry, 123(6), 1030-1040 (2012-10-13)
In situations of hypoxia, glutamate excitotoxicity induces neuronal death. The release of extracellular adenosine is also triggered and is accompanied by an increase of the stress mediator, corticotrophin-releasing factor (CRF). Adenosine A(2A) receptors contribute to glutamate excitoxicity and their blockade
Rachel E James et al.
Glia, 64(1), 105-121 (2015-09-05)
Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied
Shu-Ming Li et al.
International immunopharmacology, 87, 106814-106814 (2020-07-25)
Systemic inflammation induces cognitive impairments via unclear mechanisms. Increasing evidence has suggested complement C3/C3a receptor signaling, a key component of innate immune pathogen defense, plays an important role in cognition and neurodegeneration, whereas its dysfunction is implicated in many neurological
Dun-Sheng Yang et al.
Brain : a journal of neurology, 137(Pt 12), 3300-3318 (2014-10-02)
Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is markedly impaired in neurons in Alzheimer's disease and Alzheimer mouse models. We have previously reported that severe lysosomal and amyloid neuropathology and associated cognitive deficits in the TgCRND8
Ashley A Scherlek et al.
Brain communications, 4(1), fcac021-fcac021 (2022-03-01)
Haemorrhagic amyloid-related imaging abnormalities on MRI are frequently observed adverse events in the context of amyloid β immunotherapy trials in patients with Alzheimer's disease. The underlying histopathology and pathophysiological mechanisms of haemorrhagic amyloid-related imaging abnormalities remain largely unknown, although coexisting
Yacine Touahri et al.
Theranostics, 10(7), 2982-2999 (2020-03-21)
Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for retinal repair will require safe and effective delivery strategies for
Jingjing He et al.
Scientific reports, 6, 34339-34339 (2016-10-13)
Parkinson's disease (PD) is one common neurodegenerative disease caused by a significant loss of midbrain dopaminergic neurons. Previous reports showed that 7, 8- dihydroxyflavone (7, 8-DHF) as a potent TrkB agonist can mimic BDNF and play neuroprotective roles for mouse
Andrea Kovács-Valasek et al.
Cells, tissues, organs, 210(2), 135-150 (2021-07-05)
Imbalance of homeostasis causes permanent changes in the body with time. The central nervous system is especially prone to these changes since it possesses limited regenerative capacity. In the retina, neurons are damaged during the aging process, and this eventually
Philip Gaughwin et al.
Cerebral cortex (New York, N.Y. : 1991), 21(8), 1857-1869 (2011-01-14)
To realize the potential of microRNAs (miRs) as fine-tuning regulators of embryonic neuronal differentiation, it is critical to define their developmental function. Mmu-miR-134 (miR-134) is a powerful inducer of pluripotent stem cell differentiation. However, its functional role during embryonic, neuronal
Atalia F L Flôr et al.
Frontiers in physiology, 9, 430-430 (2018-05-17)
It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and water intake. Although ANG-II
Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker
Yang Z and Wang K K
Trends in Neurosciences, 38(6), 364-374 (2015)
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Michal Lipinski et al.
Nature communications, 11(1), 2588-2588 (2020-05-24)
The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain unclear. Here, we show that the combined elimination of both proteins in forebrain excitatory neurons of
Alejandro Medrano-Fernández et al.
Molecular neurobiology, 56(6), 4440-4454 (2018-10-20)
The development of inhibitory circuits depends on the action of a network of transcription factors and epigenetic regulators that are critical for interneuron specification and differentiation. Although the identity of many of these transcription factors is well established, much less
Laura Martínez-Palma et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(1), 203-215 (2018-08-31)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron (MN) degeneration and gliosis. Neonatal astrocytes obtained from the SOD1G93A rat model of ALS exhibit mitochondrial dysfunction and neurotoxicity that can be reduced by dichloroacetate (DCA), a
Kylie H Van der Hoek et al.
Scientific reports, 7(1), 4475-4475 (2017-07-02)
Zika virus (ZIKV) infection has emerged as a global health threat and infection of pregnant women causes intrauterine growth restriction, spontaneous abortion and microcephaly in newborns. Here we show using biologically relevant cells of neural and placental origin that following
Michelle Corkrum et al.
Neuron, 105(6), 1036-1047 (2020-01-20)
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using
Jian-Ming Li et al.
Neurotoxicity research, 24(1), 1-14 (2012-10-12)
The spinal cord is composed of distinct neuronal groups with well-defined anatomic connections. In some transgenic (Tg) models of Alzheimer's disease (AD), amyloid plaques develop in this structure, although the underlying cellular mechanism remains elusive. We attempted to explore the
Pearl P Y Lie et al.
Cell reports, 35(4), 109034-109034 (2021-04-29)
Lysosomal trafficking and maturation in neurons remain poorly understood and are unstudied in vivo despite high disease relevance. We generated neuron-specific transgenic mice to track vesicular CTSD acquisition, acidification, and traffic within the autophagic-lysosomal pathway in vivo, revealing that mature lysosomes are
Makoto Hamanoue et al.
Stem cell research, 14(1), 68-78 (2014-12-20)
Neural stem/progenitor cells (NPCs) express a variety of asparagine-linked oligosaccharide chains, called N-glycans, on the cell surface, and mainly produce hybrid-type and complex-type N-glycans. However, the expression profiles and roles of N-acetylglucosaminyltransferase-V (GnT-V), an enzyme that forms β1,6-branched N-glycans, in
Koutarou Nakamura et al.
PLoS biology, 19(5), e3000939-e3000939 (2021-05-21)
Inflammation is implicated in the onset and progression of various diseases, including cerebral pathologies. Here, we report that DJ-1, which plays a role within cells as an antioxidant protein, functions as a damage-associated molecular pattern (DAMP) and triggers inflammation if
Luis M Valor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(25), 10471-10482 (2013-06-21)
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcriptional
Paula K Yu et al.
Investigative ophthalmology & visual science, 51(1), 447-458 (2009-08-01)
To develop a new technique for detailed study of the spatial distribution of retinal and choroidal microvasculature and their relationship to neurons and glial cells at the cellular level in human cadaveric eyes. Twenty-six human donor eyes were used. Wherever
Abhishek Deshpande et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 29(11), 1806-1815 (2009-08-14)
Chronic hydrocephalus (CH) is characterized by the presence of ventricular enlargement, decreased cerebral blood flow (CBF), and brain tissue oxygen delivery. Although the underlying pathophysiological role of vascular endothelial growth factor (VEGF) is not clear, ischemic-hypoxic events in CH are
Xiaofei Gao et al.
Cell reports, 30(8), 2489-2500 (2020-02-27)
Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal
Alberto Serrano-Pozo et al.
Brain : a journal of neurology, 133(Pt 5), 1312-1327 (2010-04-03)
Anti-amyloid-beta immunization leads to amyloid clearance in patients with Alzheimer's disease, but the effect of vaccination on amyloid-beta-induced neuronal pathology has not been quantitatively examined. The objectives of this study were to address the effects of anti-amyloid-beta active immunization on
Lorenzo Romero-Ramírez et al.
Journal of biomedical science, 27(1), 35-35 (2020-02-19)
Spinal cord injury (SCI) is a highly debilitating pathology without curative treatment. One of the most promising disease modifying strategies consists in the implantation of stem cells to reduce inflammation and promote neural regeneration. In the present study we tested
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