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Joseph D Mancias et al.
Nature, 509(7498), 105-109 (2014-04-04)
Autophagy, the process by which proteins and organelles are sequestered in double-membrane structures called autophagosomes and delivered to lysosomes for degradation, is critical in diseases such as cancer and neurodegeneration. Much of our understanding of this process has emerged from...
50 years ago in the Journal of Pediatrics: Iron metabolism in premature infants: II. Prevention of iron deficiency.
Pamela J Kling
The Journal of pediatrics, 164(4), 768-768 (2014-03-22)
Keith P West et al.
JAMA, 312(24), 2649-2658 (2014-12-24)
Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal micronutrient supplementation in South Asia. To assess effects of antenatal multiple micronutrient vs iron-folic acid supplementation on...
Mary D Frame et al.
Nanotoxicology, 8(8), 867-875 (2013-09-03)
Single-walled carbon nanotubes synthesized with iron (Fe-SWCNT) or gadolinium (Gd-SWCNT) show promise as high performance multimodal contrast and drug-delivery agents. Our purpose was to evaluate potential vasoactive effects of SWCNT. Stable aqueous solutions of Fe-SWCNTs or Gd-SWCNTs were made using...
Jingrang Lu et al.
Journal of water and health, 12(4), 763-771 (2014-12-05)
A quantitative polymerase chain reaction assay (115 bp amplicon) specific to Escherichia coli K12 with an ABI(TM) internal control was developed based on sequence data encoding the rfb gene cluster. Assay specificity was evaluated using three E. coli K12 strains...
Yan Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), E1695-E1704 (2014-04-16)
Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)2-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inactivation, and reactivation are poorly...
Chenyan Lv et al.
Biochemistry, 53(14), 2232-2241 (2014-04-01)
From an evolutionary point of view, plant and animal ferritins arose from a common ancestor, but plant ferritin exhibits different features as compared with the animal analogue. One major difference is that the 4-fold channels naturally occurring in plant ferritin...
Rui C Martins et al.
Environmental technology, 35(17-20), 2380-2388 (2014-08-26)
The presence of surfactants in wastewater composition tends to jeopardize the efficiency of the traditional aerobic treatment processes. In this regard, the application of Fenton's reaction and nanofiltration as single processes and integrated (nanofiltration followed by Fenton's process) was investigated...
Eduard J van Beers et al.
Circulation research, 116(2), 298-306 (2014-11-08)
Patients with sickle cell disease (SCD) have markers of chronic inflammation, but the mechanism of inflammation and its relevance to patient survival are unknown. To assess the relationship between iron, inflammation, and early death in SCD. Using peripheral blood mononuclear...
Ramesh Kumar et al.
Environmental technology, 35(13-16), 2018-2027 (2014-06-25)
Nanofiltration (NF) of ammoniacal wastewater containing phenol and cyanide has been investigated for effective separation of these hazardous pollutants and for the subsequent downstream chemical treatment resulting in valuable by-product generation. Four different types of composite polyamide commercial NF membranes...
Ellinor I B Peerschke et al.
American journal of clinical pathology, 142(4), 506-512 (2014-09-23)
Evaluation of anemia, particularly iron deficiency, in patients with cancer is difficult. This study examined using the hemoglobin content of reticulocytes (RET-He) to rule out iron deficiency, as defined by serum iron studies (transferrin saturation <20%, serum iron <40 μg/dL...
Reference method for measurement of the hepatic iron concentration.
Gary M Brittenham
American journal of hematology, 90(2), 85-86 (2014-12-10)
Yatrik M Shah et al.
Gastroenterology, 146(3), 630-642 (2014-01-07)
Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under conditions of low levels of O2. One component of this pathway, hypoxia-inducible factor (HIF), is...
Arnold L Demain et al.
Applied microbiology and biotechnology, 73(1), 55-59 (2006-04-20)
When tetanus toxin is made by fermentation with Clostridium tetani, the traditional source of iron is an insoluble preparation called reduced iron powder. This material removes oxygen from the system by forming FeO(2) (rust). When inoculated in a newly developed...
S J Geetha et al.
TheScientificWorldJournal, 2013, 315890-315890 (2013-12-10)
Under field conditions, inoculated rhizobial strains are at a survival disadvantage as compared to indigenous strains. In order to out-compete native rhizobia it is not only important to develop strong nodulation efficiency but also increase their competence in the soil...
Sohail Amjad et al.
Pakistan journal of pharmaceutical sciences, 27(3), 445-452 (2014-05-09)
In Pakistan, a funded flour fortification program was launched for malnourished population, residing mainly in rural low income areas, but the urban population having comparatively better nutritional as well as economic status was focused wherein excessive intake of fortificants might...
Kurinchi Selvan Gurusamy et al.
The Cochrane database of systematic reviews, 12(12), CD010640-CD010640 (2015-01-01)
Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not...
Cecilia M Casadei et al.
Science (New York, N.Y.), 345(6193), 193-197 (2014-07-12)
Heme enzymes activate oxygen through formation of transient iron-oxo (ferryl) intermediates of the heme iron. A long-standing question has been the nature of the iron-oxygen bond and, in particular, the protonation state. We present neutron structures of the ferric derivative...
Robert C Hider et al.
Metal ions in life sciences, 13, 229-294 (2014-01-29)
Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in the evolution of living systems and as such is an essential element in a wide range of biological phenomena, being...
Thomas A Russo et al.
Infection and immunity, 82(6), 2356-2367 (2014-03-26)
Hypervirulent (hypermucoviscous) Klebsiella pneumoniae (hvKP) strains are an emerging variant of "classical" K. pneumoniae (cKP) that cause organ and life-threatening infection in healthy individuals. An understanding of hvKP-specific virulence mechanisms that enabled evolution from cKP is limited. Observations by our...
Janneke Balk et al.
Annual review of plant biology, 65, 125-153 (2014-02-07)
Iron is an essential element for all photosynthetic organisms. The biological use of this transition metal is as an enzyme cofactor, predominantly in electron transfer and catalysis. The main forms of iron cofactor are, in order of decreasing abundance, iron-sulfur...
B Clevenger et al.
Anaesthesia, 70 Suppl 1, 20-28 (2014-12-03)
Pre-operative anaemia is a relatively common finding, affecting a third of patients undergoing elective surgery. Traditionally associated with chronic disease, management has historically focused on the use of blood transfusion as a solution for anaemia in the peri-operative period. Data...
[Children's iron needs and how we best can protect the child's brain].
Staffan Berglund et al.
Lakartidningen, 111(11), 460-463 (2014-04-12)
Stuart B Krasnoff et al.
Journal of natural products, 77(7), 1685-1692 (2014-07-06)
Under iron-depleted culture conditions, the entomopathogenic fungus Metarhizium robertsii (Bischoff, Humber, and Rehner) (= M. anisopliae) produces a complex of extracellular siderophores including novel O-glycosylated and N-oxidized coprogen-type compounds as well as the known fungal siderophores N(α)-dimethylcoprogen (NADC) and dimerumic...
Ocean Science. Microbial proteins and oceanic nutrient cycles.
C Mark Moore
Science (New York, N.Y.), 345(6201), 1120-1121 (2014-09-06)
Ocean chemistry: Fingerprints of a trace nutrient.
Joseph A Resing et al.
Nature, 511(7508), 164-165 (2014-07-11)
Microcytic anemia.
Shraga Aviner et al.
The New England journal of medicine, 371(26), 2536-2536 (2014-12-30)
Joseph Marie Sieliechi et al.
Environmental technology, 35(13-16), 1831-1839 (2014-06-25)
In this study, spatial and seasonal variations of phosphorus fractions in Lake Bini sediments were evaluated using a sequential extraction method. The sampling of water and sediments (surface and coring) was carried out at seven sites around the lake during...
Don-Kyu Kim et al.
Nature medicine, 20(4), 419-424 (2014-03-25)
In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters...
Femkje A M Jonker et al.
Journal of clinical pathology, 67(8), 717-723 (2014-06-12)
Iron deficiency is an important child health problem. Its diagnosis in areas of high infection exposure remains complicated as inflammation may interfere with the accuracy of peripheral iron markers. With this study, we aimed to validate the conventional iron markers...
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