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H1270

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Mechanical spectroscopy of retina explants at the protein level employing nanostructured scaffolds
Rahman SM, et al.
Soft Matter, 12(14), 3431-3441 (2016)
Theodore A Slotkin et al.
Environmental health perspectives, 116(6), 716-722 (2008-06-19)
The widespread detection of perfluoroalkyl acids and their derivatives in wildlife and humans, and their entry into the immature brain, raise increasing concern about whether these agents might be developmental neurotoxicants. We evaluated perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorooctane...
George Karkoulias et al.
Cellular signalling, 66, 109446-109446 (2019-11-05)
Many aspects of neuronal development, such as neuronal survival and differentiation, are regulated by the transcription factor cAMP-response element-binding protein (CREB). We have previously reported that α2-adrenergic receptors (ARs), members of the G protein-coupled receptor (GPCR) superfamily, induce neuronal differentiation...
Taha Azad et al.
Oncogene, 39(2), 334-355 (2019-09-04)
The Hippo pathway has emerged as a key signaling pathway that regulates various biological functions. Dysregulation of the Hippo pathway has been implicated in a broad range of human cancer types. While a number of stimuli affecting the Hippo pathway...
Kantida Juncheed et al.
International journal of molecular sciences, 21(11) (2020-06-04)
Numerous eye diseases are linked to biomechanical dysfunction of the retina. However, the underlying forces are almost impossible to quantify experimentally. Here, we show how biomechanical properties of adult neuronal tissues such as porcine retinae can be investigated under tension...
Lina Han et al.
PloS one, 4(11), e7989-e7989 (2009-12-04)
Signal Transducer and Activator of Transcription 5 (STAT5) plays critical roles in normal and leukemic hematopoiesis. However, the manner in which STAT5 responds to early-acting and lineage-restricted cytokines, particularly in leukemic stem/progenitor cells, is largely unknown. We optimized a multiparametric...
Virginie Mournetas et al.
Journal of cachexia, sarcopenia and muscle, 12(1), 209-232 (2021-02-16)
Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of approximately 1/5000 male births. Symptoms appear in early childhood, with a diagnosis made mostly around 4 years old, a time where the amount...
S Mahmoudi et al.
Cell death & disease, 2, e114-e114 (2011-03-04)
We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor. The WRAP53 gene also encodes a protein essential for Cajal body formation and involved in cellular trafficking of the survival of motor neuron complex, the telomerase...
Jessica Z Kubicek-Sutherland et al.
Toxins, 11(4) (2019-04-17)
Mycolactone, the amphiphilic macrolide toxin secreted by Mycobacterium ulcerans, plays a significant role in the pathology and manifestations of Buruli ulcer (BU). Consequently, it follows that the toxin is a suitable target for the development of diagnostics and therapeutics for...
Cosmin Cătălin Mustăciosu et al.
International journal of molecular sciences, 20(8) (2019-04-25)
The neuron-specific Elav-like Hu RNA-binding proteins were described to play an important role in neuronal differentiation and plasticity by ensuring the post-transcriptional control of RNAs encoding for various proteins. Although Elav-like Hu proteins alterations were reported in diabetes or neuropathy...
Zhipeng Cao et al.
Analytical biochemistry, 606, 113877-113877 (2020-08-02)
Rapidly identifying cachexia-inducing factors that directly induce muscle wasting is an existing challenge. We developed two reporter cell lines that allow swift detection of such factors in blood from patients. C2C12 myoblasts were used for the establishment of reporter cells....
Helena Zientek-Targosz et al.
Molecular cancer, 7, 51-51 (2008-06-07)
Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in...
Max A Cayo et al.
American journal of translational research, 1(2), 178-183 (2009-12-04)
Pheochromocytoma is a neuroendocrine (NE) tumor of the adrenal medulla for which surgical resection is the only therapy. However, 10-46% of tumors are metastatic or have malignant features, and are often inoperable. Our lab has demonstrated the importance of the...
Nicole K McKinnon et al.
The Journal of general physiology, 138(4), 453-466 (2011-09-29)
5-HT3A receptors select among permeant ions based on size and charge. The membrane-associated (MA) helix lines the portals into the channel's cytoplasmic vestibule in the 4-Å resolution structure of the homologous acetylcholine receptor. 5-HT3A MA helix residues are important determinants...
Lingli He et al.
Cancer research, 79(17), 4399-4411 (2019-07-11)
The Hippo pathway plays a critical role in cell growth and tumorigenesis. The activity of TEA domain transcription factor 4 (TEAD4) determines the output of Hippo signaling; however, the regulation and function of TEAD4 has not been explored extensively. Here...
Esteban Arroyave et al.
Ticks and tick-borne diseases, 11(3), 101367-101367 (2020-01-29)
Ehrlichia canis is the etiologic agent of a highly prevalent tick-borne disease, canine monocytic ehrlichiosis (CME). Four defined E. canis genotypes based on the trp36 gene sequences have been reported, three of them identified in North or South America. The...
Justyna M Kowal et al.
Stem cells translational medicine, 9(2), 189-202 (2019-11-24)
Cultured human bone marrow stromal (mesenchymal) stem cells (hBM-MSCs) are heterogenous cell populations exhibiting variable biological properties. Quantitative high-content imaging technology allows identification of morphological markers at a single cell resolution that are determinant for cellular functions. We determined the...
H K Knych et al.
Drug testing and analysis, 7(7), 619-625 (2014-10-21)
Cobalt has been used by human athletes due to its purported performance-enhancing effects. It has been suggested that cobalt administration results in enhanced erythropoiesis, secondary to increased circulating erythropoietin (EPO) concentrations leading to improvements in athletic performance. Anecdotal reports of...
Eckhard U Alt et al.
Scientific reports, 10(1), 8834-8834 (2020-06-03)
Here we investigated the roles of Rab27a, a player in exosome release, and TRAF3IP2, an inflammatory mediator, in development and metastasis of breast cancer (BC) in vivo. Knockdown (KD) of Rab27a (MDAKDRab27a) or TRAF3IP2 (MDAKDTRAF3IP2) in triple negative MDA-MB231 cells reduced...
Animal-cell culture media: History, characteristics, and current issues
Yao T and Asayama Y
Reproductive medicine and biology, 16(2), 99-117 (2017)
Varun Balaji et al.
Autophagy, 14(12), 2139-2154 (2018-08-28)
Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using microfluidic chambers...
Melanie J Lewis et al.
Molecular immunology, 45(3), 818-827 (2007-08-03)
Recombinant versions of the seven equine IgG subclasses were expressed in CHO cells. All assembled into intact immunoglobulins stabilised by disulphide bridges, although, reminiscent of human IgG4, a small proportion of equine IgG4 and IgG7 were held together by non-covalent...
Winco Wh Wu et al.
Virology journal, 6, 68-68 (2009-06-06)
Early in infection, the genome of the influenza A virus, consisting of eight complexes of RNA and proteins (termed viral ribonucleoproteins; vRNPs), enters the nucleus of infected cells for replication. Incoming vRNPs are imported into the nucleus of infected cells...
Theodore A Slotkin et al.
Brain research bulletin, 76(4), 424-438 (2008-05-27)
Neurotrophic factors control neural cell differentiation and assembly of neural circuits. We previously showed that organophosphate pesticides differentially regulate members of the fibroblast growth factor (fgf) gene family. We administered chlorpyrifos and diazinon to neonatal rats on postnatal days 1-4...
Olga Blaževitš et al.
International journal of molecular sciences, 21(7) (2020-04-01)
The circadian transcriptional network is based on a competition between transcriptional activator and repressor complexes regulating the rhythmic expression of clock-controlled genes. We show here that the MYC-associated factor X, MAX, plays a repressive role in this network and operates...
T R Butler et al.
Neuroscience, 165(2), 525-534 (2009-10-20)
Excess glutamate release and stimulation of post-synaptic glutamatergic receptors have been implicated in the pathophysiology of many neurological diseases. The hippocampus, and the pyramidal cell layer of the cornu ammonus 1 (CA1) region in particular, has been noted for its...
Stéphanie Coumes-Florens et al.
PloS one, 6(1), e15951-e15951 (2011-02-02)
Signal transduction systems and ABC transporters often contribute jointly to adaptive bacterial responses to environmental changes. In Bacillus subtilis, three such pairs are involved in responses to antibiotics: BceRSAB, YvcPQRS and YxdJKLM. They are characterized by a histidine kinase belonging...
Balmiki Ray et al.
Journal of neuroscience methods, 184(2), 294-302 (2009-09-02)
Neurobiological studies using primary neuronal cultures commonly employ fetal-derived neurons, but much less often adult brain-derived neurons. Our goal is to perform morphological and molecular characterization of primary neuronal cultures from adult rat brain, including the relative expression of neuronal...
Sunny Nigam et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(3), 670-684 (2016-01-23)
The performance of complex networks, like the brain, depends on how effectively their elements communicate. Despite the importance of communication, it is virtually unknown how information is transferred in local cortical networks, consisting of hundreds of closely spaced neurons. To...
Rachael A Harrison et al.
Biochemical and biophysical research communications, 390(1), 171-175 (2009-10-06)
Macrophage migration inhibitory factor (MIF) expression is induced by angiotensin II (Ang II) in normal rat neurons and serves a negative regulatory role by blunting the chronotropic actions of this peptide. The aim here was to determine whether hydrogen peroxide...
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