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Eckhard U Alt et al.
Scientific reports, 10(1), 8834-8834 (2020-06-03)
Here we investigated the roles of Rab27a, a player in exosome release, and TRAF3IP2, an inflammatory mediator, in development and metastasis of breast cancer (BC) in vivo. Knockdown (KD) of Rab27a (MDAKDRab27a) or TRAF3IP2 (MDAKDTRAF3IP2) in triple negative MDA-MB231 cells reduced
Shradha Das et al.
Biology open, 7(1) (2018-01-28)
Epithelia are highly polarised tissues and several highly conserved polarity protein complexes serve to establish and maintain polarity. The transmembrane protein Crumbs (Crb), the central component of the Crb protein complex, is required, among others, for the maintenance of polarity
Line Pedersen et al.
Cancer research, 80(11), 2163-2174 (2020-04-16)
The metabolic network of sphingolipids plays important roles in cancer biology. Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate multiple aspects of growth, apoptosis, and cellular signaling. Although a significant number of enzymatic regulators of the sphingolipid pathway have been
B Rippe et al.
American journal of physiology. Heart and circulatory physiology, 280(1), H34-H41 (2000-12-21)
This study was undertaken to evaluate the role of transcytosis as a bulk transfer mechanism for the passage of albumin from blood to tissue. Isolated rat lungs were continuously weighed and perfused with an albumin-serum buffer solution under strictly controlled
Virginie Mournetas et al.
Journal of cachexia, sarcopenia and muscle, 12(1), 209-232 (2021-02-16)
Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of approximately 1/5000 male births. Symptoms appear in early childhood, with a diagnosis made mostly around 4 years old, a time where the amount
Michael S Lopez et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(42), 11223-11228 (2017-10-05)
The type VII secretion system (T7SS) of Staphylococcus aureus is a multiprotein complex dedicated to the export of several virulence factors during host infection. This virulence pathway plays a key role in promoting bacterial survival and the long-term persistence of
Matthew J Lees et al.
Nutrients, 13(2) (2021-03-07)
Fish-derived proteins, particularly fish protein hydrolysates (FPH), offer potential as high-quality sources of dietary protein, whilst enhancing economic and environmental sustainability. This study investigated the impact of a blue whiting-derived protein hydrolysate (BWPH) on aminoacidaemia in vivo and skeletal muscle
Lina Han et al.
PloS one, 4(11), e7989-e7989 (2009-12-04)
Signal Transducer and Activator of Transcription 5 (STAT5) plays critical roles in normal and leukemic hematopoiesis. However, the manner in which STAT5 responds to early-acting and lineage-restricted cytokines, particularly in leukemic stem/progenitor cells, is largely unknown. We optimized a multiparametric
T Azad et al.
Nature communications, 9(1), 1061-1061 (2018-03-15)
The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase.
Cosmin Cătălin Mustăciosu et al.
International journal of molecular sciences, 20(8) (2019-04-25)
The neuron-specific Elav-like Hu RNA-binding proteins were described to play an important role in neuronal differentiation and plasticity by ensuring the post-transcriptional control of RNAs encoding for various proteins. Although Elav-like Hu proteins alterations were reported in diabetes or neuropathy
Jessica Z Kubicek-Sutherland et al.
Toxins, 11(4) (2019-04-17)
Mycolactone, the amphiphilic macrolide toxin secreted by Mycobacterium ulcerans, plays a significant role in the pathology and manifestations of Buruli ulcer (BU). Consequently, it follows that the toxin is a suitable target for the development of diagnostics and therapeutics for
Justyna M Kowal et al.
Stem cells translational medicine, 9(2), 189-202 (2019-11-24)
Cultured human bone marrow stromal (mesenchymal) stem cells (hBM-MSCs) are heterogenous cell populations exhibiting variable biological properties. Quantitative high-content imaging technology allows identification of morphological markers at a single cell resolution that are determinant for cellular functions. We determined the
Marc D Panas et al.
Methods (San Diego, Calif.), 90, 57-64 (2015-04-22)
Stress granules are induced in many different viral infections, and in turn are inhibited by the expression of viral proteins or RNAs. It is therefore evident that these bodies are not compatible with efficient viral replication, but the mechanism by
David Flores-Benitez et al.
eLife, 4 (2015-11-07)
The evolutionarily conserved Crumbs protein is required for epithelial polarity and morphogenesis. Here we identify a novel role of Crumbs as a negative regulator of actomyosin dynamics during dorsal closure in the Drosophila embryo. Embryos carrying a mutation in the
Kantida Juncheed et al.
International journal of molecular sciences, 21(11) (2020-06-04)
Numerous eye diseases are linked to biomechanical dysfunction of the retina. However, the underlying forces are almost impossible to quantify experimentally. Here, we show how biomechanical properties of adult neuronal tissues such as porcine retinae can be investigated under tension
Ann J Johnston et al.
Neurobiology of disease, 64, 131-141 (2014-01-11)
Genetic mutations in voltage-gated and ligand-gated ion channel genes have been identified in a small number of Mendelian families with genetic generalised epilepsies (GGEs). They are commonly associated with febrile seizures (FS), childhood absence epilepsy (CAE) and particularly with generalised
Motahareh Hassanzadeh et al.
Research in pharmaceutical sciences, 16(5), 482-492 (2021-09-16)
Alzheimer's disease is considered one of the lead causes of elderly death around the world. A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer's disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and
S Mahmoudi et al.
Cell death & disease, 2, e114-e114 (2011-03-04)
We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor. The WRAP53 gene also encodes a protein essential for Cajal body formation and involved in cellular trafficking of the survival of motor neuron complex, the telomerase
Varun Balaji et al.
Autophagy, 14(12), 2139-2154 (2018-08-28)
Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of endogenous MAPT in mature primary neurons using microfluidic chambers
Aonan Tang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(2), 505-518 (2008-01-11)
Multineuron firing patterns are often observed, yet are predicted to be rare by models that assume independent firing. To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and
Sung Min Son et al.
Cell metabolism, 29(1), 192-201 (2018-09-11)
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context. Here we describe
H K Knych et al.
Drug testing and analysis, 7(7), 619-625 (2014-10-21)
Cobalt has been used by human athletes due to its purported performance-enhancing effects. It has been suggested that cobalt administration results in enhanced erythropoiesis, secondary to increased circulating erythropoietin (EPO) concentrations leading to improvements in athletic performance. Anecdotal reports of
Esteban Arroyave et al.
Ticks and tick-borne diseases, 11(3), 101367-101367 (2020-01-29)
Ehrlichia canis is the etiologic agent of a highly prevalent tick-borne disease, canine monocytic ehrlichiosis (CME). Four defined E. canis genotypes based on the trp36 gene sequences have been reported, three of them identified in North or South America. The
Zhipeng Cao et al.
Analytical biochemistry, 606, 113877-113877 (2020-08-02)
Rapidly identifying cachexia-inducing factors that directly induce muscle wasting is an existing challenge. We developed two reporter cell lines that allow swift detection of such factors in blood from patients. C2C12 myoblasts were used for the establishment of reporter cells.
Veronika Sander et al.
STAR protocols, 1(3), 100150-100150 (2020-12-31)
Kidney organoids represent a physiologically advanced model for studying the mechanisms of kidney development and disease. Here, we describe a simple two-step protocol for the differentiation of human pluripotent stem cells into kidney organoids. Our approach involves suspension culture that
Lingli He et al.
Cancer research, 79(17), 4399-4411 (2019-07-11)
The Hippo pathway plays a critical role in cell growth and tumorigenesis. The activity of TEA domain transcription factor 4 (TEAD4) determines the output of Hippo signaling; however, the regulation and function of TEAD4 has not been explored extensively. Here
Max A Cayo et al.
American journal of translational research, 1(2), 178-183 (2009-12-04)
Pheochromocytoma is a neuroendocrine (NE) tumor of the adrenal medulla for which surgical resection is the only therapy. However, 10-46% of tumors are metastatic or have malignant features, and are often inoperable. Our lab has demonstrated the importance of the
Nicole K McKinnon et al.
The Journal of general physiology, 138(4), 453-466 (2011-09-29)
5-HT3A receptors select among permeant ions based on size and charge. The membrane-associated (MA) helix lines the portals into the channel's cytoplasmic vestibule in the 4-Å resolution structure of the homologous acetylcholine receptor. 5-HT3A MA helix residues are important determinants
Kazem Nouri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(11), 12487-12499 (2019-08-23)
The Hippo pathway is an emerging signaling pathway that plays important roles in organ size control, tissue homeostasis, tumorigenesis, metastasis, drug resistance, and immune response. Although many regulators of the Hippo pathway have been reported, the extracellular stimuli and kinase
Mechanical spectroscopy of retina explants at the protein level employing nanostructured scaffolds
Rahman SM, et al.
Soft Matter, 12(14), 3431-3441 (2016)
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