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Phlebotomy as an efficient long-term treatment of congenital erythropoietic porphyria.
Arienne Mirmiran et al.
Haematologica, 106(3), 913-917 (2020-01-11)
Mohamed Abdouh et al.
Journal of experimental & clinical cancer research : CR, 36(1), 113-113 (2017-09-01)
Horizontal transfer of malignant traits from the primary tumor to distant organs, through blood circulating factors, has recently become a thoroughly studied metastatic pathway to explain cancer dissemination. Recently, we reported that oncosuppressor gene-mutated human cells undergo malignant transformation when
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-? is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.
Sagare AP et al.
Journal of Alzheimer'S Disease, 24, 25-25 (2011)
S K Sengodan et al.
Oncogenesis, 6(9), e376-e376 (2017-09-05)
Human chorionic gonadotropin β (β-hCG) has been implicated in breast tumorigenesis. However, the role of this hormone is highly controversial as certain studies suggest it has anti-tumor properties while others have found it to be pro-tumorigenic. To unveil the truth
Nassim Mahtal et al.
Toxins, 12(1) (2020-01-08)
The ionophore lasalocid is widely used as a veterinary drug against coccidiosis. We found recently that lasalocid protects cells from two unrelated bacterial toxins, the cytotoxic necrotizing factor-1 (CNF1) from Escherichia. coli and diphtheria toxin. We evaluated lasalocid's capacity to
Rui Su et al.
Cell, 172(1-2), 90-105 (2017-12-19)
R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferation/viability and by promoting
Youjin Na et al.
Oncogene, 40(5), 951-963 (2020-12-10)
MicroRNAs (miRs) are small non-coding RNAs that can have large impacts on oncogenic pathways. Possible functions of dysregulated miRs have not been studied in neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNFs). In PNFs, Schwann cells (SCs) have biallelic NF1 mutations
Abstracts of the XXIV Congress of the International Society on Thrombosis and Haemostasis. June 29-July 4, 2013. Amsterdam, The Netherlands.
Journal of thrombosis and haemostasis : JTH, 11 Suppl 2, 1-1322 (2013-06-29)
Silvia Benito-Kwiecinski et al.
Cell, 184(8), 2084-2102 (2021-03-26)
The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla, and chimpanzee cells to study developmental mechanisms
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Florian Steinberg et al.
The Journal of biological chemistry, 285(48), 37704-37715 (2010-09-21)
The fusion of mammalian cells into syncytia is a developmental process that is tightly restricted to a limited subset of cells. Besides gamete and placental trophoblast fusion, only macrophages and myogenic stem cells fuse into multinucleated syncytia. In contrast to
Siddharth Kishore et al.
Cell stem cell, 27(1), 137-146 (2020-05-23)
GATA6 is a critical regulator of pancreatic development, with heterozygous mutations in this transcription factor being the most common cause of pancreatic agenesis. To study the variability in disease phenotype among individuals harboring these mutations, a patient-induced pluripotent stem cell
Yin Xiang Setoh et al.
Nature microbiology, 4(5), 876-887 (2019-03-20)
Arboviruses cycle between, and replicate in, both invertebrate and vertebrate hosts, which for Zika virus (ZIKV) involves Aedes mosquitoes and primates1. The viral determinants required for replication in such obligate hosts are under strong purifying selection during natural virus evolution
Ursula Theocharidis et al.
Cell and tissue research, 385(3), 659-674 (2021-07-27)
Neural stem/progenitor cells (NSPCs) rely on internal and external cues determining their lineage decisions during brain development. The progenitor cells of the embryonic mammalian forebrain reside in the ventricular and subventricular zones of the lateral ventricles, where they proliferate, generate
Amita Datta-Mannan et al.
mAbs, 7(3), 483-493 (2015-02-20)
Lowering the isoelectric point (pI) through engineering the variable region or framework of an IgG can improve its exposure and half-life via a reduction in clearance mediated through non-specific interactions. As such, net charge is a potentially important property to
Liliang Ouyang et al.
Biofabrication, 7(1), 015010-015010 (2015-02-19)
3D printing has evolved into a versatile technology for fabricating tissue-engineered constructs with spatially controlled cells and biomaterial distribution to allow biomimicking of in vivo tissues. In this paper, we reported a novel study of 3D printing of cell lines
Hong Xin et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(21) (2021-05-20)
Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of
Mikhail E Kandel et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18302-18309 (2020-07-22)
The ability to evaluate sperm at the microscopic level, at high-throughput, would be useful for assisted reproductive technologies (ARTs), as it can allow specific selection of sperm cells for in vitro fertilization (IVF). The tradeoff between intrinsic imaging and external
Alfred Nguyen et al.
Lab on a chip, 21(10), 1929-1947 (2021-05-20)
Active microrheology is one of the main methods to determine the mechanical properties of cells and tissue, and the modelling of these viscoelastic properties is under heavy debate with many competing approaches. Most experimental methods of active microrheology such as
Kuerban Tulake et al.
Animal reproduction science, 154, 68-78 (2015-02-02)
High efficiency of in vitro capacitation of deer sperm has not yet been achieved as low sperm penetration rates were reported in in vitro fertilization studies. Our main goal in this study was to identify the changes of frozen-thawed sperm
Shirsa Udgata et al.
Cancer prevention research (Philadelphia, Pa.), 14(2), 223-232 (2020-10-18)
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed too late for effective therapy. The classic strategy for early detection biomarker advancement consists of initial retrospective phases of discovery and validation with tissue samples taken from individuals diagnosed with disease, compared with
Masami Shimizu-Albergine et al.
The Journal of clinical investigation, 131(22) (2021-09-08)
Loss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by augmenting the activity of lipoprotein lipase (LPL). However, by using a mouse model of type 1 diabetes mellitus
Kenia Salazar-Díaz et al.
iScience, 24(11), 103260-103260 (2021-11-13)
Spermidine (Spd) is a nitrogen sink and signaling molecule that plays pivotal roles in eukaryotic cell growth and must be finetuned to meet various energy demands. In eukaryotes, target of rapamycin (TOR) is a central nutrient sensor, especially N, and
Ajay Ashok et al.
Investigative ophthalmology & visual science, 61(3), 24-24 (2020-03-18)
Elevated levels of transforming-growth-factor (TGF)-β2 in the trabecular meshwork (TM) and aqueous humor are associated with primary open-angle glaucoma (POAG). The underlying mechanism includes alteration of extracellular matrix homeostasis through Smad-dependent and independent signaling. Smad4, an essential co-Smad, upregulates hepcidin
Gabriele Di Sante et al.
Molecular endocrinology (Baltimore, Md.), 29(2), 200-212 (2014-12-30)
Hypogonadatropic hypogonadism (HH) can be acquired through energy restriction or may be inherited as congenital hypogonadotropic hypogonadism and its anosmia-associated form, Kallmann's syndrome. Congenital hypogonadotropic hypogonadism is associated with mutations in a group of genes that impact fibroblast growth factor
Mona Abed et al.
PloS one, 14(4), e0214110-e0214110 (2019-04-06)
Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long terminal repeat) retrotransposon and retains Gag and Pol-like domains. Here we show that the Gag
Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.
Bachli EB et al.
Journal of Thrombosis and Haemostasis, 1, 1935-1935 (2003)
William Schachterle et al.
Nature communications, 8, 13963-13963 (2017-01-17)
Transplanting vascular endothelial cells (ECs) to support metabolism and express regenerative paracrine factors is a strategy to treat vasculopathies and to promote tissue regeneration. However, transplantation strategies have been challenging to develop, because ECs are difficult to culture and little
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