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ZhanTao Zhu et al.
Alcoholism, clinical and experimental research, 38(6), 1510-1519 (2014-05-07)
Alcoholic liver disease (ALD) continues to be a major cause of morbidity worldwide. The exact mechanisms for ALD pathogenesis are not fully understood. There is currently no known available drug for ALD. Previous studies have suggested that ethanol (EtOH)-induced hepatic
Cristian Pezzato et al.
Nature communications, 6, 7790-7790 (2015-07-22)
A fundamental difference exists in the way signal generation is dealt with in natural and synthetic systems. While nature uses the transient activation of signalling pathways to regulate all cellular functions, chemists rely on sensory devices that convert the presence
Ho-Hsien Lee et al.
IUCrJ, 1(Pt 5), 305-317 (2014-10-09)
CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein of Human immunodeficiency virus 1 (HIV-1), and has previously been shown to induce the production of
Yi Sun et al.
Journal of physiology and biochemistry, 71(4), 807-821 (2015-11-14)
Myeloid leukemia factor 1 (MLF1) was involved in t(3;5) chromosomal rearrangement and aberrantly expressed in myelodysplastic syndromes/acute myeloid leukemia patients. Ex vivo experiments showed that the lymphocytes from the Mlf1-deficient mice were more resistant to apoptotic stimulations than the wild-type
Jason M Wolfs et al.
Nucleic acids research, 42(13), 8816-8829 (2014-07-12)
Targeting gene disruptions in complex genomes relies on imprecise repair by the non-homologous end-joining DNA pathway, creating mutagenic insertions or deletions (indels) at the break point. DNA end-processing enzymes are often co-expressed with genome-editing nucleases to enhance the frequency of
Jaroslava Lieskovská et al.
Parasites & vectors, 8, 275-275 (2015-05-16)
Transmission of pathogens by ticks is greatly supported by tick saliva released during feeding. Dendritic cells (DC) act as immunological sentinels and interconnect the innate and adaptive immune system. They control polarization of the immune response towards Th1 or Th2
Hoai-Nghia Nguyen et al.
Scientific reports, 5, 12600-12600 (2015-07-29)
Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN controls DNA repair and
Vítor M Gaspar et al.
Pharmaceutical research, 32(2), 562-577 (2014-09-05)
Tumor targeting nanomaterials have potential for improving the efficiency of anti-tumoral therapeutics. However, the evaluation of their biological performance remains highly challenging. In this study we describe the synthesis of multifunctional nanoparticles decorated with folic acid-PEG and dual amino acid-modified
Yulong Chen et al.
International journal of molecular medicine, 34(5), 1277-1285 (2014-09-06)
Hyperhomocysteinemia (HHcy) is a risk factor for cardiovascular disease. The S-nitrosylation of proteins is involved in the regulation of cardiovascular functions. However, whether homocysteine (Hcy) impairs vascular functions through the inhibition of protein S-nitrosylation in the endothelium remains to be determined. The
Ye Zhao et al.
BMC cell biology, 15, 40-40 (2014-12-01)
Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated primary endothelial cells due to the unavailability of endothelial cell
Pedro L J Monteiro et al.
Theriogenology, 84(7), 1215-1224 (2015-08-10)
Three experiments were done to evaluate the effects of progesterone (P4) supplementation starting during metestrus on formation of the CL and on fertility of lactating dairy cows subjected to fixed-time artificial insemination (FTAI) or embryo transfer (ET). In experiment 1
Panagiotis Bouris et al.
Matrix biology : journal of the International Society for Matrix Biology, 43, 42-60 (2015-03-03)
The 17β-estradiol (E2)/estrogen receptor alpha (ERα) signaling pathway is one of the most important pathways in hormone-dependent breast cancer. E2 plays pivotal roles in cancer cell growth, survival, and architecture as well as in gene expression regulatory mechanisms. In this
Antonio Abengózar-Vela et al.
Investigative ophthalmology & visual science, 56(4), 2709-2719 (2015-06-13)
To determine the anti-inflammatory and antioxidant effects of quercetin (QCT) and/or resveratrol (RES) on human conjunctival (IOBA-NHC) and corneal (HCE) epithelial cell lines. IOBA-NHC and HCE cells were treated with QCT (0.5-25 μM), RES (0.5-50 μM) and a low-dose mixture
Ghada Bouguerra et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(4), 1537-1546 (2015-10-30)
The aldose reductase inhibitor zopolrestat has been shown to either decrease or increase apoptosis, the suicidal death of nucleated cells. Erythrocytes may similarly enter suicidal death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine
Hirotada Akiho et al.
PloS one, 9(5), e92960-e92960 (2014-05-07)
The etiology of post-inflammatory gastrointestinal (GI) motility dysfunction, after resolution of acute symptoms of inflammatory bowel diseases (IBD) and intestinal infection, is largely unknown, however, a possible involvement of T cells is suggested. Using the mouse model of T cell
Bruno St-Jacques et al.
Experimental neurology, 261, 354-366 (2014-06-10)
Prostaglandin E2 (PGE2), a well-known pain mediator enriched in inflamed tissues, plays a pivotal role in the genesis of chronic pain conditions such as inflammatory and neuropathic pain. PGE2-prolonged sensitization of nociceptive dorsal root ganglion (DRG) neurons (nociceptors) may contribute
Paola Quaranta et al.
PloS one, 9(4), e94783-e94783 (2014-04-16)
Graft vascularization is a crucial step to obtain stable normoglycemia in pancreatic islet transplantation. Endothelial progenitor cells (EPCs) contribute to neoangiogenesis and to the revascularization process during ischaemic events and play a key role in the response to pancreatic islet
Taissa M Kasahara et al.
Human immunology, 76(10), 701-710 (2015-10-03)
Aging is now a well-recognized characteristic of the HIV-infected population and both AIDS and aging are characterized by a deficiency of the T-cell compartment. The objective of the present study was to evaluate the impact of antiretroviral (ARV) therapy in
Agnieszka Bazylko et al.
Journal of photochemistry and photobiology. B, Biology, 149, 189-195 (2015-06-21)
Galinsoga species are used in folk medicine as anti-inflammatory agents and accelerators for wound healing. They also have reported antioxidant activity. We examined aqueous and ethanolic extracts derived from the Galinsoga herb as potential photoprotectors, as the role of reactive
Brian R Tuinema et al.
mBio, 5(6), e01886-e01886 (2014-11-27)
Neutrophils engulf and kill bacteria using oxidative and nonoxidative mechanisms. Despite robust antimicrobial activity, neutrophils are impaired in directing Salmonella clearance and harbor viable intracellular bacteria during early stages of infection that can subsequently escape to more-permissive cell types. The
Joseph Park et al.
Nature medicine, 27(1), 66-72 (2021-01-13)
The clinical impact of rare loss-of-function variants has yet to be determined for most genes. Integration of DNA sequencing data with electronic health records (EHRs) could enhance our understanding of the contribution of rare genetic variation to human disease1. By
Azzah M Bannunah et al.
Molecular pharmaceutics, 11(12), 4363-4373 (2014-10-21)
This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial transport. Initially, toxicity
Daniel Sohmen et al.
Nature communications, 6, 6941-6941 (2015-04-24)
Ribosomal stalling is used to regulate gene expression and can occur in a species-specific manner. Stalling during translation of the MifM leader peptide regulates expression of the downstream membrane protein biogenesis factor YidC2 (YqjG) in Bacillus subtilis, but not in
Jin Sun Choi et al.
Oncotarget, 5(20), 10084-10099 (2014-10-03)
HS-1-associated protein X-1 (HAX1) is a multi-functional protein which was first identified as a Hematopoietic cell specific Lyn Substrate 1 (HS1)-binding protein. Although the roles of HAX1 in apoptosis have been unraveled and HAX1 has been proposed to be involved
Koushik Roy et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5873-5880 (2014-05-23)
We show that Leishmania donovani-infected macrophages (MΦs) are capable of stimulating MHC class II (MHC-II)-restricted T cells at 6 h of infection. At 48 h, infected MΦs (I-MΦs) failed to stimulate MHC-II-restricted T cells but not MHC class I-restricted ones
J J Havel et al.
Oncogene, 34(12), 1487-1498 (2014-04-08)
The ribosomal protein (RP)-HDM2-p53 pathway has been shown to have key roles in oncogene-induced apoptosis and senescence, but the mechanism regulating this pathway remains elusive. The proline-rich Akt substrate of 40 kDa (PRAS40) has recently been identified as a binding partner and
Carmen A Banuelos et al.
PloS one, 9(9), e107991-e107991 (2014-10-01)
Androgen ablation therapy causes a temporary reduction in tumor burden in patients with advanced prostate cancer. Unfortunately the malignancy will return to form lethal castration-recurrent prostate cancer (CRPC). The androgen receptor (AR) remains transcriptionally active in CRPC in spite of
Nicolas Aznar et al.
eLife, 4, e07091-e07091 (2015-07-01)
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain
Jing Wang et al.
Journal of vascular surgery, 62(6), 1615-1624 (2014-07-20)
Cathepsin G (CatG) is a serine protease that mediates angiotensin I to angiotensin II (Ang-II) conversion and is highly expressed in human abdominal aortic aneurysms (AAAs). However, it remains untested whether this protease participates in the pathogenesis of AAA. Immunofluorescent
Harpreet Kaur et al.
Journal of neuropathology and experimental neurology, 74(2), 177-185 (2015-01-13)
Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive pediatric central nervous system tumor. The poor prognosis of AT/RT warrants identification of novel therapeutic targets and strategies. High-mobility Group AT-hook 2 (HMGA2) is a developmentally important chromatin-modifying protein that positively regulates tumor
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