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Hae Woong Choi et al.
Molecular immunology, 63(1), 74-79 (2014-03-19)
Mast cells (MCs) are selectively found at the host environment interface and are capable of secreting a wide array of pharmacologically active mediators, many of which are prepackaged in granules. Over the past two decades, it has become clear that
Koji Takeuchi et al.
Journal of gastroenterology and hepatology, 29 Suppl 4, 37-46 (2014-12-19)
We examined the prophylactic effect of rebamipide on gastric bleeding induced by the perfusion of aspirin (acetylsalicylic acid [ASA]) plus clopidogrel under the stimulation of acid secretion in rats. Under urethane anesthesia, acid secretion was stimulated by the i.v. infusion
Rayan Khaddaj-Mallat et al.
Pflugers Archiv : European journal of physiology, 467(7), 1591-1605 (2014-08-13)
This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuclear protein expression in 72-h-cultured and TNF-α-treated guinea pig tracheal rings. Tension measurements performed on native
Mark A Baxter et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 52(1), 34-39 (2014-07-24)
Measurement of airways resistance is an alternative to spirometry to assess airflow obstruction. This can be measured by the interrupter technique (RInt) using a handheld device. We wished to know how RInt compared to forced expiratory volume in 1 s (FEV1)
Peng-Fei Liu et al.
iScience, 25(1), 103625-103625 (2022-02-03)
Thalamic reticular nucleus (TRN) is known to be crucial for dynamically modulating sensory processing. Recently, the functional role of TRN in itch and pain sensation processing has drawn much attention. We found that ventrobasal thalamus (VB) neurons exhibited scratching behavior-related
Robert G Mannino et al.
Scientific reports, 5, 12401-12401 (2015-07-24)
Investigating biophysical cellular interactions in the circulation currently requires choosing between in vivo models, which are difficult to interpret due in part to the hemodynamic and geometric complexities of the vasculature; or in vitro systems, which suffer from non-physiologic assumptions
Therese S Salameh et al.
Journal of Alzheimer's disease : JAD, 47(3), 715-728 (2015-09-25)
Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are no preclinical studies determining whether or how it reaches the brain. Here, we showed that insulin applied at the level of the cribriform plate via the
Liborija Lugović-Mihić et al.
Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 66(5), 375-381 (2013-07-03)
Although histamine intolerance (HIT) is not very frequently encountered, it can have serious consequences. Food intolerance is a non allergic hypersensitivity to food that does not include the immune system even though the symptoms are similar to those of IgE-mediated
Carina Hillgruber et al.
The Journal of experimental medicine, 212(8), 1255-1266 (2015-07-15)
Spontaneous organ hemorrhage is the major complication in thrombocytopenia with a potential fatal outcome. However, the exact mechanisms regulating vascular integrity are still unknown. Here, we demonstrate that neutrophils recruited to inflammatory sites are the cellular culprits inducing thrombocytopenic tissue
Dominique Laroche et al.
Anesthesiology, 121(2), 272-279 (2014-05-03)
The diagnosis of acute life-threatening allergic reactions during anesthesia relies on clinical signs, histamine and/or tryptase measurements, and allergic testing. In patients who die after the reaction, skin tests cannot be performed, and the effect of resuscitation manoeuvres on mediator
Dimitrios A Kyriakidis et al.
Frontiers in bioscience (Landmark edition), 17, 1108-1119 (2011-12-29)
Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. Recent evidence implies additional actions in both eukaryotes and prokaryotes. Besides its function in host defense against bacterial infections, histamine elicits largely undefined
Yasuko Fukushi et al.
Biochemical and biophysical research communications, 447(1), 38-43 (2014-04-01)
Secretion from the gastric gland involves the activation of various types of cells in a coordinated manner. In order to elucidate the mechanisms underlying the coordination of secretion, we studied live fluorescence images of guinea pig gastric glands stained with
Dieter Buyst et al.
Nucleic acids research, 43(1), 51-62 (2014-12-19)
The predictable 3D structure of double-stranded DNA renders it ideally suited as a template for the bottom-up design of functionalized nucleic acid-based active sites. We here explore the use of a 14mer DNA duplex as a scaffold for the precise
E C Liao et al.
Journal of investigational allergology & clinical immunology, 23(2), 112-119 (2013-05-10)
Genetically modified organisms (GMOs) provide modern agriculture with improvements in efficiency and the benefits of enhanced food production; however, the potential impact of GMOs on human health has not yet been clarified. To investigate the allergenicity of isopentenyltransferase (ipt)-transformed broccoli
Q M Zhao et al.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 58(4), 440-450 (2014-02-13)
In vivo dynamic evaluation of atherosclerosis could be clinically significant in the prevention of cardiovascular events. We aimed to monitor Fluorine-18 fluorodeoxyglucose (18F-FDG) uptake in different stages of atherosclerosis, and investigate the feasibility of detecting vulnerable plaques using positron emission
Yusuke Sakota et al.
Biological & pharmaceutical bulletin, 37(6), 1014-1020 (2014-06-03)
Collagen gel contraction assay is a method for evaluating contraction of cells embedded in collagen gel matrices through measuring the gel size. In the present study, we established a protocol for collagen gel contraction assay using human bronchial smooth muscle
Giannina Descalzi et al.
Journal of neurochemistry, 126(5), 636-650 (2013-06-22)
Recent investigations into the mechanisms mediating itch transmission have focused on spinal mechanisms, whereas few studies have investigated the role of the cerebral cortex in itch-related behaviors. Human imaging studies show that several cortical regions are active in correspondence with
Lin Lin et al.
Biochemical and biophysical research communications, 463(3), 434-439 (2015-06-04)
Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechanisms in the development of skin fibrosis remain largely unclear. Here
Zhenzhen Li et al.
International journal of clinical and experimental medicine, 8(6), 8516-8524 (2015-08-27)
Asthma is a common airway inflammation, but current methods for diagnosing it are poor. Here we meta-analyze the available evidence on the ability of exhaled nitric oxide (eNO) in asthma to serve as a diagnostic marker of asthma. We systematically
Yoon-Young Sung et al.
Journal of ethnopharmacology, 156, 33-40 (2014-08-26)
Gardenia jasminoides Ellis has been used in traditional medicine for treatment of inflammation, edema, and dermaitis. The aim of this study was to investigate the mechanism by which Gardenia jasminoides extract (GJE) elicits anti-allergic effects in mast cells and in
Mizuki Watanabe et al.
Journal of medicinal chemistry, 49(18), 5587-5596 (2006-09-01)
The stereochemical diversity-oriented conformational restriction strategy can be an efficient method for developing specific ligands for drug target proteins, especially in cases where neither the bioactive conformation nor the pharmacophore is known. To develop potent H3 and H4 receptor antagonists
Asano Watanabe et al.
Biology open, 10(9) (2021-08-10)
Arf GTPase-Activating proteins (ArfGAPs) mediate the hydrolysis of GTP bound to ADP-ribosylation factors (Arfs), which are critical to form transport intermediates. ArfGAPs have been thought to be negative regulators of Arfs; however, accumulating evidence indicates that ArfGAPs are important for
Kenji Maeda et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 589-604 (2014-06-21)
Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particular, it bound with high affinity (Ki < 1 nM) to human serotonin 1A (h5-HT1A)-, h5-HT2A-
Lingli Yang et al.
The Journal of investigative dermatology, 134(8), 2105-2113 (2014-03-01)
Histamine is thought to have a critical role in the synthesis of extracellular matrix in skin and may be involved in tissue remodeling of allergic diseases. Recent studies revealed that periostin, a matricelluar protein, contributed to tissue remodeling; however, a
Kenji Abe et al.
Drug and chemical toxicology, 38(2), 167-173 (2014-06-05)
An itch is experientially well known that the scratching response of conditions such as atopic dermatitis is enhanced under psychological stress. Morphine is typical narcotic drug that induces a scratching response upon local application as an adverse drug reaction. Although
Juan-Fernando Padín et al.
American journal of physiology. Cell physiology, 305(2), C160-C172 (2013-04-19)
The activity of the plasmalemmal Na(+)/Ca(2+) exchanger (NCX) is highly sensitive to temperature. We took advantage of this fact to explore here the effects of the NCX blocker KB-R7943 (KBR) at 22 and 37°C on the kinetics of Ca(2+) currents
M Yeom et al.
Journal of applied microbiology, 119(2), 560-570 (2015-05-15)
The purpose of this study was to investigate the effect of Lactobacillus casei variety rhamnosus (LCR35) on Atopic dermatitis (AD)-like symptoms in mice. AD-like skin lesions in BALB/C mice were induced by sensitization and subsequent repeated challenges with trimellitic anhydride
Diego J Martinel Lamas et al.
Cancer biology & therapy, 16(1), 137-148 (2014-12-09)
The radioprotective potential of histamine on healthy tissue has been previously demonstrated. The aims of this work were to investigate the combinatorial effect of histamine or its receptor ligands and gamma radiation in vitro on the radiobiological response of 2
Zhi Zeng et al.
Clinical science (London, England : 1979), 127(7), 435-448 (2014-03-25)
Histamine H2 receptor (H2R) blockade has been reported to be beneficial for patients with chronic heart failure (CHF), but the mechanisms involved are not entirely clear. In the present study, we assessed the influences of H2R disruption on left ventricular
Bettina M Jensen et al.
Journal of leukocyte biology, 95(6), 893-901 (2014-02-05)
Different protocols exist for in vitro development of HuMCs from hematopoietic stem cells, which results in distinct mast cells regarding molecular markers and activation patterns. Here, we introduce a SR profile using immunological, neurogenic, and pharmacological stimuli to characterize cellular
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