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Shoji Yamada et al.
Biochimica et biophysica acta, 1840(1), 434-442 (2013-10-15)
Nα-Acetylhistidine (NAH) is present in very high concentrations exclusively in the brain and lens of ectothermic vertebrates, including ray-finned fishes, amphibians and reptiles, and not in those of endothermic birds and mammals. Although NAH is known to be synthesized from...
Maryam Rezazadeh et al.
Analytica chimica acta, 773, 52-59 (2013-04-09)
In the present work, pulsed electromembrane extraction (PEME) was performed for the first time, as a new concept of electrically enhanced microextraction method, for extraction and quantification of histidine, phenylalanine and tryptophan in different matrices. PEME offers an alternative to...
Yipin Wu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(7), R747-R756 (2015-08-01)
Inwardly rectifying potassium channels play essential roles in renal physiology across phyla. Barium-sensitive K(+) conductances are found on the basolateral membrane of a variety of insect Malpighian (renal) tubules, including Drosophila melanogaster. We found that barium decreases the lumen-positive transepithelial...
Neha Garg et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7258-7263 (2013-04-17)
The biosynthesis of several classes of ribosomally synthesized and posttranslationally modified peptides involves dehydration of serine and threonine residues. For class I lantibiotics, thiopeptides, and goadsporin, this dehydration is catalyzed by lanthionine biosynthetic enzyme B (LanB) or LanB-like proteins. Although...
Hirotsugu Hiramatsu et al.
Biochemistry, 52(13), 2371-2380 (2013-03-21)
The pH dependence of the β-galactoside binding activity of human galectin-1 (hGal-1) was investigated by fluorescence spectroscopy using lactose as a ligand. The obtained binding constant Kb was 2.94 ± 0.10 mM(-1) at pH 7.5. The Kb value decreased at...
Juleane Lunardi et al.
Current topics in medicinal chemistry, 13(22), 2866-2884 (2013-10-12)
Worldwide, tuberculosis is the leading cause of morbidity and mortality due to a single bacterial pathogen, Mycobacterium tuberculosis (Mtb). The increasing prevalence of this disease, the emergence of multi-, extensively, and totally drug-resistant strains, complicated by co-infection with the human...
Kakulavarapu V Rama Rao et al.
The American journal of pathology, 176(3), 1400-1408 (2010-01-16)
Brain edema and the associated increase in intracranial pressure are potentially lethal complications of acute liver failure (ALF). Astrocyte swelling (cytotoxic edema) represents a significant component of the brain edema in ALF, and elevated blood and brain ammonia levels have...
L De Meyer et al.
International journal of pharmaceutics, 496(1), 75-85 (2015-05-20)
Spin-freezing as alternative freezing approach was evaluated as part of an innovative continuous pharmaceutical freeze-drying concept for unit doses. The aim of this paper was to compare the sublimation rate of spin-frozen vials versus traditionally frozen vials in a batch...
Su-Yuan Lai et al.
Biochimica et biophysica acta, 1844(7), 1173-1182 (2014-04-16)
VP2 protein is the primary host-protective immunogen of infectious bursal disease virus (IBDV). His249 and His253 are two surface histidine residues in IBDV subviral particles (SVP), which is formed by twenty VP2 trimers when the VP2 protein of a local...
Chi Nguyen et al.
Nature, 505(7483), 427-431 (2013-12-24)
Acyl carrier protein (ACP) transports the growing fatty acid chain between enzymatic domains of fatty acid synthase (FAS) during biosynthesis. Because FAS enzymes operate on ACP-bound acyl groups, ACP must stabilize and transport the growing lipid chain. ACPs have a...
Cyprian E Oshoma et al.
PloS one, 10(8), e0135626-e0135626 (2015-08-19)
Formic acid is one of the major inhibitory compounds present in hydrolysates derived from lignocellulosic materials, the presence of which can significantly hamper the efficiency of converting available sugars into bioethanol. This study investigated the potential for screening formic acid...
Gurunath Surampalli et al.
The Journal of pharmacy and pharmacology, 67(8), 1083-1099 (2015-04-14)
In this study, a comprehensive and comparative cytotoxic evaluation of morin against verapamil on rat intestinal epithelium as P-gp inhibitors through in-vitro gastrointestinal short-term toxicity assays involving permeability studies for safety evaluation was investigated. In this study, the effect of...
Darío Ortiz de Orué Lucana et al.
The Journal of biological chemistry, 289(49), 34214-34228 (2014-10-25)
The extracellular protein HbpS from Streptomyces reticuli interacts with iron ions and heme. It also acts in concert with the two-component sensing system SenS-SenR in response to oxidative stress. Sequence comparisons suggested that the protein may bind a cobalamin. UV-visible...
Related (βα)8-barrel proteins in histidine and tryptophan biosynthesis: a paradigm to study enzyme evolution.
Felix List et al.
Chembiochem : a European journal of chemical biology, 12(10), 1487-1494 (2011-06-10)
Ritesh Kumar et al.
Biochemistry, 53(13), 2112-2125 (2014-03-15)
Hemophores from Pseudomonas aeruginosa (HasAp), Serratia marcescens (HasAsm), and Yersinia pestis (HasAyp) bind hemin between two loops. One of the loops harbors conserved axial ligand Tyr75 (Y75 loop) in all three structures, whereas the second loop (H32 loop) contains axial...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 19(13), 3430-3433 (2009-05-26)
An activation study of the membrane-associated carbonic anhydrase (CA, EC isoform XV with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. Murine CA XV was strongly activated by some amino acids (d-Phe, l-/d-DOPA, d-Trp...
Saroj Kumar Amar et al.
Toxicology letters, 239(3), 182-193 (2015-10-07)
Solar UV radiation is main factor of photocarcinogenesis, photoageing, and phototoxicity; thus, protection from UV radiation is major concern. Sunscreens containing UV filters are suggested as sun safe practices, but safety of UV filters remains in controversies. Benzophenone-1 (BP1) is...
Qizhao Wang et al.
Scientific reports, 5, 13593-13593 (2015-09-05)
Morphology-controlled synthesis of CdS can significantly enhance the efficiency of its photocatalytic hydrogen production. In this study, a novel three-dimensional (3D) flower-like CdS is synthesized via a facile template-free hydrothermal process using Cd(NO3)2•4H2O and thiourea as precursors and L-Histidine as...
Qais Al-Hadid et al.
Molecular and cellular biology, 34(15), 2903-2916 (2014-05-29)
Histidine protein methylation is an unusual posttranslational modification. In the yeast Saccharomyces cerevisiae, the large ribosomal subunit protein Rpl3p is methylated at histidine 243, a residue that contacts the 25S rRNA near the P site. Rpl3p methylation is dependent upon...
Gregory M Cockrell et al.
Molecular pharmaceutics, 12(6), 1784-1797 (2015-04-17)
During synthesis, purification, and especially storage, antibody-drug conjugates (ADCs) may be exposed to various types of light. Several of the drugs commonly conjugated to antibodies contain photosensitive functional groups. Exposure to light could generate an excited state of the drug...
Luz Ma González-Huerta et al.
Gene, 529(1), 181-185 (2013-08-21)
To describe at molecular level a family with pulverulent congenital cataract associated with a CRYGC gene mutation. One family with several affected members with pulverulent congenital cataract and 230 healthy controls were examined. Genomic DNA from leukocytes was isolated to...
V G Doroshenko et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 149-154 (2013-06-26)
Strain MG 1655+hisGr hisL'-Delta, purR, which produces histidine with a weight yield of approximately 12% from glucose, was constructed through directed chromosomal modifications of the laboratory Escherichia coli strain MG 1655+, which has a known genome sequence. A feedback-resistant ATP-phosphoribosyl...
Sandeep Kumar et al.
Protein and peptide letters, 19(6), 657-662 (2012-04-24)
Soybean urease has been investigated extensively to reveal the presence of histidine residue (s) in the active site and their potential role in the catalysis. The spectrophotometric studies using diethylpyrocarbonate (DEP) showed the modification of 11.76 ± 0.1 histidine residues...
Sebastian Sorge et al.
Cell reports, 31(7), 107659-107659 (2020-05-21)
The mitochondrial electron transport chain (ETC) enables essential metabolic reactions; nonetheless, the cellular responses to defects in mitochondria and the modulation of signaling pathway outputs are not understood. We show that Notch signaling and ETC attenuation via knockdown of COX7a...
K Puzio et al.
Journal of chromatography. A, 1361, 1-8 (2014-08-26)
Three molecularly imprinted polymers (MIPs) have been synthesized in order to bind efficiently glyphosate (GLY) in natural waters (mineral and underground). Since the target analyte is polar and hydrophilic, electrostatic interactions and hydrogen bonds have been favored with two templates...
Wen-Hui K Kuo et al.
Biotechnology letters, 33(6), 1075-1084 (2011-02-15)
Immobilized metal affinity chromatography (IMAC) of proteins containing poly-histidine fusion tags is an efficient research tool for purifying recombinant proteins from crude cellular feedstocks at laboratory scale. Nevertheless, to achieve successful purification of large amounts of the target protein for...
Jun Yeul Lim et al.
International journal of pharmaceutics, 492(1-2), 127-136 (2015-07-19)
To evaluate the oxidative stability of proteins, a model protein, etanercept, was exposed to oxidative stress conditions using hydrogen peroxide. Various amino acids were also evaluated on their antioxidant effect. Transition temperature (Tm), secondary structural content, hydrodynamic size, and aggregation...
Tridib K Goswami et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11988-11999 (2014-06-28)
Ferrocene-conjugated copper(ii) complexes [Cu(Fc-aa)(aip)](ClO4) () and [Cu(Fc-aa)(pyip)](ClO4) () of l-amino acid reduced Schiff bases (Fc-aa), 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip) and 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (pyip), where Fc-aa is ferrocenylmethyl-l-tyrosine (Fc-Tyr in , ), ferrocenylmethyl-l-tryptophan (Fc-Trp in , ) and ferrocenylmethyl-l-methionine (Fc-Met in , ), were...
Michael Sippach et al.
Biochimica et biophysica acta, 1838(7), 1760-1768 (2014-03-04)
The conformational dynamics of the histidine ABC transporter HisQMP2 from Salmonella enterica serovar Typhimurium, reconstituted into liposomes, is studied by site-directed spin labeling and double electron-electron resonance spectroscopy in the absence of nucleotides, in the ATP-bound, and in the post-hydrolysis...
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 18(15), 4303-4307 (2008-07-17)
An activation study of the human carbonic anhydrase (hCA, EC isoforms hCA III (cytosolic) and IV (membrane-associated) with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. hCA III was efficiently activated by d-His, serotonin...
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