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P Teismann
Deutsche medizinische Wochenschrift (1946), 139(3), 99-102 (2013-11-28)
Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that
Chao Zhao et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(10), 1035-1039 (2015-10-16)
Metal-organic framework Fe-MIL-88NH2 as a dual colorimetric and fluorometric sensor has been designed for a wide range of dopamine quantitative detection. It is easy to implement the assay for visual detection of dopamine based on restraining the color change of
Neuroscience. Jump-starting natural resilience reverses stress susceptibility.
Allyson Friedman
Science (New York, N.Y.), 346(6209), 555-555 (2014-11-02)
Audrey Beaussart et al.
Nanoscale, 7(36), 14996-15004 (2015-08-27)
Many fungal pathogens produce cell surface polysaccharides that play essential roles in host-pathogen interactions. In Aspergillus fumigatus, the newly discovered polysaccharide galactosaminogalactan (GAG) mediates adherence to a variety of substrates through molecular mechanisms that are poorly understood. Here we use
Eleni Stamellou et al.
PloS one, 9(6), e99298-e99298 (2014-06-14)
N-acyl dopamines (NADD) are gaining attention in the field of inflammatory and neurological disorders. Due to their hydrophobicity, NADD may have access to the endoplasmic reticulum (ER). We therefore investigated if NADD induce the unfolded protein response (UPR) and if
Xueni Sun et al.
Analytica chimica acta, 880, 67-76 (2015-06-21)
Rapid and selective enrichment of phosphopeptides from complex biological samples is essential and challenging in phosphorylated proteomics. In this work, for the first time, niobium ions were directly immobilized on the surface of polydopamine-coated magnetic microspheres through a facile and
Zhaojun Jia et al.
Biomaterials, 75, 203-222 (2015-10-30)
The therapeutic applications of silver nanoparticles (AgNPs) against biomedical device-associated infections (BAI), by local delivery, are encountered with risks of detachment, instability and nanotoxicity in physiological milieus. To firmly anchor AgNPs onto modified biomaterial surfaces through tight physicochemical interactions would
Rajesh Narendran et al.
The American journal of psychiatry, 171(8), 881-888 (2014-05-31)
Basic studies have demonstrated that optimal levels of prefrontal cortical dopamine are critical to various executive functions such as working memory, attention, inhibitory control, and risk/reward decisions, all of which are impaired in addictive disorders such as alcoholism. Based on
Vasopressor dosing in septic shock.
Cesar Alaniz et al.
Critical care medicine, 41(12), e483-e484 (2013-11-28)
Patrick Oeckl et al.
Experimental neurology, 257, 1-9 (2014-04-22)
The orphan G-protein coupled receptor 6 (GPR6) is a constitutively active receptor which is positively coupled to the formation of cyclic adenosine-3',5'-monophosphate (cAMP). GPR6 is predominantly expressed in striatopallidal neurons. Here, we investigated neurochemical and behavioural effects of Gpr6 deficiency
Chiyako Shimada et al.
Anticancer research, 34(7), 3543-3548 (2014-07-02)
A total of 12 phenylpropanoid amides were subjected to quantitative structure-activity relationship (QSAR) analysis, based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to investigate on their biological activities. Cytotoxicity against four human oral squamous cell carcinoma (OSCC)
Fei Wei et al.
Acta biomaterialia, 86, 480-492 (2019-01-11)
Exosomes are extracellular nanovesicles that play an important role in cellular communication. The modulatory effects of bone morphogenetic protein 2 (BMP2) on macrophages have encouraged the functionalization of scaffolds through the integration of the exosomes from the BMP2-stimulated macrophages to
Benjamin M Siemsen et al.
Journal of neurochemistry, 153(5), 599-616 (2020-01-05)
Cue-induced reinstatement of cocaine seeking after self-administration (SA) and extinction relies on glutamate release in the nucleus accumbens core (NAcore), which activates neuronal nitric oxide synthase interneurons. Nitric oxide (NO) is required for structural plasticity in NAcore medium spiny neurons
Dan Bang et al.
Neuron, 108(5), 999-1010 (2020-10-14)
Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in sensory inference and decisions based on such inference. We tested this hypothesis in humans by monitoring sub-second striatal dopamine and
A Jon Stoessl et al.
Lancet (London, England), 384(9942), 532-544 (2014-06-24)
Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging
Senthil T Kumar et al.
Neurobiology of disease, 146, 105086-105086 (2020-09-25)
Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation, and may also accumulate within LBs in Parkinson's disease (PD) and other synucleinopathies. Therefore, the development of tools
Colter Mitchell et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 5944-5949 (2014-04-09)
Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety of contexts
Yixi Liu et al.
Analytical chemistry, 87(10), 5286-5293 (2015-04-23)
We presented a decoding method of quantum dots encoded microbeads with its fluorescence spectra using line scan hyperspectral fluorescence imaging (HFI) method. A HFI method was developed to attain both the spectra of fluorescence signal and the spatial information of
Philip Wing-Lok Ho et al.
Autophagy, 16(2), 347-370 (2019-04-16)
Parkinson disease (PD) is an age-related neurodegenerative disorder associated with misfolded SNCA/α-synuclein accumulation in brain. Impaired catabolism of SNCA potentiates formation of its toxic oligomers. LRRK2 (leucine-rich repeat kinase-2) mutations predispose to familial and sporadic PD. Mutant LRRK2 perturbs chaperone-mediated-autophagy
Philippe Herman-Bausier et al.
mBio, 6(3), e00413-e00415 (2015-05-28)
Staphylococcus aureus is an important opportunistic pathogen which is a leading cause of biofilm-associated infections on indwelling medical devices. The cell surface-located fibronectin-binding protein A (FnBPA) plays an important role in the accumulation phase of biofilm formation by methicillin-resistant S. aureus
Steven Tran et al.
Psychopharmacology, 232(20), 3709-3718 (2015-07-27)
The zebrafish has become an increasingly popular animal model for investigating ethanol's actions in the brain and its effects on behavior. Acute exposure to ethanol in zebrafish has been shown to induce a dose-dependent increase of locomotor activity, to reduce
Chris A Oosterhof et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 585-595 (2014-09-17)
Brexpiprazole, a compound sharing structural molecular characteristics with aripiprazole, is currently under investigation for the treatment of schizophrenia and depression. Using electrophysiologic techniques, the present study assessed the in vivo action of brexpiprazole on serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B
Cameron S Movassaghi et al.
Analytical and bioanalytical chemistry, 413(27), 6747-6767 (2021-10-24)
Many voltammetry methods have been developed to monitor brain extracellular dopamine levels. Fewer approaches have been successful in detecting serotonin in vivo. No voltammetric techniques are currently available to monitor both neurotransmitters simultaneously across timescales, even though they play integrated
Jinhee Kim et al.
Biomolecules & therapeutics, 28(3), 282-291 (2020-04-28)
Inhaled solvents such as toluene are of particular concern due to their abuse potential that is easily exposed to the environment. The inhalation of toluene causes various behavioral problems, but, the effect of short-term exposure of toluene on changes in
Seungmi Ryu et al.
ACS nano, 9(10), 10186-10202 (2015-09-13)
Coculturing stem cells with the desired cell type is an effective method to promote the differentiation of stem cells. The features of the membrane used for coculturing are crucial to achieving the best outcome. Not only should the membrane act
Fei Liu et al.
American journal of physiology. Lung cellular and molecular physiology, 308(4), L344-L357 (2014-12-17)
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog
Hajime Hoshino et al.
Anesthesia and analgesia, 120(2), 460-466 (2014-11-27)
Antidepressants are often used for the treatment of neuropathic pain, and their analgesic effects rely on increased noradrenaline and serotonin levels in the spinal cord. Clinical studies have also shown that bupropion, a dopamine and noradrenaline reuptake inhibitor, has strong
Can lithium unmask the preclinical Parkinsonian features?
S Bhattacharjee et al.
Irish medical journal, 106(8), 254-254 (2013-11-29)
Yonghui Ding et al.
Acta biomaterialia, 15, 150-163 (2014-12-30)
A wide variety of environmental cues provided by the extracellular matrix, including biophysical and biochemical cues, are responsible for vascular cell behavior and function. In particular, substrate topography and surface chemistry have been shown to regulate blood and vascular compatibility
Peter J Hamilton et al.
Nature chemical biology, 10(7), 582-589 (2014-06-02)
Phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates the function of ion channels and transporters. Here, we demonstrate that PIP2 directly binds the human dopamine (DA) transporter (hDAT), a key regulator of DA homeostasis and a target of the psychostimulant amphetamine (AMPH). This binding
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