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Kaede Saito et al.
Journal of inorganic biochemistry, 199, 110770-110770 (2019-07-25)
Serotonin (5-HT) is a neurotransmitter that is derived from tryptophan. Owing to a hydroxyl group attached to the indole nucleus, 5-HT exhibits a considerably higher redox activity than tryptophan. To gain insight into the biological relevance of the redox activity
Harris A Weisz et al.
Learning & memory (Cold Spring Harbor, N.Y.), 24(8), 331-340 (2017-07-19)
When presented with noxious stimuli
Ethan M McBride et al.
Journal of chromatography. A, 1601, 205-213 (2019-05-08)
Saliva is increasingly being targeted for metabolic studies due to its non-invasive collection methods. Tracing levels of certain metabolites within biofluids can provide indications for a myriad of physiological conditions. This study was performed on a panel of eight analytes
Xijiang Liu et al.
Journal of pain research, 13, 3081-3094 (2020-12-03)
Chemotherapy-induced painful neuropathy (CIPN) is a severe adverse effect of many anti-neoplastic drugs that is difficult to manage. Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter in the rostral ventromedial medulla (RVM), which modulates descending spinal nociceptive transmission. However, the influence
Emily L Brooks et al.
The Analyst, 144(20), 6011-6018 (2019-09-21)
Serotonin and kynurenine are formed following metabolism of the essential amino acid tryptophan. Both molecules play important biological roles and the balance of how tryptophan metabolism varies to either the serotonin or kynurenine pathway may provide key insight into the
Rona Karahoda et al.
Acta physiologica (Oxford, England), 229(4), e13478-e13478 (2020-04-21)
Serotonin is crucial for proper foetal development, and the placenta has been described as a 'donor' of serotonin for the embryo/foetus. However, in later stages of gestation the foetus produces its own serotonin from maternally-derived tryptophan and placental supply is
Juraj Culman et al.
Cellular and molecular neurobiology, 38(6), 1271-1281 (2018-06-28)
Mice lacking the substance P (SP) neurokinin-1 (NK1) receptor (NK1R-/-mice) were used to investigate whether SP affects serotonin (5-HT) function in the brain and to assess the effects of acute immobilisation stress on the hypothalamic-pituitary-adrenocortical (HPA) axis and 5-HT turnover
Ariful Hasan et al.
Scientific reports, 9(1), 20358-20358 (2019-12-31)
Serotonin (5-hydroxytryptamine: 5-HT) is a biogenic monoamine that mediates immune responses and modulates nerve signal in insects. Se-5HTR, a specific receptor of serotonin, has been identified in the beet armyworm, Spodoptera exigua. It is classified into subtype 7 among known
Hillary R Rees et al.
Analytical chemistry, 87(7), 3849-3855 (2015-02-26)
Small, robust, sensitive electrodes are desired for in vivo neurotransmitter measurements. Carbon nanopipettes have been previously manufactured and used for single-cell drug delivery and electrophysiological measurements. Here, a modified fabrication procedure was developed to produce batches of solid carbon nanopipette
María Encarnación Blanco et al.
Journal of neuroscience methods, 341, 108760-108760 (2020-05-20)
So far, analytical investigation of neuroactive molecules in cerebrospinal fluid (CSF) of rodent models has been limited to rats, given the intrinsic anatomic difficulties related to mice sampling and the corresponding tiny amounts of CSF obtained. This poses a challenge
Tamara Coslovich et al.
Journal of neuroscience research, 96(5), 889-900 (2017-11-09)
Spinal motoneurons and locomotor networks are regulated by monoamines, among which, the contribution of histamine has yet to be fully addressed. The present study investigates histaminergic regulation of spinal activity, combining intra- and extracellular electrophysiological recordings from neonatal rat spinal
Claudia Fuchs et al.
Neuropharmacology, 167, 107746-107746 (2019-08-31)
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause a severe neurodevelopmental disorder, CDKL5 deficiency disorder (CDD). CDKL5 is fundamental for correct brain development and function, but the molecular mechanisms underlying aberrant neurologic dysfunction in CDD are incompletely understood.
Tiago Souza Dos Santos et al.
Behavioural brain research, 295, 45-63 (2015-04-07)
Serotonin 1A receptors (5-HT1ARs), which are widely distributed in the mammalian brain, participate in cognitive and emotional functions. In birds, 5-HT1ARs are expressed in prosencephalic areas involved in visual and cognitive functions. Diverse evidence supports 5-HT1AR-mediated 5-HT-induced ingestive and sleep
Hui Gu et al.
Analytical and bioanalytical chemistry, 412(15), 3727-3736 (2020-04-30)
Electrochemical detection of dopamine (DA) usually depends on electrochemical oxidation of DA. This conventional method can hardly provide sufficient sensitivity and selectivity in the determination of the cerebral DA down to nanomolar level, because the ability of DA to be
Kotaro Sugimoto et al.
International journal of molecular sciences, 22(1) (2021-01-02)
We previously reported that site-selective claudin-5 (CLDN5) breakdown and protein kinase A (PKA) activation are observed in brain microvessels of schizophrenia, but the underlying molecular basis remains unknown. The 5-HT1 receptors decline the intracellular cAMP levels and inactivate the major
M A G Rabbani et al.
Virology, 503, 46-51 (2017-01-24)
Interferon (IFN) exerts its antiviral effect by inducing a large family of cellular genes, named interferon (IFN)-stimulated genes (ISGs). An intriguing member of this family is indoleamine 2,3-dioxygenase (IDO), which catalyzes the first and rate-limiting step of the main branch
Weipang Chang et al.
Nature communications, 12(1), 4857-4857 (2021-08-13)
Physical exercise stimulates adult neurogenesis, yet the underlying mechanisms remain poorly understood. A fundamental component of the innate neuroregenerative capacity of zebrafish is the proliferative and neurogenic ability of the neural stem/progenitor cells. Here, we show that in the intact
Anita Büttner et al.
Bioorganic & medicinal chemistry, 18(10), 3387-3402 (2010-05-12)
The discovery of new templates and their subsequent elaboration to clinically useful receptor tyrosine kinase (RTK) inhibitors continues to be an important issue. RTKs are a class of enzymes responsible for the activation of different cellular signal transduction cascades. The
Burak Yaman et al.
Neuroreport, 31(12), 928-935 (2020-06-25)
Serotonin (5-HT) has an important role in the pathophysiology of the mood disorders like major depression and anxiety disorders in central nervous system. On the one hand, dorsal raphe nucleus (DRN) neurons send serotonergic projections to almost all brain regions.
Gerard Esteban et al.
The Journal of pharmacy and pharmacology, 69(3), 314-324 (2017-01-31)
To evaluate the in-vitro and in-vivo effects on monoaminergic neurotransmission of ASS234, a promising multitarget-directed ligand (MTDL), for Alzheimer's disease (AD) therapy. In vitro was explored the effect of ASS234 on the monoaminergic metabolism in SH-SY5Y and PC12 cell lines
Lydia M M Vermeer et al.
Experimental neurology, 263, 8-16 (2014-09-30)
Migraine is one of the most common neurological disorders, leading to more than 1% of total disability reported and over 68 million visits to emergency rooms or physician's offices each year in the United States. Three times as many women
Yao Tang et al.
Journal of agricultural and food chemistry, 68(8), 2437-2444 (2020-02-06)
Serotonin is an important endogenous regulatory neurotransmitter and has also been found in fruits, vegetables, and nuts. Methylglyoxal (MGO) is a reactive dicarbonyl metabolite and also a food toxin that modifies protein and DNA to cause the development of many
Wei-Cheng Wu et al.
Mikrochimica acta, 186(3), 166-166 (2019-02-11)
Stable and low-cost carbon dots (C-dots) were prepared from polyethylenimine (PEI) by a hydrothermal method. It is found that the fluorescence of the C-dots (best measured at excitation/emission wavelengths of 365/473 nm) is quenched by selective oxidation of surface PEI by
Ruo-Xiao Cheng et al.
Theranostics, 9(15), 4287-4307 (2019-07-10)
Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic
Ya-Bin Tang et al.
Analytica chimica acta, 849, 70-79 (2014-10-11)
Dynamic, continuous, and simultaneous multi-analysis of transmitters is important for the delineation of the complex interactions between the neuronal and intercellular communications. But the analysis of the whole repertoire of classical transmitters of diverse structure is challenging due to their
V S Kiran Kumar et al.
Bioorganic & medicinal chemistry letters, 16(9), 2509-2512 (2006-02-09)
The study investigated spermicidal and antitrichomonas activities of selective serotonin reuptake inhibitor (SSRI) antidepressants with a view to generate new lead for development of dual-function spermicidal microbicides, which is an urgent global need. Fluoxetine, Sertraline, and Fluvoxamine exhibited both spermicidal
Melinda A Engevik et al.
Cellular and molecular gastroenterology and hepatology, 11(1), 221-248 (2020-08-17)
The human gut microbiota can regulate production of serotonin (5-hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms underlying microbial-induced serotonin signaling are not well understood. Adult germ-free mice were treated with sterile media, live Bifidobacterium dentium, heat-killed B dentium, or
Sattar Ostadhadi et al.
Clinical and experimental pharmacology & physiology, 44(6), 680-685 (2017-03-21)
Cholestatic itch can be severe and significantly impair the quality of life of patients. The serotonin system is implicated in cholestatic itch; however, the pruritogenic properties of serotonin have not been evaluated in cholestatic mice. Here, we investigated the serotonin-induced
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