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Sonia Lefnaoui et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 23(6), 698-711 (2015-12-25)
A pregelatinized starch (PGS) was derivatized with sodium chloroacetate (SCA) in alcoholic medium under alkaline condition to produce carboxymethyl pregelatinized starch (CMPGS) with various degrees of substitution (DS). Influence of the molar ratio of SCA to the glucopyranose units (SCA/GU)
Ruben Magni et al.
Journal of translational medicine, 13, 346-346 (2015-11-06)
Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust
Vittoria Locato et al.
Journal of experimental botany, 66(10), 2991-3000 (2015-04-22)
Ophiobolin A, a tetracyclic sesterpenoid produced by phytopathogenic fungi, is responsible for catastrophic losses in crop yield but its mechanism of action is not understood. The effects of ophiobolin A were therefore investigated on the growth and redox metabolism of
Vito Colella et al.
Scientific reports, 5, 13105-13105 (2015-08-15)
Snail-borne lungworms exert an enormous toll on the health and welfare of animals and humans. Of these parasites, Aelurostrongylus abstrusus and Troglostrongylus brevior affect the respiratory tract of felids. These lungworms share both the ecological niche and the species of
Muhammad Waqas Sadiq et al.
PloS one, 10(5), e0118638-e0118638 (2015-05-02)
It is essential to establish a useful validation method for newly generated humanized mouse models. The novel approach of combining our established species-specific protein quantification method combined with in vivo functional studies is evaluated to validate a humanized mouse model
Yann S Gallot et al.
Cancer research, 74(24), 7344-7356 (2014-10-23)
Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is understood about how the severe loss of skeletal muscle characterizing this condition occurs. In the current study, we tested
Uwe Lendeckel et al.
Molecular medicine reports, 12(2), 2253-2262 (2015-04-22)
A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interaction and membrane protein shedding, ADAM proteins are involved in normal brain development, and also in cancer
Arslan Arinc Kayacelebi et al.
Amino acids, 47(9), 1893-1908 (2015-06-03)
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis, whereas L-arginine (Arg) and L-homoarginine (hArg) serve as substrates for NO synthesis. ADMA and other methylated arginines are generally believed to exclusively derive from guanidine (N (G))-methylated arginine
Philipp Kolb et al.
PloS one, 10(9), e0136180-e0136180 (2015-09-10)
Ticks are vectors for various, including pathogenic, microbes. Tick saliva contains multiple anti-host defense factors that enable ticks their bloodmeals yet also facilitate microbe transmission. Lyme disease-causing borreliae profit specifically from the broadly conserved tick histamine release factor (tHRF), and
Jonathan G Crowston et al.
Experimental eye research, 141, 3-8 (2015-03-11)
We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that induces reversible loss of inner retinal function associated with oxidative stress, glial cell activation and minimal loss of retinal ganglion cell (RGC) number. Young healthy
Dafne Franz et al.
Journal of neuroimmunology, 284, 18-29 (2015-05-31)
Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whether cAMP and ERK1/2-phosphorylation are modulated by dopamine receptor 3 (D3R) and
Shuichi Mori et al.
Bioorganic & medicinal chemistry, 23(4), 803-809 (2015-01-17)
Nonsteroidal progesterone receptor (PR) full antagonists are needed as tools for elucidating the physiological functions of PR and as candidates for treatment of various diseases. We designed and synthesized 1,3-diphenyladamantane derivatives, and investigated their PR-antagonistic activity in comparison with our
Koji Y Arai et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(6), 701-711 (2014-09-17)
Epidermal-dermal interaction plays important roles in physiological events such as wound healing. In this study, we examined a double paracrine mechanism between keratinocytes and fibroblasts through interleukin-1 (IL-1) and an IL-1-induced inflammatory mediator prostaglandin E₂ (PGE₂) using the skin equivalent.
Isabel Seiquer et al.
Food chemistry, 188, 496-503 (2015-06-05)
Argan oil is becoming increasingly popular in the edible-oil market as a luxury food with healthy properties. This paper analyzes (i) the bioavailability of the polyphenol content and antioxidant properties of extra virgin argan oil (EVA) by the combination of
Ofelia Maniti et al.
Journal of liposome research, 25(2), 122-130 (2014-09-16)
Conventional liposomes have a short life-time in blood, unless they are protected by a polymer envelope, most often polyethylene glycol. However, these stabilizing polymers frequently interfere with cellular uptake, impede liposome-membrane fusion and inhibit escape of liposome content from endosomes.
Shicheng Su et al.
Nature communications, 6, 8523-8523 (2015-10-06)
Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that
Claire Valotteau et al.
ACS applied materials & interfaces, 7(32), 18086-18095 (2015-08-08)
Classical antibacterial surfaces usually involve antiadhesive and/or biocidal strategies. Glycosylated surfaces are usually used to prevent biofilm formation via antiadhesive mechanisms. We report here the first example of a glycosylated surface with biocidal properties created by the covalent grafting of
Yajie Gao et al.
Pharmaceutical research, 32(8), 2649-2662 (2015-02-14)
The purpose of the present study was to design and fabricate endosomal pH-sensitive dual-ligand-modified micellar nanoparticles to achieve enhanced drug delivery to tumor cells and facilitated intracellular drug release. End-group-carboxylated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) and cyclic Arg-Gly-Asp-Tyr-Lys- and anti-prostate specific membrane antigen antibody-modified
Christopher A Quinto et al.
Nanoscale, 7(29), 12728-12736 (2015-07-15)
Superparamagnetic iron oxide (SPIO) nanoparticles have the potential for use as a multimodal cancer therapy agent due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, resulting in combined chemotherapy and
Veeradasan Perumal et al.
Scientific reports, 5, 12231-12231 (2015-07-17)
Hybrid gold nanostructures seeded into nanotextured zinc oxide (ZnO) nanoflowers (NFs) were created for novel biosensing applications. The selected 'spotted NFs' had a 30-nm-thick gold nanoparticle (AuNP) layer, chosen from a range of AuNP thicknesses, sputtered onto the surface. The
Paul Thellmann et al.
Environmental science and pollution research international, 22(21), 16405-16416 (2014-11-14)
In order to evaluate surface water and the sediment quality of rivers connected to wastewater treatment plants (WWTPs) with different treatment technologies, fish embryo tests (FET) with Danio rerio were conducted using native water and sediment samples collected upstream and
Suguna P Narayan et al.
Small (Weinheim an der Bergstrasse, Germany), 11(33), 4173-4182 (2015-06-23)
The sequence-dependent cellular uptake of spherical nucleic acid nanoparticle conjugates (SNAs) is investigated. This process occurs by interaction with class A scavenger receptors (SR-A) and caveolae-mediated endocytosis. It is known that linear poly(guanine) (poly G) is a natural ligand for
Yingqi Cai et al.
The Plant cell, 27(9), 2616-2636 (2015-09-13)
The lipodystrophy protein SEIPIN is important for lipid droplet (LD) biogenesis in human and yeast cells. In contrast with the single SEIPIN genes in humans and yeast, there are three SEIPIN homologs in Arabidopsis thaliana, designated SEIPIN1, SEIPIN2, and SEIPIN3.
Facundo Mattea et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 100, 101-107 (2015-03-17)
Polymer gel dosimeters have specific advantages for recording 3D radiation dose distribution in diagnostic and therapeutic medical applications. But, even in systems where the 3D structure is usually maintained for long periods of time after irradiation, it is still not
Sonam Dilwali et al.
Cancer biology & therapy, 16(1), 170-175 (2015-02-19)
Vestibular schwannoma (VS), the fourth most common intracranial tumor, arises from the Schwann cells of the vestibular nerve. Although several pathways have been independently implicated in VS pathobiology, interactions among these pathways have not been explored in depth. We have
Antonietta Manna et al.
Brain and behavior, 5(7), e00334-e00334 (2015-07-30)
Deep brain gray matter (GM) structures are involved in several neurodegenerative disorders and are affected by aging. In this study, we investigated the potential relationship between levels of brain-derived neurotrophic factor (BDNF), a putative biomarker of age- and clinically relevant
Takako Tabata et al.
Journal of virology, 89(9), 5134-5147 (2015-03-06)
Human cytomegalovirus (HCMV) is a major cause of birth defects that include severe neurological deficits, hearing and vision loss, and intrauterine growth restriction. Viral infection of the placenta leads to development of avascular villi, edema, and hypoxia associated with symptomatic
Di Xu et al.
Journal of environmental sciences (China), 25(4), 637-644 (2013-08-09)
Organic phosphorus (nonreactive P, NRP) is a major component of P in sediments, but information about its chemical forms and dynamic transformation is limited. The chemical forms and dynamic behaviors of NRP in a sediment profile from Lake Taihu, a
Michael Knösel et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 144(1), 86-96 (2013-07-03)
White spot lesions that form during orthodontic treatment are a problem for patients and clinicians. Lesion infiltration with low-viscosity light-cured resin has been proposed as a treatment to inhibit further demineralization. The purpose of this study was to assess the
Jan Lukas et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(3), 456-464 (2014-11-21)
Lysosomal storage disorders (LSD) are a group of heterogeneous diseases caused by compromised enzyme function leading to multiple organ failure. Therapeutic approaches involve enzyme replacement (ERT), which is effective for a substantial fraction of patients. However, there are still concerns
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