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Shannon Hall et al.
Sleep, 43(11) (2020-06-01)
Chronic sleep restriction (CSR) negatively impacts brain functions. Whether microglia, the brain's resident immune cells, play any role is unknown. We studied microglia responses to CSR using a rat model featuring slowly rotating wheels (3 h on/1 h off), which
Anna Badner et al.
Journal of neurotrauma, 36(15), 2298-2307 (2019-03-08)
Although the majority of traumatic spinal cord injuries (SCIs) take place at the cervical level, pre-clinical studies have been disproportionally focused on thoracic insults. With differences in anatomy, physiology, and immune response between spinal cord levels, there is evidence that
Venissa Machado et al.
Neurobiology of disease, 88, 1-15 (2016-01-07)
Growth/differentiation factor-15 (Gdf-15) is a member of the TGF-β superfamily and a pleiotropic, widely distributed cytokine, which has been shown to play roles in various pathologies, including inflammation. Analysis of Gdf-15(-/-) mice has revealed that it serves the postnatal maintenance
The Lectins: Properties, Functions, and Applications in Biology and Medicine (2012)
Lucía Rodríguez-Vázquez et al.
Neurotoxicity research, 35(2), 387-400 (2018-10-03)
The current paper presents a histological analysis of the cell death in the cerebellar external granular layer (EGL) following the treatment with a single dose (2 mg/g) of hydroxyurea (HU). The rats were examined at postnatal days (P) 5, 10, and
Xuexiang Han et al.
Nature communications, 9(1), 3390-3390 (2018-08-25)
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological
Thayer K Darling et al.
PLoS pathogens, 16(1), e1008261-e1008261 (2020-01-31)
Disruption of blood-brain barrier (BBB) function is a key feature of cerebral malaria. Increased barrier permeability occurs due to disassembly of tight and adherens junctions between endothelial cells, yet the mechanisms governing junction disassembly and vascular permeability during cerebral malaria
Yueyi Yao et al.
Journal of inflammation research, 14, 6619-6632 (2021-12-16)
Neuroinflammation runs through the whole process of nervous system diseases and brain injury. Inflammasomes are thought to be especially relevant to immune homeostasis, and their dysregulation contributes to pyroptosis. The natural compound Ginsenoside Rg1 has been shown to possess anti-inflammatory
Whole-brain vasculature reconstruction at the single capillary level
Di Giovanna AP, et al.
Scientific reports, 8(1), 12573-12573 (2018)
L Martinez-Rachadell et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 45, 25-30 (2019-03-03)
Insulin (IR) and insulin-like growth factor I (IGF-IR) receptors share structural homology and can form hybrid heterodimers. While different observations suggest that hybrid receptors are important in physiology and pathology, little is known about their function in the brain. To
Qiongyu Lin et al.
ACS chemical neuroscience, 10(5), 2560-2575 (2019-03-01)
Infectious exposure during the perinatal period may predispose to permanent neurological disorders in later life. Here we investigated whether changes in interleukin-1β (IL-1β) are associated with cognitive dysfunction in later life of septic neonatal rats through suppression of neurogenesis in
Andrew Hamilton et al.
PloS one, 10(5), e0126688-e0126688 (2015-05-16)
The serglycin proteoglycan is mainly expressed by hematopoietic cells where the major function is to retain the content of storage granules and vesicles. In recent years, expression of serglycin has also been found in different forms of human malignancies and
Loss of serglycin promotes primary tumor growth and vessel functionality in the RIP1-Tag2 mouse model for spontaneous insulinoma formation
Hamilton A, et al.
PLoS ONE, 10(5), e0126688-e0126688 (2015)
Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers
Pashkunova-Martic I, et al.
Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging, 13(3), 432-442 (2011)
Bridget R Boyle et al.
Development (Cambridge, England), 147(21) (2020-07-03)
Little is known about the effects of NPC1 deficiency in brain development and whether these effects contribute to neurodegeneration in Niemann-Pick disease type C (NPC). Degeneration of cerebellar Purkinje cells occurs at an earlier stage and to a greater extent
Christopher W Schultz et al.
Cancer biology & therapy, 22(3), 204-215 (2021-03-12)
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in the modern world, in part due to poor delivery of chemotherapeutics. Sonoporation can be used to enhance the efficacy of standard of care therapies for PDAC. Using xenograft models
Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.
Rangarajan P, et al.
Neuroscience, 311, 398-414 (2015)
Uttio Roy Chowdhury et al.
Scientific reports, 11(1), 4034-4034 (2021-02-19)
Ocular hypertension occurs due to increased resistance to aqueous humor removal through the conventional outflow pathway. Unlike the proximal region of the conventional outflow pathway, the distal region has not been well studied, mostly due to lack of model systems.
Antonino Paolo Di Giovanna et al.
Scientific reports, 8(1), 12573-12573 (2018-08-24)
The distinct organization of the brain's vascular network ensures that it is adequately supplied with oxygen and nutrients. However, despite this fundamental role, a detailed reconstruction of the brain-wide vasculature at the capillary level remains elusive, due to insufficient image
Phaseolus vulgaris lectins: A systematic review of characteristics and health implications
He S, et al.
Critical Reviews in Food Science and Nutrition, 58(1), 70-83 (2018)
Fatma M Abdel-Maksoud et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 25(4), 1052-1060 (2019-06-19)
The key role of the epididymis is contributing to sperm storage, maturation, and survival. The epididymis of camel has a unique structure called the intraepithelial gland. The present work aimed to investigate the structure of the epididymal intraepithelial gland with
C Requejo et al.
Molecular neurobiology, 54(10), 7722-7735 (2016-11-16)
The unilateral 6-hydroxydopamine (6-OHDA) lesion of medial forebrain bundle (MFB) in rats affords us to study the advanced stages of Parkinson's disease (PD). Numerous evidences suggest synergic effects when various neurotrophic factors are administered in experimental models of PD. The
Laura Calvo-Barreiro et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(2), 920-937 (2021-04-09)
Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a significant decrease of Clostridia cluster IV and XIVa has been reported. In the present study, we investigated the therapeutic
Lycopersicon esculentum lectin: an effective and versatile endothelial marker of normal and tumoral blood vessels in the central nervous system
Mazzetti S, et al.
European Journal of Histochemistry, 48(4), 423-428 (2009)
Yue-Yi Yao et al.
Brain research, 1717, 190-203 (2019-04-27)
Microglia contribute to the regulation of neuroinflammation and play an important role in the pathogenesis of brain disorders. Thus, regulation of neuroinflammation triggered by activation of microglia has become a promising therapeutic strategy. Here, we investigated the beneficial effects of
Qiao-Sheng Wang et al.
CNS neuroscience & therapeutics (2020-06-13)
The aim of this study was to explore whether the antibrain edema of hypertonic saline (HS) is associated with alleviating ischemic blood-brain barrier (BBB) permeability by downregulating astrocyte-derived vascular endothelial growth factor (VEGF), which is mediated by microglia-derived NOD-like receptor
Melatonin suppresses toll like receptor 4-dependent caspase-3 signaling activation coupled with reduced production of proinflammatory mediators in hypoxic microglia
Yao L, et al.
PLoS ONE, 11(11), e0166010-e0166010 (2016)
Gangqi Wang et al.
Arteriosclerosis, thrombosis, and vascular biology, 40(2), 350-364 (2019-12-13)
Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their surface that plays an important role in reducing vascular permeability and endothelial anti-inflammatory, antithrombotic, and antiangiogenic properties. Production and maintenance of this glycocalyx layer is dependent on
Manal T Hussein et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 26(5), 1024-1034 (2020-07-16)
The vascular and perivascular cells, including telocytes (TCs) and immune cells, play an important role in male fertility. The current study intended to describe in detail the microvascular structures harboring special regulatory devices in addition to the interstitial cellular components
Neelima Gupta et al.
Frontiers in cellular neuroscience, 14, 132-132 (2020-06-09)
Microglia, the innate immune effector cells of the mammalian central nervous system (CNS), are involved in the development, homeostasis, and pathology of CNS. Microglia become activated in response to various insults and injuries and protect the CNS by phagocytosing the
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