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Tian-Yong Hu et al.
Journal of inflammation research, 14, 587-597 (2021-03-06)
Marine natural products harbor a variety of pharmacological activities, and the sea species have been becoming a main source of new drug candidate. In pursuit of safer and more effective anti-inflammation drug, the anti-inflammatory activities, anti-oxygenation effects and underlying molecular
Jasper Lodder et al.
Autophagy, 11(8), 1280-1292 (2015-06-11)
Autophagy is a lysosomal degradation pathway of cellular components that displays antiinflammatory properties in macrophages. Macrophages are critically involved in chronic liver injury by releasing mediators that promote hepatocyte apoptosis, contribute to inflammatory cell recruitment and activation of hepatic fibrogenic
Killian Chaumonnot et al.
Cell death & disease, 12(1), 114-114 (2021-01-24)
The role of GRP94, an endoplasmic reticulum (ER) stress protein with both pro- and anti-inflammatory functions, has not been investigated in macrophages during ER stress, whereas ER stress has been reported in many diseases involving macrophages. In this work, we
Saroj Chakraborty et al.
Cell reports, 25(3), 677-689 (2018-10-18)
Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on metabolic syndrome, of which hypertension is a hallmark. We hypothesized that dietary salt impacts metabolism in a
Florence Njau et al.
Antioxidants (Basel, Switzerland), 10(11) (2021-11-28)
Monocyte-to-macrophage differentiation results in the secretion of various inflammatory mediators and oxidative stress molecules necessary for atherosclerosis pathogenesis. Consequently, this differentiation represents a potential clinical target in atherosclerosis. Calcium dobesilate (CaD), an established vasoactive and angioprotective drug in experimental models
Cynthia M de Bont et al.
Biochimica et biophysica acta. Molecular cell research, 1865(11 Pt A), 1621-1629 (2018-10-18)
Neutrophils can release their chromatin to form neutrophil extracellular traps (NETs), a process known as NETosis. Although NET formation can be induced by various stimuli, recent evidence suggests that these stimuli do so via different mechanisms. Here, we have analysed
Yulia Kiyan et al.
Frontiers in immunology, 11, 573550-573550 (2020-12-29)
GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood. In this study we demonstrate that uPAR is a part of Toll-like
Fan He et al.
Molecular medicine reports, 19(3), 1443-1452 (2019-01-11)
The present study aimed to investigate the effects of low‑dose lipopolysaccharide (LPS) on ischemia/reperfusion (I/R)‑induced brain injury, and to explore the mechanism of phosphoinositide 3‑kinase (PI3K)/Akt/forkhead box protein (Fox)O1 signaling pathway. Male Sprague‑Dawley rats were divided into control group (control)
Hana M Zegallai et al.
bioRxiv : the preprint server for biology (2021-11-04)
Barth Syndrome (BTHS) is a rare X-linked genetic disorder caused by mutation in the TAFAZZIN gene which encodes the cardiolipin (CL) transacylase tafazzin (Taz). Taz deficiency in BTHS patients results in reduced CL in their tissues and a neutropenia which
Laura F Bennett et al.
Science signaling, 12(598) (2019-09-12)
Inflammation alters bone marrow hematopoiesis to favor the production of innate immune effector cells at the expense of lymphoid cells and erythrocytes. Furthermore, proinflammatory cytokines inhibit steady-state erythropoiesis, which leads to the development of anemia in diseases with chronic inflammation.
Jun Liu et al.
World journal of gastroenterology, 15(16), 2009-2015 (2009-04-29)
To investigate the effect of Lianshu preparation on lipopolysaccharide (LPS)-induced diarrhea in rats. A diarrhea model was established in Sprague Dawley rats via injection of 1 mL of 30 mg/kg LPS. A total of 40 rats were randomly divided into
Tian-Yong Hu et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 55, 214-221 (2019-01-23)
Swertia chirayita, has been commonly used under the name "Zang-yin-chen" for the treatment of liver infections, inflammation, abdominal pain, and bacterial infection in traditional Tibetan medicine. However, the bioactive components with anti-inflammatory activities and underlying mechanisms remain poorly evaluated. Repeated
Sergio M Borghi et al.
Journal of ethnopharmacology, 273, 113980-113980 (2021-03-03)
Sphagneticola trilobata (L.) Pruski is a plant species belonging to the Asteraceae family. Kaurenoid acid (KA) is a diterpene metabolite and one of the active ingredients of Sphagneticola trilobata (L.) Pruski. Extracts containing KA are used in traditional medicine to
Claire Deligne et al.
Cancer immunology research, 8(3), 368-382 (2020-01-17)
The interplay between cancer cells and immune cells is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties of the extracellular matrix to create a microenvironment that enables their escape from immune surveillance. Using
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