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Shu Zhu et al.
Molecular medicine (Cambridge, Mass.), 15(7-8), 275-282 (2009-07-14)
The pathogenesis of sepsis is partly attributable to dysregulated inflammatory response mediated by pathogen-associated molecular patterns (PAMPs) (for example, endotoxin) and damage-associated molecular patterns (DAMPs) (for example, high-mobility group box 1 [HMGB1]). An endogenous ubiquitous polyamine, spermine, inhibits endotoxin-induced cytokine
Sarah Frush et al.
Environmental health perspectives, 119(10), 1403-1408 (2011-06-21)
Our previous work demonstrated that the extracellular matrix protein mindin contributes to allergic airways disease. However, the role of mindin in nonallergic airways disease has not previously been explored. We hypothesized that mindin would contribute to airways disease after inhalation
Zhenju Song et al.
Critical care (London, England), 15(1), R12-R12 (2011-01-12)
Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of
Rhonda H Wilson et al.
American journal of respiratory and critical care medicine, 180(8), 720-730 (2009-08-08)
In humans, immune responses to inhaled aeroallergens develop in the lung and draining lymph nodes. Many animal models of asthma bypass this route and instead use intraperitoneal injections of allergen using aluminum hydroxide as an adjuvant. We investigated whether allergic
Katherine E Wickliffe et al.
Cellular microbiology, 10(6), 1352-1362 (2008-02-13)
Macrophages from certain inbred mouse strains are rapidly killed (< 90 min) by anthrax lethal toxin (LT). LT cleaves cytoplasmic MEK proteins at 20 min and induces caspase-1 activation in sensitive macrophages at 50-60 min, but the mechanism of LT-induced
Gabrielle R Andrade et al.
Human vaccines & immunotherapeutics, 10(10), 2864-2874 (2014-12-09)
E. coli O111 strains are responsible for outbreaks of blood diarrhea and hemolytic uremic syndrome throughout the world. Because of their phenotypic variability, the development of a vaccine against these strains which targets an antigen that is common to all
Georgia Perona-Wright et al.
Cell host & microbe, 6(6), 503-512 (2009-12-17)
Surviving infection represents a balance between the proinflammatory responses needed to eliminate the pathogen, and anti-inflammatory signals limiting damage to the host. IL-10 is a potent immunosuppressive cytokine whose impact is determined by the timing and localization of release. We
Young-A Song et al.
BMC complementary and alternative medicine, 11, 91-91 (2011-10-13)
Black tea has been shown to elicit anti-oxidant, anti-carcinogenic, anti-inflammatory and anti-mutagenic properties. In this study, we investigated the impact of black tea extract (BTE) on lipopolysaccharide (LPS)-induced NF-κB signaling in bone marrow derived-macrophages (BMM) and determined the therapeutic efficacy
Mohamed El Gazzar et al.
Molecular and cellular biology, 29(7), 1959-1971 (2009-01-23)
Epigenetic silencing of tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) transcription occurs in blood leukocytes of animals and humans after the initiation of severe systemic inflammation (SSI). We previously reported that the epigenetic signature requires induction of NF-kappaB
Nathalie Busso et al.
PloS one, 3(5), e2267-e2267 (2008-05-22)
Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide. Since its expression is upregulated during inflammation, NAMPT represents a novel clinical biomarker in acute lung injury, rheumatoid arthritis, and
Marcus Mühlbauer et al.
Immunology, 124(2), 256-264 (2008-02-21)
Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial
Lucie Baudino et al.
Journal of immunology (Baltimore, Md. : 1950), 181(4), 2846-2854 (2008-08-08)
The endogenous retroviral envelope glycoprotein, gp70, implicated in murine lupus nephritis is secreted by hepatocytes as an acute phase protein, and it has been thought to be a product of an endogenous xenotropic virus, NZB-X1. However, since endogenous polytropic (PT)
Urmila Maitra et al.
Molecular immunology, 47(2-3), 420-425 (2009-09-24)
Although both inflammatory and metabolic complications occur during sepsis and endotoxemia, relatively few studies have examined the molecular mechanism underlying LPS-modulated metabolic changes during sepsis. In this report, we have demonstrated that LPS suppresses free fatty acid (FFA) oxidation, and
Xiaoxia Dai et al.
Applied and environmental microbiology, 86(4) (2019-12-08)
Lipopolysaccharide (LPS) has been reported to contribute to a ruminal acidosis of cattle by affecting ruminal bacteria. The goal of this study was to determine how LPS affects the growth of pure cultures of ruminal bacteria, including those that contribute
Camille Malouf et al.
Experimental hematology, 76, 49-59 (2019-08-06)
T(4;11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in infant and pediatric populations. Epidemiological and functional studies have highlighted the influence of an overstimulation of the immune system on leukemia development. This study aimed at assessing if
Fernando F Anhê et al.
Cell reports, 36(11), 109691-109691 (2021-09-16)
Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antagonize TLR4 yet contribute to endotoxemia measured by endotoxin units (EUs). We
Gabriela Cruz-Carrillo et al.
Frontiers in neuroscience, 14, 452-452 (2020-06-26)
Fetal programming by hypercaloric intake leads to food addiction-like behavior and brain pro-inflammatory gene expression in offspring. The role of methylome modulation during programming on central immune activation and addiction-like behavior has not been characterized. We employed a nutritional programming
Jinglin Sun et al.
Journal of virology, 82(11), 5562-5572 (2008-03-21)
Inflammatory mediators and viral products produced by human immunodeficiency virus (HIV)-infected microglia and astrocytes perturb the function and viability of adjacent uninfected neuronal and glial cells and contribute to the pathogenesis of HIV-associated neurocognitive disorders (HAND). In vivo exposure to
Xiangyang Huang et al.
Arthritis research & therapy, 10(4), R91-R91 (2008-08-19)
Using oligonucleotide microarray, many IFN-inducible genes have been found to be highly expressed in peripheral blood mononuclear cells (PBMCs) from most patients with systemic lupus erythematosus (SLE). Among these IFN-inducible genes, IFN-induced protein with tetratricopeptide repeats 4 (IFIT4) is a
Kazunori Takahashi et al.
PloS one, 7(1), e30134-e30134 (2012-01-19)
Systemic inflammatory response syndrome is a fatal disease because of multiple organ failure. Acute kidney injury is a serious complication of systemic inflammatory response syndrome and its genesis is still unclear posing a difficulty for an effective treatment. Aldose reductase
Clare M Hamilton et al.
Infection and immunity, 77(6), 2488-2498 (2009-04-01)
Parasitic worms and molecules derived from them have powerful anti-inflammatory properties and are shown to have therapeutic effects on inflammatory diseases. The helminth Fasciola hepatica has been reported to suppress antigen-specific Th1 responses in concurrent bacterial infections, thus demonstrating its
Amanda M Enstrom et al.
Brain, behavior, and immunity, 24(1), 64-71 (2009-08-12)
Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. Recent evidence has suggested that impairments of innate immunity may play an important role in ASD. To test this hypothesis, we
Lei Qiu et al.
Immunology, 128(1 Suppl), e325-e334 (2008-11-20)
Using two-dimensional sodium dodecyl sulphate-polyacrylamide gel electrophoresis, we found that copper/zinc superoxide dismutase (Cu/Zn-SOD, SOD-1) was induced in constructed CCR5 stably transfected HEK 293 cells, but not in mock cells, treated with CCL5. CCL5-induced SOD-1 expression was also confirmed in
Mohamed Lamkanfi et al.
The Journal of cell biology, 187(1), 61-70 (2009-10-07)
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1beta (IL-1beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns (DAMPs), and crystals. Inappropriate Cryopyrin activity has been incriminated in the pathogenesis
Thiago Alves Teixeira dos Santos et al.
PloS one, 6(11), e27867-e27867 (2011-12-06)
Phosphatidylserine (PS) exposure on the cell surface indicates apoptosis, but has also been related to evasion mechanisms of parasites, a concept known as apoptotic mimicry. Toxoplasma gondii mimics apoptotic cells by exposing PS, inducing secretion of TGF-beta1 by infected activated
Hua Qiu et al.
Drug design, development and therapy, 13, 589-600 (2019-02-28)
Jie-Du-Hua-Yu (JDHY) granule is a combination of six traditional Chinese medicines with known therapeutic effect in treating acute liver failure (ALF). The aim of this study was to investigate the amelioration efficacy of JDHY in lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF in rat
Marcela Medina et al.
Journal of inflammation (London, England), 5, 19-19 (2008-11-05)
Coeliac disease (CD) is an enteropathy characterized by an aberrant immune response to cereal-gluten proteins. Although gluten peptides and microorganisms activate similar pro-inflammatory pathways, the role the intestinal microbiota may play in this disorder is unknown. The purpose of this
Cristina Cigana et al.
PloS one, 4(12), e8439-e8439 (2009-12-29)
Pseudomonas aeruginosa can establish life-long airways chronic infection in patients with cystic fibrosis (CF) with pathogenic variants distinguished from initially acquired strain. Here, we analysed chemical and biological activity of P. aeruginosa Pathogen-Associated Molecular Patterns (PAMPs) in clonal strains, including
Yuhan Zhao et al.
PloS one, 6(12), e29363-e29363 (2011-12-24)
Breast cancer is the most prevalent cancer in women worldwide and metastatic breast cancer has very poor prognosis. Inflammation has been implicated in migration and metastasis of breast cancer, although the exact molecular mechanism remains elusive. We show that the
Maritza Jaramillo et al.
PloS one, 4(9), e6957-e6957 (2009-09-11)
Increasing evidence points to an important role for hemozoin (HZ), the malaria pigment, in the immunopathology related to this infection. However, there is no consensus as to whether HZ exerts its immunostimulatory activity in absence of other parasite or host
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