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L4391

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Deborah A Liberman et al.
Neurotoxicology and teratology, 79, 106880-106880 (2020-04-08)
Exposure to environmental contaminants early in life can have long lasting consequences for physiological function. Polychlorinated biphenyls (PCBs) are a group of ubiquitous contaminants that perturb endocrine signaling and have been associated with altered immune function in children. In this...
Zhenju Song et al.
Critical care (London, England), 15(1), R12-R12 (2011-01-12)
Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of...
Gladys A Shaw et al.
Brain, behavior, and immunity, 88, 203-219 (2020-05-12)
Repeated exposures to chronic stress can lead to long lasting negative behavioral and metabolic outcomes. Here, we aim to determine the impact of chronic stress and chronic low-level inflammation on behavior and synaptosomal metabolism. Male (n = 31) and female (n = 32) C57Bl/6...
Kai Xu et al.
Journal of leukocyte biology, 105(6), 1225-1234 (2019-03-26)
Neutrophil extracellular traps (NETs) are implicated in autoimmune, thrombotic, malignant, and inflammatory diseases; however, little is known of their endogenous regulation under basal conditions. Inflammatory effects of neutrophils are modulated by extracellular purines such as adenosine (ADO) that is inhibitory...
Guangliang Bi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(7), 3583-3596 (2018-02-18)
Although a deficiency of surfactant protein B (SFTPB) has been associated with lung injury, SFTPB expression has not yet been linked with nicotinamide phosphoribosyltransferase (NAMPT), a potential biomarker of acute lung injury (ALI). The effects of Nampt in the pulmonary...
Georgia Perona-Wright et al.
Cell host & microbe, 6(6), 503-512 (2009-12-17)
Surviving infection represents a balance between the proinflammatory responses needed to eliminate the pathogen, and anti-inflammatory signals limiting damage to the host. IL-10 is a potent immunosuppressive cytokine whose impact is determined by the timing and localization of release. We...
Hiroaki Tsurumaki et al.
International journal of molecular sciences, 16(12), 28931-28942 (2015-12-23)
Acute lung injury is characterized by the infiltration of neutrophils into lungs and the subsequent impairment of lung function. Here we explored the role of TDAG8 in lung injury induced by lipopolysaccharide (LPS) administrated intratracheally. In this model, cytokines and...
Gusty Rizky Teguh Ryanto et al.
Canadian journal of physiology and pharmacology, 98(9), 618-624 (2020-04-22)
Although dual endothelin receptor antagonists (ERAs) show great promise for treating various conditions, their propensity to induce liver injury limits their clinical usage. Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that...
Emily Buck et al.
ACS applied materials & interfaces, 13(6), 7021-7036 (2021-02-05)
Implants can induce a foreign body reaction that leads to chronic inflammation and fibrosis in the surrounding tissue. Macrophages help detect the foreign material, play a role in the inflammatory response, and may promote fibrosis instead of the desired tissue...
Tadayoshi Karasawa et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(4), 744-756 (2018-02-14)
Inflammation provoked by the imbalance of fatty acid composition, such as excess saturated fatty acids (SFAs), is implicated in the development of metabolic diseases. Recent investigations suggest the possible role of the NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin...
Perla Ugalde-Muñiz et al.
Oxidative medicine and cellular longevity, 2020, 4807179-4807179 (2020-02-06)
Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration. This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in...
Zhiwen Yang et al.
Frontiers in pharmacology, 11, 1206-1206 (2020-09-26)
Graphene, known as "black gold", has important applications in various fields. In previous studies, it has been proved that graphene oxide (GO) which is a derivative of graphene has low toxicity. However, the immunotoxicity of GO has not been fully...
Xiaojuan Liu et al.
Inflammation, 41(4), 1424-1436 (2018-05-03)
The inflammatory activation of microglia has double-edged effects in central nervous system (CNS) diseases. The ligand-activated transcriptional factor peroxisome proliferator-activated receptor γ (PPARγ) inhibits the inflammatory response. β-1,4-Galactosyltransferase Ι (β1, 4GalT1) mediates N-glycosylation. In this study, the N-glycosylation of PPARγ...
B J Skidmore et al.
Journal of immunology (Baltimore, Md. : 1950), 114(2 pt 2), 770-775 (1975-02-01)
Bacterial lipopolysaccharide (LPS) was demonstrated to have the capacity in mice to enhance the response to soluble bovine serum albumin (BSA) and to interfere with the induction of tolerance to human gamma-globulin (HGG). These adjuvant activities were shown to occur...
Jun Huang et al.
Brain, behavior, and immunity, 72, 89-100 (2017-11-08)
Sepsis and septic shock remain challenging for intensive care units worldwide and have limited treatment options; therefore, identification of targetable key players in systemic inflammation and multiple organ failure is urgently needed. Here, we show that AMP-activated protein kinase (AMPK)...
Hanyu Yang et al.
Frontiers in neuroscience, 14, 45-45 (2020-03-07)
Chronic neuroinflammation is of great importance in the pathogenesis of Parkinson's disease (PD). During the process of neuroinflammation, overactivated microglia release many proinflammatory factors, which eventually induce neurodegeneration. Inhibition of excessive microglial activation is regarded as a promising strategy for...
Bart Tummers et al.
Immunity, 52(6), 994-1006 (2020-05-20)
Cell death pathways regulate various homeostatic processes. Autoimmune lymphoproliferative syndrome (ALPS) in humans and lymphoproliferative (LPR) disease in mice result from abrogated CD95-induced apoptosis. Because caspase-8 mediates CD95 signaling, we applied genetic approaches to dissect the roles of caspase-8 in...
Soulixay Senouthai et al.
Inflammation, 42(4), 1287-1300 (2019-03-29)
Injury to podocytes leads to proteinuria, a hallmark of most glomerular diseases as well as being associated with the progression of kidney disease. Activation of the Wnt/β-catenin pathway is associated with the pathogenesis of podocyte dysfunction and can play a...
Sadia Zafar et al.
Oncoimmunology, 7(10), e1490856-e1490856 (2018-11-06)
Dendritic cells (DCs) are crucial players in promoting immune responses. Logically, adoptive DC therapy is a promising approach in cancer immunotherapy. One of the major obstacles in cancer immunotherapy in general is the immunosuppressive tumor microenvironment, which hampers the maturation...
Yue-Yi Yao et al.
Brain research, 1717, 190-203 (2019-04-27)
Microglia contribute to the regulation of neuroinflammation and play an important role in the pathogenesis of brain disorders. Thus, regulation of neuroinflammation triggered by activation of microglia has become a promising therapeutic strategy. Here, we investigated the beneficial effects of...
Tomer Bashi et al.
Journal of autoimmunity, 59, 1-7 (2015-04-14)
In areas where helminths infections are common, autoimmune diseases are rare. Treatment with helminths and ova from helminths, improved clinical findings of inflammatory bowel disease, multiple-sclerosis and rheumatoid-arthritis. The immunomodulatory functions of some helminths were attributed to the phosphorylcholine (PC)...
Zhen Ai et al.
Science translational medicine, 8(345), 345ra88-345ra88 (2016-07-01)
Although a major source of genetic variation, copy number variations (CNVs) and their involvement in disease development have not been well studied. Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. We performed association analysis of the DEFA1A3...
Irene García-Domínguez et al.
Frontiers in cellular neuroscience, 12, 398-398 (2018-11-22)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson's disease. Brain inflammation, microglia and astroglia activation...
Sarah Frush et al.
Environmental health perspectives, 119(10), 1403-1408 (2011-06-21)
Our previous work demonstrated that the extracellular matrix protein mindin contributes to allergic airways disease. However, the role of mindin in nonallergic airways disease has not previously been explored. We hypothesized that mindin would contribute to airways disease after inhalation...
Zizhong Hu et al.
Journal of cellular physiology, 234(10), 18849-18857 (2019-03-31)
NLRP3, as a crucial inflammasome component, plays important roles in age-related macular degeneration. Though some activators of NLRP3 have been studied, microRNAs (miRNAs) which potentially regulate NLRP3 messenger RNA (mRNA) have not been fully explored in retinal pigment epithelial (RPE)...
Tianlei Sun et al.
Theranostics, 10(22), 10106-10119 (2020-09-16)
Ulcerative colitis (UC) is featured with relapsing inflammation in the colon, where macrophages are recruited and polarized locally into M1 type to drive further inflammation. Pharmacotherapy of UC has exhibited limited efficacy, mostly due to the poor specificity. Methods: A...
Satyajeet Salunkhe et al.
Molecular immunology, 126, 46-55 (2020-08-08)
Immunological memory is a critical characteristic of a successful long-term adaptive immune response. During the initial phases of antigen:B lymphocyte interactions, B cells participate in the germinal center reaction, in which T-B cell interactions take place. CD154 on T cells...
Wu-Chang Zhang et al.
Cell research, 25(8), 893-910 (2015-07-25)
High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High...
Ji Hyun Seo et al.
BMC complementary medicine and therapies, 20(1), 176-176 (2020-06-07)
Glucocorticoids (GCs) are anti-inflammatory drugs widely used to treat acute and chronic inflammatory diseases. However, despite their excellent efficacy, the long-term use of GCs is relatively limited owing to their adverse effects. Recent studies have sought to reduce these adverse...
Lan Lin et al.
PLoS pathogens, 15(6), e1007795-e1007795 (2019-06-07)
Infection with the Streptococcus suis (S. suis) epidemic strain can cause Streptococcal toxic shock-like syndrome (STSLS), which is characterized by a cytokine storm, dysfunction of multiple organs and a high incidence of mortality despite adequate treatment. Despite some progress concerning...
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