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B H Noszczyk et al.
Biofabrication, 7(1), 015011-015011 (2015-03-03)
Albumin is rarely used for electrospinning because it does not form fibres in its native globular form. This paper presents a novel method for electrospinning human albumin from a solution containing pharmaceutical grade protein and 25% polyethylene oxide (PEO) used
Amanda M Enstrom et al.
Brain, behavior, and immunity, 24(1), 64-71 (2009-08-12)
Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. Recent evidence has suggested that impairments of innate immunity may play an important role in ASD. To test this hypothesis, we
Clare M Hamilton et al.
Infection and immunity, 77(6), 2488-2498 (2009-04-01)
Parasitic worms and molecules derived from them have powerful anti-inflammatory properties and are shown to have therapeutic effects on inflammatory diseases. The helminth Fasciola hepatica has been reported to suppress antigen-specific Th1 responses in concurrent bacterial infections, thus demonstrating its
Yang Shi et al.
Nature, 549(7673), 523-527 (2017-09-30)
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Alzheimer disease and other tauopathies, or tau-mediated
Seongdo Jeong et al.
Canadian journal of physiology and pharmacology, 95(4), 372-381 (2017-01-07)
Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix protein expressed in several cell types in response to TGF-β. TGFBIp is released by human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. Pelargonidin
Ryuta Umezu et al.
Arteriosclerosis, thrombosis, and vascular biology, 40(7), e214-e226 (2020-06-05)
Mitochondria consistently change their morphology in a process regulated by proteins, including Drp1 (dynamin-related protein 1), a protein promoting mitochondrial fission. Drp1 is involved in the mechanisms underlying various cardiovascular diseases, such as myocardial ischemia/reperfusion injury, heart failure, and pulmonary
Hayoung Yoo et al.
Inflammation, 37(5), 1705-1717 (2014-04-29)
High mobility group box-1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. Orientin has been known to have anxiolytic and antioxidative activities. However, the effect of orientin on HMGB1-induced inflammatory response has not been studied. We
Akshay Bisht et al.
Nutrients, 12(9) (2020-09-10)
The anti-inflammatory effects of curcumin are well documented. However, the bioavailability of curcumin is a major barrier to its biological efficacy. Low-dose combination of complimentary bioactives appears to be an attractive strategy for limiting barriers to efficacy of bioactive compounds.
Melanie Vincent et al.
PloS one, 5(9), e12941-e12941 (2010-10-05)
Niemann-Pick type C (NPC) disease is a lysosomal storage disease characterized by the accumulation of cholesterol and glycosphingolipids. The majority of NPC patients die in their teen years due to progressive neurodegeneration; however, half of NPC patients also suffer from
Lucien D Durosier et al.
Physiological measurement, 36(10), 2089-2102 (2015-08-21)
Fetal inflammatory response occurs during chorioamnionitis, a frequent and often subclinical inflammation associated with increased risk for brain injury and life-lasting neurologic deficits. No means of early detection exist. We hypothesized that systemic fetal inflammation without septic shock will be
Wonhwa Lee et al.
Inflammation, 38(5), 1911-1924 (2015-04-23)
High mobility group box 1 (HMGB1) was recently shown to be an important extracellular mediator of severe vascular inflammatory disease, sepsis. Lysozyme protects us from the ever-present danger of bacterial infection and binds to bacterial lipopolysaccharide (LPS) with a high
Wonhwa Lee et al.
Canadian journal of physiology and pharmacology, 93(8), 709-720 (2015-08-06)
Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against
Yuhan Zhao et al.
PloS one, 6(12), e29363-e29363 (2011-12-24)
Breast cancer is the most prevalent cancer in women worldwide and metastatic breast cancer has very poor prognosis. Inflammation has been implicated in migration and metastasis of breast cancer, although the exact molecular mechanism remains elusive. We show that the
Marcela Medina et al.
Journal of inflammation (London, England), 5, 19-19 (2008-11-05)
Coeliac disease (CD) is an enteropathy characterized by an aberrant immune response to cereal-gluten proteins. Although gluten peptides and microorganisms activate similar pro-inflammatory pathways, the role the intestinal microbiota may play in this disorder is unknown. The purpose of this
Gahee Min et al.
Archives of pharmacal research, 39(12), 1726-1738 (2016-10-26)
A certain nucleosomal protein-high mobility group box-1 (HMGB1)-has recently been established as a late mediator of sepsis, with a relatively wide therapeutic window for pharmacological intervention. Pelargonidin (PEL) is a well-known red pigment found in plants; it has important biological
Chee Seng Hee et al.
PLoS biology, 8(12), e1000557-e1000557 (2010-12-15)
Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but map outside of the core MHC region. To obtain insights into their function, we determined the structure of the YF1*7.1/β(2)-microgloblin complex by X-ray crystallography at
Soyoung Kwak et al.
Vascular pharmacology, 88, 1-10 (2015-08-05)
The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases. Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity are emerging as an attractive
Elisabeth G Vichaya et al.
Brain, behavior, and immunity, 23(7), 969-976 (2009-05-14)
Recent research indicates that glial cells control complex functions within the nervous system. For example, it has been shown that glial cells contribute to the development of pathological pain, the process of long-term potentiation, and the formation of memories. These
Hayoung Yoo et al.
Inflammation, 37(5), 1560-1574 (2014-04-08)
Sepsis is a state of disrupted inflammatory homeostasis that is initiated by infection. High mobility group box 1 (HMGB1) protein acting as a late mediator of severe vascular inflammatory conditions, such as sepsis and endothelial cell protein C receptor (EPCR)
Mark C Dessing et al.
PloS one, 4(11), e7993-e7993 (2009-12-04)
Pneumolysin (PLN) is an intracellular toxin of Streptococcus pneumoniae that has been implicated as a major virulence factor in infections caused by this pathogen. Conserved bacterial motifs are recognized by the immune system by pattern recognition receptors among which the
In-Chul Lee et al.
The American journal of Chinese medicine, 45(6), 1253-1271 (2017-08-24)
Sulforaphane (SFN), a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity is emerging as an
W Lee et al.
Thrombosis and haemostasis, 114(2), 350-363 (2015-05-08)
Sepsis is a life-threatening condition that arises when the body's response to infection causes systemic inflammation. High-mobility group box 1 (HMGB1), as a late mediator of sepsis, enhances hyperpermeability, and it is therefore a therapeutic target. Despite extensive research into
Maritza Jaramillo et al.
PloS one, 4(9), e6957-e6957 (2009-09-11)
Increasing evidence points to an important role for hemozoin (HZ), the malaria pigment, in the immunopathology related to this infection. However, there is no consensus as to whether HZ exerts its immunostimulatory activity in absence of other parasite or host
Wonhwa Lee et al.
Journal of cellular biochemistry, 120(4), 6277-6289 (2018-11-01)
Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity are emerging as attractive therapeutic strategies for the management of severe vascular inflammatory diseases. Recently, we found that JH-4, a synthesized decursin derivative, exhibited a strong anti-Hutchinson-Gilford
Lei Qiu et al.
Immunology, 128(1 Suppl), e325-e334 (2008-11-20)
Using two-dimensional sodium dodecyl sulphate-polyacrylamide gel electrophoresis, we found that copper/zinc superoxide dismutase (Cu/Zn-SOD, SOD-1) was induced in constructed CCR5 stably transfected HEK 293 cells, but not in mock cells, treated with CCL5. CCL5-induced SOD-1 expression was also confirmed in
Shanshan Cai et al.
American journal of respiratory cell and molecular biology, 40(6), 701-709 (2008-11-08)
Bacterial pneumonia remains a serious disease. Pattern recognition receptors play an integral role in neutrophil accumulation during pneumonia. Although myeloid differentiation protein (MD)-2 has been recognized as a key molecule for LPS signaling, the role of MD-2 in neutrophil accumulation
Wonhwa Lee et al.
Chemico-biological interactions, 281, 106-110 (2018-01-01)
The aim of this study was to investigate the effects of zingerone (ZGR) on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate underlying mechanisms. ZGR is a phenolic alkanone isolated from ginger, and has potential health benefits. Mice were
Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice.
Lee W, Ku SK, and Bae JS
Thrombosis and Haemostasis, 112(4), 757-769 (2014)
Abraham J Kandathil et al.
The Journal of clinical investigation, 128(10), 4501-4509 (2018-09-11)
Long-lived HIV-1 reservoirs that persist despite antiretroviral therapy (ART) are a major impediment to a cure for HIV-1. We examined whether human liver macrophages (LMs), the largest tissue macrophage population, comprise an HIV-1 reservoir. We purified LMs from liver explants
In-Chul Lee et al.
Journal of natural medicines, 74(1), 90-97 (2019-07-28)
The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously
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