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Markus W Tackenberg et al.
International journal of pharmaceutics, 478(2), 597-605 (2014-12-17)
Essential oils and other liquid active pharmaceutical ingredients (APIs) are frequently microencapsulated to improve shelf life, handling, and for tailoring release. A glassy solid solution (GSS), a single-phase system, where the excipient is plasticized by the API, could be an
Woan-Ruoh Lee et al.
Journal of pharmaceutical sciences, 103(11), 3542-3552 (2014-09-05)
Alopecia usually cannot be cured because of the available drug therapy being unsatisfactory. To improve the efficiency of treatment, erbium-yttrium-aluminum-garnet (Er-YAG) laser treatment was conducted to facilitate skin permeation of antialopecia drugs such as minoxidil (MXD), diphencyprone (DPCP), and peptide.
B L Fransen et al.
The Journal of arthroplasty, 30(11), 1931-1937 (2015-06-23)
New insert types have been developed to improve clinical and functional outcome in mobile bearing (MB-TKA) and fixed bearing total knee arthroplasty (FB-TKA). A prospective single blinded randomised controlled clinical trial was performed to evaluate 2 types of MB-TKA inserts
Fidaa Bouezzedine et al.
Virology, 481, 34-42 (2015-03-15)
Hepatitis B virus (HBV) infection is a major public health problem. Recently, the human liver bile acid transporter Na(+)/taurocholate cotransporting polypeptide (NTCP) has been identified as an HBV specific receptor. NTCP expression is known to be strongly regulated by IL-6.
Joong Sun Kim et al.
Archives of pharmacal research, 38(6), 1213-1222 (2014-09-23)
Herein, we aimed at examining the therapeutic effects of 5-androstenediol (5-AED), a natural hormone produced in the adrenal cortex, on radiation-induced myelosuppression in C3H/HeN mice. The mice were subjected to whole-body irradiation with a sublethal dose of 5 Gy gamma-irradiation
Michael J Lawrence et al.
The Journal of experimental biology, 218(Pt 13), 2124-2135 (2015-05-20)
Relative to the gills, the mechanisms by which the kidney contributes to ammonia and acid-base homeostasis in fish are poorly understood. Goldfish were exposed to a low pH environment (pH 4.0, 48 h), which induced a characteristic metabolic acidosis and an increase
Hai-Shui Shi et al.
Scientific reports, 5, 13327-13327 (2015-08-21)
Drug addiction is considered an aberrant form of learning, and drug-associated memories evoked by the presence of associated stimuli (drug context or drug-related cues) contribute to recurrent craving and reinstatement. Epigenetic changes mediated by DNA methyltransferase (DNMT) have been implicated
Ai-ting Wang et al.
Biomaterials, 53, 160-172 (2015-04-22)
There are several obstacles in the process of successful treatment of malignant tumors, including toxicity to normal cells, inefficiency of drug permeation and accumulation into the deep tissue of solid tumor, and multidrug resistance (MDR). In this work, we prepared
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Hui-Ying Liu et al.
World journal of gastroenterology, 21(10), 2918-2925 (2015-03-18)
To improve an asialoglycoprotein receptor (ASGPR)-based enrichment method for detection of circulating tumor cells (CTCs) of hepatocellular carcinoma (HCC). Peripheral blood samples were collected from healthy subjects, patients with HCC or various other cancers, and patients with hepatic lesions or
Nicola Parisi et al.
International journal of pharmaceutics, 493(1-2), 404-411 (2015-08-04)
Hexamidine diisethionate (HEX D) has been used in the personal care industry and in a number of over-the-counter (OTC) drug products as an antimicrobial agent since the 1950's. Recently, the compound has also been investigated for its beneficial effects on
Rie Yamamoto et al.
PloS one, 9(10), e110819-e110819 (2014-10-28)
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that acts through the members of a family of five G protein-coupled receptors (S1P1-S1P5). S1P1 is a major regulator of lymphocyte trafficking, and fingolimod, whose active metabolite fingolimod phosphate acts as a nonselective
Min-Chul Kim et al.
Annals of biomedical engineering, 43(12), 3004-3014 (2015-06-05)
Highly porous and interconnected scaffolds were fabricated using calcium phosphate glass (CPG) for bone tissue engineering. An avidin-biotin binding system was used to improve osteoblast-like cell adhesion to the scaffold. The scaffolds had open macro- and micro-scale pores, and continuous
Nicholas I Proellocks et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(7), 3103-3113 (2014-04-08)
The genomes of malaria parasites (Plasmodium spp.) contain a family of genes encoding proteins with a Plasmodium helical interspersed subtelomeric (PHIST) domain, most of which are predicted to be exported into the parasite-infected human red blood cell (iRBC). Here, using
Akram Ayoub et al.
International journal of biological macromolecules, 75, 13-20 (2015-01-21)
Our laboratory has developed a technique to reconstruct in vitro tissue from human cells using the self-assembly tissue-engineering method, which utilizes the ability of fibroblasts to deposit the matrix they secrete. The time necessary for tissue construction, several weeks, is
Graziano Colombo et al.
Biochimica et biophysica acta, 1850(1), 1-12 (2014-10-05)
Advanced oxidation protein products (AOPPs) are dityrosine cross-linked and carbonyl-containing protein products formed by the reaction of plasma proteins with chlorinated oxidants, such as hypochlorous acid (HOCl). Most studies consider human serum albumin (HSA) as the main protein responsible for
Christian Schröter et al.
mAbs, 7(1), 138-151 (2014-12-20)
There is growing interest in the fast and robust engineering of protein pH-sensitivity that aims to reduce binding at acidic pH, compared to neutral pH. Here, we describe a novel strategy for the incorporation of pH-sensitive antigen binding functions into
Hidehiko Kikuchi et al.
Gene, 544(1), 19-24 (2014-04-22)
GCN5 is involved in the acetylation of core histones, which is an important epigenetic event for transcriptional regulation through alterations in the chromatin structure in eukaryotes. To investigate physiological roles of GCN5, we have systematically analyzed phenotypes of homozygous GCN5-deficient
Ayo Y Simon et al.
Blood, 126(3), 378-385 (2015-05-07)
Dengue virus (DENV) infection causes ∼200 million cases of severe flulike illness annually, escalating to life-threatening hemorrhagic fever or shock syndrome in ∼500,000. Although thrombocytopenia is typical of both mild and severe diseases, the mechanism triggering platelet reduction is incompletely
Dilyana Georgieva et al.
Journal of pharmaceutical sciences, 103(8), 2406-2413 (2014-06-26)
This paper describes the synthesis and characterization of cationic copolymers with different macromolecular architecture and drug delivery properties of the corresponding dexamethasone sodium phosphate (DSP)-loaded systems. Copolyelectrolytes comprising poly[2-(acryloyloxy)ethyl] trimethylammonium chloride (PAETMAC) and poly(ethylene glycol) blocks as well as a
Weerapon Sangartit et al.
PloS one, 9(12), e114908-e114908 (2014-12-17)
Cadmium (Cd) is a nonessential heavy metal, causing oxidative damage to various tissues and associated with hypertension. Tetrahydrocurcumin (THU), a major metabolite of curcumin, has been demonstrated to be an antioxidant, anti-diabetic, anti-hypertensive and anti-inflammatory agent. In this study, we
Hüma Yılmaz et al.
Journal of separation science, 38(17), 3090-3095 (2015-07-04)
A simple, sensitive, and selective molecularly imprinted solid-phase extraction and spectrophotometric method has been developed for the clean-up and preconcentration of indapamide from human urine. Molecularly imprinted polymers were prepared by a non-covalent imprinting approach using indapamide as a template
Ming-Chang Kao et al.
Cytokine, 76(2), 442-448 (2015-09-17)
Cepharanthine possesses strong anti-inflammation capacity. We sought to clarify whether cepharanthine could mitigate pro-inflammatory cytokine production in acute lung injury induced by hemorrhagic shock/resuscitation (HS/RES). The involvement of heme oxygenase-1 (HO-1) was also investigated. Male Sprague Dawley rats were allocated
Manabu Ogita et al.
Atherosclerosis, 237(1), 374-378 (2014-12-03)
Restenosis after vascular intervention remains a major clinical problem. Circulating LR11 has been shown a novel marker of intimal smooth muscle cell (SMC) proliferation in human and animal studies. The present study was performed to clarify the clinical significance of
Olga Zagorácz et al.
Brain research bulletin, 118, 58-64 (2015-09-20)
The RFamide peptide family comprises a number of biologically active peptides sharing RF motif at their C-terminal end. These peptides are involved in the control of multiple physiological functions including regulation of metabolism and feeding behavior. QRFP-43 as well as
Claudia I Chapuy et al.
Transfusion, 55(6 Pt 2), 1545-1554 (2015-03-13)
Daratumumab (DARA), a promising novel therapy for multiple myeloma, is an IgG1κ monoclonal antibody that recognizes CD38 on myeloma cells. During routine compatibility testing, we observed that the plasma of five of five DARA-treated patients demonstrated a positive antibody screen
Huiyang Liu et al.
Nanoscale research letters, 9(1), 397-397 (2014-09-02)
Carbon dots exhibit great potential in applications such as molecular imaging and in vivo molecular tracking. However, how to enhance fluorescence intensity of carbon dots has become a great challenge. Herein, we report for the first time a new strategy
Alexandre A Arnold et al.
Biochimica et biophysica acta, 1848(1 Pt B), 369-377 (2014-07-30)
Microalgae are unicellular organisms in which plasma membrane is protected by a complex cell wall. The chemical nature of this barrier is important not only for taxonomic identification, but also for interactions with exogenous molecules such as contaminants. In this
Erkan Yilmaz et al.
Analytica chimica acta, 886, 75-82 (2015-09-01)
A switchable polarity solvent was synthesized from triethylamine (TEA)/water/CO2 (Dry ice) via proton transfer reaction has been used for the microextraction of cadmium(II) as pyrrolidinedithiocarbamate (APDC) chelate. Cd(II)-APDC chelate was extracted into the switchable polarity solvent drops by adding 2
Jiawen Lei et al.
Analytical chemistry, 86(21), 10841-10846 (2014-10-03)
Aflatoxins are a group of extremely toxic small molecules that have been involved in human hepatic and extrahepatic carcinogenesis as causative agents. Herein, we developed a real-time immuno polymerase chain reaction (IPCR) assay for the accurately quantitative detection of aflatoxins
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