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Tienthanh Nguyen et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 123, 109753-109753 (2019-12-23)
Periplaneta americana is a common traditional Chinese medicinal material which has been used to treat arthritis, fever, aches, pains, and inflammation of the extremities for several hundred years. However, little scientific data exists in literature to support its use. The
Soo Hyun Kim et al.
Autophagy, 13(10), 1767-1781 (2017-09-22)
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved agents for treating NASH, drugs that can enhance autophagy and modulate inflammasome pathways may be beneficial. Here, we investigated the novel
Maren Hillmer et al.
Theriogenology, 157, 458-466 (2020-09-04)
Uterine epithelial cells (UEC) and migrated polymorphonuclear cells (PMN) play important roles in the uterine defence against microbial infection. The aims of the present study were to investigate i) whether undiluted uterine secretions modulate the expression of genes associated with
Tracey Hurrell et al.
Cells, 9(4) (2020-04-17)
Non-alcoholic fatty liver disease affects approximately one billion adults worldwide. Non-alcoholic steatohepatitis (NASH) is a progressive disease and underlies the advancement to liver fibrosis, cirrhosis, and hepatocellular carcinoma, for which there are no FDA-approved drug therapies. We developed a hetero-cellular
Xiao Zheng et al.
Brain, behavior, and immunity, 79, 244-255 (2019-02-23)
Psychological stress is well known to increase colitis susceptibility and promote relapse. Metabolic changes are commonly observed under psychological stress, but little is known how this relates to the progression of colitis. Here we show that kynurenic acid (KA) is
Ulrike Kuebler et al.
Psychophysiology, 52(4), 499-508 (2014-10-23)
Anticipatory cognitive stress appraisal (ACSA) can affect the stress-induced release of stress hormones, which, in turn, can modulate microbicidal potential of macrophages. This study examines whether ACSA modulates wound-induced activation of macrophage microbicidal potential in 22 acutely stressed compared to
D E Heinrichs et al.
Molecular microbiology, 30(2), 221-232 (1998-10-29)
Bacterial lipopolysaccharides (LPS) are unique and complex glycolipids that provide characteristic components of the outer membranes of Gram-negative bacteria. In LPS of the Enterobacteriaceae, the core oligosaccharide links a highly conserved lipid A to the antigenic O-polysaccharide. Structural diversity in
Ye Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 11772-11785 (2020-07-12)
Sepsis, a systemic inflammatory response syndrome (SIRS) caused by infection, is a major public health concern with limited therapeutic options. Infection disturbs the homeostasis of host, resulting in excessive inflammation and immune suppression. This has prompted the clinical use of
Nils Rother et al.
Cell reports. Medicine, 1(9), 100146-100146 (2020-12-31)
Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses
Cornelia Barnowski et al.
Pharmaceutics, 11(5) (2019-05-06)
The great advantage of virus-like particle (VLP) nano-vaccines is their structural identity to wild-type viruses, ensuring that antigen-specific B-cells encounter viral proteins in their natural conformation. "Wild-type" viral nanoparticles can be further genetically or biochemically functionalized with biomolecules (antigens and
Katerina Akassoglou et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6698-6703 (2004-04-21)
In multiple sclerosis, in which brain tissue becomes permeable to blood proteins, extravascular fibrin deposition correlates with sites of inflammatory demyelination and axonal damage. To examine the role of fibrin in neuroinflammatory demyelination, we depleted fibrin in two tumor necrosis
Patty Zwollo et al.
Developmental and comparative immunology, 32(12), 1482-1496 (2008-07-12)
To date, the trout B-cell is poorly defined, as many essential molecular markers are not yet available for this species. In mammalian systems, the transcription factor Pax5, expressed from pre-B through plasmablast stages, provides an important marker for B-cell differentiation.
Masahiro Koseki et al.
Journal of lipid research, 48(2), 299-306 (2006-11-03)
Lipid rafts on the cell surface are believed to be very important as platforms for various cellular functions. The aim of this study was to know whether defective lipid efflux may influence lipid rafts on the cell surface and their
Vlad A Ionescu et al.
Brain research bulletin, 84(3), 244-251 (2010-12-28)
In vitro cultures of various glial cell types are common systems used to model neuroinflammatory processes associated with age-dependent human neurodegenerative diseases. Even though most researchers choose to use neonatal rodent brain tissues as the source of glial cells, there
Kathryn J Newhall et al.
Clinical chemistry, 56(9), 1483-1491 (2010-07-29)
Biomarker assays are often conducted on whole blood samples in the course of drug development studies. Because bacterial lipopolysaccharide (LPS) (endotoxin) contamination is known to cause spontaneous cytokine production by monocytes, contamination of blood collection tubes may interfere with biomarker
Natalie M Otto et al.
Critical care (London, England), 12(4), R107-R107 (2008-08-20)
Hyperglycemia is associated with negative outcomes in various settings of critical illness; infectious complications, especially, seem to be increased. On the other hand, intensive insulin therapy (IIT) has been shown to improve outcome in clinical trials. Whether normoglycemia itself or
Laura Ardighieri et al.
Frontiers in immunology, 12, 690201-690201 (2021-07-06)
Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs) have offered a modest benefit. In this study, high CD3+ T-cells and CD163+ tumor-associated macrophages (TAMs) densities identify a subgroup of immune infiltrated high-grade serous carcinomas (HGSCs) with better
Julianne C Barry et al.
Cytokine, 111, 460-469 (2018-06-11)
A key pathological component of obesity is chronic low-grade inflammation, which is propagated by infiltration of immune cells into tissues and overproduction of pro-inflammatory cytokines. Cytokines that possess anti-inflammatory properties, such as interleukin (IL)-10 and IL6, may also play an
Sebastian E Winter et al.
Infection and immunity, 77(5), 1904-1916 (2009-02-25)
Salmonella enterica serotype Typhimurium causes acute inflammatory diarrhea in humans. Flagella contribute to intestinal inflammation, but the mechanism remains unclear since most mutations abrogating pattern recognition of flagellin also prevent motility and reduce bacterial invasion. To determine the contribution of
Immunological Properties of Donkey?s Milk: Its Potential Use in the Prevention of Atherosclerosis.
Tafaro A, et al.
Current Pharmaceutical Design, 13(36), 3711-3717 (2007)
Ryusuke Yoshimi et al.
Journal of immunology (Baltimore, Md. : 1950), 182(12), 7527-7538 (2009-06-06)
The tripartite motif (TRIM) family member, TRIM21, is an E3 ubiquitin ligase for IFN regulatory factor (IRF)3 and IRF8 that functions in both innate and acquired immunity. It is also an autoantigen known as Ro52/SS-A. The function of TRIM21 in
Sarder Arifuzzaman et al.
Biochemical pharmacology, 137, 61-80 (2017-04-23)
Multiple studies have documented that Enhancer of zeste homolog 2 (EZH2) could play a role in inflammation and a wide range of malignancies; however, the underlying mechanisms remain largely unaddressed. Microglial activation is a key process in the production and
Suhas G Kallapur et al.
American journal of respiratory and critical care medicine, 179(10), 955-961 (2009-02-24)
Chorioamnionitis frequently associates with preterm delivery and increased amniotic fluid IL-1, and causes fetal lung and systemic inflammation. However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants. To
Nellwyn Hagan et al.
Cell death & disease, 11(10), 904-904 (2020-10-25)
Microglia serve as the innate immune cells of the central nervous system (CNS) by providing continuous surveillance of the CNS microenvironment and initiating defense mechanisms to protect CNS tissue. Upon injury, microglia transition into an activated state altering their transcriptional
K É Szabó-Taylor et al.
Free radical biology & medicine, 108, 56-65 (2017-03-23)
The redox state of cellular exofacial molecules is reflected by the amount of available thiols. Furthermore, surface thiols can be considered as indicators of immune cell activation. One group of thiol containing proteins, peroxiredoxins, in particular, have been associated with
Melanie E Mendez et al.
International journal of molecular sciences, 21(17) (2020-09-10)
Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular cartilage. Post-traumatic OA (PTOA) is a secondary form of OA that develops in ~50% of cases of severe articular injury. Inflammation and re-occurring
Peifa Yu et al.
Virology, 546, 109-121 (2020-05-27)
The inflammasome machinery has recently been recognized as an emerging pillar of innate immunity. However, little is known regarding the interaction between the classical interferon (IFN) response and inflammasome activation in response to norovirus infection. We found that murine norovirus
Siddhartha Jaiswal et al.
Cell, 138(2), 271-285 (2009-07-28)
Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47
Maya C André et al.
Journal of leukocyte biology, 91(6), 977-989 (2012-03-20)
Septic diseases are characterized by an initial systemic, proinflammatory phase, followed by a period of anti-inflammation. In the context of the latter, monocytes have been described to display altered functions, including reduced TNF secretion and T cell-stimulating capacities in response
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