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Yunzhe Ma et al.
Journal of pharmaceutical sciences, 103(11), 3621-3630 (2014-09-13)
This study demonstrates for the first time the ability to coat solid dispersions on microneedles as a means to deliver water-insoluble drugs through the skin. Polyethylene glycol (PEG) was selected as the hydrophilic matrix, and lidocaine base was selected as...
Jie Xue et al.
Pakistan journal of pharmaceutical sciences, 28(2 Suppl), 697-700 (2015-03-23)
This research aims to analyze the curative effect and security of lauromacrogol injection and absolute ethyl alcohol treating simplex hepatic cyst respectively. The simplex hepatic cyst patients were divided into lauromacrogol group (86 cases, research group) and absolute ethyl alcohol...
Elizabeth A Giuliano et al.
Veterinary ophthalmology, 17 Suppl 1, 37-45 (2014-08-16)
(i) To report the successful treatment of 10 cases of equine periocular squamous cell carcinoma (PSCC) with surgical excision and photodynamic therapy (PDT) using verteporfin. (ii) To evaluate time to first tumor recurrence between PDT-treated horses and horses treated with...
Jinghong Chen et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(1), R18-R27 (2014-11-21)
Psychological disorders are prevalent in patients with inflammatory bowel disease; the underlying mechanisms remain unknown. We tested the hypothesis that ulcerative colitis-like inflammation induced by dextran sodium sulfate (DSS) exacerbates the ongoing spontaneous activity in colon-projecting afferent neurons that induces...
Bartholomeus C M Benno Haarman et al.
Brain, behavior, and immunity, 40, 219-225 (2014-04-08)
The "monocyte-T-cell theory of mood disorders" regards neuroinflammation, i.e. marked activation of microglia, as a driving force in bipolar disorder. Microglia activation can be visualized in vivo using [(11)C]-(R)-PK11195 PET. Indirect evidence suggests the hippocampus as a potential focus of...
Timothy Smith et al.
The Journal of the Michigan Dental Association, 96(1), 34-37 (2014-03-25)
The purpose of this paper was to review the use of articaine in the pediatric dental population. Literature on use of articaine in comparison to lidocaine was reviewed. Many dental procedures on primary molars can be successfully accomplished with infiltration...
Susan H Corbett et al.
Southern medical journal, 107(7), 433-436 (2014-07-11)
To identify trends in compounding pharmacies with a focus on women's health and, more specifically, the types and combinations of medications used in the treatment of vulvodynia. This survey study was conducted with 653 nonchain pharmacies that compound medications. Each...
K W Ward et al.
Xenobiotica; the fate of foreign compounds in biological systems, 35(2), 191-210 (2005-07-16)
The prediction of human pharmacokinetics is often based on in vivo preclinical pharmacokinetic data. However, to date, no clear guidance has been available about the relative ability of the major preclinical species to estimate human oral exposure. The study was...
Jun Liu et al.
Surgical innovation, 22(2), 123-130 (2014-05-14)
The purposes of this study were to evaluate the feasibility, safety, and advantages of nonintubated video-assisted thoracoscopic surgery (VATS) under epidural anesthesia, by comparing with the performance of conventional approaches. A total of 354 patients (245 men and 109 women)...
Ludmila Mut et al.
Biomedical chromatography : BMC, 29(6), 935-952 (2014-11-18)
An automated multi-analyte screening method for the identification and quantification of 92 drugs and metabolites based on on-line solid-phase extraction-high-performance liquid chromatography-diode array detection technique was developed and successfully validated. In addition, a database with 870 entries including UV-spectra, relative/retention...
Mitochondrial injury and caspase activation by the local anesthetic lidocaine
Johnson ME, et al.
Anesthesiology, 101(5), 1184-1194 (2004)
Margarita Valero et al.
Langmuir : the ACS journal of surfaces and colloids, 26(13), 10561-10571 (2010-05-15)
The associative structures between F127 Pluronic micelles and four drugs, namely, lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL), were studied by small-angle neutron scattering (SANS). Different outcomes for the micellar aggregates are observed, which...
Improving the local anesthesia experience for our patients.
Gregori M Kurtzman
Dentistry today, 33(4), 120-120 (2014-05-06)
Ron L A P Hoogenboom et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(8), 1256-1264 (2015-06-30)
Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under the so-called Cascade rules (off-label use), with the restriction that...
iTMJ reduction.
Ronald L Hebard
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 151(6), 1086-1087 (2014-08-03)
Mark C Dessing et al.
Kidney international, 87(1), 85-94 (2014-06-19)
Upon ischemia/reperfusion (I/R)-induced injury, several damage-associated molecular patterns are expressed including the calcium-binding protein S100A8/A9 complex. S100A8/A9 can be recognized by Toll-like receptor-4 and its activation is known to deleteriously contribute to renal I/R-induced injury. To further test this, wild-type...
Matthew D Muller et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H228-H235 (2014-05-13)
Cardiac ischemia and angina pectoris are commonly experienced during exertion in a cold environment. In the current study we tested the hypotheses that oropharyngeal afferent blockade (i.e., local anesthesia of the upper airway with lidocaine) as well as systemic β-adrenergic...
Comparison of postoperative redness of eyes after sub-Tenon's block and topical anaesthesia following phacoemulsification cataract surgery.
P Huang et al.
British journal of anaesthesia, 112(2), 381-382 (2014-01-17)
China Chien et al.
Journal of pediatric urology, 11(4), 197-197 (2015-06-17)
Pediatric urinary incontinence has been proposed as a cause for adult urinary incontinence, yet animal models mimic the findings of overactive bladder more closely than dysfunctional voiding. We used the bladder reduction (BR) model to study the effects of early...
V D Khokhlov et al.
Klinicheskaia meditsina, 90(7), 62-64 (2012-10-02)
A rare case of sudden fatal anaphylactic shock is described in a 50 year-old woman after secondary lidocaine blockade to relieve lumbar pain (the first blockade was performed 4 days before by the same physician after the negative skin test)....
Roxana A Stefanescu et al.
Journal of neurophysiology, 113(3), 956-970 (2014-11-14)
Tinnitus has been associated with enhanced central gain manifested by increased spontaneous activity and sound-evoked firing rates of principal neurons at various stations of the auditory pathway. Yet, the mechanisms leading to these modifications are not well understood. In a...
Young-Mo Kim et al.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 23(7), 2090-2096 (2014-09-17)
This study was performed to compare general anesthesia, spinal anesthesia, and ultrasound (US)-guided nerve block for knee arthroscopic surgery. Also, whether US-guided nerve block is a useful method of anesthesia for arthroscopic knee surgery was investigated. In this prospective, randomized...
Sanaz Keyhan et al.
Journal of minimally invasive gynecology, 21(5), 791-798 (2014-04-01)
To evaluate the effectiveness of a multimodality local anesthetic protocol for office diagnostic and operative hysteroscopy. Retrospective cohort study (Canadian Task Force classification II-3). Academic community-based institution. Five hundred sixty-nine women undergoing 639 office-based diagnostic or operative hysteroscopic procedures. Multimodality...
Yoshitaka Tanaka et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 20(6), 999-1004 (2015-07-23)
We evaluated trigger fingers ultrasonographically and clarified differences between fingers with and without continuous locking or snapping symptoms according to the thicknesses of the A1 pulley, flexor tendon and volar plate. We evaluated 26 trigger fingers, divided into two groups:...
Jennifer C Wilhelm et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(16), 6760-6765 (2009-04-07)
When neuronal activity is reduced over a period of days, compensatory changes in synaptic strength and/or cellular excitability are triggered, which are thought to act in a manner to homeostatically recover normal activity levels. The time course over which changes...
Yoshihiko Furusawa et al.
Parkinsonism & related disorders, 21(7), 765-770 (2015-05-16)
We previously classified camptocormia of Parkinson's disease (PD) into upper and lower types based on the inflection point, and reported improvement of upper camptocormia after lidocaine injection into the external oblique. However, the exact pathophysiology of this phenomenon remains obscure....
Vincent Tedjasaputra et al.
The Journal of physiology, 593(14), 3147-3157 (2015-05-09)
Pulmonary gas exchange, as evaluated by the alveolar-arterial oxygen difference (A-aDO2), is impaired during intense exercise, and has been correlated with recruitment of intrapulmonary arteriovenous anastomoses (IPAVA) as measured by agitated saline contrast echocardiography. Previous work has shown that dopamine...
Francesco Saverio Mari et al.
Diseases of the colon and rectum, 56(6), 768-773 (2013-05-09)
Postoperative pain after stapled hemorrhoidopexy is cause for considerable concern and may be related to contracture of continence muscles. We compared glyceryl trinitrate 0.4% ointment with lidocaine chlorohydrate 2.5% gel as topical therapy to relieve the pain of anorectal muscular...
Bin Cao et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 41(1), 53-58 (2014-12-19)
Use of a random skin flap is common for repairing wounds and for reconstruction. Lidocaine is a traditional local anesthetic that blocks sodium channels and has positive effects on ischemia-reperfusion injury. To investigate the effects of lidocaine on random skin...
Joel L Cohen
Journal of drugs in dermatology : JDD, 12(9), 986-989 (2013-09-05)
Pain is a common patient complaint with dermatologic laser procedures and effective pain management is important for the comfort and satisfaction of patients undergoing these procedures. Many topical anaesthetics are available as options to decrease the pain associated with these...
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