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Hongyun Ji et al.
Neurotoxicity research, 38(2), 266-273 (2020-05-10)
To verify the role of PI3K-AKT-GSK3β pathway during manganese (Mn)-induced cell death, apoptosis, related indicators were investigated. SH-SY5Y cells were directly exposed to different concentrations of MnCl2. Then, cell viability, apoptosis, necrosis rate, and cell cycle were detected by MTT
Guoxuan Luo et al.
Journal of nanoscience and nanotechnology, 20(6), 3361-3372 (2019-11-22)
Gambogic acid (GA) is a natural compound with a polyprenylated xanthone structure that has antiinflammatory, antioxidant, and neuroprotective properties and acts as a chemopreventive agent. GA exhibits anti-tumor, antimicrobial, and anti-proliferative effects on cancer cells. In the current study, the
Wei Wang et al.
Nature communications, 13(1), 245-245 (2022-01-13)
About 15-20% of breast cancer (BCa) is triple-negative BCa (TNBC), a devastating disease with limited therapeutic options. Aberrations in the PI3K/PTEN signaling pathway are common in TNBC. However, the therapeutic impact of PI3K inhibitors in TNBC has been limited and
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
Walker EH, et al.
Molecular Cell, 6(4), 909-919 (2000)
Stephen Beesley et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(45), 28402-28411 (2020-10-28)
The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent
Ed Etxeberria et al.
American journal of botany, 94(6), 1041-1045 (2007-06-01)
We recently demonstrated the occurrence of a sucrose-enhanced, fluid-phase endocytic (FPE) mechanism of nutrient uptake in heterotrophic cells. In the present work, the possible enhancement/induction of FPE by photoassimilates other than sucrose was investigated by measuring the incorporation of the
Shijia Yu et al.
Frontiers in cellular neuroscience, 14, 193-193 (2020-08-08)
Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is
Sean L Petersen et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(26), 11936-11941 (2010-06-16)
Smac mimetics target cancer cells in a TNFalpha-dependent manner, partly via proteasome degradation of cellular inhibitor of apoptosis 1 (cIAP1) and cIAP2. Degradation of cIAPs triggers the release of receptor interacting protein kinase (RIPK1) from TNF receptor I (TNFR1) to
Christopher R Donnelly et al.
Nature, 591(7849), 275-280 (2021-01-15)
The innate immune regulator STING is a critical sensor of self- and pathogen-derived DNA. DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other cytokines, which promote immune-cell-mediated eradication of pathogens and neoplastic cells1,2. STING is
Bo Hou et al.
Cellular signalling, 75, 109744-109744 (2020-08-23)
Podocyte loss is a detrimental feature and major cause of proteinuria in diabetic nephropathy (DN). Our previous study revealed that hepatocyte growth factor (HGF) prevented high glucose-induced podocyte injury via enhancing autophagy. In the current study, we aimed to assess
Xia Wang et al.
Molecules (Basel, Switzerland), 24(13) (2019-07-03)
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is recognized as a critical regulator in physiological and pathophysiological processes of atherosclerosis (AS). However, the underlying mechanism remains unclear. As the precursor cells of endothelial cells (ECs), endothelial progenitor cells (EPCs) can prevent AS
Xiang-Jun Sheng et al.
PloS one, 12(8), e0183076-e0183076 (2017-08-15)
PTEN-induced putative kinase 1 (PINK1) is an integral protein in the mitochondrial membrane and maintains mitochondrial fidelity. Pathogenic mutations in PINK1 have been identified as a cause of early-onset autosomal recessive familial Parkinson's disease (PD). The ubiquitin proteasome pathway is
Jeewan Thapa et al.
Microbes and infection, 22(9), 441-450 (2020-05-23)
Chlamydia trachomatis LGV (CtL2) causes systemic infection and proliferates in lymph nodes as well as genital tract or rectum producing a robust inflammatory response, presumably leading to a low oxygen environment. We therefore assessed how CtL2 growth in immortal human
Oxycodone protects cardiomyocytes from ischemia-reperfusion-induced apoptosis via PI3K/Akt pathway.
Zhao, et al.
Pharmazie, 75, 430-435 (2020)
Core clock gene Bmal1 deprivation impairs steroidogenesis in mice luteinized follicle cells.
Wang, et al.
Reproduction (Cambridge, England), 160, 955-967 (2020)
Shyam S Nandi et al.
American journal of physiology. Heart and circulatory physiology, 319(6), H1414-H1437 (2020-10-17)
Increased matrix metalloprotease 9 (MMP9) after myocardial infarction (MI) exacerbates ischemia-induced chronic heart failure (CHF). Autophagy is cardioprotective during CHF; however, whether increased MMP9 suppresses autophagic activity in CHF is unknown. This study aimed to determine whether increased MMP9 suppressed
Shinichiro Fuma et al.
Biological & pharmaceutical bulletin, 39(2), 192-198 (2016-02-03)
The combination of timolol and latanoprost, which are ocular hypotensive agents, has a greater ocular hypotensive effect than each as monotherapy. However, the protective effect of the combination is not well understood. In the present study, we investigated whether latanoprost/timolol
Yanli Ma et al.
PloS one, 7(10), e47961-e47961 (2012-11-01)
Aflatoxin B1 (AFB1) is a potent carcinogen that can induce hepatocellular carcinoma. AFB1-8,9-exo-epoxide, one of AFB1 metabolites, acts as a mutagen to react with DNA and induce gene mutations, including the tumor suppressor p53. In addition, AFB1 reportedly stimulates IGF
Antonios Chronopoulos et al.
Nature materials, 19(6), 669-678 (2020-01-08)
Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical cues. We reveal here a mechanism whereby syndecan-4 tunes cell mechanics in response to localized tension via
Dong Suo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3893-3902 (2015-03-06)
Development of a functional peripheral nervous system requires axons to rapidly innervate and arborize into final target organs and then slow but not halt their growth to establish stable connections while keeping pace with organ growth. Here we examine the
Xue Yuan et al.
Cell death & disease, 10(2), 63-63 (2019-01-27)
Primary cilia and intraflagellar transport (IFT) proteins control a wide variety of processes during tissue development and homeostasis. However, their role in regulation of stem cell properties during tooth development remains elusive. Here, we revealed that dental pulp stem cells
Wei-Jian Ni et al.
Journal of diabetes investigation, 11(2), 297-306 (2019-07-25)
Amelioration of renal impairment is the key to diabetic nephropathy (DN) therapy. The progression of DN is closely related to podocyte dysfunction, but the detailed mechanism has not yet been clarified. The present study aimed to explore the renal impairment
Poonam Gupta et al.
Biochimica et biophysica acta. General subjects, 1863(3), 547-564 (2018-12-27)
Elevated endogenous phosphoinositide-3-kinase (PI3K) activity is critical for cell proliferation in gliomas. Iron availability is one of the essential factors for cell growth and proliferation. However, any relation between PI3K and cellular iron homeostasis has not been understood so far.
Christophe Glorieux et al.
Redox biology, 38, 101780-101780 (2020-11-11)
K-ras mutations are major genetic events that drive cancer development associated with aggressive malignant phenotypes, while expression of the immune checkpoint molecule PD-L1 plays a key role in cancer evasion of the immune surveillance that also profoundly affects the patient
Cheong-Yong Yun et al.
Theranostics, 10(1), 340-352 (2020-01-07)
Rationale: Microphthalmia-associated transcription factor M (MITF-M) plays important roles in the pigment production, differentiation and survival of melanocytes. Stem cell factor (SCF) and its receptor KIT stimulate MITF-M activity via phosphorylation at the post-translation level. However, the phosphorylation shortens half-life
Bin Zeng et al.
Experimental cell research, 380(2), 205-215 (2019-05-07)
Oxidative stress plays an important role in the progression of cardiac diseases, including acute myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure. Growing evidence indicates that thyroid hormone has protective properties against cardiovascular diseases. However, little is known about its
Georges E Janssens et al.
Cell reports, 27(2), 467-480 (2019-04-11)
Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of transcriptomics to predict biological age. Using age-stratified human tissue transcriptomes
Haocheng Ao et al.
Life sciences, 267, 118988-118988 (2021-01-08)
Diabetic retinopathy (DR) can cause vision loss in patients with diabetes. The present study evaluated the expression of thioredoxin interacting protein (TXNIP) and investigated the role of TXNIP in autophagy and apoptosis of DR. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR)
Qingfu Lang et al.
Acta biochimica et biophysica Sinica, 52(11), 1247-1256 (2020-11-10)
Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. The overexpression of COUP-TFII has been observed in several types of malignancies. However, its role in ICC progression remains
Jia Huang et al.
Journal of molecular and cellular cardiology, 134, 107-118 (2019-07-14)
Myocardial ischemia/reperfusion (I/R) injury is the major limitation for the cardioprotective action of revascularization after myocardial infarction. Lymphocyte adapter protein (Lnk), an adapter protein, has a regulatory role in multiple signaling pathways by functioning as a scaffold for different substrates.
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