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M V Gorbenko et al.
Biomeditsinskaia khimiia, 59(5), 541-549 (2014-02-01)
Investigation of glutathione antioxidant system activity and diene conjugates content in rats liver and blood serum at the influence of melaksen and valdoxan under experimental hyperthyroidism (EG) has been revealed. It has been established that the activities of glutathione reductase
Wei Bi et al.
Journal of medicinal chemistry, 53(18), 6763-6767 (2010-08-25)
To develop more potent therapeutic agents with therapeutic efficacy for ischemia/reperfusion (I/R) injury, we linked an antiinflammatory moiety (1,3-dioxane derivative) to the key pharmacophoric moiety of melatonin. We hypothesized that the resulting new indole derivatives might induce a synergistic protection
Perioperative melatonin: not ready for prime time.
L P H Andersen et al.
British journal of anaesthesia, 112(1), 7-8 (2013-12-10)
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Sylvie Tordjman et al.
International journal of molecular sciences, 14(10), 20508-20542 (2013-10-17)
Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin
Patricia Pablos et al.
Neuropharmacology, 99, 422-431 (2015-08-10)
Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concentration-dependently reduced subsequent
Ana Claudia Souza Palmer et al.
Frontiers in pharmacology, 10, 1382-1382 (2019-12-12)
Background: Adjuvant chemotherapy for breast cancer (ACBC) has been associated with fatigue, pain, depressive symptoms, and disturbed sleep. And, previous studies in non-cancer patients showed that melatonin could improve the descending pain modulatory system (DPMS). We tested the hypothesis that
Hongming Zhou et al.
Experimental and therapeutic medicine, 19(2), 825-832 (2020-02-06)
Neural cell apoptosis serves a key role in spinal cord injury (SCI), which is a threat to human health. The present study aimed to evaluate the neuroprotective mechanism of salvianolic acid B (Sal B) in a spinal cord injury (SCI)
Cristóbal de Los Ríos et al.
Journal of medicinal chemistry, 53(14), 5129-5143 (2010-06-26)
1,8-Naphthyridine derivatives related to 17 (ITH4012), a neuroprotective compound reported by our research group, have been synthesized. In general, they have shown better inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) than most tacrine derivatives previously synthesized in our laboratory. The
Lucio G Costa et al.
Neurotoxicology, 48, 68-76 (2015-03-24)
Polybrominated diphenyl ethers (PBDEs), used for decades as flame retardants, have become widespread environmental contaminants. Exposure is believed to occur primarily through diet and dust, and infants and toddlers have the highest body burden, raising concern for potential developmental neurotoxicity.
Yoni Baert et al.
Biofabrication, 11(3), 035011-035011 (2019-03-29)
In vitro spermatogenesis (IVS) has already been successfully achieved in rodents by organotypic and soft matrix culture systems. However, the former does not allow single cell input, and the latter presents as a simple thick layer in which all cells
Zhivko A Velkov et al.
European journal of medicinal chemistry, 44(7), 2834-2839 (2009-01-27)
Experimental and theoretical investigation of the antioxidant activity of melatonin is carried out. The theoretical approach comprises the evaluation of several appropriate descriptors of scavenging activity with the help of quantum-chemistry methods. The values obtained are compared with available data
Almudena Crooke et al.
Current eye research, 40(1), 56-65 (2014-06-04)
We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all
Yu Xi et al.
Journal of pineal research, 67(3), e12596-e12596 (2019-07-25)
Trimethyltin chloride (TMT) is a potent neurotoxin that causes neuroinflammation and neuronal cell death. Melatonin is a well-known anti-inflammatory agent with significant neuroprotective activity. Male C57BL/6J mice were intraperitoneally injected with a single dose of melatonin (10 mg/kg) before exposure to TMT (2.8 mg/kg, ip). Thereafter, the mice received
Ya-Jing Liu et al.
Neuro endocrinology letters, 34(3), 236-240 (2013-05-21)
Melatonin not only plays an important role in regulating circadian rhythms, but is also involved in antioxidative defense and immunomodulation. Circulating melatonin levels are derived primarily from the pineal gland while other sources of melatonin have also been reported. Recently
Xiaoyu Hu et al.
International immunopharmacology, 64, 101-109 (2018-09-01)
Endometritis, an inflammatory response of the uterus tissue, is characterized by the production of inflammatory cytokines and migration of neutrophil (PMN) into the uterus tissue. Melatonin has been demonstrated to have anti-inflammatory and antioxidant effects. The purpose of this study
Tobias Schmid et al.
PLoS genetics, 11(5), e1005236-e1005236 (2015-05-16)
Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are well characterized, the effect of genetic background variation on disease
Yongxiang Yu et al.
International journal of immunopathology and pharmacology, 35, 20587384211036819-20587384211036819 (2021-08-18)
Type 2 diabetes mellitus (T2DM) is commonly accompanied by obesity and non-alcoholic fatty liver disease (NAFLD), yet the mechanism underlying diabetes-related NAFLD is not fully understood. It has been reported that melatonin can regulate glucose and lipid metabolism. This study
Melatonin for sundown syndrome and delirium in dementia: is it effective?
Michiel Lammers et al.
Journal of the American Geriatrics Society, 61(6), 1045-1046 (2013-06-19)
Simone Azevedo de Zanette et al.
BMC pharmacology & toxicology, 15, 40-40 (2014-07-24)
Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in combination with amitriptyline would be superior to amitriptyline alone in modifying
Desaline Joseph et al.
Archives of disease in childhood. Fetal and neonatal edition, 100(1), F50-F54 (2014-09-24)
To investigate the emergence of biological rhythms in the first months of life in human infants, by measuring age-related changes in core body temperature during night-time sleep, hormones (cortisol and 6-sulfatoxymelatonin) and the expression of a clock-controlled gene H3f3b in
F Chen et al.
Osteoarthritis and cartilage, 28(8), 1121-1132 (2020-05-30)
This study investigated whether melatonin alleviates intervertebral disc degeneration (IVDD) by promoting autophagy through inhibiting the NF-κB signaling pathway. Magnetic resonance imaging (MRI), hematoxylin and eosin (H&E) staining and Safranin-O staining were used to measure disc degeneration in rat needle
[Experimental and clinical evidence for anticonvulsant activity of melatonin].
E B Arushanian
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(11), 111-115 (2014-01-31)
Shuxing Wang et al.
Brain research, 1288, 42-49 (2009-07-15)
Previous study has shown that administration of melatonin into the anterior cingulate cortex contralateral to peripheral nerve injury prevented exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats.
Francisco Ortiz et al.
Journal of pineal research, 58(1), 34-49 (2014-11-13)
Mucositis is a common and distressing side effect of chemotherapy or radiotherapy that has potentially severe consequences, and no treatment is available. The purpose of this study was to analyze the molecular pathways involved in the development of oral mucositis
Katie Wiggins-Dohlvik et al.
The journal of trauma and acute care surgery, 77(6), 899-905 (2014-07-23)
Burns induce systemic inflammatory reactions and vascular hyperpermeability. Breakdown of endothelial cell adherens junctions is integral in this process, and reactive oxygen species (ROS) and proteolytic enzymes such as matrix metalloproteinase-9 (MMP-9) play pivotal roles therein. Outside trauma, melatonin has
Jae-Kyo Jeong et al.
Journal of pineal research, 59(1), 24-37 (2015-03-27)
Our previous study suggested that melatonin-mediated neuroprotective effects are related with the activation of autophagy. However, the mechanism of melatonin-mediated autophagic activation in prion-mediated mitochondrial damage is not reported. Alpha-7 nicotinic acetylcholine receptors (α7nAchR) is a member of nicotinic acetylcholine
In-Sik Shin et al.
Immunobiology, 219(12), 901-908 (2014-08-28)
Asthma is a common chronic inflammatory airway disease that is recognized as a major public health problem. In this study, we evaluated the effects of melatonin on allergic asthma using a murine model of ovalbumin (OVA)-induced allergic asthma and BEAS-2B
Baitao Ma et al.
Lipids in health and disease, 19(1), 88-88 (2020-05-10)
Cigarette smoke (CS) exposure impairs serum lipid profiles and the function of vascular endothelial cells, which accelerates the atherosclerosis. However, the precise mechanism and effect on the expression of low-density lipoprotein receptor (LDLR) in the liver by CS exposure is
B D Goldman
Steroids, 64(9), 679-685 (1999-09-30)
Circadian systems in a wide variety of organisms all appear to include three basic components: 1) biological oscillators that maintain a self-sustained circadian periodicity in the absence of environmental time cues; 2) input pathways that convey environmental information, especially light
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