Search Within
M7027
Applied Filters:
Keyword:'M7027'
Showing 1-30 of 97 results for "M7027" within Papers
Daniele Ouellet et al.
Journal of pharmaceutical sciences, 102(9), 3100-3109 (2013-04-24)
Dabrafenib is a small-molecule inhibitor of BRAF kinase activity that is currently being developed for the treatment of BRAF V600 mutation-positive melanoma. This clinical, open-label, two-cohort (n = 14 per cohort), randomized study was designed to evaluate the effect of
Feng Hong et al.
Biochemistry, 52(47), 8489-8500 (2013-10-23)
During activation of smooth muscle contraction, one myosin light chain kinase (MLCK) molecule rapidly phosphorylates many smooth muscle myosin (SMM) molecules, suggesting that muscle activation rates are influenced by the kinetics of MLCK-SMM interactions. To determine the rate-limiting step underlying
Amornset Tachaprutinun et al.
International journal of pharmaceutics, 441(1-2), 801-808 (2012-12-29)
The method to prepare mucosa-plates, glass slides covalently coated with mucin, is demonstrated. The use of the plate to evaluate mucoadhesion of nanocarriers made from different four polymeric materials, N-succinylchitosan (NS-chitosan), alginate (ALG), ethylcellulose (EC), and a blend of EC
Qiuna Zhou et al.
International journal of pharmaceutics, 454(1), 125-134 (2013-07-16)
The present study aimed to prepare a chemically and physically stable formulation of baicalein (Ba) in an in situ thermally sensitive hydrogel for vaginal administration. An inclusion complex of Ba and hydroxypropyl-Ī³-cyclodextrin (HP-Ī³-CD) was first developed to increase the stability
Elizabeth R Murray et al.
Cell reports, 38(4), 110227-110227 (2022-01-27)
In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. Here, we show that the Rho effector protein kinase N2 (PKN2) is critical for PSC myofibroblast differentiation.
Zbynek SklenƔr et al.
Acta poloniae pharmaceutica, 70(4), 759-762 (2013-08-08)
Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers
Martina BajerovĆ” et al.
Acta poloniae pharmaceutica, 70(2), 271-281 (2013-04-26)
Particles preparation from biodegradable polymers as carriers for the controlled release of drugs has been the focus of many investigations and the subject of a growing field of research in recent years. The aim of this study was to develop
Ana Salgado et al.
Pharmaceutical development and technology, 19(5), 618-622 (2013-07-23)
Dermatological inflammatory diseases often affect the scalp and the eyebrows. Common dosage forms available on the market for those situations are lotions; however, the presence of hair limits their use. Gels, for their consistency and adhesiveness, are a suitable alternative
K S Sink et al.
Behavioural brain research, 243, 286-293 (2013-02-05)
Calcitonin gene-related peptide (CGRP) acting within the bed nucleus of the stria terminalis (BNST) increases anxiety as well as neural activation in anxiety-related structures, and mediates behavioral stress responses. Similar effects have been described following intra-ventricular as well as intra-BNST
Liangmei Chen et al.
Die Pharmazie, 68(10), 796-799 (2013-11-28)
The objective of this research was to develop and evaluate sustained-release matrix tablets of BKP-01-041 (tilorone derivative) based on Hypromellose (hydroxypropyl methylcellulose, HPMC) as the matrix forming polymer. The sustained-release tablets were prepared by the wet granulation method. The influence
Carmen Ferrero et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(2), 175-182 (2013-06-04)
The two main purposes of this work were: (i) to critically consider the use of thermodynamic parameters of activation for elucidating the drug release mechanism from hydroxypropyl methylcellulose (HPMC) matrices, and (ii) to examine the effect of neutral (pH 6)
Rozina Kousar et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(1), 41-45 (2013-03-08)
The objective of this study was to assess the pharmacokinetic behavior of floating hydroxypropylmethylcellulose microparticles loaded with cimetidine (FMC) prepared using the non-solvent addition coacervation technique. Based on the physico-chemical characteristics of three formulations (FMC1, FMC2 and FMC3), FMC2 having
Tomasz K Prajsnar et al.
Autophagy, 17(4), 888-902 (2020-03-17)
Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis. Although neutrophils contribute to immunity against S. aureus, multiple lines of evidence suggest that these phagocytes can provide an intracellular niche for staphylococcal dissemination.
Luiza G Tunes et al.
ACS infectious diseases, 6(5), 1121-1139 (2020-04-15)
The drugs currently used to treat leishmaniases have limitations concerning cost, efficacy, and safety, making the search for new therapeutic approaches urgent. We found that the gold(I)-derived complexes were active against L.Ā infantum and L.Ā braziliensis intracellular amastigotes with IC50 values ranging
Hisham Al-Obaidi et al.
International journal of pharmaceutics, 446(1-2), 100-105 (2013-02-16)
The role of molecular interactions in ball milled solid dispersions in determining the aqueous solubility of the poorly water-soluble drug, griseofulvin (GF) has been examined. Ball milled solid dispersions of GF and hydroxypropylmethylcellulose acetate succinate (HPMCAS) and GF and polyvinylpyrrolidone
Mohamed H Fayed et al.
Pharmaceutical development and technology, 18(5), 971-981 (2011-06-07)
The objective of this study was to evaluate the potential of Carbopol(Ā®) 71G-NF on the release of dextromethorphan hydrobromide (DM) from matrix tablets in comparison with hydroxypropyl methylcellulose (HPMC(Ā®) K15M) and Eudragit(Ā®) L100-55 polymers. Controlled release DM matrix tablets were
Paula Judith Perez Espitia et al.
Carbohydrate polymers, 94(1), 199-208 (2013-04-03)
This work aimed to develop nanocomposite films of methyl cellulose (MC) incorporated with pediocin and zinc oxide nanoparticles (nanoZnO) using the central composite design and response surface methodology. This study evaluated film physical-mechanical properties, including crystallography by X-ray diffraction, mechanical
Hakan Karaca et al.
International journal of food microbiology, 179, 72-79 (2014-04-20)
Common food preservative agents were evaluated in in vitro tests for their antifungal activity against Monilinia fructicola, the most economically important pathogen causing postharvest disease of stone fruits. Radial mycelial growth was measured in Petri dishes of PDA amended with
E Olveti et al.
Fogorvosi szemle, 85(2), 57-62 (1992-02-01)
Apparent viscosity at different shear rates was measured for two types of saliva substitutes based on methocel and CMC, and was compared with that of human whole saliva. Results indicate, that fresh mixed human saliva is viscoelastic, exhibiting pseudoplasticity. Methocel
Shrikant Harne et al.
Current biology : CB, 30(23), 4753-4762 (2020-09-26)
In most rod-shaped bacteria, the spatial coordination of cell wall synthesis machinery by MreBs is the main theme for shape determination and maintenance in cell-walled bacteria [1-9]. However, how rod or spiral shapes are achieved and maintained in cell-wall-less bacteria
Response to 'Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain'.
Vaskar Das et al.
Regional anesthesia and pain medicine, 45(3), 250-251 (2019-09-19)
Lindsay A Wegiel et al.
Pharmaceutical development and technology, 19(8), 976-986 (2013-11-07)
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydrogen bonds in the crystal. A structurally
Eyal Zur
International journal of pharmaceutical compounding, 17(1), 10-22 (2013-05-01)
Compounding pharmacists throughout the world are compounding a special type of capsule called "slow-release." This type of capsule is a compounding pharmacy application of the commercial hydrophilic matrix tablets. It is a relatively simple system that allows formulating a robust
Jumpei Kondo et al.
Gastroenterology, 149(2), 407-419 (2015-04-30)
Interstitial cells of Cajal (ICC) control intestinal smooth muscle contraction to regulate gut motility. ICC within the plane of the myenteric plexus (ICC-MY) arise from KIT-positive progenitor cells during mouse embryogenesis. However, little is known about the ontogeny of ICC
Sha Han et al.
Frontiers in pharmacology, 12, 632662-632662 (2021-03-20)
Protective strategy against hypoxic-ischemic (H/I) induced injury has been intensively discussed. Neuroserpin, an inhibitor for tissue plasminogen activator (tPA), has been proved a vital neuroprotective agent in cerebral ischemia mouse model and oxygen-glucose deprivation and reoxygenation (OGD/R) cell model. Neuroserpin
Kin Fong Lei et al.
Analytical and bioanalytical chemistry, 409(12), 3271-3277 (2017-03-08)
To predict the response of in vivo tumors, in vitro culture of cell colonies was suggested to be a standard assay to achieve high clinical relevance. To describe the responses of cell colonies, the most widely used quantification method is
Daniel Del Toro et al.
Cell, 180(2), 323-339 (2020-01-14)
Teneurins are ancient metazoan cell adhesion receptors that control brain development and neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR Latrophilin, forming a trans-cellular complex with synaptogenic functions. However, Teneurins, Latrophilins, and FLRT proteins are
Chun-Hao Huang et al.
Biomedical microdevices, 20(3), 70-70 (2018-08-11)
The use of electric field for cancer therapy has been proposed for a novel non-invasive cancer therapeutic approach that provides better quality of life for patients. However, argument of the efficacy hampers the therapeutic development for various cancer diseases. More
May S Freag et al.
International journal of pharmaceutics, 454(1), 462-471 (2013-07-09)
Scanty solubility and permeability of diosmin (DSN) are perpetrators for its poor oral absorption and high inter-subject variation. This article investigated the potential of novel DSN nanosuspensions to improve drug delivery characteristics. Bottom-up nanoprecipitation technique has been employed for nanosuspension
Pinaki Chaudhuri et al.
American journal of physiology. Cell physiology, 320(6), C943-C955 (2021-03-11)
Endothelial cell (EC) migration is critical for healing arterial injuries, such as those that occur with angioplasty. Impaired re-endothelialization following arterial injury contributes to vessel thrombogenicity, intimal hyperplasia, and restenosis. Oxidized lipid products, including lysophosphatidylcholine (lysoPC), induce canonical transient receptor
Page 1 of 4